Case and Research Letters
Generalized Eruptive Multinucleate Cell Angiohistiocytoma in a Pregnant Woman: A Case Report and Review of the Literature
Angiohistiocitomas de células multinucleadas eruptivos y generalizados en una gestante. Presentación de un caso y revisión de la literatura
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Presentación de un caso y revisión de la literatura" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "450" "paginaFinal" => "452" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Generalized Eruptive Multinucleate Cell Angiohistiocytoma in a Pregnant Woman: A Case Report and Review of the Literature" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1170 "Ancho" => 1583 "Tamanyo" => 183532 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Múltiples máculo-pápulas eritematovioláceas, redondeadas de hasta 6-7<span class="elsevierStyleHsp" style=""></span>mm en el abdomen.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C.A. 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Villanueva, J.C. Tardío, A. Romero-Maté, J. Borbujo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "C.A." "apellidos" => "Villanueva" "email" => array:2 [ 0 => "cvillanueva.hflr@salud.madrid.org" 1 => "candidavilleneuve@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.C." "apellidos" => "Tardío" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Romero-Maté" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Borbujo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario de Fuenlabrada, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Angiohistiocitomas de células multinucleadas eruptivos y generalizados en una gestante. Presentación de un caso y revisión de la literatura" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 708 "Ancho" => 1900 "Tamanyo" => 362559 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Multinucleate mesenchymal cells with angled cytoplasmic borders and small vessels with thickened walls and prominent endothelia located in the dermal collagen (hematoxylin-eosin, original magnification x400). B, Positive immune staining for estrogen receptor α in perivascular spindle-shaped cells (original magnification x400).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Multinucleate cell angiohistiocytoma (MCAH) is a rare entity that takes the form of a benign dermatologic proliferation formed by small blood vessels and multinucleate mesenchymal cells. These lesions are probably underdiagnosed because of their similarity to other disorders, such as dermatofibroma, and because of their benign, asymptomatic nature.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 35-year-old woman in the 36th week of her 4th pregnancy. The child born as a result of her second pregnancy had died 24<span class="elsevierStyleHsp" style=""></span>hours post partum. The woman had been visiting our department for many years due to multiple asymptomatic lesions on her trunk and extremities; the lesions first appeared during the first pregnancy and had increased in number over the course of the subsequent pregnancies. The physical examination revealed more than 100 round maculopapular lesions with diameters ranging between 2 and 8<span class="elsevierStyleHsp" style=""></span>mm; the lesions were erythematous-violaceous with a smooth surface and were distributed unevenly across the trunk and extremities (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Dermoscopy showed a fine pigmented reticular pattern around the borders and a whitish central patch (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>); these findings were compatible with clinical suspicion of multiple eruptive dermatofibroma. Because this presentation of dermatofibroma has been associated with autoimmune disease, an immunological study was performed. The salient findings were the presence of anti-Ro 60 antibodies and antinuclear antibodies distributed in a speckled pattern.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Biopsy specimens of 2 papules revealed poorly defined lesions involving the full thickness of the dermis. Histology showed that the papules consisted of numerous small blood vessels with prominent endothelia distributed with no clear pattern throughout the dermal collagen. Other findings included scant perivascular histiocytes and lymphocytes and multinucleate mesenchymal cells characterized by fewer than 10 nuclei, no abnormalities, and a large cytoplasm with angular contours (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>a). Immunohistochemical analysis showed estrogen receptor α expression in some perivascular spindle-shaped cells (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>b) and progesterone receptor expression in very few cells at the same location. Immune staining was negative for hormone receptors in the multinucleate cells. A diagnosis of generalized eruptive MCAH was reached.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The skin lesions were not treated because of the widespread nature of the outbreak. The patient was referred to obstetrics because of the positive anti-Ro 60 result and the history of the death of the newborn child after her earlier pregnancy. The neonate was monitored by the pediatrics department.</p><p id="par0025" class="elsevierStylePara elsevierViewall">MCAH is considered to be a dermal dendrocyte proliferation. Some authors consider it to be a variant of dermatofibroma<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>; as with dermatofibroma, it is difficult to determine whether MCAH is a true neoplasm or a reactive process.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> MCAH presents in healthy persons and reported associations with other diseases appear to be coincidental. Several factors support the idea that this is a reactive entity: the fact that some patients present with multiple lesions, the location of lesions in sites exposed to trauma and insect bites, the absence of a familial association, and the spontaneous regression reported in some cases. A link to hormone factors has been suggested, as these lesions present more frequently in women (79% of cases) and have been associated with overexpression of estrogen receptor α.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Including our patient, 5 cases of generalized MCAH have been reported to date: 3 men and 2 women<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4–7</span></a> aged between 24 and 56 years with no associated disease. Of note in our case is the coincidence of the eruptive appearance of the lesions and each pregnancy, and the finding of anti-Ro 60 antibodies with a history of the death of a newborn baby.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The dermoscopy findings concur with those reported in the literature<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and are similar to the dermoscopy pattern of dermatofibroma. Multiple eruptive dermatofibroma has been linked to an abnormal immune system. In a review of 67 cases, Zaccaria et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> found a link with intercurrent disease in 96% of their cases, 83% of which were immune-deficient conditions. Those authors therefore suggested that the multiple eruptive presentation of dermatofibroma might be a diagnostic marker for immunosuppressive conditions. The cases reviewed included that reported by Stainforth and Goodfield<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> of a healthy woman who developed 9 dermatofibromas on the trunk during pregnancy; the authors included pregnancy as a condition involving immune-system abnormality. In light of our case, we suggest that the multiple eruptive form of MCAH may bear similarities to pregnancy-associated dermatofibroma.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion, we present the first case of generalized eruptive MCAH associated with every pregnancy in a woman who remained anti-Ro/SSA-positive and who has had no other associated symptoms to date. We suggest that this unique and rare clinical form of the disease may, in the future, be an indicator of an abnormal immune system and that it may support the association, suggested by some authors, of MCAH with hormone factors.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Villanueva CA, et al. Angiohistiocitomas de células multinucleadas eruptivos y generalizados en una gestante. Presentación de un caso y revisión de la literatura. Actas Dermosifiliogr.2012;103:450-2.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 702 "Ancho" => 950 "Tamanyo" => 100699 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple round erythematous-violaceous maculopapular lesions measuring up to 6 or 7<span class="elsevierStyleHsp" style=""></span>mm, on the abdomen.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1424 "Ancho" => 950 "Tamanyo" => 101561 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic image of a lesion, showing a fine reticular pattern mainly around the borders and a central whitish patch.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 708 "Ancho" => 1900 "Tamanyo" => 362559 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Multinucleate mesenchymal cells with angled cytoplasmic borders and small vessels with thickened walls and prominent endothelia located in the dermal collagen (hematoxylin-eosin, original magnification x400). B, Positive immune staining for estrogen receptor α in perivascular spindle-shaped cells (original magnification x400).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiohistiocitoma de células multinucleadas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Requena" 1 => "C. Requena" 2 => "R.O. Pichardo" 3 => "O.P. Sangueza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Monogr Dermatol" "fecha" => "2004" "volumen" => "17" "paginaInicial" => "82" "paginaFinal" => "85" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multinucleate cell angiohystiocitoma: a fibrohistiocytic proliferation with increased mast cell numbers and vascular hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Puig" 1 => "M.T. Fernández-Figueras" 2 => "I. Bielsa" 3 => "B. Lloveras" 4 => "A. Alomar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2002" "volumen" => "29" "paginaInicial" => "232" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12028156" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estrogen receptor alpha overexpression in multinucleate cell angiohistiocytoma: new insights into pathogenesis of a reactive process" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Cesinaro" 1 => "L. Roncati" 2 => "A. Maionara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e3181d3ca49" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2010" "volumen" => "32" "paginaInicial" => "655" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20644465" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Generalized multinucleate cell angiohistiocytoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.N. Chang" 1 => "H.S. Kim" 2 => "S.C. Kim" 3 => "W.I. Yang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "320" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8698916" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiostiocytome à cellules multinucléées" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Leclerc" 1 => "T. Clerici" 2 => "M. Rybojad" 3 => "N. Girszyn" 4 => "P. Morel" 5 => "A. Janin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol Venereol" "fecha" => "2005" "volumen" => "132" "paginaInicial" => "546" "paginaFinal" => "549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16142103" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel case of generalized cell angiohistiocytoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.A. O¿Blenes" 1 => "N.M. Walsh" 2 => "P.J. Green" 3 => "R.D. Tremaine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Med Surg" "fecha" => "2010" "volumen" => "14" "paginaInicial" => "178" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20642987" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiohistiocitoma de células multinucleadas generalizado" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. López-Obregón" 1 => "M.A. Arregui-Murua" 2 => "P. Eguino" 3 => "C. Lobo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2010.08.008" "Revista" => array:7 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2011" "volumen" => "102" "paginaInicial" => "231" "paginaFinal" => "233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21382607" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0161642007006574" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hallazgos dermatoscópicos del angiohistiocitoma de células multinucleadas; ¿una variante de dermatofibroma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Valerón-Almazán" 1 => "L. Dehesa" 2 => "N. Santana" 3 => "J. Vilar" 4 => "G. Carretero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2010.04.013" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2010" "volumen" => "102" "paginaInicial" => "69" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21315868" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple eruptive dermatofibromas and immunosuppression: report of two cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Zaccaria" 1 => "A. Rebora" 2 => "F. Rongioletti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2008.03575.x" "Revista" => array:7 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2008" "volumen" => "47" "paginaInicial" => "723" "paginaFinal" => "727" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18613883" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0886335010005912" "estado" => "S300" "issn" => "08863350" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple dermatofibromata developing during pregnancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Stainforth" 1 => "M.J.D. Goodfield" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "1994" "volumen" => "19" "paginaInicial" => "59" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8313640" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010300000005/v1_201304241308/S1578219012001795/v1_201304241308/en/main.assets" "Apartado" => array:4 [ "identificador" => "6169" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Cases and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000005/v1_201304241308/S1578219012001795/v1_201304241308/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001795?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 12 | 13 | 25 |
| 2024 Octubre | 76 | 41 | 117 |
| 2024 Septiembre | 75 | 23 | 98 |
| 2024 Agosto | 106 | 51 | 157 |
| 2024 Julio | 75 | 30 | 105 |
| 2024 Junio | 85 | 38 | 123 |
| 2024 Mayo | 48 | 32 | 80 |
| 2024 Abril | 75 | 27 | 102 |
| 2024 Marzo | 87 | 25 | 112 |
| 2024 Febrero | 95 | 27 | 122 |
| 2024 Enero | 53 | 33 | 86 |
| 2023 Diciembre | 63 | 16 | 79 |
| 2023 Noviembre | 60 | 26 | 86 |
| 2023 Octubre | 60 | 34 | 94 |
| 2023 Septiembre | 61 | 34 | 95 |
| 2023 Agosto | 49 | 22 | 71 |
| 2023 Julio | 50 | 41 | 91 |
| 2023 Junio | 47 | 32 | 79 |
| 2023 Mayo | 34 | 22 | 56 |
| 2023 Abril | 63 | 28 | 91 |
| 2023 Marzo | 50 | 21 | 71 |
| 2023 Febrero | 48 | 26 | 74 |
| 2023 Enero | 44 | 45 | 89 |
| 2022 Diciembre | 48 | 55 | 103 |
| 2022 Noviembre | 43 | 26 | 69 |
| 2022 Octubre | 35 | 14 | 49 |
| 2022 Septiembre | 34 | 36 | 70 |
| 2022 Agosto | 21 | 36 | 57 |
| 2022 Julio | 26 | 30 | 56 |
| 2022 Junio | 43 | 21 | 64 |
| 2022 Mayo | 41 | 36 | 77 |
| 2022 Abril | 54 | 42 | 96 |
| 2022 Marzo | 68 | 57 | 125 |
| 2022 Febrero | 48 | 24 | 72 |
| 2022 Enero | 50 | 29 | 79 |
| 2021 Diciembre | 33 | 35 | 68 |
| 2021 Noviembre | 44 | 45 | 89 |
| 2021 Octubre | 39 | 48 | 87 |
| 2021 Septiembre | 39 | 30 | 69 |
| 2021 Agosto | 36 | 25 | 61 |
| 2021 Julio | 40 | 28 | 68 |
| 2021 Junio | 29 | 33 | 62 |
| 2021 Mayo | 33 | 35 | 68 |
| 2021 Abril | 59 | 46 | 105 |
| 2021 Marzo | 68 | 31 | 99 |
| 2021 Febrero | 46 | 37 | 83 |
| 2021 Enero | 15 | 24 | 39 |
| 2020 Diciembre | 33 | 9 | 42 |
| 2020 Noviembre | 18 | 18 | 36 |
| 2020 Octubre | 18 | 9 | 27 |
| 2020 Septiembre | 23 | 14 | 37 |
| 2020 Agosto | 17 | 22 | 39 |
| 2020 Julio | 23 | 11 | 34 |
| 2020 Junio | 24 | 20 | 44 |
| 2020 Mayo | 19 | 11 | 30 |
| 2020 Abril | 34 | 19 | 53 |
| 2020 Marzo | 27 | 19 | 46 |
| 2020 Febrero | 6 | 0 | 6 |
| 2020 Enero | 4 | 0 | 4 |
| 2019 Diciembre | 4 | 1 | 5 |
| 2019 Noviembre | 4 | 1 | 5 |
| 2019 Octubre | 0 | 10 | 10 |
| 2019 Septiembre | 4 | 10 | 14 |
| 2019 Agosto | 4 | 4 | 8 |
| 2019 Julio | 4 | 3 | 7 |
| 2019 Junio | 4 | 9 | 13 |
| 2019 Mayo | 4 | 15 | 19 |
| 2019 Abril | 2 | 10 | 12 |
| 2019 Marzo | 0 | 6 | 6 |
| 2019 Febrero | 2 | 0 | 2 |
| 2019 Enero | 1 | 0 | 1 |
| 2018 Noviembre | 3 | 0 | 3 |
| 2018 Octubre | 1 | 0 | 1 |
| 2018 Septiembre | 4 | 0 | 4 |
| 2018 Marzo | 1 | 0 | 1 |
| 2018 Febrero | 42 | 4 | 46 |
| 2018 Enero | 61 | 5 | 66 |
| 2017 Diciembre | 61 | 8 | 69 |
| 2017 Noviembre | 43 | 10 | 53 |
| 2017 Octubre | 42 | 5 | 47 |
| 2017 Septiembre | 54 | 8 | 62 |
| 2017 Agosto | 69 | 14 | 83 |
| 2017 Julio | 57 | 3 | 60 |
| 2017 Junio | 72 | 28 | 100 |
| 2017 Mayo | 65 | 17 | 82 |
| 2017 Abril | 47 | 11 | 58 |
| 2017 Marzo | 49 | 18 | 67 |
| 2017 Febrero | 43 | 12 | 55 |
| 2017 Enero | 36 | 6 | 42 |
| 2016 Diciembre | 93 | 10 | 103 |
| 2016 Noviembre | 54 | 10 | 64 |
| 2016 Octubre | 87 | 16 | 103 |
| 2016 Septiembre | 141 | 19 | 160 |
| 2016 Agosto | 49 | 11 | 60 |
| 2016 Julio | 45 | 9 | 54 |
| 2016 Junio | 15 | 19 | 34 |
| 2016 Mayo | 12 | 11 | 23 |
| 2016 Abril | 6 | 1 | 7 |
| 2016 Marzo | 9 | 12 | 21 |
| 2016 Febrero | 4 | 17 | 21 |
| 2016 Enero | 4 | 11 | 15 |
| 2015 Diciembre | 13 | 1 | 14 |
| 2015 Noviembre | 41 | 14 | 55 |
| 2015 Octubre | 43 | 13 | 56 |
| 2015 Septiembre | 20 | 1 | 21 |
| 2015 Agosto | 16 | 1 | 17 |
| 2015 Julio | 139 | 12 | 151 |
| 2015 Junio | 81 | 9 | 90 |
| 2015 Mayo | 96 | 9 | 105 |
| 2015 Abril | 75 | 12 | 87 |
| 2015 Marzo | 64 | 10 | 74 |
| 2015 Febrero | 80 | 10 | 90 |
| 2015 Enero | 67 | 14 | 81 |
| 2014 Diciembre | 67 | 13 | 80 |
| 2014 Noviembre | 54 | 7 | 61 |
| 2014 Octubre | 72 | 12 | 84 |
| 2014 Septiembre | 56 | 9 | 65 |
| 2014 Agosto | 76 | 15 | 91 |
| 2014 Julio | 92 | 19 | 111 |
| 2014 Junio | 122 | 17 | 139 |
| 2014 Mayo | 51 | 5 | 56 |
| 2014 Abril | 30 | 2 | 32 |
| 2014 Marzo | 28 | 7 | 35 |
| 2014 Febrero | 32 | 4 | 36 |
| 2014 Enero | 40 | 4 | 44 |
| 2013 Diciembre | 28 | 9 | 37 |
| 2013 Noviembre | 29 | 8 | 37 |
| 2013 Octubre | 21 | 4 | 25 |
| 2013 Septiembre | 30 | 8 | 38 |
| 2013 Agosto | 28 | 6 | 34 |
| 2013 Julio | 9 | 11 | 20 |
| 2013 Junio | 14 | 13 | 27 |
| 2013 Mayo | 18 | 13 | 31 |
| 2013 Abril | 14 | 8 | 22 |
| 2013 Marzo | 10 | 9 | 19 |
| 2013 Febrero | 46 | 3 | 49 |
| 2013 Enero | 35 | 4 | 39 |
| 2012 Diciembre | 30 | 3 | 33 |
| 2012 Noviembre | 0 | 1 | 1 |
| 2012 Agosto | 2 | 1 | 3 |
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