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3</a>&#41;&#46; In situ hybridization for high-risk human papillomavirus &#40;HPV&#41; revealed strong&#44; punctate&#44; nuclear staining&#46; Immunohistochemistry was positive for p16 in neoplastic areas&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">On elicitation of additional history&#44; the patient reported that his dog had died of leishmaniasis 4 years earlier and that he frequently traveled from his home in Valencia to Morocco on business&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Blood tests revealed a CD4 cell count of 90&#47;&#956;L&#44; an undetectable HIV load &#40;&#60;20 copies&#47;mL&#41;&#44; and an erythrocyte sedimentation rate of 116<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#46; The total white blood cell count and platelet count were normal and the patient was only slightly anemic &#40;hemoglobin 11&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient refused to undergo bone marrow sampling&#44; so the infectious diseases department started empiric treatment with meglumine antimoniate &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;kg of a pentavalent antimony compound once daily for 28 days&#41;&#46; The patient was also scheduled for excision of the tumor&#46; Histologic examination of the excised tissue confirmed the presence of <span class="elsevierStyleItalic">Leishmania</span> organisms&#44; despite completion of the antimonial treatment&#46; The patient then agreed to a bone marrow procedure&#59; involvement of the marrow was detected&#44; confirming the diagnosis of visceral leishmaniasis&#46; In view of these findings&#44; the patient was prescribed treatment with liposomal amphotericin B&#46; Because his CD4 cell count remained below 200&#47;&#956;L&#44; on completion of treatment he began secondary chemoprophylaxis with monthly administration of liposomal amphotericin B&#46; After 9 months&#44; no clinical or analytical signs of visceral leishmaniasis were evident&#46; He currently attends regular follow-up visits at the infectious diseases department&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Leishmaniasis is caused by infection with protozoa of the genus <span class="elsevierStyleItalic">Leishmania</span>&#44; which are spread by female sandflies of the genera <span class="elsevierStyleItalic">Phlebotomus</span> and <span class="elsevierStyleItalic">Lutzomyia</span>&#46; The <span class="elsevierStyleItalic">Leishmania</span> protozoa parasitize the monocyte-macrophage system in the form of amastigotes&#46; In Spain&#44; dogs are the main reservoir of the causative species&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleItalic">Leishmania infantum&#46;</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Immunocompromised patients bitten by an infected vector are at high risk of developing visceral leishmaniasis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Most cases of visceral leishmaniasis were once found in children&#44; but at present 70&#37; occur in adults&#44; and 50&#37; of such cases are in HIV-positive individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Spain and the rest of southwestern Europe have the world&#39;s highest prevalence of coinfection&#44; and intravenous drug users are at the greatest risk&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">HIV&#47;<span class="elsevierStyleItalic">Leishmania</span> organism coinfection favors the progression of both infections&#46; CD4&#43; type 1 helper T cells&#44; which are depleted in HIV-infected patients&#44; play a fundamental role in the immune response to the parasite&#46; HIV infection therefore increases the risk of developing visceral leishmaniasis by a factor of 100 to 2300&#44; worsens prognosis&#44; and decreases the likelihood of therapeutic response&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a> Furthermore&#44; the presence of <span class="elsevierStyleItalic">Leishmania</span> amastigotes has been shown to increase HIV replication&#44; diminish immune status&#44; and hasten progression to AIDS&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Visceral leishmaniasis spreads to the skin more frequently in HIV-infected patients than in immunocompetent patients<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and manifests as lesions spanning a wide clinical spectrum&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;7</span></a> In addition&#44; the presence of <span class="elsevierStyleItalic">Leishmania</span> organisms has been observed in biopsy specimens from patients with skin conditions not caused by the parasite&#44; such as Kaposi sarcoma&#44; dermatofibromas&#44; psoriasis&#44; aphthous ulcers&#44; herpes simplex&#44; herpes zoster&#44; bacillary angiomatosis&#44; tattoos&#44; and rheumatoid nodules&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In our patient&#44; the disease was detected incidentally on biopsy of a perianal squamous cell carcinoma&#46; To our knowledge&#44; this association has not been previously reported&#46; The patient&#39;s epithelioma does not appear to have been caused by the parasite&#59; had it been&#44; it would suggest a relationship with chronic HPV infection&#46; The growth was probably caused by massive dissemination of the parasite in this severely immunocompromised patient&#46; Local inflammation caused by growth of the carcinoma&#44; accompanied by an abundance of histiocytes in a heavily parasitized mononuclear phagocyte system&#44; would explain findings of abundant amastigotes&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;8</span></a> This finding in our patient led to further tests though which previously unsuspected visceral involvement was detected&#46; Appropriate systemic treatment&#44; as described elsewhere&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> was then prescribed&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">This is the first report of an association between <span class="elsevierStyleItalic">Leishmania</span> parasites and squamous cell carcinoma&#46; In HIV-positive patients in whom skin biopsy reveals evidence of <span class="elsevierStyleItalic">Leishmania</span> parasites&#44; underlying visceral leishmaniasis should be suspected&#46; Bone marrow sampling would seem to be indicated&#44; as the results will guide treatment choice and ultimately influence prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Amastigotes of the genus <span class="elsevierStyleItalic">Leishmania</span> have been observed in biopsies of apparently unrelated lesions in patients with AIDS and visceral leishmaniasis&#46; We describe the case of a 40-year-old man with human immunodeficiency virus infection and severe immunodepression in whom the presence of the parasite was detected as an incidental finding on histological study of a perianal squamous cell carcinoma&#46; This finding led to the diagnosis and subsequent treatment of previously unsuspected visceral leishmaniasis&#46; In a review of the literature we have found no previous examples of this association&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Armengot-Carb&#243; M&#44; et al&#46; Leishmaniasis visceral insospechada infiltrando un carcinoma epidermoide&#46; Actas Dermosifiliogr&#46;2012&#59;103&#58;321-323&#46;</p>"
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Case Report
Unsuspected Visceral Leishmaniasis Infiltrating a Squamous Cell Carcinoma
Leishmaniasis visceral insospechada infiltrando un carcinoma epidermoide
M. Armengot-Carbóa,
Autor para correspondencia
miquelarmengot@gmail.com

Corresponding author.
, R. Carmena-Ramóna, B. Rodrigo-Nicolása, J. Ferrando-Marcob
a Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, Spain
b Servicio de Anatomía Patológica, Hospital Arnau de Vilanova, Valencia, Spain
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etravirine&#44; and raltegravir&#41; since 2005&#46; He had been referred to our department on several occasions for evaluation of perianal condylomata&#44; which were treated with cryotherapy&#46; In April 2010&#44; he was again referred for an erosive&#44; erythematous&#44; verrucous perianal plaque that had developed several months earlier &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; A biopsy was performed to rule out malignant transformation&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathology revealed marked epidermal acanthosis&#44; pleomorphic keratinocytes&#44; and the presence of atypical mitotic figures&#44; confirming the suspected clinical diagnosis of squamous cell carcinoma &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In the dermis&#44; numerous amastigotes of the genus <span class="elsevierStyleItalic">Leishmania</span> were observed both inside the macrophages and in the intercellular matrix &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; In situ hybridization for high-risk human papillomavirus &#40;HPV&#41; revealed strong&#44; punctate&#44; nuclear staining&#46; Immunohistochemistry was positive for p16 in neoplastic areas&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">On elicitation of additional history&#44; the patient reported that his dog had died of leishmaniasis 4 years earlier and that he frequently traveled from his home in Valencia to Morocco on business&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Blood tests revealed a CD4 cell count of 90&#47;&#956;L&#44; an undetectable HIV load &#40;&#60;20 copies&#47;mL&#41;&#44; and an erythrocyte sedimentation rate of 116<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#46; The total white blood cell count and platelet count were normal and the patient was only slightly anemic &#40;hemoglobin 11&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient refused to undergo bone marrow sampling&#44; so the infectious diseases department started empiric treatment with meglumine antimoniate &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;kg of a pentavalent antimony compound once daily for 28 days&#41;&#46; The patient was also scheduled for excision of the tumor&#46; Histologic examination of the excised tissue confirmed the presence of <span class="elsevierStyleItalic">Leishmania</span> organisms&#44; despite completion of the antimonial treatment&#46; The patient then agreed to a bone marrow procedure&#59; involvement of the marrow was detected&#44; confirming the diagnosis of visceral leishmaniasis&#46; In view of these findings&#44; the patient was prescribed treatment with liposomal amphotericin B&#46; Because his CD4 cell count remained below 200&#47;&#956;L&#44; on completion of treatment he began secondary chemoprophylaxis with monthly administration of liposomal amphotericin B&#46; After 9 months&#44; no clinical or analytical signs of visceral leishmaniasis were evident&#46; 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but at present 70&#37; occur in adults&#44; and 50&#37; of such cases are in HIV-positive individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Spain and the rest of southwestern Europe have the world&#39;s highest prevalence of coinfection&#44; and intravenous drug users are at the greatest risk&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">HIV&#47;<span class="elsevierStyleItalic">Leishmania</span> organism coinfection favors the progression of both infections&#46; CD4&#43; type 1 helper T cells&#44; which are depleted in HIV-infected patients&#44; play a fundamental role in the immune response to the parasite&#46; HIV infection therefore increases the risk of developing visceral leishmaniasis by a factor of 100 to 2300&#44; worsens prognosis&#44; and decreases the likelihood of therapeutic response&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a> Furthermore&#44; the presence of <span class="elsevierStyleItalic">Leishmania</span> amastigotes has been shown to increase HIV replication&#44; diminish immune status&#44; and hasten progression to AIDS&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Visceral leishmaniasis spreads to the skin more frequently in HIV-infected patients than in immunocompetent patients<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and manifests as lesions spanning a wide clinical spectrum&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;7</span></a> In addition&#44; the presence of <span class="elsevierStyleItalic">Leishmania</span> organisms has been observed in biopsy specimens from patients with skin conditions not caused by the parasite&#44; such as Kaposi sarcoma&#44; dermatofibromas&#44; psoriasis&#44; aphthous ulcers&#44; herpes simplex&#44; herpes zoster&#44; bacillary angiomatosis&#44; tattoos&#44; and rheumatoid nodules&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In our patient&#44; the disease was detected incidentally on biopsy of a perianal squamous cell carcinoma&#46; To our knowledge&#44; this association has not been previously reported&#46; The patient&#39;s epithelioma does not appear to have been caused by the parasite&#59; had it been&#44; it would suggest a relationship with chronic HPV infection&#46; The growth was probably caused by massive dissemination of the parasite in this severely immunocompromised patient&#46; Local inflammation caused by growth of the carcinoma&#44; accompanied by an abundance of histiocytes in a heavily parasitized mononuclear phagocyte system&#44; would explain findings of abundant amastigotes&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;8</span></a> This finding in our patient led to further tests though which previously unsuspected visceral involvement was detected&#46; Appropriate systemic treatment&#44; as described elsewhere&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> was then prescribed&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">This is the first report of an association between <span class="elsevierStyleItalic">Leishmania</span> parasites and squamous cell carcinoma&#46; In HIV-positive patients in whom skin biopsy reveals evidence of <span class="elsevierStyleItalic">Leishmania</span> parasites&#44; underlying visceral leishmaniasis should be suspected&#46; Bone marrow sampling would seem to be indicated&#44; as the results will guide treatment choice and ultimately influence prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Amastigotes of the genus <span class="elsevierStyleItalic">Leishmania</span> have been observed in biopsies of apparently unrelated lesions in patients with AIDS and visceral leishmaniasis&#46; We describe the case of a 40-year-old man with human immunodeficiency virus infection and severe immunodepression in whom the presence of the parasite was detected as an incidental finding on histological study of a perianal squamous cell carcinoma&#46; This finding led to the diagnosis and subsequent treatment of previously unsuspected visceral leishmaniasis&#46; In a review of the literature we have found no previous examples of this association&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En pacientes con SIDA y leishmaniasis visceral ha sido descrita la presencia de amastigotes de <span class="elsevierStyleItalic">Leishmania</span> en biopsias realizadas para estudiar diversas lesiones con las que no guardan aparente relaci&#243;n causal&#46; Presentamos el caso de un var&#243;n de 40 a&#241;os&#44; VIH positivo severamente inmunodeprimido&#44; en el que se observ&#243; incidentalmente la presencia del par&#225;sito al estudiar histol&#243;gicamente un carcinoma epidermoide perianal&#46; Dicho hallazgo permiti&#243; el diagn&#243;stico y tratamiento de una leishmaniasis visceral insospechada&#46; No hemos encontrado en la literatura ejemplos previos de esta asociaci&#243;n&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Armengot-Carb&#243; M&#44; et al&#46; Leishmaniasis visceral insospechada infiltrando un carcinoma epidermoide&#46; Actas Dermosifiliogr&#46;2012&#59;103&#58;321-323&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Erosive&#44; erythematous&#44; verrucous plaque in the perianal region&#44; several months after initial appearance&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Epidermis with marked acanthosis&#44; epithelial immaturity&#44; cell pleomorphism&#44; and atypical mitotic figures in various strata &#40;hematoxylin-eosin&#44; original magnification &#215;40&#59; inset &#215;200&#41;&#46;</p>"
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ISSN: 15782190
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?