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associated with chronic lymphedema due to non-Hodgkin lymphoma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The only relevant history reported by the 84-year-old woman was a nodule in the lower right cervical region&#59; results of a fine-needle aspiration biopsy of the nodule were negative for malignancy&#46; Because of the growth of the nodule&#44; a new fine-needle aspiration procedure was performed a year later and cytology results indicated suspected lymphoma&#59; resection and biopsy were performed and a diagnosis of non-Hodgkin large B cell &#40;CD20<span class="elsevierStyleSup">&#43;</span>&#41; lymphoma was established&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Computed tomography &#40;CT&#41; revealed several bilateral enlarged axillary lymph nodes&#59; the largest of these&#44; measuring 2&#46;5-3<span class="elsevierStyleHsp" style=""></span>cm&#44; was on the right side and in contact with the rib&#46; The CT scan also revealed multiple enlarged hilar&#44; mediastinal&#44; para-aortic&#44; and retroesophageal lymph nodes&#44; and a 4&#46;3-cm solid mass in the anterior segment of the right upper lobe of the lung&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">An atypical segment resection of the right upper lobe and a mediastinal lymphadenectomy were performed&#44; followed by adjuvant chemotherapy with cyclophosphamide&#44; epirubicin&#44; vincristine&#44; and prednisone &#40;6 cycles&#41;&#46; Treatment response was complete&#44; except in the right axilla&#44; where the patient developed a palpable mass measuring 5 to 6<span class="elsevierStyleHsp" style=""></span>cm that was fixed to the deeper layers&#59; the mass was painful and produced a cutaneous reaction&#46; The area was treated with external radiotherapy&#44; with a fraction size of 1&#46;8<span class="elsevierStyleHsp" style=""></span>Gy to achieve a dose of 45<span class="elsevierStyleHsp" style=""></span>Gy&#59; the size of the mass decreased considerably in response to treatment&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Nine years later&#44; the woman was referred to our department with lesions on the anterior surface of the right arm&#44; at the site of the chronic lymphedema&#59; the lesions had appeared 2 weeks earlier and had begun as reddish-purple macules that transformed into plaques and&#44; finally&#44; gave rise to a tumor measuring 16<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>cm&#46; She also had erythematous-violaceous lesions measuring 1<span class="elsevierStyleHsp" style=""></span>cm in diameter which had recently appeared on the outer quadrants of the right breast &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Histopathology of the lesion on the arm and those on the breast was compatible with lymphangiosarcoma and showed clefts between the collagen bundles&#44; delineated by spindle-shaped endothelial cells and atypical hyperchromatic epithelial cells&#46; Immunohistochemistry was positive for CD34&#44; CD31&#44; and factor VIII&#44; thereby supporting the histologic diagnosis<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The staging study was negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">After evaluation by the soft-tissue sarcoma multidisciplinary committee&#44; it was decided to treat the patient with palliative chemotherapy&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Angiosarcoma that develops on a limb with chronic lymphedema or Stewart-Treves syndrome is a rare complication with a rapid and aggressive course&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> No cure exists to date and the disease is associated with poor prognosis and considerable morbidity&#46; When the disease occurs in the context of a mastectomy&#44; removal of the axillary lymph nodes and radiotherapy are thought to be predisposing factors&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The course of the disease is usually aggressive&#44; with rapid local or regional growth of lesions and a tendency toward early distant metastasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Biopsy is essential for diagnosis and fine-needle aspiration is inadequate&#46; Imaging studies&#44; such as nuclear magnetic resonance imaging&#44; are advisable in order to evaluate local spread&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">It is essential to highlight the importance of regular clinical examinations of all patients with chronic lymphedema&#46; While the lesion was first reported in lymphedema secondary to breast cancer&#44; it may occur in any primary or secondary lymphedema&#46; The limbs are the most commonly affected areas&#44; but lymphangiosarcoma has even been reported after abdominoplasty in obese patients&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Furthermore&#44; according to published research&#44; the mean time between development of lymphedema and diagnosis of angiosarcoma is between 8 and 10 years&#59; it is thus important to carry out long-term follow-up of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">When unusual lesions are found on a limb with lymphedema&#44; histologic studies should be performed to detect this complication early on&#46; Early diagnosis together with radical surgery and associated radiation therapy may increase the chance of survival in these patients&#46; Amputation or wide local excision provides the best chance of long-term survival in patients with Stewart-Treves syndrome&#46; Some ex vivo sensitivity studies have shown that chemotherapy appears to be an adequate complementary approach&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Prevention of lymphedema of the limbs&#44; when treatable secondary causes exist&#44; should be considered essential and existing medical measures to achieve this goal should be optimized&#46;</p></span>"
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Case and Research Letters
Angiosarcoma in Chronic Lymphedema (Stewart-Treves Syndrome)
Angiosarcoma en linfedema crónico (síndrome de Stewart-Treves)
M.T. Sánchez-Medinaa,
Autor para correspondencia
marisolsm_@hotmail.com

Corresponding author.
, A. Acostaa, J. Vilarb, J. Fernández-Palaciosa
a Servicio de Cirugía Plástica Estética y Reparadora, Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
b Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
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associated with chronic lymphedema due to non-Hodgkin lymphoma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The only relevant history reported by the 84-year-old woman was a nodule in the lower right cervical region&#59; results of a fine-needle aspiration biopsy of the nodule were negative for malignancy&#46; Because of the growth of the nodule&#44; a new fine-needle aspiration procedure was performed a year later and cytology results indicated suspected lymphoma&#59; resection and biopsy were performed and a diagnosis of non-Hodgkin large B cell &#40;CD20<span class="elsevierStyleSup">&#43;</span>&#41; lymphoma was established&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Computed tomography &#40;CT&#41; revealed several bilateral enlarged axillary lymph nodes&#59; the largest of these&#44; measuring 2&#46;5-3<span class="elsevierStyleHsp" style=""></span>cm&#44; was on the right side and in contact with the rib&#46; The CT scan also revealed multiple enlarged hilar&#44; mediastinal&#44; para-aortic&#44; and retroesophageal lymph nodes&#44; and a 4&#46;3-cm solid mass in the anterior segment of the right upper lobe of the lung&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">An atypical segment resection of the right upper lobe and a mediastinal lymphadenectomy were performed&#44; followed by adjuvant chemotherapy with cyclophosphamide&#44; epirubicin&#44; vincristine&#44; and prednisone &#40;6 cycles&#41;&#46; Treatment response was complete&#44; except in the right axilla&#44; where the patient developed a palpable mass measuring 5 to 6<span class="elsevierStyleHsp" style=""></span>cm that was fixed to the deeper layers&#59; the mass was painful and produced a cutaneous reaction&#46; The area was treated with external radiotherapy&#44; with a fraction size of 1&#46;8<span class="elsevierStyleHsp" style=""></span>Gy to achieve a dose of 45<span class="elsevierStyleHsp" style=""></span>Gy&#59; the size of the mass decreased considerably in response to treatment&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Nine years later&#44; the woman was referred to our department with lesions on the anterior surface of the right arm&#44; at the site of the chronic lymphedema&#59; the lesions had appeared 2 weeks earlier and had begun as reddish-purple macules that transformed into plaques and&#44; finally&#44; gave rise to a tumor measuring 16<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>cm&#46; She also had erythematous-violaceous lesions measuring 1<span class="elsevierStyleHsp" style=""></span>cm in diameter which had recently appeared on the outer quadrants of the right breast &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Histopathology of the lesion on the arm and those on the breast was compatible with lymphangiosarcoma and showed clefts between the collagen bundles&#44; delineated by spindle-shaped endothelial cells and atypical hyperchromatic epithelial cells&#46; Immunohistochemistry was positive for CD34&#44; CD31&#44; and factor VIII&#44; thereby supporting the histologic diagnosis<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The staging study was negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">After evaluation by the soft-tissue sarcoma multidisciplinary committee&#44; it was decided to treat the patient with palliative chemotherapy&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Angiosarcoma that develops on a limb with chronic lymphedema or Stewart-Treves syndrome is a rare complication with a rapid and aggressive course&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> No cure exists to date and the disease is associated with poor prognosis and considerable morbidity&#46; When the disease occurs in the context of a mastectomy&#44; removal of the axillary lymph nodes and radiotherapy are thought to be predisposing factors&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The course of the disease is usually aggressive&#44; with rapid local or regional growth of lesions and a tendency toward early distant metastasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Biopsy is essential for diagnosis and fine-needle aspiration is inadequate&#46; Imaging studies&#44; such as nuclear magnetic resonance imaging&#44; are advisable in order to evaluate local spread&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">It is essential to highlight the importance of regular clinical examinations of all patients with chronic lymphedema&#46; While the lesion was first reported in lymphedema secondary to breast cancer&#44; it may occur in any primary or secondary lymphedema&#46; The limbs are the most commonly affected areas&#44; but lymphangiosarcoma has even been reported after abdominoplasty in obese patients&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Furthermore&#44; according to published research&#44; the mean time between development of lymphedema and diagnosis of angiosarcoma is between 8 and 10 years&#59; it is thus important to carry out long-term follow-up of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">When unusual lesions are found on a limb with lymphedema&#44; histologic studies should be performed to detect this complication early on&#46; Early diagnosis together with radical surgery and associated radiation therapy may increase the chance of survival in these patients&#46; Amputation or wide local excision provides the best chance of long-term survival in patients with Stewart-Treves syndrome&#46; Some ex vivo sensitivity studies have shown that chemotherapy appears to be an adequate complementary approach&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Prevention of lymphedema of the limbs&#44; when treatable secondary causes exist&#44; should be considered essential and existing medical measures to achieve this goal should be optimized&#46;</p></span>"
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