array:23 [
  "pii" => "S1578219011001065"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.07.003"
  "estado" => "S300"
  "fechaPublicacion" => "2011-11-01"
  "aid" => "475"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2011;102:647-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3199
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 2428
      "PDF" => 723
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011003504"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.07.007"
      "estado" => "S300"
      "fechaPublicacion" => "2011-11-01"
      "aid" => "475"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2011;102:647-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7612
        "formatos" => array:3 [
          "EPUB" => 4
          "HTML" => 5398
          "PDF" => 2210
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo de Opini&#243;n</span>"
        "titulo" => "Melanoma y embarazo"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "647"
            "paginaFinal" => "649"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Melanoma and pregnancy"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "S&#46; Serrano-Ortega, A&#46; Buend&#237;a-Eisman"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Serrano-Ortega"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Buend&#237;a-Eisman"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219011001065"
          "doi" => "10.1016/j.adengl.2011.07.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011001065?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011003504?idApp=UINPBA000044"
      "url" => "/00017310/0000010200000009/v1_201304241340/S0001731011003504/v1_201304241340/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219011000904"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.11.003"
    "estado" => "S300"
    "fechaPublicacion" => "2011-11-01"
    "aid" => "353"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2011;102:650-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5687
      "formatos" => array:3 [
        "EPUB" => 45
        "HTML" => 4793
        "PDF" => 849
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Melanocytic Nevi&#44; Melanoma&#44; and Pregnancy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "650"
          "paginaFinal" => "657"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Nevus&#44; melanoma y embarazo"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V&#46; Borges, S&#46; Puig, J&#46; Malvehy"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Borges"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Puig"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Malvehy"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011000780"
        "doi" => "10.1016/j.ad.2011.02.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011000780?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000904?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000009/v1_201304241238/S1578219011000904/v1_201304241238/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>"
    "titulo" => "Melanoma and Pregnancy"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "647"
        "paginaFinal" => "649"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "S&#46; Serrano-Ortega, A&#46; Buend&#237;a-Eisman"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "S&#46;"
            "apellidos" => "Serrano-Ortega"
            "email" => array:1 [
              0 => "consultadermatologia&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Buend&#237;a-Eisman"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Professor of Dermatology&#44; Universidad de Granada&#44; Granada&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Melanoma y embarazo"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have often heard and still hear statements like &#8220;If you have had melanoma you should not get pregnant&#8221; or &#8220;If you are pregnant and you develop melanoma&#44; your pregnancy has to be terminated&#8221;&#46; We have even made such statements ourselves&#44; whether to prevent the recurrence of hypothetically residual disease or to avoid a poor prognosis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">There has been a great deal of controversy over the years regarding the links between cutaneous melanoma and pregnancy&#46; Given the existence of studies that argue for and against a worse prognosis&#44; it is essential to draw on sufficient data to be able to decide the most suitable approach to melanoma in pregnant women&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The incidence of melanoma is increasing steadily in most developed countries&#44; whereas the birth rate is falling&#46; In Spain the highest incidence of cutaneous melanoma is 11&#46;9 cases per 100&#160;000 population for males in Zaragoza&#44; and 8&#46;7 cases per 100&#160;000 population for women in Tarragona&#59; the lowest incidence&#44; for both men and women&#44; is in Cuenca&#44; with 3&#46;3 and 2 cases per 100&#160;000 population&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 2009 in Spain&#44; the average number of births per 1000 inhabitants was 10&#46;75&#44; ranging from 18&#46;07 in Melilla to 7&#46;76 in Asturias&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The incidence of melanoma during pregnancy ranges from 2&#46;8 to 8&#46;5 cases per 100&#160;000 pregnant women&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The estimated incidence of cancer during pregnancy is 1 case per 1000 pregnancies&#8212;the most frequent being cervical cancer&#44; breast cancer&#44; melanoma&#44; lymphoma&#44; and acute leukemia&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Pregnancy may affect prognosis and treatment&#44; and there may be fetal involvement&#44; due both to the disease and the treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The debate over the possible negative link between pregnancy and cutaneous melanoma began in 1951 with the publication of an article in <span class="elsevierStyleItalic">Cancer</span> by Pack and Scharnagel&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> who described a series of 10 pregnant women with melanoma&#44; half of whom died within 2 to 30 months&#46; Subsequent studies seemed to confirm this poor prognosis&#44; giving possible hormonal influences as the explanation&#46; However&#44; these studies lacked scientific rigor&#44; as they failed to take into account other prognostic factors or to draw comparisons with control groups&#46; The first case-control studies&#44; dating from the mid-1980<span class="elsevierStyleHsp" style=""></span>s&#44; demonstrated that survival was comparable for similarly aged pregnant and nonpregnant women with melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;10</span></a> Today we can say&#44; with a certain margin of certainty&#44; that pregnancy does not alter melanoma prognosis&#46;Published in this issue of <span class="elsevierStyleItalic">Actas Dermosifiliogr&#225;ficas</span> is an excellent review by Borges et al&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> which depicts the various scenarios that arise regarding a pregnant woman with pigmented lesions&#58; changes in nevi&#59; melanomas diagnosed during&#44; before&#44; and after pregnancy&#59; and the use of oral contraceptives or hormone replacement therapy&#46; This excellent review has inspired our commentary below&#46;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8211;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Changes in nevi&#46;</span> Skin pigmentation may change or darken&#44; and nevi may change or grow during pregnancy&#46; As a broadly applied generalization&#44; however&#44; this statement is potentially dangerous&#46; This is because a changing or new nevus during pregnancy may be interpreted as a &#8216;normal&#8217; aspect of pregnancy&#44; when&#44; in fact&#44; it could mark the onset of cutaneous melanoma that is actually diagnosed when it is thicker&#44; and therefore indicative of a poorer prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> We are of the opinion that pregnant women&#8212;like those who are not pregnant&#8212;with numerous moles or dysplastic nevi should be monitored&#44; and biopsies should be performed if there are any suspicious changes&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8211;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Influence of pregnancy on skin melanoma&#46;</span> There is no difference in the prognosis for women diagnosed with skin melanoma&#8212;irrespective of whether or not they are pregnant&#8212;once the diagnosis is adjusted to take into account tumor thickness and development stage&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">The repercussions of pregnancy on the natural history of cutaneous melanoma can be explained in 2 ways&#58; the overall increase in melanoma incidence and the influence exerted by hormones&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A recent study demonstrated an annual 2&#46;7&#37; increase in the incidence of cutaneous melanoma in women aged between 15 and 39 years&#44; with exposure to UV radiation identified as the main cause&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> The incidence of melanoma in women doubles with every 10 additional years of life&#59; thus&#44; for women of childbearing age&#44; women aged 20-30 years account for 5&#37; of all women diagnosed with melanoma&#44; those aged 30-39 years for 11&#37;&#44; and those aged 40-49 years for 19&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> A frequent practice nowadays is for women to postpone motherhood for career reasons&#44; or&#44; as often happens&#44; for women to start a new family after the age of 35-40 years&#46; According to the National Institute of Statistics&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> there were 486&#160;127 births in Spain in 2009&#46; These births showed an increasing distribution up to age 31-35 years&#58; 4&#46;1&#37; for women in the 15-20 age bracket&#44; 11&#37; for the 21-25 age bracket&#44; 25&#46;85&#37; for the 26-30 age bracket&#44; and 37&#46;8&#37; for the peak 31-35 age bracket&#46; There was then a drop to 24&#37; for those in the 36-40 age bracket&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">A prospective cohort study examined the possible links between gynecological history and cutaneous melanoma&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> No differences in risk were found between nulliparous women and women who had given birth 1 or more times&#44; and no association was found between age during the first or last pregnancy and the risk of skin melanoma&#46; In contrast&#44; a lower risk was reported for women whose menarche commenced after 15 years &#40;RR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#44; 95&#37; CI&#58; 0&#46;46-0&#46;49&#41;&#44; and for women with irregular menstrual cycles&#46; There were no differences in risk associated with age at menopause&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">There is sufficient evidence available to indicate that pregnancy does not alter the melanoma prognosis&#44; irrespective of whether the cutaneous melanoma develops before&#44; during&#44; or after pregnancy&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> However&#44; since melanoma recurrence is more frequent in the first 3 years post-intervention&#44; high-risk patients should be advised to wait 3 years before becoming pregnant&#46;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8211;</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Melanoma treatment during pregnancy&#46;</span> The main goal is to avoid complications for the mother and fetus&#46; Surgical treatment is theoretically not contraindicated&#46; Once a diagnosis is established&#44; the tumor along with a surgical margin is removed&#44; and the wound is closed applying the general principles of surgical dermatology&#46; In our hospital we proceed as follows&#46; We first check that the fetus is alive&#44; if possible by means of a gynecological examination on the same day as surgery&#46; We always use local anesthesia &#40;lidocaine or mepivacaine without adrenaline&#41;&#46; General anesthesia is usually not necessary if the tumor is small and reconstruction is possible by drawing the wound edges together or use of a small local flap&#46; For more serious surgery&#44; we use general anesthesia&#44; but also locally infiltrate the surgery site with lidocaine or mepivacaine without adrenaline&#44; as this means we can reduce post-operative analgesia&#46; Anesthetic drugs can be safely used after the first trimester&#46;</p></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall">When indicated&#44; a sentinel node biopsy can be performed&#46; The International Committee on Radiological Protection considers risk to be negligible for a dose of less than 1&#160;mSv for the radiotracer&#44; and for a dose of about 0&#46;4 mSv during the sentinel node biopsy&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The time elapsing between radiocolloid injection and surgery should be kept to a minimum&#46; In our hospital we inject the radiocolloid&#44; perform the lymphoscintigraphy&#44; and immediately dispatch the patient to surgery&#44; all within an hour&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">When lymphadenectomy is necessary&#44; modern anesthesia techniques are such that surgery can be performed without any problems for the mother or the fetus&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; current knowledge indicates that melanoma does not contraindicate pregnancy&#44; and that pregnancy should not alter the therapeutic approach to skin melanoma&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#46; Serrano-Ortega S&#44; Buend&#237;a-Eisman A&#46; Actas Dermosifilior&#46;2011&#59;102&#58;647-649&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "IARC&#46; Cancer Incidence in five continents&#46; Vol&#46; IX&#46; <a class="elsevierStyleInterRef" href="http://www.iarc.fr/en/publications/pdfs-online/epi/sp160/index.php">http&#58;&#47;&#47;www&#46;iarc&#46;fr&#47;en&#47;publications&#47;pdfs-online&#47;epi&#47;sp160&#47;index&#46;php</a> &#40;Accessed July 6&#44; 2011&#41;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Instituto Nacional de Estad&#237;stica&#46; Datos demogr&#225;ficos b&#225;sicos&#46; <a class="elsevierStyleInterRef" href="http://www.ine.es/jaxi/tabla.do%3Fper=12%26type=db%26divi=IDB%26idtab=2">http&#58;&#47;&#47;www&#46;ine&#46;es&#47;jaxi&#47;tabla&#46;do&#63;per&#61;12&#38;type&#61;db&#247;i&#61;IDB&#38;idtab&#61;2</a> &#40;Accessed July 6&#44; 2011&#41;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma in pregnancy&#46; A population-based evaluation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;T&#46; O&#8217;Meara"
                            1 => "R&#46; Cress"
                            2 => "XingG"
                            3 => "B&#46; Danielsen"
                            4 => "L&#46;H&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.20925"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2005"
                        "volumen" => "103"
                        "paginaInicial" => "1217"
                        "paginaFinal" => "1226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15712209"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma in relation to reproductive and hormonal factors in women&#58; current review on controversial issues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Lens"
                            1 => "V&#46; Bataille"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10552-008-9110-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Causes Control"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "437"
                        "paginaFinal" => "442"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18197460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer&#44; fertility and pregnancy&#58; ESMO Clinical Practice Guidelines for diagnosis&#44; treatment and follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; Pentheroudakis"
                            1 => "R&#46; Orecchia"
                            2 => "H&#46;J&#46; Hoekstra"
                            3 => "N&#46; Pavlidis"
                            4 => "E&#46;S&#46;M&#46;O&#46; Guidelines Working Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2010"
                        "volumen" => "2010"
                        "numero" => "Suppl 5"
                        "paginaInicial" => "266"
                        "paginaFinal" => "273"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prognosis for malignant melanoma in the pregnant woman"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;T&#46; Pack"
                            1 => "I&#46;M&#46; Scharnagel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1951"
                        "volumen" => "4"
                        "paginaInicial" => "324"
                        "paginaFinal" => "334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14821926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma and pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;S&#46; Reintgen"
                            1 => "K&#46;S&#46; McCarty Jr&#46;"
                            2 => "R&#46; Vollmer"
                            3 => "E&#46; Cox"
                            4 => "H&#46;F&#46; Seigler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1985"
                        "volumen" => "55"
                        "paginaInicial" => "1340"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3971302"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of effect of pregnancy on outcome of melanoma&#46; For The World Health Organisation Melanoma Programme"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;M&#46; MacKie"
                            1 => "R&#46; Bufalino"
                            2 => "A&#46; Morabito"
                            3 => "C&#46; Sutherland"
                            4 => "N&#46; Cascinelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1991"
                        "volumen" => "337"
                        "paginaInicial" => "653"
                        "paginaFinal" => "655"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1672000"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma and pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Silipo"
                            1 => "P&#46; De Simone"
                            2 => "G&#46; Mariani"
                            3 => "P&#46; Buccini"
                            4 => "A&#46; Ferrari"
                            5 => "C&#46; Catricala"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.cmr.0000232295.91536.09"
                      "Revista" => array:6 [
                        "tituloSerie" => "Melanoma Res"
                        "fecha" => "2006"
                        "volumen" => "16"
                        "paginaInicial" => "497"
                        "paginaFinal" => "500"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17119450"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Birth outcome in women with breast cancer&#44; cutaneous malignant melanoma&#44; or Hodgkin&#39;s disease&#58; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46; Langagergaard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/CLEP.S12190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Epidemiol"
                        "fecha" => "2011"
                        "volumen" => "3"
                        "paginaInicial" => "7"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21326655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma y embarazo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Borges"
                            1 => "S&#46; Puig"
                            2 => "J&#46; Malvehy"
                            3 => "Nevus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Actas Dermo-Sifiliogr"
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recent trends in incidence of cutaneous melanoma among US Caucasian young adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;P&#46; Purdue"
                            1 => "L&#46;E&#46; Freeman"
                            2 => "W&#46;F&#46; Anderson"
                            3 => "M&#46;A&#46; Tucker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2008.159"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2008"
                        "volumen" => "128"
                        "paginaInicial" => "2905"
                        "paginaFinal" => "2908"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18615112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increases in Melanoma Among Adolescent Girls and Young Women in California&#58; Trends by Socioeconomic Status and UV Radiation Exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;K&#46; Hausauer"
                            1 => "S&#46;M&#46; Swetter"
                            2 => "M&#46;G&#46; Cockburn"
                            3 => "C&#46;A&#46; Clarke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2011.44"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2001"
                        "volumen" => "147"
                        "paginaInicial" => "783"
                        "paginaFinal" => "789"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21422322"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous malignant melanoma in Scotland&#58; incidence&#44; survival&#44; and mortality&#44; 1979-94&#46; The Scottish Melanoma Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;M&#46; MacKie"
                            1 => "D&#46; Hole"
                            2 => "J&#46;A&#46; Hunter"
                            3 => "R&#46; Rankin"
                            4 => "A&#46; Evans"
                            5 => "K&#46; McLaren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1997"
                        "volumen" => "315"
                        "paginaInicial" => "1117"
                        "paginaFinal" => "1121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9374883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Instituto Nacional de Estad&#237;stica&#46; 2009&#46; <a class="elsevierStyleInterRef" href="http://www.ine.es/jaxi/tabla.do%3Fpath=/t20/e301/parto/a2009/l0/%26file=09002.px%26type=pcaxis%26L=0">http&#58;&#47;&#47;www&#46;ine&#46;es&#47;jaxi&#47;tabla&#46;do&#63;path&#61;&#47;t20&#47;e301&#47;parto&#47;a2009&#47;l0&#47;&#38;file&#61;09002&#46;px&#38;type&#61;pcaxis&#38;L&#61;0</a>&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous melanoma and endogenous hormonal factors&#58; a large french prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Kvaskoff"
                            1 => "A&#46; Bijon"
                            2 => "S&#46; Mesrine"
                            3 => "M&#46;C&#46; Boutron-Ruault"
                            4 => "F&#46; Clavel-Chapelon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/aje/kwq503"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2011"
                        "volumen" => "173"
                        "paginaInicial" => "1192"
                        "paginaFinal" => "1202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21415032"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of pregnancy on the recurrence of cutaneous malignant melanoma in women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Albersen"
                            1 => "V&#46;I&#46; Westerling"
                            2 => "P&#46;A&#46; van Leeuwen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2010/214745"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Res Pract"
                        "fecha" => "2010"
                        "volumen" => "2010"
                        "paginaInicial" => "214745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20811591"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "ICRP&#44; 2000&#46; Pregnancy and Medical Radiation&#46; ICRP Publication 84&#46; Ann&#46; ICRP 30&#46;"
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010200000009/v1_201304241238/S1578219011001065/v1_201304241238/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6152"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Opinion Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000009/v1_201304241238/S1578219011001065/v1_201304241238/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011001065?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Opinion Article
Melanoma and Pregnancy
Melanoma y embarazo
S. Serrano-Ortega
Autor para correspondencia
consultadermatologia@gmail.com

Corresponding author.
, A. Buendía-Eisman
Professor of Dermatology, Universidad de Granada, Granada, Spain
Leído
7651
Veces
se ha leído el artículo
2337
Total PDF
5314
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1578219011001065"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2011.07.003"
  "estado" => "S300"
  "fechaPublicacion" => "2011-11-01"
  "aid" => "475"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2011;102:647-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3199
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 2428
      "PDF" => 723
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731011003504"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2011.07.007"
      "estado" => "S300"
      "fechaPublicacion" => "2011-11-01"
      "aid" => "475"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2011;102:647-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7612
        "formatos" => array:3 [
          "EPUB" => 4
          "HTML" => 5398
          "PDF" => 2210
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo de Opini&#243;n</span>"
        "titulo" => "Melanoma y embarazo"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "647"
            "paginaFinal" => "649"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Melanoma and pregnancy"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "S&#46; Serrano-Ortega, A&#46; Buend&#237;a-Eisman"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Serrano-Ortega"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Buend&#237;a-Eisman"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219011001065"
          "doi" => "10.1016/j.adengl.2011.07.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011001065?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011003504?idApp=UINPBA000044"
      "url" => "/00017310/0000010200000009/v1_201304241340/S0001731011003504/v1_201304241340/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219011000904"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2011.11.003"
    "estado" => "S300"
    "fechaPublicacion" => "2011-11-01"
    "aid" => "353"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2011;102:650-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5687
      "formatos" => array:3 [
        "EPUB" => 45
        "HTML" => 4793
        "PDF" => 849
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Melanocytic Nevi&#44; Melanoma&#44; and Pregnancy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "650"
          "paginaFinal" => "657"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Nevus&#44; melanoma y embarazo"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V&#46; Borges, S&#46; Puig, J&#46; Malvehy"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Borges"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Puig"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Malvehy"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731011000780"
        "doi" => "10.1016/j.ad.2011.02.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011000780?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000904?idApp=UINPBA000044"
    "url" => "/15782190/0000010200000009/v1_201304241238/S1578219011000904/v1_201304241238/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>"
    "titulo" => "Melanoma and Pregnancy"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "647"
        "paginaFinal" => "649"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "S&#46; Serrano-Ortega, A&#46; Buend&#237;a-Eisman"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "S&#46;"
            "apellidos" => "Serrano-Ortega"
            "email" => array:1 [
              0 => "consultadermatologia&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Buend&#237;a-Eisman"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Professor of Dermatology&#44; Universidad de Granada&#44; Granada&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Melanoma y embarazo"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have often heard and still hear statements like &#8220;If you have had melanoma you should not get pregnant&#8221; or &#8220;If you are pregnant and you develop melanoma&#44; your pregnancy has to be terminated&#8221;&#46; We have even made such statements ourselves&#44; whether to prevent the recurrence of hypothetically residual disease or to avoid a poor prognosis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">There has been a great deal of controversy over the years regarding the links between cutaneous melanoma and pregnancy&#46; Given the existence of studies that argue for and against a worse prognosis&#44; it is essential to draw on sufficient data to be able to decide the most suitable approach to melanoma in pregnant women&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The incidence of melanoma is increasing steadily in most developed countries&#44; whereas the birth rate is falling&#46; In Spain the highest incidence of cutaneous melanoma is 11&#46;9 cases per 100&#160;000 population for males in Zaragoza&#44; and 8&#46;7 cases per 100&#160;000 population for women in Tarragona&#59; the lowest incidence&#44; for both men and women&#44; is in Cuenca&#44; with 3&#46;3 and 2 cases per 100&#160;000 population&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 2009 in Spain&#44; the average number of births per 1000 inhabitants was 10&#46;75&#44; ranging from 18&#46;07 in Melilla to 7&#46;76 in Asturias&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The incidence of melanoma during pregnancy ranges from 2&#46;8 to 8&#46;5 cases per 100&#160;000 pregnant women&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The estimated incidence of cancer during pregnancy is 1 case per 1000 pregnancies&#8212;the most frequent being cervical cancer&#44; breast cancer&#44; melanoma&#44; lymphoma&#44; and acute leukemia&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Pregnancy may affect prognosis and treatment&#44; and there may be fetal involvement&#44; due both to the disease and the treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The debate over the possible negative link between pregnancy and cutaneous melanoma began in 1951 with the publication of an article in <span class="elsevierStyleItalic">Cancer</span> by Pack and Scharnagel&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> who described a series of 10 pregnant women with melanoma&#44; half of whom died within 2 to 30 months&#46; Subsequent studies seemed to confirm this poor prognosis&#44; giving possible hormonal influences as the explanation&#46; However&#44; these studies lacked scientific rigor&#44; as they failed to take into account other prognostic factors or to draw comparisons with control groups&#46; The first case-control studies&#44; dating from the mid-1980<span class="elsevierStyleHsp" style=""></span>s&#44; demonstrated that survival was comparable for similarly aged pregnant and nonpregnant women with melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;10</span></a> Today we can say&#44; with a certain margin of certainty&#44; that pregnancy does not alter melanoma prognosis&#46;Published in this issue of <span class="elsevierStyleItalic">Actas Dermosifiliogr&#225;ficas</span> is an excellent review by Borges et al&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> which depicts the various scenarios that arise regarding a pregnant woman with pigmented lesions&#58; changes in nevi&#59; melanomas diagnosed during&#44; before&#44; and after pregnancy&#59; and the use of oral contraceptives or hormone replacement therapy&#46; This excellent review has inspired our commentary below&#46;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8211;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Changes in nevi&#46;</span> Skin pigmentation may change or darken&#44; and nevi may change or grow during pregnancy&#46; As a broadly applied generalization&#44; however&#44; this statement is potentially dangerous&#46; This is because a changing or new nevus during pregnancy may be interpreted as a &#8216;normal&#8217; aspect of pregnancy&#44; when&#44; in fact&#44; it could mark the onset of cutaneous melanoma that is actually diagnosed when it is thicker&#44; and therefore indicative of a poorer prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> We are of the opinion that pregnant women&#8212;like those who are not pregnant&#8212;with numerous moles or dysplastic nevi should be monitored&#44; and biopsies should be performed if there are any suspicious changes&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8211;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Influence of pregnancy on skin melanoma&#46;</span> There is no difference in the prognosis for women diagnosed with skin melanoma&#8212;irrespective of whether or not they are pregnant&#8212;once the diagnosis is adjusted to take into account tumor thickness and development stage&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">The repercussions of pregnancy on the natural history of cutaneous melanoma can be explained in 2 ways&#58; the overall increase in melanoma incidence and the influence exerted by hormones&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A recent study demonstrated an annual 2&#46;7&#37; increase in the incidence of cutaneous melanoma in women aged between 15 and 39 years&#44; with exposure to UV radiation identified as the main cause&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> The incidence of melanoma in women doubles with every 10 additional years of life&#59; thus&#44; for women of childbearing age&#44; women aged 20-30 years account for 5&#37; of all women diagnosed with melanoma&#44; those aged 30-39 years for 11&#37;&#44; and those aged 40-49 years for 19&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> A frequent practice nowadays is for women to postpone motherhood for career reasons&#44; or&#44; as often happens&#44; for women to start a new family after the age of 35-40 years&#46; According to the National Institute of Statistics&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> there were 486&#160;127 births in Spain in 2009&#46; These births showed an increasing distribution up to age 31-35 years&#58; 4&#46;1&#37; for women in the 15-20 age bracket&#44; 11&#37; for the 21-25 age bracket&#44; 25&#46;85&#37; for the 26-30 age bracket&#44; and 37&#46;8&#37; for the peak 31-35 age bracket&#46; There was then a drop to 24&#37; for those in the 36-40 age bracket&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">A prospective cohort study examined the possible links between gynecological history and cutaneous melanoma&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> No differences in risk were found between nulliparous women and women who had given birth 1 or more times&#44; and no association was found between age during the first or last pregnancy and the risk of skin melanoma&#46; In contrast&#44; a lower risk was reported for women whose menarche commenced after 15 years &#40;RR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#44; 95&#37; CI&#58; 0&#46;46-0&#46;49&#41;&#44; and for women with irregular menstrual cycles&#46; There were no differences in risk associated with age at menopause&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">There is sufficient evidence available to indicate that pregnancy does not alter the melanoma prognosis&#44; irrespective of whether the cutaneous melanoma develops before&#44; during&#44; or after pregnancy&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> However&#44; since melanoma recurrence is more frequent in the first 3 years post-intervention&#44; high-risk patients should be advised to wait 3 years before becoming pregnant&#46;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8211;</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Melanoma treatment during pregnancy&#46;</span> The main goal is to avoid complications for the mother and fetus&#46; Surgical treatment is theoretically not contraindicated&#46; Once a diagnosis is established&#44; the tumor along with a surgical margin is removed&#44; and the wound is closed applying the general principles of surgical dermatology&#46; In our hospital we proceed as follows&#46; We first check that the fetus is alive&#44; if possible by means of a gynecological examination on the same day as surgery&#46; We always use local anesthesia &#40;lidocaine or mepivacaine without adrenaline&#41;&#46; General anesthesia is usually not necessary if the tumor is small and reconstruction is possible by drawing the wound edges together or use of a small local flap&#46; For more serious surgery&#44; we use general anesthesia&#44; but also locally infiltrate the surgery site with lidocaine or mepivacaine without adrenaline&#44; as this means we can reduce post-operative analgesia&#46; Anesthetic drugs can be safely used after the first trimester&#46;</p></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall">When indicated&#44; a sentinel node biopsy can be performed&#46; The International Committee on Radiological Protection considers risk to be negligible for a dose of less than 1&#160;mSv for the radiotracer&#44; and for a dose of about 0&#46;4 mSv during the sentinel node biopsy&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The time elapsing between radiocolloid injection and surgery should be kept to a minimum&#46; In our hospital we inject the radiocolloid&#44; perform the lymphoscintigraphy&#44; and immediately dispatch the patient to surgery&#44; all within an hour&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">When lymphadenectomy is necessary&#44; modern anesthesia techniques are such that surgery can be performed without any problems for the mother or the fetus&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; current knowledge indicates that melanoma does not contraindicate pregnancy&#44; and that pregnancy should not alter the therapeutic approach to skin melanoma&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#46; Serrano-Ortega S&#44; Buend&#237;a-Eisman A&#46; Actas Dermosifilior&#46;2011&#59;102&#58;647-649&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "IARC&#46; Cancer Incidence in five continents&#46; Vol&#46; IX&#46; <a class="elsevierStyleInterRef" href="http://www.iarc.fr/en/publications/pdfs-online/epi/sp160/index.php">http&#58;&#47;&#47;www&#46;iarc&#46;fr&#47;en&#47;publications&#47;pdfs-online&#47;epi&#47;sp160&#47;index&#46;php</a> &#40;Accessed July 6&#44; 2011&#41;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Instituto Nacional de Estad&#237;stica&#46; Datos demogr&#225;ficos b&#225;sicos&#46; <a class="elsevierStyleInterRef" href="http://www.ine.es/jaxi/tabla.do%3Fper=12%26type=db%26divi=IDB%26idtab=2">http&#58;&#47;&#47;www&#46;ine&#46;es&#47;jaxi&#47;tabla&#46;do&#63;per&#61;12&#38;type&#61;db&#247;i&#61;IDB&#38;idtab&#61;2</a> &#40;Accessed July 6&#44; 2011&#41;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma in pregnancy&#46; A population-based evaluation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;T&#46; O&#8217;Meara"
                            1 => "R&#46; Cress"
                            2 => "XingG"
                            3 => "B&#46; Danielsen"
                            4 => "L&#46;H&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.20925"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2005"
                        "volumen" => "103"
                        "paginaInicial" => "1217"
                        "paginaFinal" => "1226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15712209"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma in relation to reproductive and hormonal factors in women&#58; current review on controversial issues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Lens"
                            1 => "V&#46; Bataille"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10552-008-9110-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Causes Control"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "437"
                        "paginaFinal" => "442"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18197460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer&#44; fertility and pregnancy&#58; ESMO Clinical Practice Guidelines for diagnosis&#44; treatment and follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; Pentheroudakis"
                            1 => "R&#46; Orecchia"
                            2 => "H&#46;J&#46; Hoekstra"
                            3 => "N&#46; Pavlidis"
                            4 => "E&#46;S&#46;M&#46;O&#46; Guidelines Working Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2010"
                        "volumen" => "2010"
                        "numero" => "Suppl 5"
                        "paginaInicial" => "266"
                        "paginaFinal" => "273"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prognosis for malignant melanoma in the pregnant woman"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;T&#46; Pack"
                            1 => "I&#46;M&#46; Scharnagel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1951"
                        "volumen" => "4"
                        "paginaInicial" => "324"
                        "paginaFinal" => "334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14821926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma and pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;S&#46; Reintgen"
                            1 => "K&#46;S&#46; McCarty Jr&#46;"
                            2 => "R&#46; Vollmer"
                            3 => "E&#46; Cox"
                            4 => "H&#46;F&#46; Seigler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1985"
                        "volumen" => "55"
                        "paginaInicial" => "1340"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3971302"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of effect of pregnancy on outcome of melanoma&#46; For The World Health Organisation Melanoma Programme"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;M&#46; MacKie"
                            1 => "R&#46; Bufalino"
                            2 => "A&#46; Morabito"
                            3 => "C&#46; Sutherland"
                            4 => "N&#46; Cascinelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1991"
                        "volumen" => "337"
                        "paginaInicial" => "653"
                        "paginaFinal" => "655"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1672000"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma and pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Silipo"
                            1 => "P&#46; De Simone"
                            2 => "G&#46; Mariani"
                            3 => "P&#46; Buccini"
                            4 => "A&#46; Ferrari"
                            5 => "C&#46; Catricala"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.cmr.0000232295.91536.09"
                      "Revista" => array:6 [
                        "tituloSerie" => "Melanoma Res"
                        "fecha" => "2006"
                        "volumen" => "16"
                        "paginaInicial" => "497"
                        "paginaFinal" => "500"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17119450"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Birth outcome in women with breast cancer&#44; cutaneous malignant melanoma&#44; or Hodgkin&#39;s disease&#58; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46; Langagergaard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/CLEP.S12190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Epidemiol"
                        "fecha" => "2011"
                        "volumen" => "3"
                        "paginaInicial" => "7"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21326655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma y embarazo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Borges"
                            1 => "S&#46; Puig"
                            2 => "J&#46; Malvehy"
                            3 => "Nevus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Actas Dermo-Sifiliogr"
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recent trends in incidence of cutaneous melanoma among US Caucasian young adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;P&#46; Purdue"
                            1 => "L&#46;E&#46; Freeman"
                            2 => "W&#46;F&#46; Anderson"
                            3 => "M&#46;A&#46; Tucker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2008.159"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2008"
                        "volumen" => "128"
                        "paginaInicial" => "2905"
                        "paginaFinal" => "2908"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18615112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increases in Melanoma Among Adolescent Girls and Young Women in California&#58; Trends by Socioeconomic Status and UV Radiation Exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;K&#46; Hausauer"
                            1 => "S&#46;M&#46; Swetter"
                            2 => "M&#46;G&#46; Cockburn"
                            3 => "C&#46;A&#46; Clarke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2011.44"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2001"
                        "volumen" => "147"
                        "paginaInicial" => "783"
                        "paginaFinal" => "789"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21422322"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous malignant melanoma in Scotland&#58; incidence&#44; survival&#44; and mortality&#44; 1979-94&#46; The Scottish Melanoma Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;M&#46; MacKie"
                            1 => "D&#46; Hole"
                            2 => "J&#46;A&#46; Hunter"
                            3 => "R&#46; Rankin"
                            4 => "A&#46; Evans"
                            5 => "K&#46; McLaren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1997"
                        "volumen" => "315"
                        "paginaInicial" => "1117"
                        "paginaFinal" => "1121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9374883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Instituto Nacional de Estad&#237;stica&#46; 2009&#46; <a class="elsevierStyleInterRef" href="http://www.ine.es/jaxi/tabla.do%3Fpath=/t20/e301/parto/a2009/l0/%26file=09002.px%26type=pcaxis%26L=0">http&#58;&#47;&#47;www&#46;ine&#46;es&#47;jaxi&#47;tabla&#46;do&#63;path&#61;&#47;t20&#47;e301&#47;parto&#47;a2009&#47;l0&#47;&#38;file&#61;09002&#46;px&#38;type&#61;pcaxis&#38;L&#61;0</a>&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous melanoma and endogenous hormonal factors&#58; a large french prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Kvaskoff"
                            1 => "A&#46; Bijon"
                            2 => "S&#46; Mesrine"
                            3 => "M&#46;C&#46; Boutron-Ruault"
                            4 => "F&#46; Clavel-Chapelon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/aje/kwq503"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2011"
                        "volumen" => "173"
                        "paginaInicial" => "1192"
                        "paginaFinal" => "1202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21415032"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of pregnancy on the recurrence of cutaneous malignant melanoma in women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Albersen"
                            1 => "V&#46;I&#46; Westerling"
                            2 => "P&#46;A&#46; van Leeuwen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2010/214745"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Res Pract"
                        "fecha" => "2010"
                        "volumen" => "2010"
                        "paginaInicial" => "214745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20811591"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "ICRP&#44; 2000&#46; Pregnancy and Medical Radiation&#46; ICRP Publication 84&#46; Ann&#46; ICRP 30&#46;"
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010200000009/v1_201304241238/S1578219011001065/v1_201304241238/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6152"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Opinion Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000009/v1_201304241238/S1578219011001065/v1_201304241238/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011001065?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 9 13 22
2024 Octubre 78 40 118
2024 Septiembre 92 29 121
2024 Agosto 123 43 166
2024 Julio 99 34 133
2024 Junio 94 33 127
2024 Mayo 95 27 122
2024 Abril 81 26 107
2024 Marzo 80 24 104
2024 Febrero 74 26 100
2024 Enero 81 40 121
2023 Diciembre 53 21 74
2023 Noviembre 69 27 96
2023 Octubre 69 15 84
2023 Septiembre 73 32 105
2023 Agosto 41 17 58
2023 Julio 63 29 92
2023 Junio 66 19 85
2023 Mayo 74 23 97
2023 Abril 66 23 89
2023 Marzo 52 36 88
2023 Febrero 44 12 56
2023 Enero 59 26 85
2022 Diciembre 61 51 112
2022 Noviembre 18 37 55
2022 Octubre 29 19 48
2022 Septiembre 27 23 50
2022 Agosto 26 34 60
2022 Julio 32 33 65
2022 Junio 27 22 49
2022 Mayo 38 32 70
2022 Abril 63 34 97
2022 Marzo 49 55 104
2022 Febrero 42 30 72
2022 Enero 37 39 76
2021 Diciembre 27 34 61
2021 Noviembre 41 39 80
2021 Octubre 40 40 80
2021 Septiembre 29 36 65
2021 Agosto 35 26 61
2021 Julio 39 29 68
2021 Junio 30 25 55
2021 Mayo 32 48 80
2021 Abril 89 52 141
2021 Marzo 63 30 93
2021 Febrero 50 19 69
2021 Enero 37 18 55
2020 Diciembre 43 16 59
2020 Noviembre 29 18 47
2020 Octubre 15 22 37
2020 Septiembre 32 7 39
2020 Agosto 25 18 43
2020 Julio 17 11 28
2020 Junio 37 30 67
2020 Mayo 26 20 46
2020 Abril 39 20 59
2020 Marzo 26 27 53
2020 Febrero 2 7 9
2020 Enero 0 5 5
2019 Diciembre 4 2 6
2019 Septiembre 4 0 4
2019 Agosto 0 5 5
2019 Julio 0 2 2
2019 Junio 2 5 7
2019 Mayo 0 12 12
2019 Abril 0 5 5
2019 Marzo 2 6 8
2019 Febrero 0 6 6
2019 Enero 2 0 2
2018 Diciembre 1 0 1
2018 Octubre 1 1 2
2018 Septiembre 3 0 3
2018 Junio 0 1 1
2018 Marzo 1 2 3
2018 Febrero 25 2 27
2018 Enero 43 6 49
2017 Diciembre 44 9 53
2017 Noviembre 43 5 48
2017 Octubre 30 5 35
2017 Septiembre 27 6 33
2017 Agosto 32 6 38
2017 Julio 29 3 32
2017 Junio 41 23 64
2017 Mayo 40 7 47
2017 Abril 33 19 52
2017 Marzo 24 31 55
2017 Febrero 41 12 53
2017 Enero 31 4 35
2016 Diciembre 41 5 46
2016 Noviembre 56 5 61
2016 Octubre 56 12 68
2016 Septiembre 55 11 66
2016 Agosto 53 15 68
2016 Julio 43 12 55
2016 Junio 15 13 28
2016 Mayo 8 10 18
2016 Abril 5 2 7
2016 Marzo 7 1 8
2016 Febrero 7 3 10
2016 Enero 16 1 17
2015 Diciembre 13 1 14
2015 Noviembre 20 1 21
2015 Octubre 16 3 19
2015 Septiembre 15 2 17
2015 Agosto 15 7 22
2015 Julio 44 16 60
2015 Junio 63 18 81
2015 Mayo 85 8 93
2015 Abril 61 13 74
2015 Marzo 65 9 74
2015 Febrero 45 8 53
2015 Enero 47 12 59
2014 Diciembre 60 16 76
2014 Noviembre 31 9 40
2014 Octubre 51 9 60
2014 Septiembre 42 16 58
2014 Agosto 47 10 57
2014 Julio 74 15 89
2014 Junio 80 11 91
2014 Mayo 105 13 118
2014 Abril 77 10 87
2014 Marzo 99 17 116
2014 Febrero 54 12 66
2014 Enero 58 14 72
2013 Diciembre 59 16 75
2013 Noviembre 45 20 65
2013 Octubre 18 9 27
2013 Septiembre 14 7 21
2013 Agosto 20 11 31
2013 Julio 19 23 42
2013 Junio 11 17 28
2013 Mayo 8 45 53
2013 Abril 12 14 26
2013 Marzo 19 9 28
2013 Febrero 34 8 42
2013 Enero 17 4 21
2012 Diciembre 16 7 23
2012 Octubre 0 1 1
2012 Agosto 2 0 2
2012 Julio 1 0 1
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?