array:24 [
  "pii" => "S1578219012002806"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.07.010"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "aid" => "532"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2012;103:820-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5136
    "formatos" => array:3 [
      "EPUB" => 41
      "HTML" => 4246
      "PDF" => 849
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011005254"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.07.018"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "aid" => "532"
      "copyright" => "Elsevier España, S.L. and AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2012;103:820-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5237
        "formatos" => array:3 [
          "EPUB" => 1
          "HTML" => 4101
          "PDF" => 1135
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "&#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "820"
            "paginaFinal" => "823"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Perianal Ulcers on a Segmental Hemangioma With Minimal or Arrested Growth"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 826
                "Ancho" => 1300
                "Tamanyo" => 391644
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">a&#41; H-E 10 x&#46; A nivel de la dermis superficial se observa proliferaci&#243;n de vasos con endotelios prominentes&#46; b&#41; Inmunomarcaci&#243;n&#58; c&#233;lulas endoteliales positivas para GLUT-1&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Lanoel, V&#46; Tosi, M&#46; Bocian, F&#46; Lubieniecki, S&#46;B&#46; Poblete, H&#46;O&#46; Garc&#237;a, A&#46;M&#46; Pierini"
            "autores" => array:7 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Lanoel"
              ]
              1 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Tosi"
              ]
              2 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Bocian"
              ]
              3 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "Lubieniecki"
              ]
              4 => array:2 [
                "nombre" => "S&#46;B&#46;"
                "apellidos" => "Poblete"
              ]
              5 => array:2 [
                "nombre" => "H&#46;O&#46;"
                "apellidos" => "Garc&#237;a"
              ]
              6 => array:2 [
                "nombre" => "A&#46;M&#46;"
                "apellidos" => "Pierini"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219012002806"
          "doi" => "10.1016/j.adengl.2011.07.010"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002806?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005254?idApp=UINPBA000044"
      "url" => "/00017310/0000010300000009/v1_201304241717/S0001731011005254/v1_201304241717/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012002818"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.020"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "610"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:825-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3183
      "formatos" => array:3 [
        "EPUB" => 46
        "HTML" => 2476
        "PDF" => 661
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
      "titulo" => "Violaceous Papules on the Dorsum of the Hand"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "825"
          "paginaFinal" => "826"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "P&#225;pulas viol&#225;ceas en el dorso de la mano"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 706
              "Ancho" => 951
              "Tamanyo" => 124618
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "B&#46; Garc&#237;a-Garc&#237;a, L&#46; Palacios-Garc&#237;a, B&#46; Vivanco-Allende"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Garc&#237;a-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Palacios-Garc&#237;a"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Vivanco-Allende"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012001858"
        "doi" => "10.1016/j.ad.2012.01.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001858?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002818?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002818/v1_201304241357/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S157821901200279X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.06.004"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "520"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2012;103:816-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5382
      "formatos" => array:3 [
        "EPUB" => 45
        "HTML" => 4232
        "PDF" => 1105
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Bullous Hemorrhagic Dermatosis at Distant Sites&#58; A Report of 2 New Cases Due to Enoxaparin Injection and a Review of the Literature"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "816"
          "paginaFinal" => "819"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1425
              "Ancho" => 1587
              "Tamanyo" => 173600
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Multiple noninflammatory hemorrhagic vesicles in the right malar region&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46;A&#46; Villanueva, L&#46; N&#225;jera, P&#46; Espinosa, J&#46; Borbujo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;A&#46;"
              "apellidos" => "Villanueva"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "N&#225;jera"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Espinosa"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Borbujo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011005138"
        "doi" => "10.1016/j.ad.2011.06.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005138?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901200279X?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S157821901200279X/v1_201304241357/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Perianal Ulcers on a Segmental Hemangioma With Minimal or Arrested Growth"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "820"
        "paginaFinal" => "823"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Lanoel, V&#46; Tosi, M&#46; Bocian, F&#46; Lubieniecki, S&#46;B&#46; Poblete, H&#46;O&#46; Garc&#237;a, A&#46;M&#46; Pierini"
        "autores" => array:7 [
          0 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Lanoel"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "V&#46;"
            "apellidos" => "Tosi"
            "email" => array:1 [
              0 => "verotosi&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Bocian"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "Lubieniecki"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "S&#46;B&#46;"
            "apellidos" => "Poblete"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "H&#46;O&#46;"
            "apellidos" => "Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "A&#46;M&#46;"
            "apellidos" => "Pierini"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio Anatom&#237;a Patol&#243;gica&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio Cirug&#237;a Pl&#225;stica&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio Cuidados Paliativos&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2275
            "Ancho" => 1252
            "Tamanyo" => 176922
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hemangioma with minimal or arrested growth&#46; There is a pale&#44; erythematous macule with multiple fine telangiectasias&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Infantile hemangiomas have a characteristic natural history&#44; with rapid growth during the first weeks of life followed by slow&#44; spontaneous involution&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 30&#37; to 50&#37; of cases&#44; the appearance of the hemangioma is preceded by a precursor or herald lesion&#44; which can present as a blanched&#44; telangiectatic&#44; or pink-red macule or a pseudoecchymotic lesion&#46; In hemangiomas with minimal or arrested growth &#40;H-MAG&#41;&#44; these precursor lesions are congenital and grow slowly or not at all&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Because of this they are frequently confused with capillary vascular malformations or may even remain undetected&#46; It is important to be aware of these lesions as they can develop complications or have associations similar to those of typical infantile hemangiomas&#59; they must therefore be recognized in order to provide appropriate management&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 3-month-old infant who had been seen in Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina&#44; for perianal ulcers since 20 days of life&#46; According to the mother&#44; the condition had started with perianal erythema&#46; The health area pediatrician had prescribed usual skincare and the application of a paste containing vitamin A&#44; zinc oxide&#44; and boric acid&#46; Seven days later&#44; 2 small erosions with erythematous borders were observed in the left perianal region&#59; these lesions increased in size and depth&#44; producing a large&#44; very painful ulcer with a blood-stained watery discharge from the base&#46; The patient was admitted because of the poor response to outpatient treatment over the previous 40 days&#46; Antibiotic therapy&#44; initially intravenous and subsequently oral&#44; combined with local antiseptic and antibiotic treatment and use of a hyperbaric chamber achieved no response&#46; On discharge&#44; the patient was seen in the dermatology department&#46; There was a large&#44; very painful ulcer measuring approximately 10<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm in the perianal region&#44; predominantly affecting the left side&#46; The ulcer had erythematous-violaceous geographic borders and a shiny erythematous base&#44; and there was a small volume of yellowish secretion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In the right perianal region there were 2 small lesions of similar characteristics&#46; There was a large&#44; pale erythematous macule affecting the left gluteal region and posterior aspect of the left thigh&#44; extending down to the popliteal fossa&#46; This macule had a reticular pattern that did not blanch and fine telangiectasias &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The external genitalia and lower limbs were normal&#46; With a provisional diagnosis of ulcers due to H-MAG or infectious ulcers&#44; the lesion was biopsied for histology and culture&#46; On histology there was a proliferation of small vessels with a prominent endothelium in the superficial dermis&#46; Immune staining for glucose transporter-1 &#40;GLUT-1&#41; was positive&#44; indicating a lesion compatible with infantile hemangioma &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Culture was negative&#46; Cerebral&#44; abdominal&#44; and lumbosacral ultrasound studies were performed to exclude associated abnormalities&#59; the results were normal&#46; After pediatric cardiology evaluation including electrocardiography and echocardiography&#44; treatment was started with propanolol at a dosage of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; with adjustment to 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d a week later&#46; Jointly with the palliative care department&#44; paracetamol and morphine syrup were prescribed to control the pain&#46; Local wound care was performed with soap and water lavage&#44; drying with cold air&#44; and the application of a silver sulfadiazine&#44; vitamin A&#44; and lidocaine cream 3 times a day&#46; The response was favorable&#44; and complete re-epithelialization was achieved after 4 weeks &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#59; the treatment was continued for a total of 2 months&#46; At the time of writing&#44; the patient continued on follow-up with no evidence of new lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Infantile hemangiomas are the most common childhood tumors&#46; They arise from the endothelial cells and have a unique biological behavior&#58; rapid growth followed by slow regression and no recurrences&#46; There are 3 phases in the natural history of hemangiomas&#58; <span class="elsevierStyleItalic">1&#41;</span> proliferative phase &#40;from 0 to 1 year&#41;&#59; <span class="elsevierStyleItalic">2&#41;</span> involution phase &#40;from 1 to 5 years&#41;&#44; and <span class="elsevierStyleItalic">3&#41;</span> the involuted phase &#40;after 5 years&#41;&#46; Histopathology in all phases of infantile hemangioma is positive for a specific marker&#44; GLUT-1&#44; an erythrocyte-type glucose transport protein that is expressed in the vascular endothelia of hemangiomas and of the human placenta&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Histology study is not usually required for diagnosis as these hemangiomas have highly characteristic features on clinical examination and routine imaging studies&#46; In 30&#37; to 50&#37; of cases the appearance of these tumors is preceded by a precursor or herald lesion&#44; which can present as a blanched&#44; telangiectatic&#44; or pink-red macule or a pseudoecchymotic lesion&#46; Although the growth characteristics are the most salient features of hemangiomas and an important key to diagnosis&#44; in recent years attention has been drawn to a minority of infantile hemangiomas that present slow or arrested growth&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Various terms have been used to refer to these hemangiomas in the literature&#58; <span class="elsevierStyleItalic">frustrated</span> or <span class="elsevierStyleItalic">abortive</span>&#44; <span class="elsevierStyleItalic">with minimal growth</span>&#44; <span class="elsevierStyleItalic">precursor</span>&#44; <span class="elsevierStyleItalic">macular with port-wine stain appearance</span>&#44; <span class="elsevierStyleItalic">infantile reticular</span>&#44; and <span class="elsevierStyleItalic">telangiectatic plaque</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Recent publications by Corella et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> have helped to clarify this type of hemangioma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">H-MAGs very often present as a pale&#44; erythematous macule with a reticular pattern on which there may be fine or coarse telangiectasias&#46; In some cases there is a pale peripheral halo&#46; On other occasions&#44; the lesions have small&#44; peripheral erythematous-reddish papules&#44; which are a sign of the minimal growth of the hemangioma&#46; The article by Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> defined this latter type of lesion as a hemangioma in which the proliferative component accounts for up to 25&#37; of the surface area of the lesion&#44; and they described H-MAGs as resembling the precursor lesions of typical proliferative hemangiomas&#46; Corella et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> in their study of 4 patients with clinically diagnosed H-MAG&#44; reported that histopathology was positive for GLUT-1&#44; confirming that the lesions were true hemangiomas&#46; The pathogenesis of infantile hemangiomas is still unknown&#44; as is the reason why H-MAGs arrest in their early stages&#44; without proliferating&#46; There are several theories about the origin of hemangiomas&#46; Some authors have suggested that they may be due to local hypoxemia&#44; which would act as the trigger leading to the recruitment of endothelial progenitor cells and activation of a vasculogenesis process&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Following this line&#44; Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> speculated that the absence of sufficient recruitment of these endothelial progenitor cells could give rise to the formation of H-MAGs&#46; This would explain why the majority of these hemangiomas are situated on the lower half of the body&#44; in contrast to typical infantile hemangiomas&#44; which are mainly located on the head and neck&#46; Those authors suggested that this anatomical distribution was due to the presence of local factors&#44; such as the density of the underlying blood vessels&#44; which is lower in the lower half of the body&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cases have been described in the literature in which typical infantile hemangiomas coexist with H-MAG&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Ulceration is a common and recognized complication of infantile hemangiomas&#44; occurring in 15&#37; to 23&#37; of cases&#59; it has been described less commonly &#40;9&#37;&#41; in H-MAGs&#46; Both infantile hemangiomas and H-MAGs have a higher risk of ulceration when located in the anogenital region &#40;50&#37; in both cases&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7</span></a> Ulceration in infantile hemangioma is more common during the late proliferative stage&#44; and it was always considered to be associated with proliferation of the hemangioma&#46; Now that it is known that H-MAGs also ulcerate&#44; Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> suggested that other factors apart from proliferation are involved in the pathophysiology&#44; including hypoxemia or local factors such as friction or the presence of a specific microbial flora &#40;as is the case in perianal hemangiomas&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7</span></a> Just like in infantile hemangioma&#44; segmental H-MAGs &#40;large hemangiomas&#41; can be associated with different syndromes&#44; depending on their location<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#58; PHACES syndrome &#40;posterior fossa malformations&#44; hemangiomas&#44; arterial anomalies&#44; coarctation of the aorta and cardiac defects&#44; and eye abnormalities&#41;&#59; PELVIS syndrome &#40;perineal hemangioma&#44; external genitalia malformations&#44; lipomyelomeningocele&#44; vesicorenal abnormalities&#44; imperforate anus&#44; and skin tag&#41;&#59; and SACRAL syndrome &#40;spinal dysraphism&#44; anogenital anomalies&#44; cutaneous anomalies&#44; and renal and urologic anomalies&#41;&#46; In patients with segmental H-MAGs it is therefore very important to screen for associated abnormalities&#46; Recommended tests&#44; even in the absence of external malformations&#44; include imaging studies of the lumbosacral column to look for spinal dysraphism and of the pelvis and perineal area to exclude occult urogenital malformations and the presence of visceral hemangiomatosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In 2007&#44; Mulliken et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> published a series of 6 newborn infants &#40;5 girls and 1 boy&#41; with H-MAG of the lower limbs that they called <span class="elsevierStyleItalic">reticular infantile hemangioma</span>&#46; All the patients presented perianal ulcers that were difficult to manage&#46; In 5 of those cases&#44; the authors observed anogenital&#44; urinary&#44; and sacral abnormalities including anal atresia&#44; rectovaginal fistulas&#44; genital ambiguity&#44; omphalocele&#44; solitary or duplex kidney&#44; vaginal and uterine duplication&#44; tethered spinal cord&#44; and hypoplastic iliofemoral arterial system&#46; Two of the children presented hepatic hemangiomas and one of them also had heart failure that required inotropes&#46; One of the girls had no associated abnormalities&#46; Systemic corticosteroid therapy was selected as the treatment of choice in 5 of those patients and the lesions started to involute after the first year of life in all 6 children&#46; We believe it is important to note that the majority of children with associated anogenital&#44; urinary&#44; and&#47;or sacral abnormalities had large H-MAGs affecting the lumbosacral region&#46; In our patient&#44; in whom no associated alterations were detected&#44; the hemangioma did not affect that region&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">It is believed that the natural course of H-MAG is probably the same as that of infantile hemangioma&#44; and that involution would occur after a certain time&#59; however&#44; confirmation of this has not been possible as there have been no long-term studies of these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0045" class="elsevierStylePara elsevierViewall">We believe it is important to be aware of H-MAG in order to avoid incorrect diagnoses&#46; The majority of children do not usually have significant complications&#44; but as in the case we present&#44; a missed diagnosis can lead to unnecessary investigations and&#47;or incorrect treatments&#46; It is also important to note that large&#44; segmental H-MAGs can be associated with internal abnormalities&#44; and careful screening of these patients is therefore recommended&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres96610"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec83769"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres96611"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec83768"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case Description"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conclusion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of Interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec83769"
          "palabras" => array:4 [
            0 => "Minimal or arrested growth hemangioma"
            1 => "Abortive hemangioma"
            2 => "Perianal ulcers"
            3 => "Children"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec83768"
          "palabras" => array:4 [
            0 => "Hemangioma con crecimiento m&#237;nimo o detenido"
            1 => "Hemangioma abortivo"
            2 => "&#218;lceras perianales"
            3 => "Ni&#241;os"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hemangiomas with minimal or arrested growth are a type of infantile hemangioma in which the proliferative component characteristic of such lesions is not observed or accounts for less than 25&#37; of the surface area of the hemangioma&#46; For this reason&#44; these lesions are frequently confused with capillary vascular malformations or may even go undetected&#46; Awareness of these lesions is&#44; however&#44; important because they can become ulcerated&#44; as occurs with typical infantile hemangiomas&#46; A proper diagnosis is therefore important to enable administration of appropriate treatment&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the case of a 3-month-old girl with slowly progressing perianal ulcers first detected when she was 20 days old&#46; She had received many different therapies without any response&#46; A pathology study of the ulcer showed a GLUT-1&#8211;positive infantile hemangioma&#46; Response to treatment with propranolol 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d and local wound care was excellent&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los hemangiomas con crecimiento m&#237;nimo o detenido son un tipo de hemangioma infantil en donde no se observa la fase proliferativa caracter&#237;stica de los mismos o esta es menor o igual al 25&#37; de la superficie del hemangioma&#46; Esto lleva a que muchas veces sean confundidos con malformaciones vasculares capilares o incluso que pasen inadvertidos&#46; Es importante conocerlos ya que pueden ulcerarse como lo hacen los hemangiomas infantiles t&#237;picos y por lo tanto merecen ser tenidos en cuenta para poder tratarlos en forma adecuada&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Presentamos una ni&#241;a de 3 meses de edad con &#250;lceras perianales de evoluci&#243;n t&#243;rpida desde los 20 d&#237;as de vida&#46; Hab&#237;a recibido m&#250;ltiples esquemas terap&#233;uticos sin respuesta&#46; En el estudio histopatol&#243;gico de la &#250;lcera se constat&#243; la presencia de un hemangioma infantil&#44; GLUT-1 positivo&#46; Realiz&#243; tratamiento con propranolol a 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#237;a y cuidados locales con excelente respuesta&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Lanoel A&#44; et al&#46; &#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario&#46; Actas Dermosifiliogr&#46; 2012&#59;103&#58;820-3&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1182
            "Ancho" => 1585
            "Tamanyo" => 150241
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Ulcer with erythematous-violaceous borders and a shiny base in the left perianal region&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2275
            "Ancho" => 1252
            "Tamanyo" => 176922
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hemangioma with minimal or arrested growth&#46; There is a pale&#44; erythematous macule with multiple fine telangiectasias&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1378
            "Ancho" => 2168
            "Tamanyo" => 469343
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A&#44; There is a proliferation of blood vessels with a prominent endothelium in the superficial dermis &#40;hematoxylin-eosin&#44; original magnification &#215;10&#41;&#46; B&#44; Immune staining&#58; endothelial cells positive for glucose transporter-1&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1858
            "Ancho" => 1585
            "Tamanyo" => 178770
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Healed ulcer&#46; In the center there is a more erythematous area corresponding to the minimal growth of the hemangioma&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth characteristics of infantile hemangiomas&#58; implications for management"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Hemangioma Investigator Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;C&#46; Chang"
                            1 => "A&#46;N&#46; Haggstrom"
                            2 => "B&#46;A&#46; Drolet"
                            3 => "E&#46; Baselga"
                            4 => "S&#46;L&#46; Chamlin"
                            5 => "M&#46;C&#46; Garzon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2007-2767"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2008"
                        "volumen" => "122"
                        "paginaInicial" => "360"
                        "paginaFinal" => "367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18676554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infantile hemangiomas with minimal or arrested growth&#58; a retrospective case series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;Y&#46; Suh"
                            1 => "I&#46;J&#46; Frieden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2010.197"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2010"
                        "volumen" => "146"
                        "paginaInicial" => "971"
                        "paginaFinal" => "976"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20855695"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642009004849"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abortive or minimal-growth hemangiomas&#58; Immunohistochemical evidence that they represent true infantile hemangiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Corella"
                            1 => "X&#46; Garcia-Navarro"
                            2 => "A&#46; Ribe"
                            3 => "A&#46; Alomar"
                            4 => "E&#46; Baselga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.08.007"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "685"
                        "paginaFinal" => "690"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18342717"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939412001274"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reticular infantile hemangioma of the limb can be associated with ventral-caudal anomalies&#44; refractory ulceration&#44; and cardiac overload"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;B&#46; Mulliken"
                            1 => "J&#46;J&#46; Marler"
                            2 => "P&#46;E&#46; Burrows"
                            3 => "H&#46;P&#46; Kozakewich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2007.00496.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2007"
                        "volumen" => "24"
                        "paginaInicial" => "356"
                        "paginaFinal" => "362"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17845155"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypoxia&#44; hormones&#44; and endothelial progenitor cells in hemangioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;I&#46; Chang"
                            1 => "E&#46;I&#46; Chang"
                            2 => "H&#46; Thangarajah"
                            3 => "C&#46; Hamou"
                            4 => "G&#46;C&#46; Gurtner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/lrb.2007.1014"
                      "Revista" => array:7 [
                        "tituloSerie" => "Lymphat Res Biol"
                        "fecha" => "2007"
                        "volumen" => "5"
                        "paginaInicial" => "237"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18370914"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335009001436"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vasculogenesis in infantile hemangioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Boscolo"
                            1 => "J&#46; Bischoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10456-009-9148-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "Angiogenesis"
                        "fecha" => "2009"
                        "volumen" => "12"
                        "paginaInicial" => "197"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19430954"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010007098"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multicenter prospective study of ulcerated hemangiomas &#91;published correction appears in J Pediatr&#46; 2008&#59;152&#58;597&#46;&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Chamlin"
                            1 => "A&#46;N&#46; Haggstrom"
                            2 => "B&#46;A&#46; Drolet"
                            3 => "E&#46; Baselga"
                            4 => "I&#46;J&#46; Frieden"
                            5 => "M&#46;C&#46; Garzon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2007.04.055"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2007"
                        "volumen" => "151"
                        "paginaInicial" => "684"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18035154"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335010011910"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PELVIS Syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Girard"
                            1 => "M&#46; Bigorre"
                            2 => "B&#46; Guillot"
                            3 => "D&#46; Bessis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.142.7.884"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2006"
                        "volumen" => "142"
                        "paginaInicial" => "884"
                        "paginaFinal" => "888"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16847205"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002806/v1_201304241357/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6183"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000009/v1_201304241357/S1578219012002806/v1_201304241357/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002806?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case report
Perianal Ulcers on a Segmental Hemangioma With Minimal or Arrested Growth
Úlceras perianales sobre hemangioma con crecimiento mínimo o detenido segmentario
A. Lanoela, V. Tosia,
Autor para correspondencia
verotosi@hotmail.com

Corresponding author.
, M. Bociana, F. Lubienieckib, S.B. Pobletec, H.O. Garcíad, A.M. Pierinia
a Servicio de Dermatología, Hospital de Pediatría J.P. Garrahan, Buenos Aires, Argentina
b Servicio Anatomía Patológica, Hospital de Pediatría J.P. Garrahan, Buenos Aires, Argentina
c Servicio Cirugía Plástica, Hospital de Pediatría J.P. Garrahan, Buenos Aires, Argentina
d Servicio Cuidados Paliativos, Hospital de Pediatría J.P. Garrahan, Buenos Aires, Argentina
Leído
11186
Veces
se ha leído el artículo
2677
Total PDF
8509
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219012002806"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.07.010"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "aid" => "532"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2012;103:820-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5136
    "formatos" => array:3 [
      "EPUB" => 41
      "HTML" => 4246
      "PDF" => 849
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011005254"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.07.018"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "aid" => "532"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2012;103:820-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5237
        "formatos" => array:3 [
          "EPUB" => 1
          "HTML" => 4101
          "PDF" => 1135
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "&#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "820"
            "paginaFinal" => "823"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Perianal Ulcers on a Segmental Hemangioma With Minimal or Arrested Growth"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 826
                "Ancho" => 1300
                "Tamanyo" => 391644
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">a&#41; H-E 10 x&#46; A nivel de la dermis superficial se observa proliferaci&#243;n de vasos con endotelios prominentes&#46; b&#41; Inmunomarcaci&#243;n&#58; c&#233;lulas endoteliales positivas para GLUT-1&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Lanoel, V&#46; Tosi, M&#46; Bocian, F&#46; Lubieniecki, S&#46;B&#46; Poblete, H&#46;O&#46; Garc&#237;a, A&#46;M&#46; Pierini"
            "autores" => array:7 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Lanoel"
              ]
              1 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Tosi"
              ]
              2 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Bocian"
              ]
              3 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "Lubieniecki"
              ]
              4 => array:2 [
                "nombre" => "S&#46;B&#46;"
                "apellidos" => "Poblete"
              ]
              5 => array:2 [
                "nombre" => "H&#46;O&#46;"
                "apellidos" => "Garc&#237;a"
              ]
              6 => array:2 [
                "nombre" => "A&#46;M&#46;"
                "apellidos" => "Pierini"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219012002806"
          "doi" => "10.1016/j.adengl.2011.07.010"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002806?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005254?idApp=UINPBA000044"
      "url" => "/00017310/0000010300000009/v1_201304241717/S0001731011005254/v1_201304241717/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012002818"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.020"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "610"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:825-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3183
      "formatos" => array:3 [
        "EPUB" => 46
        "HTML" => 2476
        "PDF" => 661
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
      "titulo" => "Violaceous Papules on the Dorsum of the Hand"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "825"
          "paginaFinal" => "826"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "P&#225;pulas viol&#225;ceas en el dorso de la mano"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 706
              "Ancho" => 951
              "Tamanyo" => 124618
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "B&#46; Garc&#237;a-Garc&#237;a, L&#46; Palacios-Garc&#237;a, B&#46; Vivanco-Allende"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Garc&#237;a-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Palacios-Garc&#237;a"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Vivanco-Allende"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012001858"
        "doi" => "10.1016/j.ad.2012.01.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001858?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002818?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002818/v1_201304241357/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S157821901200279X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.06.004"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "520"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2012;103:816-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5382
      "formatos" => array:3 [
        "EPUB" => 45
        "HTML" => 4232
        "PDF" => 1105
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Bullous Hemorrhagic Dermatosis at Distant Sites&#58; A Report of 2 New Cases Due to Enoxaparin Injection and a Review of the Literature"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "816"
          "paginaFinal" => "819"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1425
              "Ancho" => 1587
              "Tamanyo" => 173600
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Multiple noninflammatory hemorrhagic vesicles in the right malar region&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46;A&#46; Villanueva, L&#46; N&#225;jera, P&#46; Espinosa, J&#46; Borbujo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;A&#46;"
              "apellidos" => "Villanueva"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "N&#225;jera"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Espinosa"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Borbujo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011005138"
        "doi" => "10.1016/j.ad.2011.06.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005138?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901200279X?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S157821901200279X/v1_201304241357/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Perianal Ulcers on a Segmental Hemangioma With Minimal or Arrested Growth"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "820"
        "paginaFinal" => "823"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Lanoel, V&#46; Tosi, M&#46; Bocian, F&#46; Lubieniecki, S&#46;B&#46; Poblete, H&#46;O&#46; Garc&#237;a, A&#46;M&#46; Pierini"
        "autores" => array:7 [
          0 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Lanoel"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "V&#46;"
            "apellidos" => "Tosi"
            "email" => array:1 [
              0 => "verotosi&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Bocian"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "Lubieniecki"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "S&#46;B&#46;"
            "apellidos" => "Poblete"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "H&#46;O&#46;"
            "apellidos" => "Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "A&#46;M&#46;"
            "apellidos" => "Pierini"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio Anatom&#237;a Patol&#243;gica&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio Cirug&#237;a Pl&#225;stica&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio Cuidados Paliativos&#44; Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2275
            "Ancho" => 1252
            "Tamanyo" => 176922
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hemangioma with minimal or arrested growth&#46; There is a pale&#44; erythematous macule with multiple fine telangiectasias&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Infantile hemangiomas have a characteristic natural history&#44; with rapid growth during the first weeks of life followed by slow&#44; spontaneous involution&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 30&#37; to 50&#37; of cases&#44; the appearance of the hemangioma is preceded by a precursor or herald lesion&#44; which can present as a blanched&#44; telangiectatic&#44; or pink-red macule or a pseudoecchymotic lesion&#46; In hemangiomas with minimal or arrested growth &#40;H-MAG&#41;&#44; these precursor lesions are congenital and grow slowly or not at all&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Because of this they are frequently confused with capillary vascular malformations or may even remain undetected&#46; It is important to be aware of these lesions as they can develop complications or have associations similar to those of typical infantile hemangiomas&#59; they must therefore be recognized in order to provide appropriate management&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 3-month-old infant who had been seen in Hospital de Pediatr&#237;a J&#46;P&#46; Garrahan&#44; Buenos Aires&#44; Argentina&#44; for perianal ulcers since 20 days of life&#46; According to the mother&#44; the condition had started with perianal erythema&#46; The health area pediatrician had prescribed usual skincare and the application of a paste containing vitamin A&#44; zinc oxide&#44; and boric acid&#46; Seven days later&#44; 2 small erosions with erythematous borders were observed in the left perianal region&#59; these lesions increased in size and depth&#44; producing a large&#44; very painful ulcer with a blood-stained watery discharge from the base&#46; The patient was admitted because of the poor response to outpatient treatment over the previous 40 days&#46; Antibiotic therapy&#44; initially intravenous and subsequently oral&#44; combined with local antiseptic and antibiotic treatment and use of a hyperbaric chamber achieved no response&#46; On discharge&#44; the patient was seen in the dermatology department&#46; There was a large&#44; very painful ulcer measuring approximately 10<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm in the perianal region&#44; predominantly affecting the left side&#46; The ulcer had erythematous-violaceous geographic borders and a shiny erythematous base&#44; and there was a small volume of yellowish secretion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In the right perianal region there were 2 small lesions of similar characteristics&#46; There was a large&#44; pale erythematous macule affecting the left gluteal region and posterior aspect of the left thigh&#44; extending down to the popliteal fossa&#46; This macule had a reticular pattern that did not blanch and fine telangiectasias &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The external genitalia and lower limbs were normal&#46; With a provisional diagnosis of ulcers due to H-MAG or infectious ulcers&#44; the lesion was biopsied for histology and culture&#46; On histology there was a proliferation of small vessels with a prominent endothelium in the superficial dermis&#46; Immune staining for glucose transporter-1 &#40;GLUT-1&#41; was positive&#44; indicating a lesion compatible with infantile hemangioma &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Culture was negative&#46; Cerebral&#44; abdominal&#44; and lumbosacral ultrasound studies were performed to exclude associated abnormalities&#59; the results were normal&#46; After pediatric cardiology evaluation including electrocardiography and echocardiography&#44; treatment was started with propanolol at a dosage of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; with adjustment to 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d a week later&#46; Jointly with the palliative care department&#44; paracetamol and morphine syrup were prescribed to control the pain&#46; Local wound care was performed with soap and water lavage&#44; drying with cold air&#44; and the application of a silver sulfadiazine&#44; vitamin A&#44; and lidocaine cream 3 times a day&#46; The response was favorable&#44; and complete re-epithelialization was achieved after 4 weeks &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#59; the treatment was continued for a total of 2 months&#46; At the time of writing&#44; the patient continued on follow-up with no evidence of new lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Infantile hemangiomas are the most common childhood tumors&#46; They arise from the endothelial cells and have a unique biological behavior&#58; rapid growth followed by slow regression and no recurrences&#46; There are 3 phases in the natural history of hemangiomas&#58; <span class="elsevierStyleItalic">1&#41;</span> proliferative phase &#40;from 0 to 1 year&#41;&#59; <span class="elsevierStyleItalic">2&#41;</span> involution phase &#40;from 1 to 5 years&#41;&#44; and <span class="elsevierStyleItalic">3&#41;</span> the involuted phase &#40;after 5 years&#41;&#46; Histopathology in all phases of infantile hemangioma is positive for a specific marker&#44; GLUT-1&#44; an erythrocyte-type glucose transport protein that is expressed in the vascular endothelia of hemangiomas and of the human placenta&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Histology study is not usually required for diagnosis as these hemangiomas have highly characteristic features on clinical examination and routine imaging studies&#46; In 30&#37; to 50&#37; of cases the appearance of these tumors is preceded by a precursor or herald lesion&#44; which can present as a blanched&#44; telangiectatic&#44; or pink-red macule or a pseudoecchymotic lesion&#46; Although the growth characteristics are the most salient features of hemangiomas and an important key to diagnosis&#44; in recent years attention has been drawn to a minority of infantile hemangiomas that present slow or arrested growth&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Various terms have been used to refer to these hemangiomas in the literature&#58; <span class="elsevierStyleItalic">frustrated</span> or <span class="elsevierStyleItalic">abortive</span>&#44; <span class="elsevierStyleItalic">with minimal growth</span>&#44; <span class="elsevierStyleItalic">precursor</span>&#44; <span class="elsevierStyleItalic">macular with port-wine stain appearance</span>&#44; <span class="elsevierStyleItalic">infantile reticular</span>&#44; and <span class="elsevierStyleItalic">telangiectatic plaque</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Recent publications by Corella et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> have helped to clarify this type of hemangioma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">H-MAGs very often present as a pale&#44; erythematous macule with a reticular pattern on which there may be fine or coarse telangiectasias&#46; In some cases there is a pale peripheral halo&#46; On other occasions&#44; the lesions have small&#44; peripheral erythematous-reddish papules&#44; which are a sign of the minimal growth of the hemangioma&#46; The article by Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> defined this latter type of lesion as a hemangioma in which the proliferative component accounts for up to 25&#37; of the surface area of the lesion&#44; and they described H-MAGs as resembling the precursor lesions of typical proliferative hemangiomas&#46; Corella et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> in their study of 4 patients with clinically diagnosed H-MAG&#44; reported that histopathology was positive for GLUT-1&#44; confirming that the lesions were true hemangiomas&#46; The pathogenesis of infantile hemangiomas is still unknown&#44; as is the reason why H-MAGs arrest in their early stages&#44; without proliferating&#46; There are several theories about the origin of hemangiomas&#46; Some authors have suggested that they may be due to local hypoxemia&#44; which would act as the trigger leading to the recruitment of endothelial progenitor cells and activation of a vasculogenesis process&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> Following this line&#44; Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> speculated that the absence of sufficient recruitment of these endothelial progenitor cells could give rise to the formation of H-MAGs&#46; This would explain why the majority of these hemangiomas are situated on the lower half of the body&#44; in contrast to typical infantile hemangiomas&#44; which are mainly located on the head and neck&#46; Those authors suggested that this anatomical distribution was due to the presence of local factors&#44; such as the density of the underlying blood vessels&#44; which is lower in the lower half of the body&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cases have been described in the literature in which typical infantile hemangiomas coexist with H-MAG&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Ulceration is a common and recognized complication of infantile hemangiomas&#44; occurring in 15&#37; to 23&#37; of cases&#59; it has been described less commonly &#40;9&#37;&#41; in H-MAGs&#46; Both infantile hemangiomas and H-MAGs have a higher risk of ulceration when located in the anogenital region &#40;50&#37; in both cases&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7</span></a> Ulceration in infantile hemangioma is more common during the late proliferative stage&#44; and it was always considered to be associated with proliferation of the hemangioma&#46; Now that it is known that H-MAGs also ulcerate&#44; Suh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> suggested that other factors apart from proliferation are involved in the pathophysiology&#44; including hypoxemia or local factors such as friction or the presence of a specific microbial flora &#40;as is the case in perianal hemangiomas&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7</span></a> Just like in infantile hemangioma&#44; segmental H-MAGs &#40;large hemangiomas&#41; can be associated with different syndromes&#44; depending on their location<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#58; PHACES syndrome &#40;posterior fossa malformations&#44; hemangiomas&#44; arterial anomalies&#44; coarctation of the aorta and cardiac defects&#44; and eye abnormalities&#41;&#59; PELVIS syndrome &#40;perineal hemangioma&#44; external genitalia malformations&#44; lipomyelomeningocele&#44; vesicorenal abnormalities&#44; imperforate anus&#44; and skin tag&#41;&#59; and SACRAL syndrome &#40;spinal dysraphism&#44; anogenital anomalies&#44; cutaneous anomalies&#44; and renal and urologic anomalies&#41;&#46; In patients with segmental H-MAGs it is therefore very important to screen for associated abnormalities&#46; Recommended tests&#44; even in the absence of external malformations&#44; include imaging studies of the lumbosacral column to look for spinal dysraphism and of the pelvis and perineal area to exclude occult urogenital malformations and the presence of visceral hemangiomatosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In 2007&#44; Mulliken et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> published a series of 6 newborn infants &#40;5 girls and 1 boy&#41; with H-MAG of the lower limbs that they called <span class="elsevierStyleItalic">reticular infantile hemangioma</span>&#46; All the patients presented perianal ulcers that were difficult to manage&#46; In 5 of those cases&#44; the authors observed anogenital&#44; urinary&#44; and sacral abnormalities including anal atresia&#44; rectovaginal fistulas&#44; genital ambiguity&#44; omphalocele&#44; solitary or duplex kidney&#44; vaginal and uterine duplication&#44; tethered spinal cord&#44; and hypoplastic iliofemoral arterial system&#46; Two of the children presented hepatic hemangiomas and one of them also had heart failure that required inotropes&#46; One of the girls had no associated abnormalities&#46; Systemic corticosteroid therapy was selected as the treatment of choice in 5 of those patients and the lesions started to involute after the first year of life in all 6 children&#46; We believe it is important to note that the majority of children with associated anogenital&#44; urinary&#44; and&#47;or sacral abnormalities had large H-MAGs affecting the lumbosacral region&#46; In our patient&#44; in whom no associated alterations were detected&#44; the hemangioma did not affect that region&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">It is believed that the natural course of H-MAG is probably the same as that of infantile hemangioma&#44; and that involution would occur after a certain time&#59; however&#44; confirmation of this has not been possible as there have been no long-term studies of these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0045" class="elsevierStylePara elsevierViewall">We believe it is important to be aware of H-MAG in order to avoid incorrect diagnoses&#46; The majority of children do not usually have significant complications&#44; but as in the case we present&#44; a missed diagnosis can lead to unnecessary investigations and&#47;or incorrect treatments&#46; It is also important to note that large&#44; segmental H-MAGs can be associated with internal abnormalities&#44; and careful screening of these patients is therefore recommended&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres96610"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec83769"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres96611"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec83768"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case Description"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conclusion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of Interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec83769"
          "palabras" => array:4 [
            0 => "Minimal or arrested growth hemangioma"
            1 => "Abortive hemangioma"
            2 => "Perianal ulcers"
            3 => "Children"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec83768"
          "palabras" => array:4 [
            0 => "Hemangioma con crecimiento m&#237;nimo o detenido"
            1 => "Hemangioma abortivo"
            2 => "&#218;lceras perianales"
            3 => "Ni&#241;os"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hemangiomas with minimal or arrested growth are a type of infantile hemangioma in which the proliferative component characteristic of such lesions is not observed or accounts for less than 25&#37; of the surface area of the hemangioma&#46; For this reason&#44; these lesions are frequently confused with capillary vascular malformations or may even go undetected&#46; Awareness of these lesions is&#44; however&#44; important because they can become ulcerated&#44; as occurs with typical infantile hemangiomas&#46; A proper diagnosis is therefore important to enable administration of appropriate treatment&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the case of a 3-month-old girl with slowly progressing perianal ulcers first detected when she was 20 days old&#46; She had received many different therapies without any response&#46; A pathology study of the ulcer showed a GLUT-1&#8211;positive infantile hemangioma&#46; Response to treatment with propranolol 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d and local wound care was excellent&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los hemangiomas con crecimiento m&#237;nimo o detenido son un tipo de hemangioma infantil en donde no se observa la fase proliferativa caracter&#237;stica de los mismos o esta es menor o igual al 25&#37; de la superficie del hemangioma&#46; Esto lleva a que muchas veces sean confundidos con malformaciones vasculares capilares o incluso que pasen inadvertidos&#46; Es importante conocerlos ya que pueden ulcerarse como lo hacen los hemangiomas infantiles t&#237;picos y por lo tanto merecen ser tenidos en cuenta para poder tratarlos en forma adecuada&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Presentamos una ni&#241;a de 3 meses de edad con &#250;lceras perianales de evoluci&#243;n t&#243;rpida desde los 20 d&#237;as de vida&#46; Hab&#237;a recibido m&#250;ltiples esquemas terap&#233;uticos sin respuesta&#46; En el estudio histopatol&#243;gico de la &#250;lcera se constat&#243; la presencia de un hemangioma infantil&#44; GLUT-1 positivo&#46; Realiz&#243; tratamiento con propranolol a 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#237;a y cuidados locales con excelente respuesta&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Lanoel A&#44; et al&#46; &#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario&#46; Actas Dermosifiliogr&#46; 2012&#59;103&#58;820-3&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1182
            "Ancho" => 1585
            "Tamanyo" => 150241
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Ulcer with erythematous-violaceous borders and a shiny base in the left perianal region&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2275
            "Ancho" => 1252
            "Tamanyo" => 176922
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hemangioma with minimal or arrested growth&#46; There is a pale&#44; erythematous macule with multiple fine telangiectasias&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1378
            "Ancho" => 2168
            "Tamanyo" => 469343
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A&#44; There is a proliferation of blood vessels with a prominent endothelium in the superficial dermis &#40;hematoxylin-eosin&#44; original magnification &#215;10&#41;&#46; B&#44; Immune staining&#58; endothelial cells positive for glucose transporter-1&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1858
            "Ancho" => 1585
            "Tamanyo" => 178770
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Healed ulcer&#46; In the center there is a more erythematous area corresponding to the minimal growth of the hemangioma&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth characteristics of infantile hemangiomas&#58; implications for management"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Hemangioma Investigator Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;C&#46; Chang"
                            1 => "A&#46;N&#46; Haggstrom"
                            2 => "B&#46;A&#46; Drolet"
                            3 => "E&#46; Baselga"
                            4 => "S&#46;L&#46; Chamlin"
                            5 => "M&#46;C&#46; Garzon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2007-2767"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2008"
                        "volumen" => "122"
                        "paginaInicial" => "360"
                        "paginaFinal" => "367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18676554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infantile hemangiomas with minimal or arrested growth&#58; a retrospective case series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;Y&#46; Suh"
                            1 => "I&#46;J&#46; Frieden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2010.197"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2010"
                        "volumen" => "146"
                        "paginaInicial" => "971"
                        "paginaFinal" => "976"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20855695"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642009004849"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abortive or minimal-growth hemangiomas&#58; Immunohistochemical evidence that they represent true infantile hemangiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Corella"
                            1 => "X&#46; Garcia-Navarro"
                            2 => "A&#46; Ribe"
                            3 => "A&#46; Alomar"
                            4 => "E&#46; Baselga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.08.007"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "685"
                        "paginaFinal" => "690"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18342717"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939412001274"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reticular infantile hemangioma of the limb can be associated with ventral-caudal anomalies&#44; refractory ulceration&#44; and cardiac overload"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;B&#46; Mulliken"
                            1 => "J&#46;J&#46; Marler"
                            2 => "P&#46;E&#46; Burrows"
                            3 => "H&#46;P&#46; Kozakewich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2007.00496.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2007"
                        "volumen" => "24"
                        "paginaInicial" => "356"
                        "paginaFinal" => "362"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17845155"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypoxia&#44; hormones&#44; and endothelial progenitor cells in hemangioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;I&#46; Chang"
                            1 => "E&#46;I&#46; Chang"
                            2 => "H&#46; Thangarajah"
                            3 => "C&#46; Hamou"
                            4 => "G&#46;C&#46; Gurtner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/lrb.2007.1014"
                      "Revista" => array:7 [
                        "tituloSerie" => "Lymphat Res Biol"
                        "fecha" => "2007"
                        "volumen" => "5"
                        "paginaInicial" => "237"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18370914"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335009001436"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vasculogenesis in infantile hemangioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Boscolo"
                            1 => "J&#46; Bischoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10456-009-9148-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "Angiogenesis"
                        "fecha" => "2009"
                        "volumen" => "12"
                        "paginaInicial" => "197"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19430954"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010007098"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multicenter prospective study of ulcerated hemangiomas &#91;published correction appears in J Pediatr&#46; 2008&#59;152&#58;597&#46;&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Chamlin"
                            1 => "A&#46;N&#46; Haggstrom"
                            2 => "B&#46;A&#46; Drolet"
                            3 => "E&#46; Baselga"
                            4 => "I&#46;J&#46; Frieden"
                            5 => "M&#46;C&#46; Garzon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2007.04.055"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2007"
                        "volumen" => "151"
                        "paginaInicial" => "684"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18035154"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335010011910"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PELVIS Syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Girard"
                            1 => "M&#46; Bigorre"
                            2 => "B&#46; Guillot"
                            3 => "D&#46; Bessis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.142.7.884"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2006"
                        "volumen" => "142"
                        "paginaInicial" => "884"
                        "paginaFinal" => "888"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16847205"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002806/v1_201304241357/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6183"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000009/v1_201304241357/S1578219012002806/v1_201304241357/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002806?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 13 10 23
2024 Octubre 106 43 149
2024 Septiembre 136 34 170
2024 Agosto 144 72 216
2024 Julio 146 44 190
2024 Junio 107 90 197
2024 Mayo 117 44 161
2024 Abril 101 24 125
2024 Marzo 91 27 118
2024 Febrero 83 28 111
2024 Enero 62 27 89
2023 Diciembre 94 23 117
2023 Noviembre 118 29 147
2023 Octubre 102 14 116
2023 Septiembre 109 35 144
2023 Agosto 74 17 91
2023 Julio 104 36 140
2023 Junio 71 26 97
2023 Mayo 83 19 102
2023 Abril 72 27 99
2023 Marzo 81 22 103
2023 Febrero 87 17 104
2023 Enero 60 40 100
2022 Diciembre 71 47 118
2022 Noviembre 49 21 70
2022 Octubre 46 18 64
2022 Septiembre 68 44 112
2022 Agosto 57 24 81
2022 Julio 47 30 77
2022 Junio 72 29 101
2022 Mayo 96 42 138
2022 Abril 93 35 128
2022 Marzo 76 63 139
2022 Febrero 60 23 83
2022 Enero 56 43 99
2021 Diciembre 46 46 92
2021 Noviembre 39 45 84
2021 Octubre 74 48 122
2021 Septiembre 41 42 83
2021 Agosto 54 33 87
2021 Julio 47 35 82
2021 Junio 69 43 112
2021 Mayo 77 29 106
2021 Abril 330 73 403
2021 Marzo 104 38 142
2021 Febrero 72 27 99
2021 Enero 52 15 67
2020 Diciembre 35 21 56
2020 Noviembre 38 13 51
2020 Octubre 36 12 48
2020 Septiembre 32 9 41
2020 Agosto 23 15 38
2020 Julio 24 18 42
2020 Junio 35 29 64
2020 Mayo 23 20 43
2020 Abril 27 22 49
2020 Marzo 31 26 57
2020 Febrero 2 6 8
2020 Enero 4 16 20
2019 Diciembre 8 12 20
2019 Noviembre 4 7 11
2019 Octubre 0 4 4
2019 Septiembre 8 2 10
2019 Agosto 4 1 5
2019 Julio 4 4 8
2019 Junio 6 16 22
2019 Mayo 6 8 14
2019 Abril 4 8 12
2019 Marzo 2 12 14
2019 Febrero 2 2 4
2019 Enero 1 1 2
2018 Diciembre 4 8 12
2018 Noviembre 2 0 2
2018 Octubre 4 0 4
2018 Septiembre 8 0 8
2018 Mayo 0 8 8
2018 Abril 0 2 2
2018 Marzo 4 3 7
2018 Febrero 29 5 34
2018 Enero 25 10 35
2017 Diciembre 49 9 58
2017 Noviembre 25 10 35
2017 Octubre 33 2 35
2017 Septiembre 22 8 30
2017 Agosto 33 19 52
2017 Julio 35 8 43
2017 Junio 37 42 79
2017 Mayo 34 12 46
2017 Abril 76 26 102
2017 Marzo 20 11 31
2017 Febrero 28 7 35
2017 Enero 39 12 51
2016 Diciembre 37 13 50
2016 Noviembre 53 12 65
2016 Octubre 80 22 102
2016 Septiembre 93 11 104
2016 Agosto 114 17 131
2016 Julio 61 13 74
2016 Junio 11 13 24
2016 Mayo 4 15 19
2016 Abril 10 22 32
2016 Marzo 13 10 23
2016 Febrero 10 1 11
2016 Enero 5 8 13
2015 Diciembre 13 1 14
2015 Noviembre 10 4 14
2015 Octubre 13 9 22
2015 Septiembre 12 10 22
2015 Agosto 19 8 27
2015 Julio 185 11 196
2015 Junio 159 14 173
2015 Mayo 181 19 200
2015 Abril 131 13 144
2015 Marzo 127 12 139
2015 Febrero 110 7 117
2015 Enero 104 12 116
2014 Diciembre 100 9 109
2014 Noviembre 98 9 107
2014 Octubre 81 3 84
2014 Septiembre 60 2 62
2014 Agosto 98 3 101
2014 Julio 130 4 134
2014 Junio 123 4 127
2014 Mayo 106 10 116
2014 Abril 115 3 118
2014 Marzo 135 16 151
2014 Febrero 128 11 139
2014 Enero 117 7 124
2013 Diciembre 113 10 123
2013 Noviembre 115 13 128
2013 Octubre 102 19 121
2013 Septiembre 64 5 69
2013 Agosto 68 19 87
2013 Julio 21 42 63
2013 Junio 17 27 44
2013 Mayo 12 20 32
2013 Abril 17 17 34
2013 Marzo 22 5 27
2013 Febrero 37 5 42
2013 Enero 185 4 189
2012 Diciembre 67 6 73
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?