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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We appreciate the comments made by Garc&#237;a-Gav&#237;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> concerning the article &#8220;Products for Hand Hygiene and Antisepsis&#58; Use by Health Professionals and Relationship With Hand Eczema&#46;&#8221;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The focus of the article in question was skin irritation in health care professionals caused by hygiene and antisepsis products&#44; particularly alcohol-based sanitizers&#46; Skin irritation is one of the main reasons for the scant use of these products in clinical practice&#46; Alcohol-based hand rubs are better tolerated by the skin than soap and water&#44; and the guidelines of the Centers for Disease Control and Prevention and the World Health Organization clearly recommend the use of these products over traditional handwashing&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">It has been reported previously<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> that such irritation may be erroneously diagnosed by health professionals as an allergic reaction&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a> That said&#44; this does not mean that these products can never cause true allergies&#46; Cases have been reported of allergic contact dermatitis associated with alcohol-based products&#46; In addition to the published cases of allergy to isopropanol&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> there have also been reports of allergic contact dermatitis caused by ethanol&#44; 1-propanol&#44; and 2-propanol&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> However&#44; given the large number of people using alcohol-based rubs today&#44; the incidence of such allergies&#44; while certainly not negligible and potentially considerable&#44; is low&#44; and in most cases the allergy is caused by impurities&#44; contaminants&#44; or additives&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;5&#44;8</span></a> Therefore&#44; the possibility that a user may develop an allergy should not be an obstacle to recommending the use of these products&#46; For example&#44; in a study of 50 nurses who reported erythema&#44; desquamation&#44; blistering&#44; itching&#44; or stinging after using alcohol-based products&#44; none had a positive reaction to ethanol&#44; 1-propanol&#44; or 2-propanol on patch testing&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> When&#44; in the same study&#44; the nurses underwent patch testing with the products they were using at the workplace&#44; only 3 exhibited a mild positive reaction after application of 2 of the products &#40;Desmanol and Sterillium&#41;&#46; When the components of these products were tested separately in 2 of these patients&#44; a positive reaction was observed to the cetearyl octanoate in Desmanol and no reactions were seen at 72<span class="elsevierStyleHsp" style=""></span>hours in the case of the components of Sterillium&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Moreover&#44; we should not forget that the most common causes of allergic contact dermatitis in health care professionals are the substances found in gloves&#44; such as latex&#44; rubber&#44; and starch&#44; or the ingredients in antiseptic soaps&#44; including glutaraldehyde&#44; formaldehyde&#44; and glyoxal&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">As indicated in the management algorithm in our article on this topic&#44; irritant contact dermatitis favors the development of allergic contact dermatitis&#46; Thus&#44; reducing irritation and preserving the integrity of the skin barrier will reduce the risk of sensitization&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">We agree entirely that when there is a temporal relationship in the case of lesions that are persistent or are exacerbated by the use of alcohol-based products&#44; patch tests should be performed to rule out the possibility of an allergy to the alcohol component of the product used or the additives it contains&#46; As Garc&#237;a-Gav&#237;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> point out&#44; the repeated open application test is a quick&#44; practical&#44; and economical alternative diagnostic method&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; we believe that the possibility that certain patients may develop allergic contact dermatitis to alcohol-based products should not distract from the main message of our article<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#58; hygiene is mandatory in health care and the use of alcohol-based sanitizers causes less irritation than handwashing with soap and water&#46; Moreover&#44; irritation should not be considered a limiting factor in the use of such products&#46;</p></span>"
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Letter to the Editor
Response to: «Hand Eczema Due to Hygiene and Antisepsis Products: Not Only an Irritative Etiology»
Réplica a: « Productos de higiene, antisepsia y eccema de manos: no solo etiología irritativa»
A. Batalla
Autor para correspondencia
anacebey@yahoo.es

Corresponding author.
, I. García-Doval
Servicio de Dermatología, Complejo Hospitalario de Pontevedra, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We appreciate the comments made by Garc&#237;a-Gav&#237;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> concerning the article &#8220;Products for Hand Hygiene and Antisepsis&#58; Use by Health Professionals and Relationship With Hand Eczema&#46;&#8221;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The focus of the article in question was skin irritation in health care professionals caused by hygiene and antisepsis products&#44; particularly alcohol-based sanitizers&#46; Skin irritation is one of the main reasons for the scant use of these products in clinical practice&#46; Alcohol-based hand rubs are better tolerated by the skin than soap and water&#44; and the guidelines of the Centers for Disease Control and Prevention and the World Health Organization clearly recommend the use of these products over traditional handwashing&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">It has been reported previously<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> that such irritation may be erroneously diagnosed by health professionals as an allergic reaction&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a> That said&#44; this does not mean that these products can never cause true allergies&#46; Cases have been reported of allergic contact dermatitis associated with alcohol-based products&#46; In addition to the published cases of allergy to isopropanol&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> there have also been reports of allergic contact dermatitis caused by ethanol&#44; 1-propanol&#44; and 2-propanol&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> However&#44; given the large number of people using alcohol-based rubs today&#44; the incidence of such allergies&#44; while certainly not negligible and potentially considerable&#44; is low&#44; and in most cases the allergy is caused by impurities&#44; contaminants&#44; or additives&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;5&#44;8</span></a> Therefore&#44; the possibility that a user may develop an allergy should not be an obstacle to recommending the use of these products&#46; For example&#44; in a study of 50 nurses who reported erythema&#44; desquamation&#44; blistering&#44; itching&#44; or stinging after using alcohol-based products&#44; none had a positive reaction to ethanol&#44; 1-propanol&#44; or 2-propanol on patch testing&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> When&#44; in the same study&#44; the nurses underwent patch testing with the products they were using at the workplace&#44; only 3 exhibited a mild positive reaction after application of 2 of the products &#40;Desmanol and Sterillium&#41;&#46; When the components of these products were tested separately in 2 of these patients&#44; a positive reaction was observed to the cetearyl octanoate in Desmanol and no reactions were seen at 72<span class="elsevierStyleHsp" style=""></span>hours in the case of the components of Sterillium&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Moreover&#44; we should not forget that the most common causes of allergic contact dermatitis in health care professionals are the substances found in gloves&#44; such as latex&#44; rubber&#44; and starch&#44; or the ingredients in antiseptic soaps&#44; including glutaraldehyde&#44; formaldehyde&#44; and glyoxal&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">As indicated in the management algorithm in our article on this topic&#44; irritant contact dermatitis favors the development of allergic contact dermatitis&#46; Thus&#44; reducing irritation and preserving the integrity of the skin barrier will reduce the risk of sensitization&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">We agree entirely that when there is a temporal relationship in the case of lesions that are persistent or are exacerbated by the use of alcohol-based products&#44; patch tests should be performed to rule out the possibility of an allergy to the alcohol component of the product used or the additives it contains&#46; As Garc&#237;a-Gav&#237;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> point out&#44; the repeated open application test is a quick&#44; practical&#44; and economical alternative diagnostic method&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; we believe that the possibility that certain patients may develop allergic contact dermatitis to alcohol-based products should not distract from the main message of our article<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#58; hygiene is mandatory in health care and the use of alcohol-based sanitizers causes less irritation than handwashing with soap and water&#46; Moreover&#44; irritation should not be considered a limiting factor in the use of such products&#46;</p></span>"
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