array:24 [
  "pii" => "S157821901200279X"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.06.004"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "aid" => "520"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2012;103:816-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5382
    "formatos" => array:3 [
      "EPUB" => 45
      "HTML" => 4232
      "PDF" => 1105
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011005138"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.06.012"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "aid" => "520"
      "copyright" => "Elsevier España, S.L. and AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2012;103:816-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7686
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 6170
          "PDF" => 1514
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "816"
            "paginaFinal" => "819"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Bullous Hemorrhagic Dermatosis at Distant Sites&#58; A Report of 2 New Cases Due to Enoxaparin Injection and a Review of the Literature"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 854
                "Ancho" => 950
                "Tamanyo" => 134875
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">M&#250;ltiples ves&#237;culo-ampollas de contenido hemorr&#225;gico&#44; no inflamatorias en la regi&#243;n malar derecha&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46;A&#46; Villanueva, L&#46; N&#225;jera, P&#46; Espinosa, J&#46; Borbujo"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#46;A&#46;"
                "apellidos" => "Villanueva"
              ]
              1 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "N&#225;jera"
              ]
              2 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "Espinosa"
              ]
              3 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Borbujo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S157821901200279X"
          "doi" => "10.1016/j.adengl.2011.06.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901200279X?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005138?idApp=UINPBA000044"
      "url" => "/00017310/0000010300000009/v1_201304241717/S0001731011005138/v1_201304241717/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012002806"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.07.010"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "532"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2012;103:820-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5136
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 4246
        "PDF" => 849
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Perianal Ulcers on a Segmental Hemangioma With Minimal or Arrested Growth"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "820"
          "paginaFinal" => "823"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "&#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2275
              "Ancho" => 1252
              "Tamanyo" => 176922
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hemangioma with minimal or arrested growth&#46; There is a pale&#44; erythematous macule with multiple fine telangiectasias&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Lanoel, V&#46; Tosi, M&#46; Bocian, F&#46; Lubieniecki, S&#46;B&#46; Poblete, H&#46;O&#46; Garc&#237;a, A&#46;M&#46; Pierini"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Lanoel"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Tosi"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Bocian"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Lubieniecki"
            ]
            4 => array:2 [
              "nombre" => "S&#46;B&#46;"
              "apellidos" => "Poblete"
            ]
            5 => array:2 [
              "nombre" => "H&#46;O&#46;"
              "apellidos" => "Garc&#237;a"
            ]
            6 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Pierini"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011005254"
        "doi" => "10.1016/j.ad.2011.07.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005254?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002806?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002806/v1_201304241357/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219012002788"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.019"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "607"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2012;103:806-15"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 10409
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 9566
        "PDF" => 794
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Outpatient Treatment of Infantile Hemangiomas With Propranolol&#58; A Prospective Study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "806"
          "paginaFinal" => "815"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tratamiento de hemangiomas infantiles con propranolol en r&#233;gimen de control ambulatorio&#46; Estudio prospectivo"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 813
              "Ancho" => 2337
              "Tamanyo" => 151732
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Case 6&#46; A&#44; Scalp hemangioma before treatment with propranolol&#46; B&#44; Excellent results after 6 months&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; Betlloch-Mas, M&#46;T&#46; Mart&#237;nez-Miravete, A&#46; Lucas-Costa, A&#46;I&#46; Martin de Lara, J&#46; Selva-Otalaurruchi"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Betlloch-Mas"
            ]
            1 => array:2 [
              "nombre" => "M&#46;T&#46;"
              "apellidos" => "Mart&#237;nez-Miravete"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Lucas-Costa"
            ]
            3 => array:2 [
              "nombre" => "A&#46;I&#46;"
              "apellidos" => "Martin de Lara"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Selva-Otalaurruchi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012001640"
        "doi" => "10.1016/j.ad.2012.01.017"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001640?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002788?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002788/v1_201304241357/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Bullous Hemorrhagic Dermatosis at Distant Sites&#58; A Report of 2 New Cases Due to Enoxaparin Injection and a Review of the Literature"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "816"
        "paginaFinal" => "819"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46;A&#46; Villanueva, L&#46; N&#225;jera, P&#46; Espinosa, J&#46; Borbujo"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#46;A&#46;"
            "apellidos" => "Villanueva"
            "email" => array:2 [
              0 => "cvillanueva&#46;hflr&#64;salud&#46;madrid&#46;org"
              1 => "candidavilleneuve&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "N&#225;jera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Espinosa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Borbujo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de Fuenlabrada&#44; Fuenlabrada&#44; Madrid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitario de Fuenlabrada&#44; Fuenlabrada&#44; Madrid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1425
            "Ancho" => 1587
            "Tamanyo" => 173600
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Multiple noninflammatory hemorrhagic vesicles in the right malar region&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Enoxaparin is a low-molecular-weight heparin &#40;LMWH&#41; that is used for the prevention and treatment of pulmonary venous thromboembolism and other thrombotic disorders&#44; such as myocardial infarction&#46; The drug is administered once or twice daily&#44; depending on the indication&#46; The most common complication associated with these anticoagulants is bleeding&#46; Adverse skin reactions may be localized or generalized and can be immediate or delayed&#59; the most common are ecchymoses&#44; skin necrosis&#44; urticaria&#44; angioedema&#44; and eczema&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Seven cases of hemorrhagic bullous dermatosis occurring in areas distant from the site of injection have been reported in patients receiving treatment with various LMWHs &#40;dalteparin&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> enoxaparin&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> tinzaparin<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a>&#41; or unfractionated heparins &#40;calcium heparin<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#41;&#46; We present 2 new cases related to the administration of enoxaparin&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patient 1</span><p id="par0015" class="elsevierStylePara elsevierViewall">Our first patient was a 68-year-old man with a past history of systemic hypertension&#44; diabetes mellitus&#44; hypercholesterolemia and a progressive&#44; stage IV undifferentiated carcinoma&#44; probably of pulmonary origin&#44; diagnosed in 2009 and for which he had received 3 cycles of palliative chemotherapy with cisplatin and etoposide&#46; He was also on treatment with prednisone&#44; metformin&#44; enalapril&#44; and simvastatin&#46; During his most recent admission he had been started on treatment with enoxaparin&#44; 60<span class="elsevierStyleHsp" style=""></span>mg subcutaneously every 12<span class="elsevierStyleHsp" style=""></span>hours&#44; for superior vena cava syndrome&#46; Fifteen days later he came to the emergency department for asymptomatic&#44; hemorrhagic vesicular-bullous lesions on the dorsum of the hand&#44; around the lower jaw and in the malar region on the right side&#46; The lesions had appeared 1 week earlier and had been treated with silver nitrate&#46; The patient did not report bleeding in any other area of the body&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">On physical examination there was a tense&#44; noninflammatory blood-filled vesicle of 7<span class="elsevierStyleHsp" style=""></span>mm in diameter on the dorsum of the hand right and about 15 vesicular lesions of the same characteristics&#44; measuring between 2 and 8<span class="elsevierStyleHsp" style=""></span>mm in diameter&#44; in groups on the right side of the neck and right malar region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Laboratory tests were within the normal ranges for platelet count and coagulation studies &#40;prothrombin time &#91;PT&#93;&#44; prothrombin activity&#44; international normalized ratio &#91;INR&#93;&#44; thromboplastin time&#44; and fibrinogen level&#41;&#46; A biopsy taken from the lesion on the dorsum of the hand revealed a purulent&#44; fibrin-covered necrotic ulcer&#44; with fibrosis and granulation tissue in its base and residual reparative epithelial changes&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patient 2</span><p id="par0030" class="elsevierStylePara elsevierViewall">The second patient was a 78-year-old man with a past history of recently diagnosed stage IV non-small-cell lung cancer with lung and liver metastases&#44; ischemic heart disease&#44; and a biological mitral valve replacement in 2006&#46; He was on treatment with prednisone&#44; codeine&#44; ticlopidine&#44; omeprazole&#44; atorvastatin&#44; nitroglycerine&#44; and enoxaparin&#44; 80<span class="elsevierStyleHsp" style=""></span>mg by subcutaneous injection every 12<span class="elsevierStyleHsp" style=""></span>hours&#46; We were asked to evaluate asymptomatic hemorrhagic skin lesions that had developed 10 days earlier on both knees&#44; the right forearm&#44; and the facial region&#46; The patient reported that 10 days before the lesions appeared&#44; he had started treatment with enoxaparin&#46; There were no other symptoms&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Examination revealed dry&#44; tense hemorrhagic vesicles of up to 5<span class="elsevierStyleHsp" style=""></span>mm in diameter occurring in groups on the right knee and forearm and an isolated vesicle in the facial region&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A complete blood count&#44; biochemistry&#44; and coagulation studies were performed&#44; as well as biopsy of a lesion on the right forearm&#46; Histology revealed an intraepidermal vesicle containing blood&#44; fibrin and occasional neutrophils&#46; There was red blood cell extravasation in the underlying dermis and a mixed inflammatory infiltrate with neutrophils&#59; there were no signs of vasculitis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The results of the complete blood count&#44; including platelet count&#44; and coagulation studies &#40;PT&#44; INR&#44; prothrombin activity&#44; thromboplastin time&#44; fibrinogen&#44; antithrombin III&#44; protein C&#44; and protein S&#41; were within normal limits&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Treatment was continued with enoxaparin at the recommended dose in both cases&#44; and no topical or systemic treatments were added&#46; The lesions resolved without sequelae in 2 to 3 weeks&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Enoxaparin&#44; a LMWH obtained by depolymerization of standard heparin&#44; is used both for prophylaxis and for the treatment of thrombotic phenomena&#46; It acts by binding to antithrombin III&#44; causing inhibition of factor Xa&#46; Bleeding is the most common complication of enoxaparin therapy&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In 2006&#44; Perrinaud et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> were the first to describe patients with hemorrhagic bullous lesions occurring at a distance from the site of injection and that were related to the administration of 2 types of heparin molecule&#58; LMWHs &#40;dalteparin&#44; tinzaparin&#41; and an unfractionated heparin &#40;calcium heparin&#41;&#46; Those authors described 3 patients with eruptions of tense&#44; noninflammatory hemorrhagic blisters distributed in groups at a distance from the site of subcutaneous injection of the heparin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Later&#44; in 2009&#44; Beltraminelli et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Thuillier et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and Gonzales et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported a total of 4 cases similar to those described by Perrinaud et al&#46; and that were associated with the administration of enoxaparin sodium and tinzaparin &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of these lesions is unknown&#46; In our cases there were no alterations of routine coagulation studies&#46; Two of the patients reported by Perrinaud et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> were also taking acetylsalicylic acid and the third was on dipyridamole &#40;an antiplatelet drug&#41; concomitantly with the heparin&#46; Our second patient was also taking ticlopidine&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">As in the 2 cases we present&#44; the histopathology of lesions in the previously published cases was nonspecific&#58; blood-filled intraepidermal or subcorneal vesicles and blisters with no signs of vasculitis or capillary thrombosis&#46; Subepidermal spongiosis and the presence of eosinophils were only observed in the patient described by Thuillier et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Management of the lesions and the decision on whether to interrupt heparin treatment varied in the previously published cases&#46; Perrinaud et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> stated that they replaced the heparin with oral anticoagulants in their first patient&#44; but the patient died 7 days later due to hemorrhagic stroke&#44; and thus the clinical course could not be studied&#46; In their second patient&#44; they discontinued tinzaparin and the lesions resolved at 10 days&#59; in their third patient the lesions resolved even with no change in therapy&#46; Beltraminelli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> only described the clinical course of 1 of their patients&#44; in whom they substituted the heparin with an oral anticoagulant&#59; the lesions resolved within 2 weeks&#46; In the patients reported by Gonzales et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and Thuiller et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> the authors decided to withdraw the heparin and the lesions disappeared within a few weeks&#46; We decided to maintain heparin therapy in our patients and the lesions resolved without treatment within 2 to 3 weeks&#46; As occurred in our patients&#44; the lesions in at least 3 of the patients described in the literature resolved despite continuing heparin treatment&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Enoxaparin belongs to the group of LMWHs&#44; which also includes bemiparin&#44; dalteparin&#44; nadroparin&#44; and tinzaparin&#46; In the literature reviewed&#44; enoxaparin was the heparin most frequently associated with the appearance of hemorrhagic blisters&#8212;it was being administered in 6 of the 9 cases reported&#44; including ours&#46; The more frequent use of enoxaparin may be due to the influence on prescribers of its ease of administration&#44; the absence of a need for blood tests to monitor therapy&#44; and its safety profile&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; heparin-induced hemorrhagic bullous dermatosis occurring at a distance from the site of injection is a rare adverse skin reaction&#44; although the fact that it is typically self-limiting&#44; even without discontinuation of the medication&#44; could mean that it is an underdiagnosed phenomenon or one that is under-reported in the literature&#46; Only 7 cases have been reported prior to the cases we describe&#46; We would like to draw attention to the favourable clinical course of these eruptions in our patients and in those described in the literature&#44; even without treatment modification&#44; and to the absence of associated complications&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres96607"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec83762"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres96606"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec83763"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Patient 1"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Patient 2"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of Interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec83762"
          "palabras" => array:3 [
            0 => "Bullous hemorrhagic dermatosis"
            1 => "Enoxaparin"
            2 => "Heparin"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec83763"
          "palabras" => array:3 [
            0 => "Dermatosis ampollosa hemorr&#225;gica"
            1 => "Enoxaparina"
            2 => "Heparinas"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Enoxaparin is a low-molecular-weight heparin used in the prevention and treatment of pulmonary thromboembolism and other thrombotic disorders&#46; The most common adverse reactions to enoxaparin are ecchymosis&#44; skin necrosis&#44; urticaria&#44; angioedema&#44; and eczema&#46; The first 2 cases of bullous hemorrhagic dermatosis in areas distant from heparin injection sites were described in 2006&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the cases of 2 men&#44; aged 68 and 78 years&#44; with progressive&#44; advanced-stage lung cancer&#44; who consulted with bullous hemorrhagic lesions without associated symptoms&#46; Both patients reported that the lesions had appeared after initiation of heparin therapy at therapeutic doses&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In our review of the literature&#44; we found just 7 cases of heparin-induced bullous hemorrhagic dermatosis&#46; We report a further 2 cases&#44; caused by enoxaparin&#44; in which treatment was continued and in which the lesions resolved in 2 to 3 weeks&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La enoxaparina pertenece al grupo de heparinas de bajo peso molecular&#46; Se utiliza en el manejo terap&#233;utico y profil&#225;ctico del tromboembolismo venoso pulmonar y otros cuadros tromb&#243;ticos&#46; Las reacciones adversas cut&#225;neas m&#225;s frecuentes son equimosis&#44; necrosis cut&#225;nea&#44; urticaria&#44; angioedema y eccema&#46; En el a&#241;o 2006 se describieron los primeros casos de dermatosis ampollosa hemorr&#225;gica a distancia por heparina&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Presentamos dos varones de 68 y 78 a&#241;os&#44; con carcinomas de pulm&#243;n en estadios avanzados y en progresi&#243;n&#44; que consultaban por lesiones ampollosas hemorr&#225;gicas&#44; sin otra sintomatolog&#237;a acompa&#241;ante&#46; Ambos refer&#237;an la aparici&#243;n de las lesiones tras comenzar con la administraci&#243;n de heparina a dosis terap&#233;uticas&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En la literatura revisada solo hemos encontrado descritos 7 casos de dermatosis ampollosa hemorr&#225;gica por heparina&#46; Aportamos dos nuevos casos por enoxaparina&#44; en los que se mantuvo el tratamiento y se resolvi&#243; el cuadro en dos a tres semanas&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Villanueva CA&#44; et al&#46; Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura&#46; Actas Dermosifiliogr&#46; 2012&#59;103&#58;816-9&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1425
            "Ancho" => 1587
            "Tamanyo" => 173600
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Multiple noninflammatory hemorrhagic vesicles in the right malar region&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1132
            "Ancho" => 1587
            "Tamanyo" => 91712
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Intraepidermal vesicle containing blood&#44; fibrin and occasional neutrophils&#46; There are no signs of vasculitis &#40;hematoxylin-eosin&#44; original magnification &#215;10&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Heparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Time to Onset<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&#44; d&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Histology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment Withdrawal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Perrinaud et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dalteparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tinzaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sodium heparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Beltraminelli et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal and subcorneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gonzales et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subcorneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Thuillier et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&#47;tinzaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subcorneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Present cases</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fibronecrotic scar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab182580.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara">Time to onset defined as the time between starting the administration of the drug and the appearance of the lesions<span class="elsevierStyleSup">&#46;</span></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Heparin-induced Hemorrhagic Bullous Dermatosis at a Site Distant From the Injection&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrosis cut&#225;nea por heparina&#58; una forma posiblemente fatal de hipersensibilidad a la heparina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Campo"
                            1 => "C&#46; Gonz&#225;lez"
                            2 => "J&#46; Soler"
                            3 => "L&#46; G&#243;mez"
                            4 => "J&#46; Piulachs"
                            5 => "J&#46; Palou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "1998"
                        "volumen" => "89"
                        "paginaInicial" => "613"
                        "paginaFinal" => "619"
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510707024066"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Placas eritematosas por heparina de bajo peso molecular"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Ruiz-Genao"
                            1 => "T&#46; Sanz-S&#225;nchez"
                            2 => "J&#46; S&#225;nchez-P&#233;rez"
                            3 => "J&#46; Fern&#225;ndez-Herrera"
                            4 => "A&#46; Garc&#237;a-D&#237;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2001"
                        "volumen" => "92"
                        "paginaInicial" => "93"
                        "paginaFinal" => "96"
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709017623"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fondaparinux and lepirudin as therapeutic alternatives in a disseminated eczematous skin reaction to low-molecular-weight heparin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;I&#46; Santiago S&#225;nchez-Mateos"
                            1 => "C&#46; Eguren"
                            2 => "D&#46; Argila"
                            3 => "J&#46; S&#225;nchez-P&#233;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "101"
                        "paginaInicial" => "556"
                        "paginaFinal" => "558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20738979"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin&#58; Three cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Perrinaud"
                            1 => "D&#46; Jacobi"
                            2 => "M&#46;C&#46; Machet"
                            3 => "C&#46; Grodet"
                            4 => "Y&#46; Gruel"
                            5 => "L&#46; Machet Bullous"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2006"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "S5"
                        "paginaFinal" => "S7"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraepidermal bullous haemorrhage during anticoagulation with low-molecular-weight heparin&#59; two cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Beltraminelli"
                            1 => "P&#46; Itin"
                            2 => "L&#46; Cerroni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2009.09162.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "161"
                        "paginaInicial" => "191"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19416231"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatose bulleuse h&#233;morragique associ&#233;e a une r&#233;action d&#8217;hypersensibilit&#233; retard&#233;e sous h&#233;parine de bas poids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Thuillier"
                            1 => "G&#46; Chaby"
                            2 => "A&#46; Dadban"
                            3 => "E&#46; Dascotte"
                            4 => "D&#46; Miquel-Christophe"
                            5 => "M&#46; Andrejak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Dermatol Venereol"
                        "fecha" => "2009"
                        "volumen" => "136"
                        "paginaInicial" => "706"
                        "paginaFinal" => "770"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Remote hemorrhagic bullae occurring in a patient treated with subcutaneous heparin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "U&#46;P&#46; Gonzales"
                            1 => "G&#46;A&#46; Scott"
                            2 => "A&#46;J&#46; Briones"
                            3 => "A&#46;P&#46; Pentland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2009.70"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2009"
                        "volumen" => "145"
                        "paginaInicial" => "604"
                        "paginaFinal" => "605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19451517"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411008191"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010300000009/v1_201304241357/S157821901200279X/v1_201304241357/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6183"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000009/v1_201304241357/S157821901200279X/v1_201304241357/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901200279X?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case report
Bullous Hemorrhagic Dermatosis at Distant Sites: A Report of 2 New Cases Due to Enoxaparin Injection and a Review of the Literature
Dermatosis ampollosa hemorrágica a distancia; dos nuevos casos por enoxaparina y revisión de la literatura
C.A. Villanuevaa,
Autor para correspondencia
, L. Nájerab, P. Espinosaa, J. Borbujoa
a Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain
Leído
10720
Veces
se ha leído el artículo
3170
Total PDF
7550
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S157821901200279X"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.06.004"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "aid" => "520"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2012;103:816-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5382
    "formatos" => array:3 [
      "EPUB" => 45
      "HTML" => 4232
      "PDF" => 1105
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011005138"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.06.012"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "aid" => "520"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2012;103:816-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7686
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 6170
          "PDF" => 1514
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "816"
            "paginaFinal" => "819"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Bullous Hemorrhagic Dermatosis at Distant Sites&#58; A Report of 2 New Cases Due to Enoxaparin Injection and a Review of the Literature"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 854
                "Ancho" => 950
                "Tamanyo" => 134875
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">M&#250;ltiples ves&#237;culo-ampollas de contenido hemorr&#225;gico&#44; no inflamatorias en la regi&#243;n malar derecha&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46;A&#46; Villanueva, L&#46; N&#225;jera, P&#46; Espinosa, J&#46; Borbujo"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "C&#46;A&#46;"
                "apellidos" => "Villanueva"
              ]
              1 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "N&#225;jera"
              ]
              2 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "Espinosa"
              ]
              3 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Borbujo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S157821901200279X"
          "doi" => "10.1016/j.adengl.2011.06.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901200279X?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005138?idApp=UINPBA000044"
      "url" => "/00017310/0000010300000009/v1_201304241717/S0001731011005138/v1_201304241717/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219012002806"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.07.010"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "532"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2012;103:820-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5136
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 4246
        "PDF" => 849
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Perianal Ulcers on a Segmental Hemangioma With Minimal or Arrested Growth"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "820"
          "paginaFinal" => "823"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "&#218;lceras perianales sobre hemangioma con crecimiento m&#237;nimo o detenido segmentario"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2275
              "Ancho" => 1252
              "Tamanyo" => 176922
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hemangioma with minimal or arrested growth&#46; There is a pale&#44; erythematous macule with multiple fine telangiectasias&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Lanoel, V&#46; Tosi, M&#46; Bocian, F&#46; Lubieniecki, S&#46;B&#46; Poblete, H&#46;O&#46; Garc&#237;a, A&#46;M&#46; Pierini"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Lanoel"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Tosi"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Bocian"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Lubieniecki"
            ]
            4 => array:2 [
              "nombre" => "S&#46;B&#46;"
              "apellidos" => "Poblete"
            ]
            5 => array:2 [
              "nombre" => "H&#46;O&#46;"
              "apellidos" => "Garc&#237;a"
            ]
            6 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Pierini"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011005254"
        "doi" => "10.1016/j.ad.2011.07.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005254?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002806?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002806/v1_201304241357/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219012002788"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.01.019"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "607"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2012;103:806-15"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 10409
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 9566
        "PDF" => 794
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Outpatient Treatment of Infantile Hemangiomas With Propranolol&#58; A Prospective Study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "806"
          "paginaFinal" => "815"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tratamiento de hemangiomas infantiles con propranolol en r&#233;gimen de control ambulatorio&#46; Estudio prospectivo"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 813
              "Ancho" => 2337
              "Tamanyo" => 151732
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Case 6&#46; A&#44; Scalp hemangioma before treatment with propranolol&#46; B&#44; Excellent results after 6 months&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; Betlloch-Mas, M&#46;T&#46; Mart&#237;nez-Miravete, A&#46; Lucas-Costa, A&#46;I&#46; Martin de Lara, J&#46; Selva-Otalaurruchi"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Betlloch-Mas"
            ]
            1 => array:2 [
              "nombre" => "M&#46;T&#46;"
              "apellidos" => "Mart&#237;nez-Miravete"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Lucas-Costa"
            ]
            3 => array:2 [
              "nombre" => "A&#46;I&#46;"
              "apellidos" => "Martin de Lara"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Selva-Otalaurruchi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012001640"
        "doi" => "10.1016/j.ad.2012.01.017"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001640?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002788?idApp=UINPBA000044"
    "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012002788/v1_201304241357/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Bullous Hemorrhagic Dermatosis at Distant Sites&#58; A Report of 2 New Cases Due to Enoxaparin Injection and a Review of the Literature"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "816"
        "paginaFinal" => "819"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46;A&#46; Villanueva, L&#46; N&#225;jera, P&#46; Espinosa, J&#46; Borbujo"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#46;A&#46;"
            "apellidos" => "Villanueva"
            "email" => array:2 [
              0 => "cvillanueva&#46;hflr&#64;salud&#46;madrid&#46;org"
              1 => "candidavilleneuve&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "N&#225;jera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Espinosa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Borbujo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de Fuenlabrada&#44; Fuenlabrada&#44; Madrid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitario de Fuenlabrada&#44; Fuenlabrada&#44; Madrid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1425
            "Ancho" => 1587
            "Tamanyo" => 173600
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Multiple noninflammatory hemorrhagic vesicles in the right malar region&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Enoxaparin is a low-molecular-weight heparin &#40;LMWH&#41; that is used for the prevention and treatment of pulmonary venous thromboembolism and other thrombotic disorders&#44; such as myocardial infarction&#46; The drug is administered once or twice daily&#44; depending on the indication&#46; The most common complication associated with these anticoagulants is bleeding&#46; Adverse skin reactions may be localized or generalized and can be immediate or delayed&#59; the most common are ecchymoses&#44; skin necrosis&#44; urticaria&#44; angioedema&#44; and eczema&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Seven cases of hemorrhagic bullous dermatosis occurring in areas distant from the site of injection have been reported in patients receiving treatment with various LMWHs &#40;dalteparin&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> enoxaparin&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> tinzaparin<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a>&#41; or unfractionated heparins &#40;calcium heparin<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#41;&#46; We present 2 new cases related to the administration of enoxaparin&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patient 1</span><p id="par0015" class="elsevierStylePara elsevierViewall">Our first patient was a 68-year-old man with a past history of systemic hypertension&#44; diabetes mellitus&#44; hypercholesterolemia and a progressive&#44; stage IV undifferentiated carcinoma&#44; probably of pulmonary origin&#44; diagnosed in 2009 and for which he had received 3 cycles of palliative chemotherapy with cisplatin and etoposide&#46; He was also on treatment with prednisone&#44; metformin&#44; enalapril&#44; and simvastatin&#46; During his most recent admission he had been started on treatment with enoxaparin&#44; 60<span class="elsevierStyleHsp" style=""></span>mg subcutaneously every 12<span class="elsevierStyleHsp" style=""></span>hours&#44; for superior vena cava syndrome&#46; Fifteen days later he came to the emergency department for asymptomatic&#44; hemorrhagic vesicular-bullous lesions on the dorsum of the hand&#44; around the lower jaw and in the malar region on the right side&#46; The lesions had appeared 1 week earlier and had been treated with silver nitrate&#46; The patient did not report bleeding in any other area of the body&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">On physical examination there was a tense&#44; noninflammatory blood-filled vesicle of 7<span class="elsevierStyleHsp" style=""></span>mm in diameter on the dorsum of the hand right and about 15 vesicular lesions of the same characteristics&#44; measuring between 2 and 8<span class="elsevierStyleHsp" style=""></span>mm in diameter&#44; in groups on the right side of the neck and right malar region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Laboratory tests were within the normal ranges for platelet count and coagulation studies &#40;prothrombin time &#91;PT&#93;&#44; prothrombin activity&#44; international normalized ratio &#91;INR&#93;&#44; thromboplastin time&#44; and fibrinogen level&#41;&#46; A biopsy taken from the lesion on the dorsum of the hand revealed a purulent&#44; fibrin-covered necrotic ulcer&#44; with fibrosis and granulation tissue in its base and residual reparative epithelial changes&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patient 2</span><p id="par0030" class="elsevierStylePara elsevierViewall">The second patient was a 78-year-old man with a past history of recently diagnosed stage IV non-small-cell lung cancer with lung and liver metastases&#44; ischemic heart disease&#44; and a biological mitral valve replacement in 2006&#46; He was on treatment with prednisone&#44; codeine&#44; ticlopidine&#44; omeprazole&#44; atorvastatin&#44; nitroglycerine&#44; and enoxaparin&#44; 80<span class="elsevierStyleHsp" style=""></span>mg by subcutaneous injection every 12<span class="elsevierStyleHsp" style=""></span>hours&#46; We were asked to evaluate asymptomatic hemorrhagic skin lesions that had developed 10 days earlier on both knees&#44; the right forearm&#44; and the facial region&#46; The patient reported that 10 days before the lesions appeared&#44; he had started treatment with enoxaparin&#46; There were no other symptoms&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Examination revealed dry&#44; tense hemorrhagic vesicles of up to 5<span class="elsevierStyleHsp" style=""></span>mm in diameter occurring in groups on the right knee and forearm and an isolated vesicle in the facial region&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A complete blood count&#44; biochemistry&#44; and coagulation studies were performed&#44; as well as biopsy of a lesion on the right forearm&#46; Histology revealed an intraepidermal vesicle containing blood&#44; fibrin and occasional neutrophils&#46; There was red blood cell extravasation in the underlying dermis and a mixed inflammatory infiltrate with neutrophils&#59; there were no signs of vasculitis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The results of the complete blood count&#44; including platelet count&#44; and coagulation studies &#40;PT&#44; INR&#44; prothrombin activity&#44; thromboplastin time&#44; fibrinogen&#44; antithrombin III&#44; protein C&#44; and protein S&#41; were within normal limits&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Treatment was continued with enoxaparin at the recommended dose in both cases&#44; and no topical or systemic treatments were added&#46; The lesions resolved without sequelae in 2 to 3 weeks&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Enoxaparin&#44; a LMWH obtained by depolymerization of standard heparin&#44; is used both for prophylaxis and for the treatment of thrombotic phenomena&#46; It acts by binding to antithrombin III&#44; causing inhibition of factor Xa&#46; Bleeding is the most common complication of enoxaparin therapy&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In 2006&#44; Perrinaud et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> were the first to describe patients with hemorrhagic bullous lesions occurring at a distance from the site of injection and that were related to the administration of 2 types of heparin molecule&#58; LMWHs &#40;dalteparin&#44; tinzaparin&#41; and an unfractionated heparin &#40;calcium heparin&#41;&#46; Those authors described 3 patients with eruptions of tense&#44; noninflammatory hemorrhagic blisters distributed in groups at a distance from the site of subcutaneous injection of the heparin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Later&#44; in 2009&#44; Beltraminelli et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Thuillier et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and Gonzales et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported a total of 4 cases similar to those described by Perrinaud et al&#46; and that were associated with the administration of enoxaparin sodium and tinzaparin &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of these lesions is unknown&#46; In our cases there were no alterations of routine coagulation studies&#46; Two of the patients reported by Perrinaud et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> were also taking acetylsalicylic acid and the third was on dipyridamole &#40;an antiplatelet drug&#41; concomitantly with the heparin&#46; Our second patient was also taking ticlopidine&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">As in the 2 cases we present&#44; the histopathology of lesions in the previously published cases was nonspecific&#58; blood-filled intraepidermal or subcorneal vesicles and blisters with no signs of vasculitis or capillary thrombosis&#46; Subepidermal spongiosis and the presence of eosinophils were only observed in the patient described by Thuillier et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Management of the lesions and the decision on whether to interrupt heparin treatment varied in the previously published cases&#46; Perrinaud et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> stated that they replaced the heparin with oral anticoagulants in their first patient&#44; but the patient died 7 days later due to hemorrhagic stroke&#44; and thus the clinical course could not be studied&#46; In their second patient&#44; they discontinued tinzaparin and the lesions resolved at 10 days&#59; in their third patient the lesions resolved even with no change in therapy&#46; Beltraminelli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> only described the clinical course of 1 of their patients&#44; in whom they substituted the heparin with an oral anticoagulant&#59; the lesions resolved within 2 weeks&#46; In the patients reported by Gonzales et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and Thuiller et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> the authors decided to withdraw the heparin and the lesions disappeared within a few weeks&#46; We decided to maintain heparin therapy in our patients and the lesions resolved without treatment within 2 to 3 weeks&#46; As occurred in our patients&#44; the lesions in at least 3 of the patients described in the literature resolved despite continuing heparin treatment&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Enoxaparin belongs to the group of LMWHs&#44; which also includes bemiparin&#44; dalteparin&#44; nadroparin&#44; and tinzaparin&#46; In the literature reviewed&#44; enoxaparin was the heparin most frequently associated with the appearance of hemorrhagic blisters&#8212;it was being administered in 6 of the 9 cases reported&#44; including ours&#46; The more frequent use of enoxaparin may be due to the influence on prescribers of its ease of administration&#44; the absence of a need for blood tests to monitor therapy&#44; and its safety profile&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; heparin-induced hemorrhagic bullous dermatosis occurring at a distance from the site of injection is a rare adverse skin reaction&#44; although the fact that it is typically self-limiting&#44; even without discontinuation of the medication&#44; could mean that it is an underdiagnosed phenomenon or one that is under-reported in the literature&#46; Only 7 cases have been reported prior to the cases we describe&#46; We would like to draw attention to the favourable clinical course of these eruptions in our patients and in those described in the literature&#44; even without treatment modification&#44; and to the absence of associated complications&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:2 [
          "identificador" => "xres96607"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec83762"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres96606"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec83763"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Patient 1"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Patient 2"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of Interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec83762"
          "palabras" => array:3 [
            0 => "Bullous hemorrhagic dermatosis"
            1 => "Enoxaparin"
            2 => "Heparin"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec83763"
          "palabras" => array:3 [
            0 => "Dermatosis ampollosa hemorr&#225;gica"
            1 => "Enoxaparina"
            2 => "Heparinas"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Enoxaparin is a low-molecular-weight heparin used in the prevention and treatment of pulmonary thromboembolism and other thrombotic disorders&#46; The most common adverse reactions to enoxaparin are ecchymosis&#44; skin necrosis&#44; urticaria&#44; angioedema&#44; and eczema&#46; The first 2 cases of bullous hemorrhagic dermatosis in areas distant from heparin injection sites were described in 2006&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present the cases of 2 men&#44; aged 68 and 78 years&#44; with progressive&#44; advanced-stage lung cancer&#44; who consulted with bullous hemorrhagic lesions without associated symptoms&#46; Both patients reported that the lesions had appeared after initiation of heparin therapy at therapeutic doses&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In our review of the literature&#44; we found just 7 cases of heparin-induced bullous hemorrhagic dermatosis&#46; We report a further 2 cases&#44; caused by enoxaparin&#44; in which treatment was continued and in which the lesions resolved in 2 to 3 weeks&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La enoxaparina pertenece al grupo de heparinas de bajo peso molecular&#46; Se utiliza en el manejo terap&#233;utico y profil&#225;ctico del tromboembolismo venoso pulmonar y otros cuadros tromb&#243;ticos&#46; Las reacciones adversas cut&#225;neas m&#225;s frecuentes son equimosis&#44; necrosis cut&#225;nea&#44; urticaria&#44; angioedema y eccema&#46; En el a&#241;o 2006 se describieron los primeros casos de dermatosis ampollosa hemorr&#225;gica a distancia por heparina&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Presentamos dos varones de 68 y 78 a&#241;os&#44; con carcinomas de pulm&#243;n en estadios avanzados y en progresi&#243;n&#44; que consultaban por lesiones ampollosas hemorr&#225;gicas&#44; sin otra sintomatolog&#237;a acompa&#241;ante&#46; Ambos refer&#237;an la aparici&#243;n de las lesiones tras comenzar con la administraci&#243;n de heparina a dosis terap&#233;uticas&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En la literatura revisada solo hemos encontrado descritos 7 casos de dermatosis ampollosa hemorr&#225;gica por heparina&#46; Aportamos dos nuevos casos por enoxaparina&#44; en los que se mantuvo el tratamiento y se resolvi&#243; el cuadro en dos a tres semanas&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Villanueva CA&#44; et al&#46; Dermatosis ampollosa hemorr&#225;gica a distancia&#59; dos nuevos casos por enoxaparina y revisi&#243;n de la literatura&#46; Actas Dermosifiliogr&#46; 2012&#59;103&#58;816-9&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1425
            "Ancho" => 1587
            "Tamanyo" => 173600
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Multiple noninflammatory hemorrhagic vesicles in the right malar region&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1132
            "Ancho" => 1587
            "Tamanyo" => 91712
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Intraepidermal vesicle containing blood&#44; fibrin and occasional neutrophils&#46; There are no signs of vasculitis &#40;hematoxylin-eosin&#44; original magnification &#215;10&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Heparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Time to Onset<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&#44; d&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Histology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment Withdrawal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Perrinaud et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dalteparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tinzaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sodium heparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Beltraminelli et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal and subcorneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gonzales et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subcorneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Thuillier et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&#47;tinzaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subcorneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Present cases</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fibronecrotic scar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enoxaparin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepidermal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab182580.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara">Time to onset defined as the time between starting the administration of the drug and the appearance of the lesions<span class="elsevierStyleSup">&#46;</span></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Heparin-induced Hemorrhagic Bullous Dermatosis at a Site Distant From the Injection&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrosis cut&#225;nea por heparina&#58; una forma posiblemente fatal de hipersensibilidad a la heparina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Campo"
                            1 => "C&#46; Gonz&#225;lez"
                            2 => "J&#46; Soler"
                            3 => "L&#46; G&#243;mez"
                            4 => "J&#46; Piulachs"
                            5 => "J&#46; Palou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "1998"
                        "volumen" => "89"
                        "paginaInicial" => "613"
                        "paginaFinal" => "619"
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510707024066"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Placas eritematosas por heparina de bajo peso molecular"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Ruiz-Genao"
                            1 => "T&#46; Sanz-S&#225;nchez"
                            2 => "J&#46; S&#225;nchez-P&#233;rez"
                            3 => "J&#46; Fern&#225;ndez-Herrera"
                            4 => "A&#46; Garc&#237;a-D&#237;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2001"
                        "volumen" => "92"
                        "paginaInicial" => "93"
                        "paginaFinal" => "96"
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709017623"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fondaparinux and lepirudin as therapeutic alternatives in a disseminated eczematous skin reaction to low-molecular-weight heparin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;I&#46; Santiago S&#225;nchez-Mateos"
                            1 => "C&#46; Eguren"
                            2 => "D&#46; Argila"
                            3 => "J&#46; S&#225;nchez-P&#233;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "101"
                        "paginaInicial" => "556"
                        "paginaFinal" => "558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20738979"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin&#58; Three cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Perrinaud"
                            1 => "D&#46; Jacobi"
                            2 => "M&#46;C&#46; Machet"
                            3 => "C&#46; Grodet"
                            4 => "Y&#46; Gruel"
                            5 => "L&#46; Machet Bullous"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2006"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "S5"
                        "paginaFinal" => "S7"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraepidermal bullous haemorrhage during anticoagulation with low-molecular-weight heparin&#59; two cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Beltraminelli"
                            1 => "P&#46; Itin"
                            2 => "L&#46; Cerroni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2009.09162.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "161"
                        "paginaInicial" => "191"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19416231"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatose bulleuse h&#233;morragique associ&#233;e a une r&#233;action d&#8217;hypersensibilit&#233; retard&#233;e sous h&#233;parine de bas poids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Thuillier"
                            1 => "G&#46; Chaby"
                            2 => "A&#46; Dadban"
                            3 => "E&#46; Dascotte"
                            4 => "D&#46; Miquel-Christophe"
                            5 => "M&#46; Andrejak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Dermatol Venereol"
                        "fecha" => "2009"
                        "volumen" => "136"
                        "paginaInicial" => "706"
                        "paginaFinal" => "770"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Remote hemorrhagic bullae occurring in a patient treated with subcutaneous heparin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "U&#46;P&#46; Gonzales"
                            1 => "G&#46;A&#46; Scott"
                            2 => "A&#46;J&#46; Briones"
                            3 => "A&#46;P&#46; Pentland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2009.70"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2009"
                        "volumen" => "145"
                        "paginaInicial" => "604"
                        "paginaFinal" => "605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19451517"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411008191"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010300000009/v1_201304241357/S157821901200279X/v1_201304241357/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6183"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000009/v1_201304241357/S157821901200279X/v1_201304241357/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901200279X?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 9 9 18
2024 Octubre 83 45 128
2024 Septiembre 85 24 109
2024 Agosto 93 76 169
2024 Julio 81 28 109
2024 Junio 92 40 132
2024 Mayo 88 40 128
2024 Abril 84 20 104
2024 Marzo 98 35 133
2024 Febrero 78 32 110
2024 Enero 64 33 97
2023 Diciembre 87 40 127
2023 Noviembre 102 66 168
2023 Octubre 89 35 124
2023 Septiembre 102 26 128
2023 Agosto 68 29 97
2023 Julio 101 33 134
2023 Junio 63 22 85
2023 Mayo 74 34 108
2023 Abril 58 22 80
2023 Marzo 76 31 107
2023 Febrero 55 22 77
2023 Enero 44 36 80
2022 Diciembre 54 52 106
2022 Noviembre 38 32 70
2022 Octubre 34 36 70
2022 Septiembre 28 37 65
2022 Agosto 26 34 60
2022 Julio 35 42 77
2022 Junio 27 21 48
2022 Mayo 80 41 121
2022 Abril 81 46 127
2022 Marzo 129 69 198
2022 Febrero 68 34 102
2022 Enero 80 53 133
2021 Diciembre 73 55 128
2021 Noviembre 67 49 116
2021 Octubre 55 59 114
2021 Septiembre 51 52 103
2021 Agosto 42 48 90
2021 Julio 40 42 82
2021 Junio 50 39 89
2021 Mayo 35 49 84
2021 Abril 93 68 161
2021 Marzo 52 36 88
2021 Febrero 52 35 87
2021 Enero 29 25 54
2020 Diciembre 19 19 38
2020 Noviembre 19 18 37
2020 Octubre 26 17 43
2020 Septiembre 25 20 45
2020 Agosto 17 21 38
2020 Julio 20 14 34
2020 Junio 28 27 55
2020 Mayo 19 38 57
2020 Abril 19 31 50
2020 Marzo 28 23 51
2020 Febrero 7 10 17
2020 Enero 2 13 15
2019 Diciembre 4 8 12
2019 Noviembre 4 3 7
2019 Octubre 0 4 4
2019 Septiembre 4 5 9
2019 Agosto 4 12 16
2019 Julio 4 10 14
2019 Junio 4 30 34
2019 Mayo 4 64 68
2019 Abril 5 40 45
2019 Marzo 0 12 12
2019 Febrero 2 2 4
2018 Diciembre 4 7 11
2018 Noviembre 3 0 3
2018 Septiembre 6 0 6
2018 Junio 0 2 2
2018 Marzo 3 1 4
2018 Febrero 73 9 82
2018 Enero 78 9 87
2017 Diciembre 66 10 76
2017 Noviembre 57 17 74
2017 Octubre 67 12 79
2017 Septiembre 45 10 55
2017 Agosto 79 8 87
2017 Julio 86 15 101
2017 Junio 101 17 118
2017 Mayo 83 15 98
2017 Abril 70 15 85
2017 Marzo 64 18 82
2017 Febrero 61 24 85
2017 Enero 50 7 57
2016 Diciembre 95 19 114
2016 Noviembre 128 18 146
2016 Octubre 143 20 163
2016 Septiembre 244 19 263
2016 Agosto 196 28 224
2016 Julio 76 16 92
2016 Junio 7 29 36
2016 Mayo 5 27 32
2016 Abril 4 6 10
2016 Marzo 10 14 24
2016 Febrero 6 4 10
2016 Enero 6 2 8
2015 Diciembre 11 10 21
2015 Noviembre 12 9 21
2015 Octubre 9 5 14
2015 Septiembre 11 2 13
2015 Agosto 19 3 22
2015 Julio 181 1 182
2015 Junio 106 21 127
2015 Mayo 114 33 147
2015 Abril 129 33 162
2015 Marzo 101 19 120
2015 Febrero 101 18 119
2015 Enero 114 23 137
2014 Diciembre 73 26 99
2014 Noviembre 105 20 125
2014 Octubre 79 15 94
2014 Septiembre 68 10 78
2014 Agosto 122 11 133
2014 Julio 78 11 89
2014 Junio 91 6 97
2014 Mayo 89 9 98
2014 Abril 57 12 69
2014 Marzo 74 14 88
2014 Febrero 72 19 91
2014 Enero 52 11 63
2013 Diciembre 48 6 54
2013 Noviembre 44 16 60
2013 Octubre 40 7 47
2013 Septiembre 40 11 51
2013 Agosto 39 25 64
2013 Julio 18 24 42
2013 Junio 15 10 25
2013 Mayo 13 6 19
2013 Abril 9 12 21
2013 Marzo 19 6 25
2013 Febrero 41 10 51
2013 Enero 58 14 72
2012 Diciembre 22 9 31
2012 Noviembre 3 2 5
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?