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Armengot-Carbó, M.J. Roca-Estellés, E. Quecedo-Estébanez, E. Gimeno-Carpio" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Armengot-Carbó" "email" => array:1 [ 0 => "miquelarmengot@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.J." "apellidos" => "Roca-Estellés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "E." "apellidos" => "Quecedo-Estébanez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Gimeno-Carpio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Arnau de Vilanova, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Angiosarcoma cutáneo tras radioterapia por cáncer de mama" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1299 "Ancho" => 1750 "Tamanyo" => 814325 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Cell proliferation affecting the entire dermis, in which interstitial hemorrhage and vascular lumens are visible (hematoxylin-eosin [H&E], original magnification ×40). B, Vascular channels lined by endothelial cells with atypia infiltrating the collagen bundles (H&E, original magnification ×200). C, Pleomorphic epithelioid cells, between which several atypical mitoses are visible (H&E, original magnification ×400). D, Immunohistochemical staining with anti-CD31 antibody was positive for proliferating cells (H&E, original magnification ×200).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In recent years, there has been a trend towards conservative management of breast cancer, which involves the use of adjuvant radiotherapy. This approach carries a risk of radiation-induced secondary malignancy.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 70-year-old woman who underwent quadrantectomy combined with adjuvant radiotherapy to treat invasive ductal carcinoma in her right breast in 2007. She was referred to our center 3 years later with a 1-month history of skin lesions. Examination revealed several red-violaceous nodules and papules, with multifocal involvement of the treated breast (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathology of 1 of the nodules revealed a poorly defined dermal tumor infiltrating the subcutaneous layer, which was formed by a proliferation of vascular structures alternating with undifferentiated solid areas (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The vascular structures were covered by endothelial cells with atypia, whereas the solid areas contained highly proliferative pleomorphic epithelioid cells (6 mitoses per 10 high-power fields) and interstitial hemorrhaging. The tumor cells proved to be immunoreactive to vascular markers (CD31 and CD34) and negative to epithelial markers (epithelial membrane antigen and pancytokeratin). Immunostaining for herpes simplex virus type 8 was negative.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">These findings confirmed the diagnosis of angiosarcoma, and the patient underwent simple mastectomy. Pathological examination of the surgical specimen showed the presence of several dermal nodules (the largest measuring 4<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>cm) and foci in the breast parenchyma (2-5<span class="elsevierStyleHsp" style=""></span>mm). Histopathology confirmed the diagnosis of high-grade angiosarcoma, with disease-free margins. The results of the staging study (computed tomography of the thorax, abdomen, and pelvis and positron emission tomography) were negative. After a 9-month follow-up period, the patient remains disease-free.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Angiosarcoma is a very uncommon endothelial cell tumor.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It accounts for less than 1% of cases of sarcoma and most frequently affects the skin.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> Cutaneous angiosarcoma can be divided into 3 main types: the classic or idiopathic type, the chronic lymphedema–associated type, and the radiation-induced type. Classic idiopathic angiosarcoma affects the skin of the head and neck in elderly patients<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> and is the most frequent variety (50%-60%).<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Chronic lymphedema–associated angiosarcoma appears after a period ranging from 4 to 27 years<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and almost always (><span class="elsevierStyleHsp" style=""></span>90% of cases) develops in a limb with chronic lymphedema following radical mastectomy with axillary lymph node dissection (Stewart-Treves syndrome). Radiation-induced angiosarcoma appears in an irradiated field after a latency period.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In previous decades, this variety mostly affected the abdomen after radiotherapy for abdominopelvic tumors.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> Today, however, angiosarcoma is detected mainly on the skin of the breast in women aged more than 60 years who have undergone adjuvant radiotherapy after conservative surgery for breast cancer. The latency period is 3 to 5 years in most cases.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In any case, angiosarcoma remains a very uncommon complication (0.05%-0.16% of patients<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3,6</span></a>).</p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically, angiosarcoma is characterized by the onset of erythematous-violaceous nodules or plaques that are typically multifocal. Histopathology findings correspond to those reported in our case. Growth is explosive in high-grade tumors and more insidious in low-grade tumors.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Its appearance may be similar to that of cutaneous metastases and of erysipelatoid carcinoma (cutaneous metastasis whose symptoms are similar to those of erysipelas). The differential diagnosis should include atypical vascular lesions (AVLs), which are cutaneous vascular proliferations that appear after radiotherapy for breast cancer with a latency period of 3 to 6 years.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Unlike angiosarcoma, AVLs are not characterized by multiple layers of endothelial cells, prominent nucleoli, mitosis, atypia, destruction of skin appendages, areas of solid growth, invasion of the subcutis, or hemorrhage. Furthermore, AVLs are circumscribed lesions with frequent chronic inflammation and stromal projections in the lumen, which are not found in angiosarcoma.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,7</span></a> Radiation-induced angiosarcoma was recently shown to involve an amplification of the v-myc myelocytomatosis viral oncogene homolog (avian) gene (<span class="elsevierStyleItalic">MYC</span>), which is not found in AVLs. The presence of this gene could be used to confirm a diagnosis in complex cases or when the available tissue is limited.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> It is therefore important to remember that sufficient sample material must be obtained, since punch biopsy findings can lead to an erroneous diagnosis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Treatment involves aggressive surgical excision.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Hyperfractionated accelerated adjuvant radiotherapy has been reported to achieve better control of the disease.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Prognosis is poor, with high recurrence rates and a strong tendency to metastasize.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Overall survival at 5 years is 12% to 20%, and mean survival is 18 to 28 months.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Some data suggest that radiation-induced angiosarcoma could have a poorer prognosis than sporadic angiosarcoma.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion, we present a case of multifocal angiosarcoma of the skin of the breast. This condition is a very uncommon yet very aggressive complication of radiotherapy that should be suspected in patients with erythematous-violaceous nodules on a previously irradiated breast. Given the recent trend towards conservative management of breast cancer, we should be on the alert for possible increases in the incidence of this tumor.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: M. Armengot-Carbó, M.J. Roca-Estellés, E. Quecedo-Estébanez, E. Gimeno-Carpio. Angiosarcoma cutáneo tras radioterapia por cáncer de mama. Actas Dermosifiliogr. 2012;103:557-9.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 671 "Ancho" => 951 "Tamanyo" => 104572 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple erythematous-violaceous nodules and papules on the irradiated breast.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1299 "Ancho" => 1750 "Tamanyo" => 814325 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Cell proliferation affecting the entire dermis, in which interstitial hemorrhage and vascular lumens are visible (hematoxylin-eosin [H&E], original magnification ×40). B, Vascular channels lined by endothelial cells with atypia infiltrating the collagen bundles (H&E, original magnification ×200). C, Pleomorphic epithelioid cells, between which several atypical mitoses are visible (H&E, original magnification ×400). D, Immunohistochemical staining with anti-CD31 antibody was positive for proliferating cells (H&E, original magnification ×200).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiosarcoma en mama irradiada: descripción de un caso" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Peramiquel" 1 => "M.A. Barnadas" 2 => "J. Sancho" 3 => "R. Curell" 4 => "M.C. Alonso" 5 => "M.J. 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año/Mes | Html | Total | |
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2024 Noviembre | 18 | 19 | 37 |
2024 Octubre | 83 | 49 | 132 |
2024 Septiembre | 89 | 39 | 128 |
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2023 Diciembre | 150 | 22 | 172 |
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2022 Diciembre | 92 | 47 | 139 |
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2022 Octubre | 148 | 23 | 171 |
2022 Septiembre | 90 | 41 | 131 |
2022 Agosto | 100 | 37 | 137 |
2022 Julio | 105 | 36 | 141 |
2022 Junio | 164 | 29 | 193 |
2022 Mayo | 192 | 30 | 222 |
2022 Abril | 166 | 44 | 210 |
2022 Marzo | 99 | 42 | 141 |
2022 Febrero | 117 | 29 | 146 |
2022 Enero | 170 | 47 | 217 |
2021 Diciembre | 104 | 43 | 147 |
2021 Noviembre | 97 | 44 | 141 |
2021 Octubre | 110 | 49 | 159 |
2021 Septiembre | 91 | 43 | 134 |
2021 Agosto | 110 | 31 | 141 |
2021 Julio | 102 | 30 | 132 |
2021 Junio | 85 | 28 | 113 |
2021 Mayo | 56 | 50 | 106 |
2021 Abril | 48 | 54 | 102 |
2021 Marzo | 58 | 27 | 85 |
2021 Febrero | 51 | 30 | 81 |
2021 Enero | 40 | 20 | 60 |
2020 Diciembre | 30 | 12 | 42 |
2020 Noviembre | 18 | 14 | 32 |
2020 Octubre | 19 | 10 | 29 |
2020 Septiembre | 38 | 14 | 52 |
2020 Agosto | 26 | 16 | 42 |
2020 Julio | 25 | 12 | 37 |
2020 Junio | 21 | 29 | 50 |
2020 Mayo | 26 | 10 | 36 |
2020 Abril | 30 | 25 | 55 |
2020 Marzo | 29 | 18 | 47 |
2020 Febrero | 7 | 2 | 9 |
2020 Enero | 6 | 0 | 6 |
2019 Diciembre | 8 | 0 | 8 |
2019 Noviembre | 4 | 1 | 5 |
2019 Octubre | 0 | 8 | 8 |
2019 Septiembre | 4 | 11 | 15 |
2019 Agosto | 4 | 5 | 9 |
2019 Julio | 4 | 8 | 12 |
2019 Junio | 4 | 14 | 18 |
2019 Mayo | 6 | 7 | 13 |
2019 Abril | 2 | 16 | 18 |
2019 Marzo | 4 | 12 | 16 |
2019 Febrero | 0 | 8 | 8 |
2019 Enero | 2 | 2 | 4 |
2018 Diciembre | 4 | 7 | 11 |
2018 Noviembre | 1 | 0 | 1 |
2018 Octubre | 3 | 0 | 3 |
2018 Septiembre | 5 | 0 | 5 |
2018 Mayo | 0 | 2 | 2 |
2018 Marzo | 15 | 1 | 16 |
2018 Febrero | 98 | 11 | 109 |
2018 Enero | 104 | 7 | 111 |
2017 Diciembre | 108 | 6 | 114 |
2017 Noviembre | 78 | 5 | 83 |
2017 Octubre | 121 | 6 | 127 |
2017 Septiembre | 106 | 5 | 111 |
2017 Agosto | 93 | 17 | 110 |
2017 Julio | 122 | 8 | 130 |
2017 Junio | 142 | 19 | 161 |
2017 Mayo | 104 | 22 | 126 |
2017 Abril | 47 | 13 | 60 |
2017 Marzo | 42 | 44 | 86 |
2017 Febrero | 163 | 10 | 173 |
2017 Enero | 123 | 16 | 139 |
2016 Diciembre | 104 | 6 | 110 |
2016 Noviembre | 91 | 21 | 112 |
2016 Octubre | 212 | 13 | 225 |
2016 Septiembre | 190 | 17 | 207 |
2016 Agosto | 211 | 12 | 223 |
2016 Julio | 82 | 20 | 102 |
2016 Junio | 9 | 22 | 31 |
2016 Mayo | 7 | 19 | 26 |
2016 Abril | 5 | 1 | 6 |
2016 Marzo | 8 | 2 | 10 |
2016 Febrero | 14 | 3 | 17 |
2016 Enero | 8 | 1 | 9 |
2015 Diciembre | 13 | 1 | 14 |
2015 Noviembre | 49 | 1 | 50 |
2015 Octubre | 64 | 1 | 65 |
2015 Septiembre | 73 | 4 | 77 |
2015 Agosto | 45 | 5 | 50 |
2015 Julio | 224 | 12 | 236 |
2015 Junio | 141 | 7 | 148 |
2015 Mayo | 195 | 16 | 211 |
2015 Abril | 127 | 8 | 135 |
2015 Marzo | 211 | 12 | 223 |
2015 Febrero | 194 | 7 | 201 |
2015 Enero | 136 | 22 | 158 |
2014 Diciembre | 145 | 9 | 154 |
2014 Noviembre | 157 | 17 | 174 |
2014 Octubre | 175 | 24 | 199 |
2014 Septiembre | 138 | 19 | 157 |
2014 Agosto | 127 | 15 | 142 |
2014 Julio | 161 | 16 | 177 |
2014 Junio | 96 | 4 | 100 |
2014 Mayo | 90 | 9 | 99 |
2014 Abril | 99 | 5 | 104 |
2014 Marzo | 110 | 15 | 125 |
2014 Febrero | 82 | 16 | 98 |
2014 Enero | 103 | 7 | 110 |
2013 Diciembre | 80 | 10 | 90 |
2013 Noviembre | 60 | 11 | 71 |
2013 Octubre | 65 | 15 | 80 |
2013 Septiembre | 37 | 8 | 45 |
2013 Agosto | 12 | 34 | 46 |
2013 Julio | 14 | 27 | 41 |
2013 Junio | 17 | 18 | 35 |
2013 Mayo | 14 | 18 | 32 |
2013 Abril | 10 | 26 | 36 |
2013 Marzo | 15 | 9 | 24 |
2013 Febrero | 40 | 4 | 44 |
2013 Enero | 142 | 14 | 156 |
2012 Diciembre | 61 | 9 | 70 |
2012 Noviembre | 1 | 4 | 5 |
2012 Octubre | 3 | 0 | 3 |
2012 Septiembre | 0 | 5 | 5 |