array:24 [
  "pii" => "S1578219013000590"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.04.021"
  "estado" => "S300"
  "fechaPublicacion" => "2013-04-01"
  "aid" => "682"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:254-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1310
    "formatos" => array:3 [
      "EPUB" => 44
      "HTML" => 792
      "PDF" => 474
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0001731012003109"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.04.015"
      "estado" => "S300"
      "fechaPublicacion" => "2013-04-01"
      "aid" => "682"
      "copyright" => "Elsevier España, S.L. and AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:254-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2274
        "formatos" => array:3 [
          "EPUB" => 46
          "HTML" => 1707
          "PDF" => 521
        ]
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "New Perspectives in the Treatment of Leg Ulcers"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "254"
            "paginaFinal" => "255"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Nuevas perspectivas en el tratamiento de &#250;lceras en las piernas"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "E&#46; Godoy-Gij&#243;n, M&#46; Qiang Man, J&#46;P&#46; Thyssen, P&#46;M&#46; Elias"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Godoy-Gij&#243;n"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Qiang Man"
              ]
              2 => array:2 [
                "nombre" => "J&#46;P&#46;"
                "apellidos" => "Thyssen"
              ]
              3 => array:2 [
                "nombre" => "P&#46;M&#46;"
                "apellidos" => "Elias"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013000590"
          "doi" => "10.1016/j.adengl.2012.04.021"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000590?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003109?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000003/v1_201304241344/S0001731012003109/v1_201304241344/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013000449"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.04.019"
    "estado" => "S300"
    "fechaPublicacion" => "2013-04-01"
    "aid" => "677"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:255-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2720
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 2088
        "PDF" => 579
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Radiodermatitis with Signs of Eccrine Squamous Syringometaplasia Following a Diagnostic Procedure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "255"
          "paginaFinal" => "257"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Radiodermitis secundaria a procedimiento diagn&#243;stico con signos de siringometaplasia escamosa ecrina"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2812
              "Ancho" => 1667
              "Tamanyo" => 543800
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Hyperkeratosis and irregular acanthosis&#46; Signs of epidermal dysmaturation&#58; dyskeratotic cells&#44; with keratinocytes of altered size and polarity&#44; some of which are binucleated &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10&#41;&#46; B&#44; Eccrine duct in which areas of squamous metaplasia and a neutrophilic infiltrate can be observed inside the coil&#44; as well as a moderate perieccrine inflammatory infiltrate &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;J&#46; Concha Garz&#243;n, M&#46; Llamas-Velasco, J&#46; S&#225;nchez-P&#233;rez, J&#46; Fraga"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;J&#46;"
              "apellidos" => "Concha Garz&#243;n"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Llamas-Velasco"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "S&#225;nchez-P&#233;rez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Fraga"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012003043"
        "doi" => "10.1016/j.ad.2012.04.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003043?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000449?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000003/v1_201304241622/S1578219013000449/v1_201304241622/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013000437"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.03.025"
    "estado" => "S300"
    "fechaPublicacion" => "2013-04-01"
    "aid" => "676"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:253-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3434
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 2820
        "PDF" => 571
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Localized Cutaneous Argyria&#58; A Report of 2 Cases"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "253"
          "paginaFinal" => "254"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Argiria cut&#225;nea localizada&#46; A prop&#243;sito de 2 casos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1197
              "Ancho" => 1608
              "Tamanyo" => 195844
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and B&#44; The first patient presented several blue-gray macules on the dorsum of the fourth finger of the right hand and on the palmar surface of the fifth finger of the right hand&#46; C&#44; Dermoscopy revealed a homogeneous blue-gray pattern&#46; D&#44; The second patient presented similar lesions on the dorsum of both hands&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Garcias-Ladaria, P&#46; Hernandez-Bel, J&#46;L&#46; Torregrosa-Calatayud, A&#46; Mart&#237;nez-Aparicio"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Garcias-Ladaria"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Hernandez-Bel"
            ]
            2 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "Torregrosa-Calatayud"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;nez-Aparicio"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012003031"
        "doi" => "10.1016/j.ad.2012.03.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003031?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000437?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000003/v1_201304241622/S1578219013000437/v1_201304241622/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "New Perspectives in the Treatment of Leg Ulcers"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "254"
        "paginaFinal" => "255"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "E&#46; Godoy-Gij&#243;n, M&#46; Qiang Man, J&#46;P&#46; Thyssen, P&#46;M&#46; Elias"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "E&#46;"
            "apellidos" => "Godoy-Gij&#243;n"
            "email" => array:1 [
              0 => "e&#46;godoy&#46;gijon&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Qiang Man"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;P&#46;"
            "apellidos" => "Thyssen"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "P&#46;M&#46;"
            "apellidos" => "Elias"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de Cabue&#241;es&#44; Gij&#243;n&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Dermatology Service&#44; Veterans Affairs Medical Center&#44; and Department of Dermatology&#44; University of California&#44; San Francisco&#44; USA"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "National Allergy Research Centre&#44; Department of Dermato-Allergology&#44; Copenhagen University Hospital Gentofte&#44; Copenhagen&#44; Denmark"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Nuevas perspectivas en el tratamiento de &#250;lceras en las piernas"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">After carefully reading the comprehensive review article by Velasco<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> on the diagnosis and treatment of leg ulcers&#44; we write to comment further on a new therapeutic option referred to by that author&#46; Several studies have reported the positive effect on skin and mucosal healing of the activation of &#946;-adrenergic receptors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> as the author of the above-mentioned review points out with a reference to the work of Margolis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> However&#44; research in the field of wound healing is now focusing on the significant impact on the healing process of glucocorticoid &#40;GC&#41; activity&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The presence of high GC levels is associated with delayed cutaneous wound healing and barrier recovery after mechanical disruption&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The present group has shown the negative effect of GCs on epidermal differentiation and proliferation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Using models based on exogenous GC administration or endogenous release secondary to psychological stress&#44; several authors have demonstrated the inhibitory action of GCs on fibroblast proliferation&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In both models&#44; systemic GC blockade improved wound healing and barrier recovery&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Because of the potential complications of systemic blockade of GC activity&#44; current research on new treatments is focusing on both the blockade of GC receptors and on the activity of 11&#946;-hydroxysteroid dehydrogenase-1 &#40;11&#946;-HSD1&#41;&#44; the enzyme responsible for the peripheral conversion of cortisone to its active form cortisol&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;8&#44;9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the high levels of GC observed in diabetic patients and the recent suggestion of a possible association between GC activity and systemic complications in diabetes mellitus&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> topical treatments that block such activity would appear to be a promising therapeutic tool in wound healing&#46; The dermatological application of such topical treatments could therefore be very useful in the treatment of leg ulcers&#46; This is a field in which&#44; as Velasco has pointed out<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; dermatologists should play a greater role&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Godoy-Gij&#243;n E&#46; New Perspectives in the Treatment of Leg Ulcers&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;254&#8211;5&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aspectos diagn&#243;sticos y terap&#233;uticos de las &#250;lceras de las piernas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Velasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2011.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "paginaInicial" => "780"
                        "paginaFinal" => "790"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21890074"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;J&#46; Margolis"
                            1 => "O&#46; Hoffstad"
                            2 => "R&#46;R&#46; Isseroff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.143.10.1275"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2007"
                        "volumen" => "143"
                        "paginaInicial" => "1275"
                        "paginaFinal" => "1280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17938341"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beta-adrenergic receptor antagonists accelerate skin wound healing&#58; evidence for a catecholamine synthesis network in the epidermis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;E&#46; Pullar"
                            1 => "A&#46; Rizzo"
                            2 => "R&#46;R&#46; Isseroff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M601007200"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2006"
                        "volumen" => "281"
                        "paginaInicial" => "21225"
                        "paginaFinal" => "21235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16714291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beta-2-adrenergic receptor blockade accelerates burn wound healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;K&#46; Sivamani"
                            1 => "C&#46;E&#46; Pullar"
                            2 => "B&#46; Griffths"
                            3 => "R&#46;R&#46; Isseroff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2006"
                        "volumen" => "126"
                        "paginaInicial" => "59"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411004788"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adrenergic signaling in human oral keratinocytes and wound repair"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Steenhuis"
                            1 => "R&#46;E&#46; Huntley"
                            2 => "Z&#46; Gurenko"
                            3 => "L&#46; Yin"
                            4 => "B&#46;A&#46; Dale"
                            5 => "N&#46; Fazel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0022034510388034"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dent Res"
                        "fecha" => "2011"
                        "volumen" => "90"
                        "paginaInicial" => "186"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21127260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Vukelic"
                            1 => "O&#46; Stojadinovic"
                            2 => "I&#46; Pastar"
                            3 => "C&#46; Vouthounis"
                            4 => "A&#46; Krzyzanowska"
                            5 => "S&#46; Das"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M109.016741"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2010"
                        "volumen" => "285"
                        "paginaInicial" => "1980"
                        "paginaFinal" => "1988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19903814"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocortid blockade reverses psychological stress-induced abnormalities in epidermal structure and function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;H&#46; Choi"
                            1 => "M&#46; Demerjian"
                            2 => "D&#46; Crumrine"
                            3 => "B&#46;E&#46; Brown"
                            4 => "Mauro Th"
                            5 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpregu.00010.2006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Regul Integr Comp Physiol"
                        "fecha" => "2006"
                        "volumen" => "291"
                        "paginaInicial" => "R1657"
                        "paginaFinal" => "R1662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16857896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "11&#946;-Hydroxysteroid dehydrogenase-1 is a novel regulator of skin homeostasis and a candidate target for promoting tissue repair"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Terao"
                            1 => "H&#46; Murota"
                            2 => "A&#46; Kimura"
                            3 => "A&#46; Kato"
                            4 => "A&#46; Ishikawa"
                            5 => "K&#46; Igawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0025039"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "e25039"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21949844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid receptors&#44; epidermal homeostasis and hair follicle differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; P&#233;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatoendocrinology"
                        "fecha" => "2011"
                        "volumen" => "3"
                        "paginaInicial" => "166"
                        "paginaFinal" => "174"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939412000992"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:3 [
        "identificador" => "xack35293"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0025" class="elsevierStylePara elsevierViewall">ISDIN S&#46;A&#46; provided support as a postdoctoral fellow for Elena Godoy Gij&#243;n&#46; Mrs&#46; Joan Wakefield provided invaluable editorial assistance&#46;</p>"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000003/v1_201304241622/S1578219013000590/v1_201304241622/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000003/v1_201304241622/S1578219013000590/v1_201304241622/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000590?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
New Perspectives in the Treatment of Leg Ulcers
Nuevas perspectivas en el tratamiento de úlceras en las piernas
E. Godoy-Gijóna,
Autor para correspondencia
e.godoy.gijon@gmail.com

Corresponding author.
, M. Qiang Manb, J.P. Thyssenc, P.M. Eliasc
a Servicio de Dermatología, Hospital de Cabueñes, Gijón, Spain
b Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, USA
c National Allergy Research Centre, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Copenhagen, Denmark
Leído
4781
Veces
se ha leído el artículo
2045
Total PDF
2736
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219013000590"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.04.021"
  "estado" => "S300"
  "fechaPublicacion" => "2013-04-01"
  "aid" => "682"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:254-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1310
    "formatos" => array:3 [
      "EPUB" => 44
      "HTML" => 792
      "PDF" => 474
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0001731012003109"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.04.015"
      "estado" => "S300"
      "fechaPublicacion" => "2013-04-01"
      "aid" => "682"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:254-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2274
        "formatos" => array:3 [
          "EPUB" => 46
          "HTML" => 1707
          "PDF" => 521
        ]
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "New Perspectives in the Treatment of Leg Ulcers"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "254"
            "paginaFinal" => "255"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Nuevas perspectivas en el tratamiento de &#250;lceras en las piernas"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "E&#46; Godoy-Gij&#243;n, M&#46; Qiang Man, J&#46;P&#46; Thyssen, P&#46;M&#46; Elias"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Godoy-Gij&#243;n"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Qiang Man"
              ]
              2 => array:2 [
                "nombre" => "J&#46;P&#46;"
                "apellidos" => "Thyssen"
              ]
              3 => array:2 [
                "nombre" => "P&#46;M&#46;"
                "apellidos" => "Elias"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013000590"
          "doi" => "10.1016/j.adengl.2012.04.021"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000590?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003109?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000003/v1_201304241344/S0001731012003109/v1_201304241344/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013000449"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.04.019"
    "estado" => "S300"
    "fechaPublicacion" => "2013-04-01"
    "aid" => "677"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:255-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2720
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 2088
        "PDF" => 579
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Radiodermatitis with Signs of Eccrine Squamous Syringometaplasia Following a Diagnostic Procedure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "255"
          "paginaFinal" => "257"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Radiodermitis secundaria a procedimiento diagn&#243;stico con signos de siringometaplasia escamosa ecrina"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2812
              "Ancho" => 1667
              "Tamanyo" => 543800
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Hyperkeratosis and irregular acanthosis&#46; Signs of epidermal dysmaturation&#58; dyskeratotic cells&#44; with keratinocytes of altered size and polarity&#44; some of which are binucleated &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10&#41;&#46; B&#44; Eccrine duct in which areas of squamous metaplasia and a neutrophilic infiltrate can be observed inside the coil&#44; as well as a moderate perieccrine inflammatory infiltrate &#40;hematoxylin-eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;J&#46; Concha Garz&#243;n, M&#46; Llamas-Velasco, J&#46; S&#225;nchez-P&#233;rez, J&#46; Fraga"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;J&#46;"
              "apellidos" => "Concha Garz&#243;n"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Llamas-Velasco"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "S&#225;nchez-P&#233;rez"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Fraga"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012003043"
        "doi" => "10.1016/j.ad.2012.04.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003043?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000449?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000003/v1_201304241622/S1578219013000449/v1_201304241622/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013000437"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.03.025"
    "estado" => "S300"
    "fechaPublicacion" => "2013-04-01"
    "aid" => "676"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:253-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3434
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 2820
        "PDF" => 571
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Localized Cutaneous Argyria&#58; A Report of 2 Cases"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "253"
          "paginaFinal" => "254"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Argiria cut&#225;nea localizada&#46; A prop&#243;sito de 2 casos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1197
              "Ancho" => 1608
              "Tamanyo" => 195844
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and B&#44; The first patient presented several blue-gray macules on the dorsum of the fourth finger of the right hand and on the palmar surface of the fifth finger of the right hand&#46; C&#44; Dermoscopy revealed a homogeneous blue-gray pattern&#46; D&#44; The second patient presented similar lesions on the dorsum of both hands&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Garcias-Ladaria, P&#46; Hernandez-Bel, J&#46;L&#46; Torregrosa-Calatayud, A&#46; Mart&#237;nez-Aparicio"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Garcias-Ladaria"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Hernandez-Bel"
            ]
            2 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "Torregrosa-Calatayud"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;nez-Aparicio"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012003031"
        "doi" => "10.1016/j.ad.2012.03.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003031?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000437?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000003/v1_201304241622/S1578219013000437/v1_201304241622/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "New Perspectives in the Treatment of Leg Ulcers"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "254"
        "paginaFinal" => "255"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "E&#46; Godoy-Gij&#243;n, M&#46; Qiang Man, J&#46;P&#46; Thyssen, P&#46;M&#46; Elias"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "E&#46;"
            "apellidos" => "Godoy-Gij&#243;n"
            "email" => array:1 [
              0 => "e&#46;godoy&#46;gijon&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Qiang Man"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;P&#46;"
            "apellidos" => "Thyssen"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "P&#46;M&#46;"
            "apellidos" => "Elias"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de Cabue&#241;es&#44; Gij&#243;n&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Dermatology Service&#44; Veterans Affairs Medical Center&#44; and Department of Dermatology&#44; University of California&#44; San Francisco&#44; USA"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "National Allergy Research Centre&#44; Department of Dermato-Allergology&#44; Copenhagen University Hospital Gentofte&#44; Copenhagen&#44; Denmark"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Nuevas perspectivas en el tratamiento de &#250;lceras en las piernas"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">After carefully reading the comprehensive review article by Velasco<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> on the diagnosis and treatment of leg ulcers&#44; we write to comment further on a new therapeutic option referred to by that author&#46; Several studies have reported the positive effect on skin and mucosal healing of the activation of &#946;-adrenergic receptors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> as the author of the above-mentioned review points out with a reference to the work of Margolis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> However&#44; research in the field of wound healing is now focusing on the significant impact on the healing process of glucocorticoid &#40;GC&#41; activity&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The presence of high GC levels is associated with delayed cutaneous wound healing and barrier recovery after mechanical disruption&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The present group has shown the negative effect of GCs on epidermal differentiation and proliferation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Using models based on exogenous GC administration or endogenous release secondary to psychological stress&#44; several authors have demonstrated the inhibitory action of GCs on fibroblast proliferation&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In both models&#44; systemic GC blockade improved wound healing and barrier recovery&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Because of the potential complications of systemic blockade of GC activity&#44; current research on new treatments is focusing on both the blockade of GC receptors and on the activity of 11&#946;-hydroxysteroid dehydrogenase-1 &#40;11&#946;-HSD1&#41;&#44; the enzyme responsible for the peripheral conversion of cortisone to its active form cortisol&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;8&#44;9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the high levels of GC observed in diabetic patients and the recent suggestion of a possible association between GC activity and systemic complications in diabetes mellitus&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> topical treatments that block such activity would appear to be a promising therapeutic tool in wound healing&#46; The dermatological application of such topical treatments could therefore be very useful in the treatment of leg ulcers&#46; This is a field in which&#44; as Velasco has pointed out<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; dermatologists should play a greater role&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Godoy-Gij&#243;n E&#46; New Perspectives in the Treatment of Leg Ulcers&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;254&#8211;5&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aspectos diagn&#243;sticos y terap&#233;uticos de las &#250;lceras de las piernas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Velasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2011.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "paginaInicial" => "780"
                        "paginaFinal" => "790"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21890074"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;J&#46; Margolis"
                            1 => "O&#46; Hoffstad"
                            2 => "R&#46;R&#46; Isseroff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.143.10.1275"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2007"
                        "volumen" => "143"
                        "paginaInicial" => "1275"
                        "paginaFinal" => "1280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17938341"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beta-adrenergic receptor antagonists accelerate skin wound healing&#58; evidence for a catecholamine synthesis network in the epidermis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;E&#46; Pullar"
                            1 => "A&#46; Rizzo"
                            2 => "R&#46;R&#46; Isseroff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M601007200"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2006"
                        "volumen" => "281"
                        "paginaInicial" => "21225"
                        "paginaFinal" => "21235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16714291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beta-2-adrenergic receptor blockade accelerates burn wound healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;K&#46; Sivamani"
                            1 => "C&#46;E&#46; Pullar"
                            2 => "B&#46; Griffths"
                            3 => "R&#46;R&#46; Isseroff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2006"
                        "volumen" => "126"
                        "paginaInicial" => "59"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411004788"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adrenergic signaling in human oral keratinocytes and wound repair"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Steenhuis"
                            1 => "R&#46;E&#46; Huntley"
                            2 => "Z&#46; Gurenko"
                            3 => "L&#46; Yin"
                            4 => "B&#46;A&#46; Dale"
                            5 => "N&#46; Fazel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0022034510388034"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dent Res"
                        "fecha" => "2011"
                        "volumen" => "90"
                        "paginaInicial" => "186"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21127260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Vukelic"
                            1 => "O&#46; Stojadinovic"
                            2 => "I&#46; Pastar"
                            3 => "C&#46; Vouthounis"
                            4 => "A&#46; Krzyzanowska"
                            5 => "S&#46; Das"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M109.016741"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2010"
                        "volumen" => "285"
                        "paginaInicial" => "1980"
                        "paginaFinal" => "1988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19903814"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocortid blockade reverses psychological stress-induced abnormalities in epidermal structure and function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;H&#46; Choi"
                            1 => "M&#46; Demerjian"
                            2 => "D&#46; Crumrine"
                            3 => "B&#46;E&#46; Brown"
                            4 => "Mauro Th"
                            5 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpregu.00010.2006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Regul Integr Comp Physiol"
                        "fecha" => "2006"
                        "volumen" => "291"
                        "paginaInicial" => "R1657"
                        "paginaFinal" => "R1662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16857896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "11&#946;-Hydroxysteroid dehydrogenase-1 is a novel regulator of skin homeostasis and a candidate target for promoting tissue repair"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Terao"
                            1 => "H&#46; Murota"
                            2 => "A&#46; Kimura"
                            3 => "A&#46; Kato"
                            4 => "A&#46; Ishikawa"
                            5 => "K&#46; Igawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0025039"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "e25039"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21949844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid receptors&#44; epidermal homeostasis and hair follicle differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; P&#233;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatoendocrinology"
                        "fecha" => "2011"
                        "volumen" => "3"
                        "paginaInicial" => "166"
                        "paginaFinal" => "174"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939412000992"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:3 [
        "identificador" => "xack35293"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0025" class="elsevierStylePara elsevierViewall">ISDIN S&#46;A&#46; provided support as a postdoctoral fellow for Elena Godoy Gij&#243;n&#46; Mrs&#46; Joan Wakefield provided invaluable editorial assistance&#46;</p>"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000003/v1_201304241622/S1578219013000590/v1_201304241622/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000003/v1_201304241622/S1578219013000590/v1_201304241622/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000590?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 15 16 31
2024 Octubre 60 41 101
2024 Septiembre 57 27 84
2024 Agosto 94 39 133
2024 Julio 60 32 92
2024 Junio 57 27 84
2024 Mayo 55 26 81
2024 Abril 45 20 65
2024 Marzo 55 29 84
2024 Febrero 42 28 70
2024 Enero 42 34 76
2023 Diciembre 42 22 64
2023 Noviembre 49 21 70
2023 Octubre 54 25 79
2023 Septiembre 46 31 77
2023 Agosto 35 14 49
2023 Julio 28 31 59
2023 Junio 49 23 72
2023 Mayo 36 24 60
2023 Abril 27 23 50
2023 Marzo 17 20 37
2023 Febrero 35 21 56
2023 Enero 29 22 51
2022 Diciembre 33 34 67
2022 Noviembre 18 27 45
2022 Octubre 16 25 41
2022 Septiembre 26 37 63
2022 Agosto 16 31 47
2022 Julio 17 40 57
2022 Junio 23 23 46
2022 Mayo 21 36 57
2022 Abril 26 28 54
2022 Marzo 37 52 89
2022 Febrero 24 24 48
2022 Enero 23 30 53
2021 Diciembre 29 38 67
2021 Noviembre 29 35 64
2021 Octubre 47 62 109
2021 Septiembre 21 41 62
2021 Agosto 58 28 86
2021 Julio 28 34 62
2021 Junio 23 29 52
2021 Mayo 29 51 80
2021 Abril 52 57 109
2021 Marzo 44 19 63
2021 Febrero 38 27 65
2021 Enero 34 19 53
2020 Diciembre 20 9 29
2020 Noviembre 20 17 37
2020 Octubre 19 6 25
2020 Septiembre 26 15 41
2020 Agosto 23 16 39
2020 Julio 18 16 34
2020 Junio 17 21 38
2020 Mayo 15 9 24
2020 Abril 21 26 47
2020 Marzo 23 11 34
2020 Febrero 3 2 5
2020 Enero 0 2 2
2019 Diciembre 4 2 6
2019 Noviembre 0 1 1
2019 Octubre 0 2 2
2019 Septiembre 4 1 5
2019 Julio 0 1 1
2019 Junio 2 0 2
2019 Mayo 1 19 20
2019 Abril 0 1 1
2019 Marzo 2 7 9
2019 Enero 1 0 1
2018 Octubre 1 0 1
2018 Septiembre 2 0 2
2018 Marzo 0 2 2
2018 Febrero 16 3 19
2018 Enero 23 7 30
2017 Diciembre 23 6 29
2017 Noviembre 24 6 30
2017 Octubre 12 9 21
2017 Septiembre 16 2 18
2017 Agosto 15 5 20
2017 Julio 14 7 21
2017 Junio 23 8 31
2017 Mayo 27 6 33
2017 Abril 24 10 34
2017 Marzo 13 43 56
2017 Febrero 7 12 19
2017 Enero 9 11 20
2016 Diciembre 22 1 23
2016 Noviembre 21 6 27
2016 Octubre 25 3 28
2016 Septiembre 24 5 29
2016 Agosto 24 5 29
2016 Julio 15 2 17
2016 Junio 8 6 14
2016 Mayo 5 7 12
2016 Abril 4 5 9
2016 Marzo 3 3 6
2016 Febrero 3 2 5
2016 Enero 4 2 6
2015 Diciembre 6 0 6
2015 Noviembre 6 3 9
2015 Octubre 2 4 6
2015 Septiembre 9 3 12
2015 Agosto 6 4 10
2015 Julio 35 111 146
2015 Junio 22 13 35
2015 Mayo 36 12 48
2015 Abril 31 6 37
2015 Marzo 9 8 17
2015 Febrero 5 4 9
2015 Enero 7 3 10
2014 Diciembre 8 5 13
2014 Noviembre 2 5 7
2014 Octubre 12 8 20
2014 Septiembre 8 4 12
2014 Agosto 5 6 11
2014 Julio 8 5 13
2014 Junio 15 5 20
2014 Mayo 12 7 19
2014 Abril 15 2 17
2014 Marzo 13 5 18
2014 Febrero 20 5 25
2014 Enero 20 3 23
2013 Diciembre 15 5 20
2013 Noviembre 9 6 15
2013 Octubre 12 2 14
2013 Septiembre 7 1 8
2013 Agosto 5 1 6
2013 Julio 3 4 7
2013 Junio 2 1 3
2013 Mayo 2 1 3
2013 Abril 2 2 4
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?