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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">UV radiation is the main modifiable risk factor for the development of cutaneous melanoma&#46; Many people in the Spanish province of Granada live at high altitudes and&#44; therefore&#44; receive high doses of UV-B radiation&#46; The aims of this study were to assess the possible association between melanoma and altitude and to measure the daily erythemal dose at different altitudes&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An epidemiological study was carried out between 1982 and 2007 to assess the relationship between altitude&#44; daily erythemal dose&#44; and the prevalence of melanoma&#46; We calculated the prevalence of melanoma in patients with a clinical and histological diagnosis of melanoma at Hospital Cl&#237;nico Universitario San Cecilio in Granada&#44; Spain&#46; All individuals were required to be residents of the province of Granada in order to be included in the study&#46; The prevalence of melanoma was calculated for altitude intervals of 100<span class="elsevierStyleHsp" style=""></span>m&#46; Daily erythemal dose was estimated using measures of UV-B radiation obtained with pyranometers at altitudes of 0&#44; 680&#44; 1200&#44; and 3398 m above sea level during the Evaluation of the Effects of Elevation and Aerosols on UV Radiation &#40;VELETA&#41; 2002 field campaign&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The highest prevalence of melanoma was found between 1400 and 1499<span class="elsevierStyleHsp" style=""></span>m above sea level &#40;the interval at which the highest settlements are found&#41;&#44; with a rate of 2&#46;36 cases per 1000 inhabitants &#40;95&#37; confidence interval&#44; 0&#46;64&#8211;6&#46;03&#41;&#46; Above 700<span class="elsevierStyleHsp" style=""></span>m&#44; the daily erythemal dose increased exponentially with increasing altitude&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We observed a tendency toward increased prevalence of melanoma at higher altitude&#44; with higher prevalences observed beyond 700<span class="elsevierStyleHsp" style=""></span>m above sea level&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La radiaci&#243;n ultravioleta &#40;UV&#41; es el principal factor de riesgo ambiental modificable en el desarrollo del melanoma cut&#225;neo&#46; Muchas de las poblaciones de nuestra provincia est&#225;n situadas a gran altitud&#44; recibiendo elevadas dosis de radiaci&#243;n UVB&#46; Nuestro objetivo es analizar una posible asociaci&#243;n entre melanoma y altitud y medir la dosis eritem&#225;tica diaria a diferentes altitudes&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio ecol&#243;gico&#44; en el que se trat&#243; de relacionar la prevalencia de melanoma&#44; la altitud y la dosis eritem&#225;tica diaria&#46; El periodo de estudio comprendi&#243; los &#250;ltimos 25 a&#241;os &#40;1982&#8211;2007&#41;&#46; Calculamos la prevalencia de melanoma con aquellos pacientes diagnosticados cl&#237;nica e histol&#243;gicamente de melanoma&#44; procedentes del Hospital Cl&#237;nico Universitario &#8220;San Cecilio&#8221;&#46; Los individuos del estudio deb&#237;an tener su lugar de residencia en la provincia de Granada&#46; Calculamos la prevalencia de melanoma a intervalos de 100<span class="elsevierStyleHsp" style=""></span>m de altitud y estimamos la dosis eritem&#225;tica diaria a partir de las medidas de radiaci&#243;n UVB realizadas con piran&#243;metros situados a 0&#44; 680&#44; 1&#46;200&#44; 2&#46;100 y 3&#46;398<span class="elsevierStyleHsp" style=""></span>m de altitud durante la campa&#241;a VELETA-2002&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de melanoma m&#225;s alta est&#225; situada en el intervalo comprendido entre los 1&#46;400&#8211;1&#46;499<span class="elsevierStyleHsp" style=""></span>m a&#46;s&#46;l &#40;intervalo con n&#250;cleos de poblaci&#243;n situados a mayor altitud&#41; con 2&#44;36 por 1&#46;000 habitantes IC al 95&#37; &#40;0&#44;64&#8211;6&#44;03&#41; por 1&#46;000 habitantes&#46; A partir de los 700<span class="elsevierStyleHsp" style=""></span>m de altura la dosis eritem&#225;tica diaria aumenta de forma exponencial a medida que ascendemos en altitud&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Este estudio encuentra una tendencia al aumento en la prevalencia de melanoma al ascender en altitud&#44; siendo m&#225;s intenso a partir de los 700<span class="elsevierStyleHsp" style=""></span>m a&#46;s&#46;l&#46;</p>"
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Original Article
Melanoma, Altitude, and UV-B Radiation
Melanoma, altitud y radiación UVB
P. Aceituno-Maderaa,
Autor para correspondencia
pedroaceituno40@hotmail.com

Corresponding author.
, A. Buendía-Eismanb, F.J. Olmoc, J.J. Jiménez-Moleónd, S. Serrano-Ortegab
a Servicio de Dermatología, Hospital Clínico Universitario San Cecilio, Granada, Spain
b Departamento de Dermatología, Facultad de Medicina, Universidad de Granada, Spain
c Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Granada, Granada, Spain
d Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Granada, Granada, Spain
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            "entidad" => "Departamento de F&#237;sica Aplicada&#44; Facultad de Ciencias&#44; Universidad de Granada&#44; Granada&#44; Spain"
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            "entidad" => "Departamento de Medicina Preventiva y Salud P&#250;blica&#44; Facultad de Medicina&#44; Universidad de Granada&#44; Granada&#44; Spain"
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      "es" => array:1 [
        "titulo" => "Melanoma&#44; altitud y radiaci&#243;n UVB"
      ]
    ]
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    "tienePdf" => true
    "fechaRecibido" => "2010-04-05"
    "fechaAceptado" => "2010-08-23"
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      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec84865"
          "palabras" => array:3 [
            0 => "Melanoma incidence"
            1 => "Altitude"
            2 => "UVB radiation"
          ]
        ]
      ]
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:3 [
            0 => "Incidencia melanoma"
            1 => "Altitud"
            2 => "Radiaci&#243;n UVB"
          ]
        ]
      ]
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">UV radiation is the main modifiable risk factor for the development of cutaneous melanoma&#46; Many people in the Spanish province of Granada live at high altitudes and&#44; therefore&#44; receive high doses of UV-B radiation&#46; The aims of this study were to assess the possible association between melanoma and altitude and to measure the daily erythemal dose at different altitudes&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An epidemiological study was carried out between 1982 and 2007 to assess the relationship between altitude&#44; daily erythemal dose&#44; and the prevalence of melanoma&#46; We calculated the prevalence of melanoma in patients with a clinical and histological diagnosis of melanoma at Hospital Cl&#237;nico Universitario San Cecilio in Granada&#44; Spain&#46; All individuals were required to be residents of the province of Granada in order to be included in the study&#46; The prevalence of melanoma was calculated for altitude intervals of 100<span class="elsevierStyleHsp" style=""></span>m&#46; Daily erythemal dose was estimated using measures of UV-B radiation obtained with pyranometers at altitudes of 0&#44; 680&#44; 1200&#44; and 3398 m above sea level during the Evaluation of the Effects of Elevation and Aerosols on UV Radiation &#40;VELETA&#41; 2002 field campaign&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The highest prevalence of melanoma was found between 1400 and 1499<span class="elsevierStyleHsp" style=""></span>m above sea level &#40;the interval at which the highest settlements are found&#41;&#44; with a rate of 2&#46;36 cases per 1000 inhabitants &#40;95&#37; confidence interval&#44; 0&#46;64&#8211;6&#46;03&#41;&#46; Above 700<span class="elsevierStyleHsp" style=""></span>m&#44; the daily erythemal dose increased exponentially with increasing altitude&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We observed a tendency toward increased prevalence of melanoma at higher altitude&#44; with higher prevalences observed beyond 700<span class="elsevierStyleHsp" style=""></span>m above sea level&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La radiaci&#243;n ultravioleta &#40;UV&#41; es el principal factor de riesgo ambiental modificable en el desarrollo del melanoma cut&#225;neo&#46; Muchas de las poblaciones de nuestra provincia est&#225;n situadas a gran altitud&#44; recibiendo elevadas dosis de radiaci&#243;n UVB&#46; Nuestro objetivo es analizar una posible asociaci&#243;n entre melanoma y altitud y medir la dosis eritem&#225;tica diaria a diferentes altitudes&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio ecol&#243;gico&#44; en el que se trat&#243; de relacionar la prevalencia de melanoma&#44; la altitud y la dosis eritem&#225;tica diaria&#46; El periodo de estudio comprendi&#243; los &#250;ltimos 25 a&#241;os &#40;1982&#8211;2007&#41;&#46; Calculamos la prevalencia de melanoma con aquellos pacientes diagnosticados cl&#237;nica e histol&#243;gicamente de melanoma&#44; procedentes del Hospital Cl&#237;nico Universitario &#8220;San Cecilio&#8221;&#46; Los individuos del estudio deb&#237;an tener su lugar de residencia en la provincia de Granada&#46; Calculamos la prevalencia de melanoma a intervalos de 100<span class="elsevierStyleHsp" style=""></span>m de altitud y estimamos la dosis eritem&#225;tica diaria a partir de las medidas de radiaci&#243;n UVB realizadas con piran&#243;metros situados a 0&#44; 680&#44; 1&#46;200&#44; 2&#46;100 y 3&#46;398<span class="elsevierStyleHsp" style=""></span>m de altitud durante la campa&#241;a VELETA-2002&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de melanoma m&#225;s alta est&#225; situada en el intervalo comprendido entre los 1&#46;400&#8211;1&#46;499<span class="elsevierStyleHsp" style=""></span>m a&#46;s&#46;l &#40;intervalo con n&#250;cleos de poblaci&#243;n situados a mayor altitud&#41; con 2&#44;36 por 1&#46;000 habitantes IC al 95&#37; &#40;0&#44;64&#8211;6&#44;03&#41; por 1&#46;000 habitantes&#46; A partir de los 700<span class="elsevierStyleHsp" style=""></span>m de altura la dosis eritem&#225;tica diaria aumenta de forma exponencial a medida que ascendemos en altitud&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Este estudio encuentra una tendencia al aumento en la prevalencia de melanoma al ascender en altitud&#44; siendo m&#225;s intenso a partir de los 700<span class="elsevierStyleHsp" style=""></span>m a&#46;s&#46;l&#46;</p>"
      ]
    ]
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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