array:24 [
  "pii" => "S1578219013000140"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.10.004"
  "estado" => "S300"
  "fechaPublicacion" => "2013-03-01"
  "aid" => "753"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:173-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2232
    "formatos" => array:3 [
      "EPUB" => 42
      "HTML" => 1514
      "PDF" => 676
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012004838"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.10.009"
      "estado" => "S300"
      "fechaPublicacion" => "2013-03-01"
      "aid" => "753"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:173-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5260
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3680
          "PDF" => 1578
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "173"
            "paginaFinal" => "174"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "F&#46; Urbina, E&#46; Sudy"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "Urbina"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Sudy"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013000140"
          "doi" => "10.1016/j.adengl.2012.10.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000140?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004838?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000002/v1_201304241237/S0001731012004838/v1_201304241237/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013000152"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.10.005"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "751"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:174"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1990
      "formatos" => array:3 [
        "EPUB" => 48
        "HTML" => 1360
        "PDF" => 582
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Response to&#58; &#171;Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;&#187;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "174"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "R&#233;plica a&#58; &#171;Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;&#187;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Marcoval-Caus"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Marcoval-Caus"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004814"
        "doi" => "10.1016/j.ad.2012.10.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004814?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000152?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000152/v1_201304241618/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013000139"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.02.008"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "673"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:170-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6999
      "formatos" => array:3 [
        "EPUB" => 48
        "HTML" => 5418
        "PDF" => 1533
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and research letter</span>"
      "titulo" => "Papular Acantholytic Dermatosis in the Genito-Crural Region&#58; A Localized Form of Darier Disease or Hailey-Hailey Disease&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "170"
          "paginaFinal" => "172"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1250
              "Ancho" => 1667
              "Tamanyo" => 329066
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; and focal acantholysis with suprabasal clefts&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;C&#46; Montis-Palos, E&#46; Acebo-Mari&#241;as, B&#46; Cat&#243;n-Santar&#233;n, R&#46; Soloeta-Arechavala"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;C&#46;"
              "apellidos" => "Montis-Palos"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Acebo-Mari&#241;as"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Cat&#243;n-Santar&#233;n"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Soloeta-Arechavala"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012003006"
        "doi" => "10.1016/j.ad.2012.02.017"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003006?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000139?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000139/v1_201304241618/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "173"
        "paginaFinal" => "174"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46; Urbina, E&#46; Sudy"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "F&#46;"
            "apellidos" => "Urbina"
            "email" => array:1 [
              0 => "fcourbina&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "E&#46;"
            "apellidos" => "Sudy"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Dermatologists in private practice&#44; Santiago de Chile&#44; Chile"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with interest the case and research letter by Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> regarding 2 cases of pigmented fungiform papillae of the tongue&#46; We were surprised that the letter did not mention Laugier disease &#40;or Laugier-Hunziker syndrome&#41;&#44; an entity characterized by essential cutaneous and mucosal pigmentation&#44; originally described on the lips and oral mucosa and&#44; at times&#44; associated with longitudinal melanonychia&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In 1998&#44; we reported 9 cases of Laugier disease&#44; in 1 man and 8 women&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Two of the women presented punctate pigmentation of the tongue identical to the cases reported by Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> One of these patients also had hyperpigmented lesions affecting the oral mucosa&#44; gums&#44; labia menora&#44; and nails&#46; The other presented pigmentation of the lips&#44; gums&#44; oral mucosa&#44; and lateral nail folds on some fingers&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We have found reports of other similar cases described as Laugier-Hunziker syndrome&#59; these patients presented punctate pigmentation of the lingual papillae as described by Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in association with pigmentation of the nails&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> the lower lip and the toes and fingers&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and in one case the oral mucosa&#44; the lips&#44; and the nails&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> We believe that all of these case reports&#44; including that of Marcoval et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> correspond to the same process&#8212;hyperpigmentation of unknown etiology affecting the lips&#44; oral mucosa&#44; tongue &#40;fungiform papillae&#41;&#44; nails&#44; genitals&#44; and perhaps other areas in a variety of ways&#44; in combination or alone&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">After we reported our series as Laugier disease&#44; we were criticized for omitting Hunziker from the eponymous name&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Our use of the term <span class="elsevierStyleItalic">Laugier disease</span> followed the example of French authors&#44; who preferred this name to that of <span class="elsevierStyleItalic">idiopathic pigmentation of the mucosa</span>&#44; a term that does not include the involvement of the nails&#46; Another reason for our choice was that&#44; in several published reports&#44; the process was considered to be Laugier-Hunziker syndrome only when pigmentation of the oral mucosa was associated with longitudinal melanonychia&#44; a distinction that gave rise to some confusion&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In response to the criticism&#44; we put forward our view of what the process should be called when new reports appeared of combined involvement of the oral mucosa and the nails&#44; and in the case of similar lesions affecting the genitals&#44; conjunctiva&#44; larynx&#44; or esophagus as well as other combinations of pigmentation and even isolated lesions affecting only the nails or only a mucosal membrane&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Shortly thereafter&#44; in line with our reasoning concerning variations of the earlier descriptions&#44; a report was published of a case involving the oral mucosa&#44; lip&#44; palate&#44; palm&#44; and esophagus in which the authors referred to the process as Laugier-Hunziker syndrome associated with esophageal melanocytosis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This was the first description of such a combination&#46; Histologic study of biopsy specimens showed acanthosis and basal pigmentation in the esophagus&#44; on the lip and on the palms&#46; Three years earlier&#44; a case had been reported of a patient with pigmented lesions on the lips and oral mucosa associated with pigmentation of several fingers&#44; the eyebrows&#44; and the heels&#46; The title of that article described the case as Laugier-Hunziker syndrome with atypical features and the authors reported that they had considered the possibility of Peutz-Jeghers syndrome&#44; albeit incomplete because of the absence of intestinal polyposis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In summary&#44; several different idiopathic pigmentation disorders of the skin&#44; nails&#44; oral mucosa&#44; and genitals exist&#44; and a variety of names have been used to denominate them&#46; Because of the large number of names used&#44; all probably referring to the same entity&#44; we approve of the proposal by Seoane et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> that this condition be called <span class="elsevierStyleItalic">essential mucocutaneous hyperpigmentation&#46;</span> However&#44; as this term encompasses the idea of concurrent involvement of the skin and mucous membranes&#44; which&#8212;as we have shown&#8212;is extremely variable&#44; we consider that the designation should be <span class="elsevierStyleItalic">essential cutaneous and&#47;or mucosal hyperpigmentation</span> or even <span class="elsevierStyleItalic">essential melanin pigmentation of the skin&#44; mucous membranes&#44; or nails</span>&#46; This last designation reflects the melanocytic origin of the condition and the variable involvement in a more detailed and well-defined way&#59; it could also be rendered simply as <span class="elsevierStyleItalic">essential melanin pigmentation</span> &#40;of Laugier-Hunziker if you will&#41;&#44; a name that would do justice to the initial description&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The condition is not as rare as it was thought and we believe that its incidence is influenced by a certain racial predisposition in which some unknown factor triggers the appearance of lesions by way of an increase in the synthesis of melanosomes&#44; with idiosyncratic involvement of a variety of sites which&#44; for unknown reasons&#44; are more susceptible to this condition and vary from case to case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The principal histologic features are hyperpigmentation of the basal layer without increased melanocytes&#44; associated with acanthosis and the presence of melanophages&#44; and a variable chronic inflammatory infiltrate in the dermis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">As this is not a disease or a syndrome&#44; to facilitate naming the entity&#44; some form of eponym will probably come to predominate over the long term&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Urbina F&#44; Sudy E&#46; Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;173-4&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales&#46; A prop&#243;sito de dos casos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Marcoval"
                            1 => "J&#46; Notario"
                            2 => "S&#46; Mart&#237;n-Sala"
                            3 => "I&#46; Figueras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2011.01.012"
                      "Revista" => array:7 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "numero" => "9"
                        "paginaInicial" => "739"
                        "paginaFinal" => "740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21641566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentation m&#233;lanique lenticulaire essentielle de la muqueuse jugale et des levres"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Laugier"
                            1 => "N&#46; Hunziker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Belg Dermatol Syph"
                        "fecha" => "1970"
                        "volumen" => "26"
                        "paginaInicial" => "391"
                        "paginaFinal" => "399"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enfermedad de Laugier"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Urbina"
                            1 => "E&#46; Sudy"
                            2 => "C&#46; Misad"
                            3 => "R&#46; Sandoval"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Piel"
                        "fecha" => "1998"
                        "volumen" => "13"
                        "numero" => "7"
                        "paginaInicial" => "333"
                        "paginaFinal" => "338"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laugier Hunziker syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Jabbari"
                            1 => "M&#46;E&#46; Gonz&#225;lez"
                            2 => "A&#46;G&#46; Franks Jr&#46;"
                            3 => "M&#46; S&#225;nchez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "numero" => "11"
                        "paginaInicial" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21163174"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laugier-Hunziker syndrome&#58; A rare cause of oral and acral pigmentation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Sachdeva"
                            1 => "S&#46; Sachdeva"
                            2 => "P&#46; Kapoor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0974-2077.79199"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Aesthet Surg"
                        "fecha" => "2011"
                        "volumen" => "4"
                        "numero" => "1"
                        "paginaInicial" => "58"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21572687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyperpigmentation in Laugier-Hunziker syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;L&#46; Ma"
                            1 => "S&#46; Vano-Galv&#225;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1503/cmaj.110211"
                      "Revista" => array:6 [
                        "tituloSerie" => "CMAJ"
                        "fecha" => "2011"
                        "volumen" => "183"
                        "numero" => "12"
                        "paginaInicial" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21825050"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentaci&#243;n cut&#225;neomucosa esencial adquirida"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Seoane"
                            1 => "J&#46; V&#225;zquez"
                            2 => "P&#46;I&#46; Varela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "numero" => "6"
                        "paginaInicial" => "328"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Enfermedad de Laugier o Laugier-Hunziker&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Urbina"
                            1 => "E&#46; Sudy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "numero" => "6"
                        "paginaInicial" => "328"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Laugier-Hunziker syndrome associated with esophageal melanocytosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Yamamoto"
                            1 => "K&#46; Yoshinaga"
                            2 => "M&#46; Asahi"
                            3 => "I&#46; Murata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "18227"
                      "Revista" => array:7 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "1999"
                        "volumen" => "199"
                        "numero" => "2"
                        "paginaInicial" => "162"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10559586"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Idiopathic lenticular mucocutaneous pigmentation of Laugier-Hunziker with atypical features"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;W&#46; Gerbig"
                            1 => "T&#46; Hunziker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1996"
                        "volumen" => "132"
                        "paginaInicial" => "844"
                        "paginaFinal" => "845"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8678590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laugier-Hunziker syndrome&#46; A clinical and anatomopathological study&#46; Presentation of 13 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Seoane"
                            1 => "J&#46; V&#225;zquez"
                            2 => "A&#46;M&#46; Casenave"
                            3 => "A&#46; De la Cruz"
                            4 => "A&#46; Aguado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Stomatol Chir Maxillofac"
                        "fecha" => "1998"
                        "volumen" => "99"
                        "numero" => "1"
                        "paginaInicial" => "44"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9615354"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000140/v1_201304241618/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6208"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000002/v1_201304241618/S1578219013000140/v1_201304241618/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000140?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Letter to the Editor
Pigmented Fungiform Papillae of the Tongue in Laugier Disease (or Laugier-Hunziker Syndrome)
Pigmentación de las papilas fungiformes linguales en la enfermedad de Laugier (o síndrome de Laugier-Hunziker)
F. Urbina
Autor para correspondencia
fcourbina@hotmail.com

Corresponding author.
, E. Sudy
Dermatologists in private practice, Santiago de Chile, Chile
Leído
6542
Veces
se ha leído el artículo
2346
Total PDF
4196
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219013000140"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.10.004"
  "estado" => "S300"
  "fechaPublicacion" => "2013-03-01"
  "aid" => "753"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:173-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2232
    "formatos" => array:3 [
      "EPUB" => 42
      "HTML" => 1514
      "PDF" => 676
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012004838"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.10.009"
      "estado" => "S300"
      "fechaPublicacion" => "2013-03-01"
      "aid" => "753"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:173-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5260
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 3680
          "PDF" => 1578
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "173"
            "paginaFinal" => "174"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "F&#46; Urbina, E&#46; Sudy"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "Urbina"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Sudy"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013000140"
          "doi" => "10.1016/j.adengl.2012.10.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000140?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004838?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000002/v1_201304241237/S0001731012004838/v1_201304241237/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013000152"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.10.005"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "751"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:174"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1990
      "formatos" => array:3 [
        "EPUB" => 48
        "HTML" => 1360
        "PDF" => 582
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Response to&#58; &#171;Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;&#187;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "174"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "R&#233;plica a&#58; &#171;Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;&#187;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Marcoval-Caus"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Marcoval-Caus"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004814"
        "doi" => "10.1016/j.ad.2012.10.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004814?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000152?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000152/v1_201304241618/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013000139"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.02.008"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "673"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:170-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6999
      "formatos" => array:3 [
        "EPUB" => 48
        "HTML" => 5418
        "PDF" => 1533
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and research letter</span>"
      "titulo" => "Papular Acantholytic Dermatosis in the Genito-Crural Region&#58; A Localized Form of Darier Disease or Hailey-Hailey Disease&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "170"
          "paginaFinal" => "172"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1250
              "Ancho" => 1667
              "Tamanyo" => 329066
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; and focal acantholysis with suprabasal clefts&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;C&#46; Montis-Palos, E&#46; Acebo-Mari&#241;as, B&#46; Cat&#243;n-Santar&#233;n, R&#46; Soloeta-Arechavala"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;C&#46;"
              "apellidos" => "Montis-Palos"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Acebo-Mari&#241;as"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Cat&#243;n-Santar&#233;n"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Soloeta-Arechavala"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012003006"
        "doi" => "10.1016/j.ad.2012.02.017"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003006?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000139?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000139/v1_201304241618/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "173"
        "paginaFinal" => "174"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46; Urbina, E&#46; Sudy"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "F&#46;"
            "apellidos" => "Urbina"
            "email" => array:1 [
              0 => "fcourbina&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "E&#46;"
            "apellidos" => "Sudy"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Dermatologists in private practice&#44; Santiago de Chile&#44; Chile"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with interest the case and research letter by Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> regarding 2 cases of pigmented fungiform papillae of the tongue&#46; We were surprised that the letter did not mention Laugier disease &#40;or Laugier-Hunziker syndrome&#41;&#44; an entity characterized by essential cutaneous and mucosal pigmentation&#44; originally described on the lips and oral mucosa and&#44; at times&#44; associated with longitudinal melanonychia&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In 1998&#44; we reported 9 cases of Laugier disease&#44; in 1 man and 8 women&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Two of the women presented punctate pigmentation of the tongue identical to the cases reported by Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> One of these patients also had hyperpigmented lesions affecting the oral mucosa&#44; gums&#44; labia menora&#44; and nails&#46; The other presented pigmentation of the lips&#44; gums&#44; oral mucosa&#44; and lateral nail folds on some fingers&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We have found reports of other similar cases described as Laugier-Hunziker syndrome&#59; these patients presented punctate pigmentation of the lingual papillae as described by Marcoval et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in association with pigmentation of the nails&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> the lower lip and the toes and fingers&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and in one case the oral mucosa&#44; the lips&#44; and the nails&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> We believe that all of these case reports&#44; including that of Marcoval et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> correspond to the same process&#8212;hyperpigmentation of unknown etiology affecting the lips&#44; oral mucosa&#44; tongue &#40;fungiform papillae&#41;&#44; nails&#44; genitals&#44; and perhaps other areas in a variety of ways&#44; in combination or alone&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">After we reported our series as Laugier disease&#44; we were criticized for omitting Hunziker from the eponymous name&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Our use of the term <span class="elsevierStyleItalic">Laugier disease</span> followed the example of French authors&#44; who preferred this name to that of <span class="elsevierStyleItalic">idiopathic pigmentation of the mucosa</span>&#44; a term that does not include the involvement of the nails&#46; Another reason for our choice was that&#44; in several published reports&#44; the process was considered to be Laugier-Hunziker syndrome only when pigmentation of the oral mucosa was associated with longitudinal melanonychia&#44; a distinction that gave rise to some confusion&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In response to the criticism&#44; we put forward our view of what the process should be called when new reports appeared of combined involvement of the oral mucosa and the nails&#44; and in the case of similar lesions affecting the genitals&#44; conjunctiva&#44; larynx&#44; or esophagus as well as other combinations of pigmentation and even isolated lesions affecting only the nails or only a mucosal membrane&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Shortly thereafter&#44; in line with our reasoning concerning variations of the earlier descriptions&#44; a report was published of a case involving the oral mucosa&#44; lip&#44; palate&#44; palm&#44; and esophagus in which the authors referred to the process as Laugier-Hunziker syndrome associated with esophageal melanocytosis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This was the first description of such a combination&#46; Histologic study of biopsy specimens showed acanthosis and basal pigmentation in the esophagus&#44; on the lip and on the palms&#46; Three years earlier&#44; a case had been reported of a patient with pigmented lesions on the lips and oral mucosa associated with pigmentation of several fingers&#44; the eyebrows&#44; and the heels&#46; The title of that article described the case as Laugier-Hunziker syndrome with atypical features and the authors reported that they had considered the possibility of Peutz-Jeghers syndrome&#44; albeit incomplete because of the absence of intestinal polyposis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In summary&#44; several different idiopathic pigmentation disorders of the skin&#44; nails&#44; oral mucosa&#44; and genitals exist&#44; and a variety of names have been used to denominate them&#46; Because of the large number of names used&#44; all probably referring to the same entity&#44; we approve of the proposal by Seoane et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> that this condition be called <span class="elsevierStyleItalic">essential mucocutaneous hyperpigmentation&#46;</span> However&#44; as this term encompasses the idea of concurrent involvement of the skin and mucous membranes&#44; which&#8212;as we have shown&#8212;is extremely variable&#44; we consider that the designation should be <span class="elsevierStyleItalic">essential cutaneous and&#47;or mucosal hyperpigmentation</span> or even <span class="elsevierStyleItalic">essential melanin pigmentation of the skin&#44; mucous membranes&#44; or nails</span>&#46; This last designation reflects the melanocytic origin of the condition and the variable involvement in a more detailed and well-defined way&#59; it could also be rendered simply as <span class="elsevierStyleItalic">essential melanin pigmentation</span> &#40;of Laugier-Hunziker if you will&#41;&#44; a name that would do justice to the initial description&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The condition is not as rare as it was thought and we believe that its incidence is influenced by a certain racial predisposition in which some unknown factor triggers the appearance of lesions by way of an increase in the synthesis of melanosomes&#44; with idiosyncratic involvement of a variety of sites which&#44; for unknown reasons&#44; are more susceptible to this condition and vary from case to case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The principal histologic features are hyperpigmentation of the basal layer without increased melanocytes&#44; associated with acanthosis and the presence of melanophages&#44; and a variable chronic inflammatory infiltrate in the dermis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">As this is not a disease or a syndrome&#44; to facilitate naming the entity&#44; some form of eponym will probably come to predominate over the long term&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Urbina F&#44; Sudy E&#46; Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;173-4&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales&#46; A prop&#243;sito de dos casos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Marcoval"
                            1 => "J&#46; Notario"
                            2 => "S&#46; Mart&#237;n-Sala"
                            3 => "I&#46; Figueras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2011.01.012"
                      "Revista" => array:7 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "numero" => "9"
                        "paginaInicial" => "739"
                        "paginaFinal" => "740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21641566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentation m&#233;lanique lenticulaire essentielle de la muqueuse jugale et des levres"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Laugier"
                            1 => "N&#46; Hunziker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Belg Dermatol Syph"
                        "fecha" => "1970"
                        "volumen" => "26"
                        "paginaInicial" => "391"
                        "paginaFinal" => "399"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enfermedad de Laugier"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Urbina"
                            1 => "E&#46; Sudy"
                            2 => "C&#46; Misad"
                            3 => "R&#46; Sandoval"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Piel"
                        "fecha" => "1998"
                        "volumen" => "13"
                        "numero" => "7"
                        "paginaInicial" => "333"
                        "paginaFinal" => "338"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laugier Hunziker syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Jabbari"
                            1 => "M&#46;E&#46; Gonz&#225;lez"
                            2 => "A&#46;G&#46; Franks Jr&#46;"
                            3 => "M&#46; S&#225;nchez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "numero" => "11"
                        "paginaInicial" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21163174"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laugier-Hunziker syndrome&#58; A rare cause of oral and acral pigmentation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Sachdeva"
                            1 => "S&#46; Sachdeva"
                            2 => "P&#46; Kapoor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0974-2077.79199"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Aesthet Surg"
                        "fecha" => "2011"
                        "volumen" => "4"
                        "numero" => "1"
                        "paginaInicial" => "58"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21572687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyperpigmentation in Laugier-Hunziker syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;L&#46; Ma"
                            1 => "S&#46; Vano-Galv&#225;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1503/cmaj.110211"
                      "Revista" => array:6 [
                        "tituloSerie" => "CMAJ"
                        "fecha" => "2011"
                        "volumen" => "183"
                        "numero" => "12"
                        "paginaInicial" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21825050"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentaci&#243;n cut&#225;neomucosa esencial adquirida"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Seoane"
                            1 => "J&#46; V&#225;zquez"
                            2 => "P&#46;I&#46; Varela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "numero" => "6"
                        "paginaInicial" => "328"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Enfermedad de Laugier o Laugier-Hunziker&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Urbina"
                            1 => "E&#46; Sudy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "numero" => "6"
                        "paginaInicial" => "328"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Laugier-Hunziker syndrome associated with esophageal melanocytosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Yamamoto"
                            1 => "K&#46; Yoshinaga"
                            2 => "M&#46; Asahi"
                            3 => "I&#46; Murata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "18227"
                      "Revista" => array:7 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "1999"
                        "volumen" => "199"
                        "numero" => "2"
                        "paginaInicial" => "162"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10559586"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Idiopathic lenticular mucocutaneous pigmentation of Laugier-Hunziker with atypical features"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;W&#46; Gerbig"
                            1 => "T&#46; Hunziker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1996"
                        "volumen" => "132"
                        "paginaInicial" => "844"
                        "paginaFinal" => "845"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8678590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laugier-Hunziker syndrome&#46; A clinical and anatomopathological study&#46; Presentation of 13 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Seoane"
                            1 => "J&#46; V&#225;zquez"
                            2 => "A&#46;M&#46; Casenave"
                            3 => "A&#46; De la Cruz"
                            4 => "A&#46; Aguado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Stomatol Chir Maxillofac"
                        "fecha" => "1998"
                        "volumen" => "99"
                        "numero" => "1"
                        "paginaInicial" => "44"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9615354"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000140/v1_201304241618/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6208"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000002/v1_201304241618/S1578219013000140/v1_201304241618/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000140?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 15 10 25
2024 Octubre 76 40 116
2024 Septiembre 89 25 114
2024 Agosto 103 59 162
2024 Julio 86 37 123
2024 Junio 97 28 125
2024 Mayo 61 37 98
2024 Abril 64 20 84
2024 Marzo 64 31 95
2024 Febrero 40 29 69
2024 Enero 38 35 73
2023 Diciembre 53 18 71
2023 Noviembre 59 31 90
2023 Octubre 63 22 85
2023 Septiembre 65 22 87
2023 Agosto 48 19 67
2023 Julio 53 31 84
2023 Junio 85 30 115
2023 Mayo 67 28 95
2023 Abril 40 27 67
2023 Marzo 43 39 82
2023 Febrero 37 15 52
2023 Enero 35 33 68
2022 Diciembre 47 33 80
2022 Noviembre 23 23 46
2022 Octubre 26 32 58
2022 Septiembre 17 32 49
2022 Agosto 24 26 50
2022 Julio 23 39 62
2022 Junio 26 30 56
2022 Mayo 36 39 75
2022 Abril 39 22 61
2022 Marzo 41 41 82
2022 Febrero 36 31 67
2022 Enero 21 31 52
2021 Diciembre 25 48 73
2021 Noviembre 38 49 87
2021 Octubre 34 42 76
2021 Septiembre 35 40 75
2021 Agosto 39 35 74
2021 Julio 40 29 69
2021 Junio 29 25 54
2021 Mayo 43 31 74
2021 Abril 95 65 160
2021 Marzo 70 25 95
2021 Febrero 83 22 105
2021 Enero 58 28 86
2020 Diciembre 26 21 47
2020 Noviembre 35 18 53
2020 Octubre 34 8 42
2020 Septiembre 35 4 39
2020 Agosto 45 24 69
2020 Julio 26 9 35
2020 Junio 46 25 71
2020 Mayo 36 16 52
2020 Abril 27 32 59
2020 Marzo 35 21 56
2020 Febrero 9 10 19
2020 Enero 0 7 7
2019 Diciembre 4 0 4
2019 Septiembre 4 0 4
2019 Julio 0 9 9
2019 Junio 2 12 14
2019 Mayo 1 27 28
2019 Abril 0 6 6
2019 Marzo 2 8 10
2019 Febrero 0 4 4
2019 Enero 1 0 1
2018 Diciembre 3 2 5
2018 Noviembre 2 0 2
2018 Octubre 2 2 4
2018 Septiembre 2 0 2
2018 Marzo 10 2 12
2018 Febrero 27 4 31
2018 Enero 28 5 33
2017 Diciembre 22 6 28
2017 Noviembre 33 8 41
2017 Octubre 28 4 32
2017 Septiembre 31 10 41
2017 Agosto 57 22 79
2017 Julio 66 9 75
2017 Junio 36 27 63
2017 Mayo 33 8 41
2017 Abril 34 15 49
2017 Marzo 20 24 44
2017 Febrero 28 9 37
2017 Enero 16 9 25
2016 Diciembre 33 12 45
2016 Noviembre 36 10 46
2016 Octubre 47 26 73
2016 Septiembre 46 17 63
2016 Agosto 45 20 65
2016 Julio 29 4 33
2016 Junio 12 16 28
2016 Mayo 6 10 16
2016 Abril 3 3 6
2016 Marzo 8 1 9
2016 Febrero 4 12 16
2016 Enero 8 1 9
2015 Diciembre 13 3 16
2015 Noviembre 16 9 25
2015 Octubre 11 2 13
2015 Septiembre 4 2 6
2015 Agosto 9 4 13
2015 Julio 51 13 64
2015 Junio 52 7 59
2015 Mayo 75 14 89
2015 Abril 57 10 67
2015 Marzo 50 9 59
2015 Febrero 16 11 27
2015 Enero 22 5 27
2014 Diciembre 20 9 29
2014 Noviembre 9 5 14
2014 Octubre 27 3 30
2014 Septiembre 10 6 16
2014 Agosto 15 4 19
2014 Julio 24 6 30
2014 Junio 39 4 43
2014 Mayo 28 8 36
2014 Abril 31 6 37
2014 Marzo 30 9 39
2014 Febrero 18 10 28
2014 Enero 24 9 33
2013 Diciembre 33 7 40
2013 Noviembre 15 6 21
2013 Octubre 8 5 13
2013 Septiembre 6 7 13
2013 Agosto 3 10 13
2013 Julio 5 23 28
2013 Junio 4 21 25
2013 Mayo 3 17 20
2013 Abril 7 32 39
2013 Marzo 9 7 16
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?