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array:24 [ "pii" => "S1578219011000722" "issn" => "15782190" "doi" => "10.1016/j.adengl.2011.05.001" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "429" "copyright" => "Elsevier España, S.L. and AEDV" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2011;102:589-98" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4085 "formatos" => array:3 [ "EPUB" => 56 "HTML" => 3069 "PDF" => 960 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731011002869" "issn" => "00017310" "doi" => "10.1016/j.ad.2011.05.010" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "429" "copyright" => "Elsevier España, S.L. y AEDV" "documento" => "article" "crossmark" => 0 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2011;102:589-98" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6782 "formatos" => array:3 [ "EPUB" => 2 "HTML" => 4662 "PDF" => 2118 ] ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Controversias en Dermatología</span>" "titulo" => "Ganglio centinela en cáncer de piel no melanoma" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "589" "paginaFinal" => "598" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Sentinel Lymph Node in Nonmelanoma Skin Cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Salguero-Fernández, L. Rios-Buceta, P. Jaén-Olasolo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Salguero-Fernández" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Rios-Buceta" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Jaén-Olasolo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219011000722" "doi" => "10.1016/j.adengl.2011.05.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000722?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002869?idApp=UINPBA000044" "url" => "/00017310/0000010200000008/v1_201304241336/S0001731011002869/v1_201304241336/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219011000680" "issn" => "15782190" "doi" => "10.1016/j.adengl.2011.03.011" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "389" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2011;102:599-604" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3249 "formatos" => array:3 [ "EPUB" => 51 "HTML" => 2571 "PDF" => 627 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Analysis of Phenotypic Characteristics and Exposure to UV Radiation in a Group of Patients With Cutaneous Melanoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "599" "paginaFinal" => "604" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio de las características fenotípicas y exposición a radiación ultravioleta en pacientes diagnosticados de melanoma cutáneo" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 868 "Ancho" => 1674 "Tamanyo" => 106914 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Total cumulative sun exposure according to tumor type. ALM indicates acral lentiginous melanoma; LMM, lentigo maligna melanoma; NC, not classified; NM, nodular melanoma; SSM, superficial spreading melanoma.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Fagundo, C. Rodríguez-García, S. González, R. Sánchez, A. Jiménez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Fagundo" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Rodríguez-García" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Rodríguez" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "González" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Sánchez" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Jiménez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731011001736" "doi" => "10.1016/j.ad.2011.03.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001736?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000680?idApp=UINPBA000044" "url" => "/15782190/0000010200000008/v1_201304241234/S1578219011000680/v1_201304241234/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219011000709" "issn" => "15782190" "doi" => "10.1016/j.adengl.2011.03.013" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "394" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "article" "crossmark" => 0 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2011;102:572-88" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5490 "formatos" => array:3 [ "EPUB" => 48 "HTML" => 4310 "PDF" => 1132 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Vitamin D: Evidence and Controversies" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "572" "paginaFinal" => "588" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La vitamina D: evidencias y controversias" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2250 "Ancho" => 2465 "Tamanyo" => 482263 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Immunomodulatory effect of vitamin D in the skin. Vitamin D production promotes the innate immune response by activating the cathelicidin type immune receptors CD14 and TLR2 in the epidermal keratinocyte and the CCR27 ligand, which attracts T-cells. Vitamin D also stimulates the differentiation and activation of monocytes and macrophages through induction of p21 and C/EBPb. Conversely, vitamin D reduces the antigen recognition capacity of Langerhans cells, the maturation of dendritic cells, and antigenic presentation (reduction of CD40 and CD80/86 receptors. It inhibits the production of T<span class="elsevierStyleInf">H</span>1 by downregulating IL-12 synthesis and upregulating that of TGFβ1. Moreover, it partially inhibits the action of T<span class="elsevierStyleInf">H</span>1 by reducing the production of the cytokines IL-2, IFNγ, TNF-α, and IP-10. In addition, it stimulates the differentiation of T<span class="elsevierStyleInf">H</span>2 (overexpression of the T1/ST2 receptor of IL-1). Vitamin D also produces overexpression of <span class="elsevierStyleItalic">GATA-3</span> and <span class="elsevierStyleItalic">D-maf</span> genes, promoting the release of the cytokines IL-4, 5, 10, and 13 in these lymphocytes. CCR indicates carbon catabolite repression; IFN, interferon; IL, interleukin; IP-10, interferon-gamma–induced protein-10; NFKB, nuclear factor kappa B; TGF, transforming growth factor, TLR, toll-like receptor; TNF, tumor necrosis factor; T<span class="elsevierStyleInf">H</span>, T helper cell.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Y. Gilaberte, J. Aguilera, J.M. Carrascosa, F.L. Figueroa, J. Romaní de Gabriel, E. Nagore" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Y." "apellidos" => "Gilaberte" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Aguilera" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Carrascosa" ] 3 => array:2 [ "nombre" => "F.L." "apellidos" => "Figueroa" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Romaní de Gabriel" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Nagore" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731011001931" "doi" => "10.1016/j.ad.2011.03.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001931?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000709?idApp=UINPBA000044" "url" => "/15782190/0000010200000008/v1_201304241234/S1578219011000709/v1_201304241234/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Controversies in Dermatology</span>" "titulo" => "Sentinel Lymph Node in Nonmelanoma Skin Cancer" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "589" "paginaFinal" => "598" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Salguero-Fernández, L. Rios-Buceta, P. Jaén-Olasolo" "autores" => array:3 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Salguero-Fernández" "email" => array:1 [ 0 => "irenebsf@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Rios-Buceta" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Jaén-Olasolo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Ganglio centinela en cáncer de piel no melanoma" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sentinel lymph node biopsy is based on the hypothesis that efferent lymphatic flow from solid tumors is not random but rather follows a pattern in which there is spread to an initial node. From there, secondary spread occurs to other nodes. If this first lymph node is identified and selectively biopsied, a direct histological assessment of lymphatic spread is possible. In contrast, negative pathology findings for this lymph node would preclude unnecessary lymphadenectomies.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The technique has been shown to provide the most accurate prognosis for survival in patients with melanoma.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Likewise, such an approach means that prophylactic lymphadenectomies can be avoided as these are usually unnecessary.</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Mechanism of Lymphatic Metastasis</span><p id="par0015" class="elsevierStylePara elsevierViewall">The cells responsible for lymphatic metastasis reach the lymph nodes via afferent lymphatic vessels in the subcapsular sinusoids, either individually or as small groups of cells. Once the tumor cells reach the subcapsular space, capsule involvement can occur at any time after lymph node invasion.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The tumor cells proliferate, in principle in the cortex. From there, they can spread to the lymph node medulla and replace normal lymph node structure. Tumor cells spread through efferent lymph vessels in the hila of lymph nodes.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The pattern of growth of lymph node metastases has been well established; these begin as isolated tumor cells, then turn into micromestases, before finally becoming macrometastases.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Technique</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Tracers</span><p id="par0030" class="elsevierStylePara elsevierViewall">For the detection of sentinel lymph nodes, specific tracers are injected intradermally close to the tumor to trace the characteristic drainage pattern for each patient. In general, radioactive isotopes are used (technetium [Tc]) in the form of colloidal particles that may or may not be associated with vital dyes.</p><p id="par0035" class="elsevierStylePara elsevierViewall">After the administration of tracer, increased interstitial pressure drives the particles through the vessels to the draining nodes, where they remain (in what is the sentinel lymph node). Appropriate imaging techniques are then used to detect the tracers.</p><p id="par0040" class="elsevierStylePara elsevierViewall">According to the size of the colloid used to vehiculize the Tc (between 2<span class="elsevierStyleHsp" style=""></span>nm and 400<span class="elsevierStyleHsp" style=""></span>nm), the rate of transport to and residence time in the lymph node will vary. The most widely used radiomarkers include <span class="elsevierStyleSup">99m</span>Tc-albumin nanocolloid, filtered <span class="elsevierStyleSup">99m</span>Tc-sulfur colloid, and <span class="elsevierStyleSup">99m</span>Tc-amonium sulfide. It should be noted that none of these colloidal systems have a uniform particle diameter but rather a range of diameters distributed around a mean value. The most widely used are intermediate colloids, between 5 and 80<span class="elsevierStyleHsp" style=""></span>nm. These include nanocolloidal albumin, colloidal sulfide, and colloidal rhenium sulfide, which all have the advantage of lower systemic penetration and sharply outline the draining nodes.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Detection</span><p id="par0045" class="elsevierStylePara elsevierViewall">Preoperative detection is performed in the following ways:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1.</span><p id="par0050" class="elsevierStylePara elsevierViewall">Dynamic scintigraphy, which allows the direction and number of outflow paths to be visualized.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2.</span><p id="par0055" class="elsevierStylePara elsevierViewall">Static scintigraphy, which visualizes the final site of the tracer, marking a “hot spot” with dye in the skin.</p></li></ul></p><p id="par0060" class="elsevierStylePara elsevierViewall">In recent years, studies have been performed with new tracer systems such as the following<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–6</span></a>:<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">1.</span><p id="par0065" class="elsevierStylePara elsevierViewall">Imaging of indocyanine green (Dianogreen) fluorescence with infrared cameras. A fluorescent tracer is used that can be visualized with cameras set up to detect the wavelength emitted. This is a real-time system.The advantages of this method are that a) it does not depend on γ-ray counters or radioisotope detectors; b) lymph node detection is easier than with radiotracers; c) it is more useful for detecting nodes close to the tumor; and d) neither the patients nor the operators are exposed to ionizing radiation.</p><p id="par0070" class="elsevierStylePara elsevierViewall">The disadvantages of this method are that a) it only detects lymph nodes up to 2<span class="elsevierStyleHsp" style=""></span>cm deep and b) quantitative study of tissue fluorescence is difficult, and so there is a risk of missing sentinel lymph nodes when other larger ones are resected.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">2.</span><p id="par0075" class="elsevierStylePara elsevierViewall">Gold nanocages detected by photoacoustic systems. These nanocages are readily conjugated to antibodies for specific receptors.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p></li></ul></p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Pathology</span><p id="par0080" class="elsevierStylePara elsevierViewall">The histopathology of resected nodes involves examining multiple slices from the entire node, taken from a central section along the main axis of the node (sections of 200<span class="elsevierStyleHsp" style=""></span>μm every 2<span class="elsevierStyleHsp" style=""></span>mm)</p><p id="par0085" class="elsevierStylePara elsevierViewall">Hematoxylin-eosin staining should be used; immunohistochemical (IHC) techniques are then used when hematoxylin-eosin staining is negative. Immunohistochemical reagents used in the case of melanoma are S-100, MELAN-A, and HMB-45.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Indications for the Technique</span><p id="par0090" class="elsevierStylePara elsevierViewall">To date, this approach has been shown to provide useful prognostic information when lymph node spread is a concern in a wide range of solid tumors, such as melanoma,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> breast cancer,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> cancer of the penis<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and vulva,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> thyroid carcinoma,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> lung cancer,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> colorectal cancer,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> prostate cancer,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and gastrointestinal cancer.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Nodes in Nonmelanoma Skin Cancer</span><p id="par0095" class="elsevierStylePara elsevierViewall">In addition to the established indications, there are a number of nonmelanoma skin cancers for which the possible benefit of this technique is under investigation.</p><p id="par0100" class="elsevierStylePara elsevierViewall">At present, sufficiently large studies have not been performed to provide clear indications.</p><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Squamous Cell Carcinoma of the Skin</span><p id="par0105" class="elsevierStylePara elsevierViewall">Squamous cell carcinoma of the skin accounts for approximately 20% of skin cancers and is the second most common form of skin cancer in whites.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16–18</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">This type of tumor can grow until it forms a large mass and becomes invasive. Unlike basal cell carcinomas, squamous cell carcinomas spread readily to regional and distant lymph nodes. The overall rate of metastasis is 5% and the 5-year survival after metastasis is 26%.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Metastases usually occur within 2 years of diagnosis (80%)<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,19–21</span></a>; however there have been reports of later metastasis.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The essential points to analyze here are what we consider high-risk squamous cell carcinoma of the skin and how we manage these patients if there is no clinical or radiological evidence of lymph node involvement (N0).<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">1.</span><p id="par0125" class="elsevierStylePara elsevierViewall">We understand high-risk squamous cell carcinoma of the skin as a primary tumor with a risk of metastasis of greater than 5%, where the risk is assessed according to unfavorable patient-related factors (for example, immunosuppression) or tumor-related factors.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Several studies have assessed these factors.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,24,25</span></a> However, we believe it important to highlight the study by Breuninger et al,<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> which included 615 patients who underwent surgery for squamous cell carcinoma of the skin. The multivariate analysis performed included tumor thickness, size, site, degree of histologic differentiation, desmoplastic histologic subtype, history of multiple squamous cell carcinomas, and immunosuppression.</p><p id="par0135" class="elsevierStylePara elsevierViewall">The primary objective of the study was to determine the moment in which metastases occurred and/or the time to local recurrence (defined as the time from tumor diagnosis to diagnosis of the metastasis or recurrence). The mean duration of follow-up was 43 months.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Metastasis occurred in 26 (4%) of the 615 patients, and local recurrence occurred in 20 (3%). No patient presented with metastasis after more than 4 years.</p><p id="par0145" class="elsevierStylePara elsevierViewall">The authors reported that the squamous cell carcinomas of the skin less than 2<span class="elsevierStyleHsp" style=""></span>mm thick did not metastasize, those 2-6<span class="elsevierStyleHsp" style=""></span>mm thick were associated with an intermediate risk of metastasis (4%), and those more than 6<span class="elsevierStyleHsp" style=""></span>mm thick had a high risk of metastasis (16%). The authors concluded that the current TNM staging system for squamous cell carcinoma of the skin should be revised, and tumor thickness included in the classification.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">2.</span><p id="par0150" class="elsevierStylePara elsevierViewall">Regarding the management of high-risk squamous cell carcinoma of the skin without clinical or radiological evidence of lymph node involvement (N0), the problem is that, to date, there are no universally accepted guidelines. The alternative approaches available are a) close monitoring, b) adjuvant postoperative radiotherapy, c) prophylactic regional lymphadenectomy, and d) lymphadenectomy with or without radiation therapy.</p></li></ul></p><p id="par0155" class="elsevierStylePara elsevierViewall">In recent years, several studies have been carried out to assess the usefulness of sentinel lymph node biopsy in these patients. A review of the studies performed to date highlights the difficulty of interpreting the results and the problems in drawing conclusions, as squamous cell carcinomas of the skin at different sites are often mixed (for example, squamous cell carcinomas on the face with carcinomas on the tongue).</p><p id="par0160" class="elsevierStylePara elsevierViewall">Most of the studies are performed by ear-nose-throat specialists, plastic surgeons, and maxillofacial surgeons. We did not find any studies that assessed the usefulness of this technique in exclusively cutaneous tumors on the face, for example.</p><p id="par0165" class="elsevierStylePara elsevierViewall">The Clinical Practice Guidelines in Oncology (issued by the National Comprehensive Cancer Network [NCCN])<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> state that that sentinel lymph node biopsy should be considered in certain high-risk tumors, although the benefit of this technique has not been confirmed.The technique has been practiced for years for squamous cell carcinoma of the oral cavity, oropharynx, and genitals, and the results of several studies have suggested that this approach to the management of these tumors is promising, given the high sensitivity for detection of lymph node metastases.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27–30</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">The advantages of sentinel lymph node biopsy in this group of patients are as follows:<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">1.</span><p id="par0175" class="elsevierStylePara elsevierViewall">The biopsy provides information on the staging of squamous cell carcinoma, identifying the draining nodes and subclinical metastases.</p><p id="par0180" class="elsevierStylePara elsevierViewall">The superficial lymphatic system of the head and neck is characterized by the unpredictability of the drainage paths. Previous studies have shown that performing elective lymphadenectomy, without lymphoscintigraphy prior to the operation, could lead to inappropriate target node dissection in up to half the cases.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">2.</span><p id="par0185" class="elsevierStylePara elsevierViewall">The biopsy provides prognostic information.</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">3.</span><p id="par0190" class="elsevierStylePara elsevierViewall">Biopsy findings help in subsequent decision making: lymphadenectomy or administration of radiotherapy or chemotherapy in patients with positive lymph node biopsy.</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">4.</span><p id="par0195" class="elsevierStylePara elsevierViewall">The morbidity associated with radiotherapy or prophylactic lymphadenectomy (secondary lymphedema and neural damage) is avoided.</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">5.</span><p id="par0200" class="elsevierStylePara elsevierViewall">The findings might have repercussions for the survival of these patients, given that mapping and early treatment of metastasis could enable a more targeted therapeutic approach, applied in theory in earlier stages of the disease.</p></li></ul></p><p id="par0205" class="elsevierStylePara elsevierViewall">Some authors indicate that it is possible to have greater control over metastatic disease in squamous cell carcinoma than in melanoma due to the greater propensity of squamous cell carcinoma for orderly dissemination and its greater sensitivity to radiotherapy.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> On the other hand, resection of micrometastases themselves could be beneficial in terms of survival.</p><p id="par0210" class="elsevierStylePara elsevierViewall">We believe it is of interest to highlight the following studies, as they are the ones that included the largest numbers of patients. Renzi et al<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> performed sentinel lymph node biopsy in 22 patients with high-grade N0 squamous cell carcinoma of the skin. The authors defined high-grade squamous cell carcinoma as tumors with one of the following characteristics: size greater than 2<span class="elsevierStyleHsp" style=""></span>cm; site on the lip or in front of the ear; local recurrence or recurrence over previously damaged skin; poor histologic differentiation; perineural invasion; depth greater than 4<span class="elsevierStyleHsp" style=""></span>mm; involvement of the reticular dermis or subcutaneous fat; involvement of bone, muscle, or cartilage; and immunosuppression. Of the 22 patients studied, positive sentinel lymph nodes were detected in just 1 (4.5%). This patient had local recurrence of the disease, whereas the remaining patients with negative sentinel lymph node did not have recurrence during follow-up (mean of 17 months). The authors recognize the limitations of the study. These include the small number of patients, the duration of follow-up, and the lack of uniform criteria for including patients with high-risk squamous cell carcinoma.</p><p id="par0215" class="elsevierStylePara elsevierViewall">Reschly et al<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> resected or biopsied the sentinel lymph node of 9 patients with squamous cell carcinoma of the skin located on the face or limbs. They considered high-risk tumors as those that met at least one of the following 9 criteria: certain types of treatment used, recurrent tumor (previous treatments), size greater than 2<span class="elsevierStyleHsp" style=""></span>cm, site on the lip or in front of the ear, deep invasion, poor histologic differentiation, histologic evidence of perineural invasion, precipitating factors other than UV radiation, and immunosuppression.</p><p id="par0220" class="elsevierStylePara elsevierViewall">A positive sentinel lymph node was found in 4 patients (44%). Two of the 4 patients with positive sentinel lymph node biopsy died of metastatic disease within 2 years. The 5 patients with negative sentinel lymph node biopsy were alive with no evidence of recurrent disease after 8 months of follow-up.</p><p id="par0225" class="elsevierStylePara elsevierViewall">The rates of positive lymph node biopsy reported by these authors are as high as those reported for high-risk squamous cell carcinoma of the genitals or oropharyngeal cavity. This could be due to the low number of patients and the lack of uniform criteria for defining high-risk squamous cell carcinoma. The authors concluded that this technique is useful for the management of these patients.</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion for Squamous Cell Carcinoma of the Skin</span><p id="par0230" class="elsevierStylePara elsevierViewall">Although the studies performed to date have included low numbers of patients, most suggest that this technique could be useful in high-risk squamous cell carcinoma. Patients with positive sentinel lymph node biopsy can be given more aggressive treatments and follow-up protocols, which could translate into longer survival.</p><p id="par0235" class="elsevierStylePara elsevierViewall">Morbidity would be decreased in patients with negative sentinel lymph node biopsy as more aggressive and unnecessary treatments would be avoided.</p><p id="par0240" class="elsevierStylePara elsevierViewall">The main difficulty comes when establishing the indication, that is, when we have to define what constitutes high risk, given the different criteria used in the studies. The study by Brantsch et al<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> could be used as a starting point, with subsequent studies designed with unified criteria.</p><p id="par0245" class="elsevierStylePara elsevierViewall">With the data currently available, sentinel lymph node biopsy seems appropriate in squamous cell carcinoma with a risk of metastasis of greater than 5%, which in the studies reviewed is when the squamous cell carcinoma has a depth greater than 6<span class="elsevierStyleHsp" style=""></span>mm.</p><p id="par0250" class="elsevierStylePara elsevierViewall">We also believe that it is important not to lose sight of the life context of our patients. They are usually very old, and performing these types of techniques would not make sense in terms of risk-benefit.</p><p id="par0255" class="elsevierStylePara elsevierViewall">Likewise, we should take into account the erratic nature of lymphatic drainage in the head (a common site for squamous cell carcinoma of the skin), and this could also limit the usefulness of the technique.</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Merkel Cell Carcinoma</span><p id="par0260" class="elsevierStylePara elsevierViewall">Merkel cell carcinoma is a rare, clinically aggressive neuroendocrine tumor that tends to spread locally and metastasize at a distance.This tumor affects elderly people, and its incidence is higher in immunosuppressed patients, HIV-positive patients, and organ transplant recipients. More recently, the etiology of this tumor has been linked to the Merkel cell polyomavirus, which is found integrated into the cellular genome in more than 80% of the cases.<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">33–35</span></a></p><p id="par0265" class="elsevierStylePara elsevierViewall">The incidence is on the rise, possibly because of more frequent detection in clinical practice, an increase in the population older than 70 years, and the use of cytokeratin 20, a very specific marker for Merkel cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a></p><p id="par0270" class="elsevierStylePara elsevierViewall">This tumor occurs much more frequently in whites (93% of the cases), and is rarely reported in blacks. Slightly more are diagnosed in men than in women (a ratio of between 2 and 3 to 1).</p><p id="par0275" class="elsevierStylePara elsevierViewall">The most frequent site is the head and neck (essentially in the periocular and perioral area), followed by the limbs, and, more rarely, the trunk.</p><p id="par0280" class="elsevierStylePara elsevierViewall">The tumor presents as nodular, erythematous, bluish lesions. Telangiectasias may be apparent on its surface, and so it is often confused with basal cell carcinoma. Tumor sizes vary between 0.2 and 20<span class="elsevierStyleHsp" style=""></span>cm, although most are less than 2<span class="elsevierStyleHsp" style=""></span>cm in diameter. At the time of diagnosis, lymph node involvement is observed in 15% to 60% of the patients, and distant metastases in 1% to 6% of the patients. Immunohistochemical staining can help in the differential diagnosis of the tumor. Typically, staining is positive for cytokeratin 20 and negative for thyroid transcription factor 1 (ruling out small cell lung cancers). Other markers of diagnostic utility are specific neuronal enolase, chromogranin, and synaptophysin, among others.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a></p><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Staging in Merkel Cell Carcinoma</span><p id="par0285" class="elsevierStylePara elsevierViewall">No staging system has been universally accepted; in fact, until 2009, 5 different staging systems were being used to describe Merkel cell carcinoma. For this reason, the American Joint Committee on Cancer established a new staging system based on consensus<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0290" class="elsevierStylePara elsevierViewall">Clinical staging is considered the most important factor; thus, survival at 5 years is 81% for stage Ia, 67% for stage Ib, 52% for stage II, and 11% at 2 years for stage III.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a></p><p id="par0295" class="elsevierStylePara elsevierViewall">Recurrence rates between 40% and 45% have been reported, and can be as high as 77% when tumors are located on the head and neck. The mean time to recurrence is 8 months, and 90% recur within 2 years.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a></p><p id="par0300" class="elsevierStylePara elsevierViewall">Patients with Merkel cell carcinoma should undergo detailed study that includes a search for satellite skin lesions, lymph node palpation, and computed tomography, although Sheela et al<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> concluded in their review that computed tomography has poor sensitivity for detecting lymph node involvement and a high specificity for detecting distant metastases.</p><p id="par0305" class="elsevierStylePara elsevierViewall">In fact, when tumor involvement is visible in computed tomography, the chance of curative treatment vanishes. However, several recent studies discuss the use of positron emission tomography combined with computed tomography in the follow-up and subsequent management of patients with this diagnosis.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a></p><p id="par0310" class="elsevierStylePara elsevierViewall">Lesion size greater than 2<span class="elsevierStyleHsp" style=""></span>cm and the presence of local recurrence or distant metastases are considered factors for poor prognosis. Some authors have also found that histology showing small or intermediate cells with a high mitotic index can also be considered as predictors of poor prognosis. Other authors, however, have found no prognostic value in histologic type (solid, trabecular, or diffuse) or in cell size (small, medium, or large).<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43,44</span></a> The most important prognostic factor at present is the presence of lymph node involvement, making sentinel lymph node biopsy a valuable diagnostic technique.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Merkel Cell Carcinoma</span><p id="par0315" class="elsevierStylePara elsevierViewall">The presence of lymph node involvement and the presence of distant metastases are the prognostic factors associated with the poorest survival rates in Merkel cell carcinoma. The need for prophylactic regional lymphadenectomy is being debated in view of the associated morbidity and the lack of improvement in survival.</p><p id="par0320" class="elsevierStylePara elsevierViewall">Complete lymph node dissection has been proposed for large tumors, those on the head and neck, those with a small-cell histology, and those with lymphovascular invasion.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a></p><p id="par0325" class="elsevierStylePara elsevierViewall">Performing sentinel lymph node biopsy is an attractive alternative to elective complete lymphadenectomy in that it allows more appropriate selection of candidates and also early detection of lymph node involvement.The contribution of sentinel lymph node biopsy in Merkel cell carcinoma is generally accepted.<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">46–49</span></a><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarizes the studies conducted on this topic to date.<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37,45–64</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0330" class="elsevierStylePara elsevierViewall">Several authors have reached the conclusion that the risk of recurrence and metastatic disease is greater if a sentinel lymph node biopsy is positive, while a negative biopsy is predictive of better short-term survival.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a></p><p id="par0335" class="elsevierStylePara elsevierViewall">It is important to note that Merkel cell carcinoma is a rare condition, and so experience with sentinel lymph node biopsy in this setting is necessarily limited. Gupta et al<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> described their experience in 61 patients with Merkel cell carcinoma. Thirty of these underwent sentinel lymph node biopsy and they also performed a metaanalysis of a further 92 case reports of patients diagnosed with Merkel cell carcinoma who underwent sentinel lymph node biopsy. Overall, then, 122 patients with Merkel cell carcinoma with no clinical evidence of lymph node spread were studied. Sentinel lymph node biopsy was performed, and found to be positive, in 39 (32%). The authors also found that the incidence of positive sentinel lymph node biopsy increased with increasing primary tumor size such that in patients with Merkel cell carcinoma larger than 2<span class="elsevierStyleHsp" style=""></span>cm, 52% had a positive sentinel lymph node biopsy compared to 29% of patients with a tumor size less than 2<span class="elsevierStyleHsp" style=""></span>cm (although the differences were not statistically significant, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.23). At 3 years, the recurrence rate in patients with a positive sentinel lymph node biopsy (32%) was 60%, 3 times higher than the rate in patients with a negative sentinel lymph node biopsy (20%). This study demonstrates the high rate of positive sentinel lymph node biopsies in patients with no clinical or radiologic evidence of involvement of lymphatic territories; from a prognostic point of view, the authors found survival benefit in association with a positive lymph node biopsy when patients underwent early lymphadenectomy compared to those who did not undergo the procedure. The authors concluded that sentinel lymph node biopsy should be performed in patients with N0 Merkel cell carcinoma to establish prognosis and determine treatment.</p><p id="par0340" class="elsevierStylePara elsevierViewall">In the largest series published to date, 251 patients were included. The authors reported a 5-year survival of 97% in patients without lymph node involvement, compared to a survival of 52% in those with lymph node involvement.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions About Sentinel Lymph Node Biopsy in Merkel Cell Carcinoma</span><p id="par0345" class="elsevierStylePara elsevierViewall">By way of conclusion, and according to the 2010 NCCN guidelines, when there is no clinical or radiologic evidence of lymph node involvement in most patients with Merkel cell carcinoma, sentinel lymph node biopsy should be performed as part of the routine management of the tumor (regardless of size), unless the procedure is contraindicated for other medical reasons.</p><p id="par0350" class="elsevierStylePara elsevierViewall">One exception would be Merkel cell carcinoma located on the head and neck. In this case, the rate of false negatives is very high and so the technique is not routinely recommended, even though it may provide prognostic information.</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Other Skin Tumors</span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Extramammary Paget Disease</span><p id="par0355" class="elsevierStylePara elsevierViewall">Extramammary Paget disease is a term for a type of rare tumor usually located on the genitals, although it has been reported at many other sites. Clinically, it presents as a hypo- or hyperpigmented erythematous plaque with poorly defined edges. The rate of local recurrence is high. Generally, prognosis is good, as the tumor cells tend to remain in the epidermis and rarely metastasize. Nevertheless, lymph node metastasis rates of up to 26% have been reported for invasive primary tumors.<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a></p><p id="par0360" class="elsevierStylePara elsevierViewall">Management of patients with extramammary Paget disease, with no clinical evidence of lymph node involvement, is subject to debate. In patients with an invasive primary tumor with no clinical evidence of lymph node involvement, elective lymphadenectomy is recommended. Sentinel lymph node biopsy might be a useful approach in these patients.</p><p id="par0365" class="elsevierStylePara elsevierViewall">In 2008, Hatta et al<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">66,67</span></a> published a series of 76 patients, 24 of whom had undergone sentinel lymph node biopsy. The biopsy was positive in 12, and these patients underwent complete lymph node dissection. Among the parameters analyzed in this study was degree of tumor invasion. Tumors were thus divided into tumors that were wholly within the epidermis, those with microinvasion of the papillary dermis, and those with invasion of the reticular dermis and subcutaneous cell tissue. The authors found that 43 of the 76 patients studied (57%) had intraepidermal tumors, 22 (29%) had tumors with microinvasion of the papillary dermis, and 22 (14%) had tumors with invasion of the reticular dermis and subcutaneous cell tissue.</p><p id="par0370" class="elsevierStylePara elsevierViewall">The authors’ univariate analysis found that patients with tumors showing invasion of the reticular dermis and subcutaneous cell tissue had a higher risk of mortality than those with intraepidermal tumors or those with tumors showing microinvasion of the papillary dermis (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.01). They concluded that sentinel lymph node biopsy would be indicated in this study and in another conducted in 13 patients, all with invasive extramammary Paget disease, as the frequency of lymph node involvement, even when not clinically evident, is greater than in noninvasive disease.</p><p id="par0375" class="elsevierStylePara elsevierViewall">The technique normally used for detection in sentinel lymph node biopsy is less sensitive for detecting lymph nodes located close to the tumor in extramammary Paget disease, as the radiotracer signal for the node overlaps with that of the primary tumor. In these cases, some authors have suggested that fluorescence with indocyanine green, detected with an infrared camera, could be useful.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Sweat Gland Carcinoma</span><p id="par0380" class="elsevierStylePara elsevierViewall">Adenocarcinomas of sweat glands form a heterogeneous group of tumors derived from eccrine or apocrine sweat glands. Given the low incidence of these tumors, randomized controlled trials are difficult to perform. Several studies have reported that these tumors, and aggressive digital papillary adenocarcinoma and the hidradenocarcinomas in particular, often spread to regional lymph nodes. In general, adnexal adenocarcinomas do not share a typical clinical presentation. The tumor grows rapidly, and bleeding and ulceration are common. Biopsy is usually required for diagnosis.</p><p id="par0385" class="elsevierStylePara elsevierViewall">Little has been reported in the literature about sentinel lymph node biopsy in these patients.<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">68–70</span></a> The largest study in which the procedure was used included 6 patients with sweat gland adenocarcinomas (3 hidradenocarcinomas, 2 eccrine duct cell carcinomas, and a porocarcinoma).<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> Sentinel lymph node biopsy was positive in 4 patients, 2 of whom underwent regional lymphadenectomy while the other 2 did not undergo the procedure for medical reasons. All patients were alive and free of disease at the end of follow-up, which ranged from 2 to 19 months, with a mean of 12 months.</p><p id="par0390" class="elsevierStylePara elsevierViewall">The authors indicated that although sentinel lymph node biopsy could be useful for staging in these patients, the prognostic value or usefulness for guiding treatment decisions would need studies with larger numbers of patients.</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Sebaceous Gland Carcinoma</span><p id="par0395" class="elsevierStylePara elsevierViewall">Sebaceous gland carcinoma is an uncommon tumor that arises in the adnexal epithelium of sebaceous glands. It is most frequently located in the palpebral region (75%), although nonocular sites have also been reported. Clinical diagnosis is difficult and the tumor can easily be mistaken for other skin tumors or chronic inflammatory disease. The most frequent ocular presentation is in the form of a solitary, small, firm, raised nodule of yellow-orange color.</p><p id="par0400" class="elsevierStylePara elsevierViewall">Nonocular tumors are usually on the head and neck, and their appearance is that of a yellow-orange nodule.</p><p id="par0405" class="elsevierStylePara elsevierViewall">The tumor is aggressive and associated with high mortality and metastasis rates. Mortality rates range from 9% to 50%, but it seems that with early diagnosis these rates are declining.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a></p><p id="par0410" class="elsevierStylePara elsevierViewall">The mortality rates for ocular sebaceous carcinoma range from 11% to 30%, with distant metastases in 3% to 25%. In principle, it was thought that nonocular sebaceous carcinoma had a better prognosis than its ocular counterpart, but in a study of 91 patients with nonocular sebaceous carcinoma, a recurrence rate of 29% was reported with a metastasis rate of 21%.<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a></p><p id="par0415" class="elsevierStylePara elsevierViewall">Several articles report studies of sentinel lymph node biopsy in ocular sebaceous carcinomas, suggesting that the technique is safe and simple, and that it could be useful for better staging and clinical management.</p><p id="par0420" class="elsevierStylePara elsevierViewall">When the authors performed sentinel lymph node biopsy on 10 patients with sebaceous carcinoma on the eyelid (primary tumor in 4 and recurrent tumor in 6), the sentinal node was negative in all, but lymph node metastasis was detected in 2 of the 10 patients during follow-up. Despite these findings, the authors concluded that sentinel lymph node biopsy is a safe technique and that it should be considered in sebaceous carcinomas with a high risk of metastasis (recurrent, large size, or those involving postseptal structures).<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">74,75</span></a></p><p id="par0425" class="elsevierStylePara elsevierViewall">Nijhawan et al<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">76</span></a> studied 6 patients with sebaceous carcinoma of the eyelid with clinically negative lymph nodes, and 5 of them underwent sentinel lymph node biopsy. This was negative in all cases, although the authors concluded that the technique could be useful given the high rate of lymph node involvement reported for such patients.</p><p id="par0430" class="elsevierStylePara elsevierViewall">By way of conclusion, we could say that the data currently available do not support the usefulness of this technique in sebaceous carcinoma.</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sentinel Lymph Node Biopsy in Cutaneous Lymphomas</span><p id="par0435" class="elsevierStylePara elsevierViewall">Sentinel lymph node biopsy could play an important part in staging of primary cutaneous lymphomas. Several authors point out that, in their experience, lymph node involvement is the first stage of extracutaneous spread.</p><p id="par0440" class="elsevierStylePara elsevierViewall">Very little has been published on the topic, however, and so larger, robustly designed studies would be needed to substantiate the theories put forward by these authors.<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">63,77–79</span></a> Our literature review did not find any study that concluded that sentinel lymph node biopsy can determine whether lymph node involvement is primary or an extension of a cutaneous lymphoma, only whether there is lymph node involvement or not.</p></span></span></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0445" class="elsevierStylePara elsevierViewall">With the data currently available, sentinel lymph node biopsy can be recommended for certain aggressive tumors, such as squamous cell carcinoma of the skin more than 6<span class="elsevierStyleHsp" style=""></span>mm thick, Merkel cell carcinoma, invasive extramammary Paget disease, and perhaps sweat gland carcinomas.</p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0450" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "xres95388" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec82549" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres95387" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec82550" "titulo" => "Palabras clave" ] 4 => array:3 [ "identificador" => "sec0005" "titulo" => "Introduction" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Mechanism of Lymphatic Metastasis" ] 1 => array:3 [ "identificador" => "sec0015" "titulo" => "Sentinel Lymph Node Technique" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Tracers" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Detection" ] ] ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Pathology" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "Indications for the Technique" ] ] ] 5 => array:3 [ "identificador" => "sec0040" "titulo" => "Sentinel Lymph Nodes in Nonmelanoma Skin Cancer" "secciones" => array:3 [ 0 => array:3 [ "identificador" => "sec0045" "titulo" => "Sentinel Lymph Node Biopsy in Squamous Cell Carcinoma of the Skin" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusion for Squamous Cell Carcinoma of the Skin" ] ] ] 1 => array:3 [ "identificador" => "sec0055" "titulo" => "Sentinel Lymph Node Biopsy in Merkel Cell Carcinoma" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0060" "titulo" => "Staging in Merkel Cell Carcinoma" ] 1 => array:2 [ "identificador" => "sec0065" "titulo" => "Sentinel Lymph Node Biopsy in Merkel Cell Carcinoma" ] 2 => array:2 [ "identificador" => "sec0070" "titulo" => "Conclusions About Sentinel Lymph Node Biopsy in Merkel Cell Carcinoma" ] ] ] 2 => array:3 [ "identificador" => "sec0075" "titulo" => "Sentinel Lymph Node Biopsy in Other Skin Tumors" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0080" "titulo" => "Sentinel Lymph Node Biopsy in Extramammary Paget Disease" ] 1 => array:2 [ "identificador" => "sec0085" "titulo" => "Sentinel Lymph Node Biopsy in Sweat Gland Carcinoma" ] 2 => array:2 [ "identificador" => "sec0090" "titulo" => "Sentinel Lymph Node Biopsy in Sebaceous Gland Carcinoma" ] 3 => array:2 [ "identificador" => "sec0095" "titulo" => "Sentinel Lymph Node Biopsy in Cutaneous Lymphomas" ] ] ] ] ] 6 => array:2 [ "identificador" => "sec0100" "titulo" => "Conclusions" ] 7 => array:2 [ "identificador" => "sec0105" "titulo" => "Conflicts of Interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-11-25" "fechaAceptado" => "2011-05-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec82549" "palabras" => array:7 [ 0 => "Sentinel lymph node" 1 => "Merkel cell carcinoma" 2 => "Squamous cell carcinoma" 3 => "Extramammary Paget disease" 4 => "Eccrine carcinoma" 5 => "Apocrine carcinoma" 6 => "Sebaceous carcinoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82550" "palabras" => array:7 [ 0 => "Ganglio centinela" 1 => "Carcinoma de células de Merkel" 2 => "Carcinoma espinocelular" 3 => "Enfermedad de Paget extramamaria" 4 => "Carcinoma ecrino" 5 => "Carcinoma apocrino" 6 => "Carcinoma sebáceo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sentinel lymph node biopsy is performed routinely in melanoma because lymph node progression has been shown to be the strongest predictor of survival. Given the proven relevance of biopsy findings in this type of skin cancer, the procedure has been extended to other skin tumors. Experience in nonmelanoma cancer is much more limited and the prognostic usefulness of biopsy results remains to be shown. This critical review of the literature on the various skin tumors in which sentinal node biopsy has been practiced discusses the usefulness of this procedure.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La biopsia del ganglio centinela es una técnica que se realiza de forma rutinaria en el manejo del melanoma, en el cual la afectación ganglionar ha demostrado ser el mejor indicador pronóstico de supervivencia. Dado que la utilidad de la misma en este tipo de neoplasia cutánea está demostrada, se ha venido realizando en otros tumores cutáneos en los cuales la experiencia es mucho menor y cuya utilidad en la mayoría de los casos está todavía por demostrar. Realizamos una revisión crítica de los distintos tumores cutáneos en los cuales se ha realizado esta técnica y se discute acerca de su utilidad.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Salguero-Fernández I, et al. Ganglio centinela en cáncer de piel no melanoma. Actas Dermosifiliogr.2011;102:589-598.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Taken from AJCC: Merkel cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a></p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Primary Tumor (T)</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TX \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nonevaluable primary tumor \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Evidence of a primary tumor (for example, lymphatic or metastatic presentation without associated primary tumor) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">In situ primary tumor \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Maximum tumor size: ≤ 2 cm \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Maximum tumor size: > 2<span class="elsevierStyleHsp" style=""></span>cm, but ≤ 5<span class="elsevierStyleHsp" style=""></span>cm \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Maximum tumor size: > 5 cm \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bone, muscle, fascia, or cartilage invasion by primary tumor \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Regional Lymph Nodes (N)</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NX \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nonevaluable regional lymph nodes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No metastasis in regional lymph nodes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">cN0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative lymph nodes in clinical examination<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> (pathology study not performed) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">pN0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative lymph nodes in pathology study \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Metastases in regional lymph node(s) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N1a \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Micrometastases<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N1b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Macrometastases<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">In transit metastases<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Distant Metastasis (M)</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No distant metastasis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Metastases beyond regional lymph nodes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M1a \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Metastases to the skin, subcutaneous tissue, or distant lymph nodes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M1b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung metastases \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M1c \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Metastases to other visceral sites \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab181854.png" ] ] ] "notaPie" => array:4 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara">Clinical detection of the lymph node disease can be performed by inspection, palpation, or imaging studies.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara">Micrometastases are diagnosed after sentinel lymph node dissection or a lymphadenectomy.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara">Macrometastases are defined as clinically detectable lymph node metastases, with confirmation by therapeutic lymphadenectomy or fine needle biopsy.</p>" ] 3 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "d" "nota" => "<p class="elsevierStyleNotepara">In-transit metastases: tumor differentiated from the primary lesions and located between the primary lesion and the regional draining lymph nodes or distal to the primary lesion.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Current Staging in Merkel Cell Carcinoma.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Sources: Gupta SG et al,<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Messina JL et al,<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> Sian KU et al,<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> Pfeifer T et al,<a 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[ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">No. of Patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">SN+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Recurrence \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">SN- \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Recurrence \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Messina et al<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sian et al<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pfeifer et al<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ames et al<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bilchik et al<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hill et al<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kurul et al<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Wasserberg et al<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Zeitouni et al<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Allen et al<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duker et al<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rodrigues et al<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vandeweyer et al<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mehrany et al<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pan et al<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Su et al<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Blom et al<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Michl et al<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Schamalbach et al<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Maza et al<a 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class="elsevierStyleNotepara">Patients with positive sentinel node (SN<span class="elsevierStyleSup">+</span>) and recurrence and negative SN (SN-) and recurrence reported in the literature.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Studies Conducted to Date on Sentinel Lymph Node Biopsy in Merkel Cell Carcinoma.<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a></p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:79 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of sentinel lymph node biopsy in the diagnosis and prognosis of malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 10 | 10 | 20 |
2024 Octubre | 81 | 49 | 130 |
2024 Septiembre | 88 | 24 | 112 |
2024 Agosto | 112 | 68 | 180 |
2024 Julio | 92 | 41 | 133 |
2024 Junio | 103 | 61 | 164 |
2024 Mayo | 80 | 45 | 125 |
2024 Abril | 77 | 33 | 110 |
2024 Marzo | 67 | 36 | 103 |
2024 Febrero | 87 | 31 | 118 |
2024 Enero | 59 | 43 | 102 |
2023 Diciembre | 64 | 19 | 83 |
2023 Noviembre | 79 | 32 | 111 |
2023 Octubre | 64 | 45 | 109 |
2023 Septiembre | 92 | 42 | 134 |
2023 Agosto | 44 | 22 | 66 |
2023 Julio | 63 | 44 | 107 |
2023 Junio | 65 | 25 | 90 |
2023 Mayo | 64 | 28 | 92 |
2023 Abril | 60 | 30 | 90 |
2023 Marzo | 60 | 30 | 90 |
2023 Febrero | 58 | 30 | 88 |
2023 Enero | 42 | 40 | 82 |
2022 Diciembre | 80 | 52 | 132 |
2022 Noviembre | 37 | 37 | 74 |
2022 Octubre | 53 | 35 | 88 |
2022 Septiembre | 22 | 57 | 79 |
2022 Agosto | 33 | 40 | 73 |
2022 Julio | 28 | 42 | 70 |
2022 Junio | 23 | 27 | 50 |
2022 Mayo | 56 | 43 | 99 |
2022 Abril | 70 | 42 | 112 |
2022 Marzo | 46 | 53 | 99 |
2022 Febrero | 41 | 38 | 79 |
2022 Enero | 49 | 31 | 80 |
2021 Diciembre | 27 | 39 | 66 |
2021 Noviembre | 39 | 39 | 78 |
2021 Octubre | 34 | 57 | 91 |
2021 Septiembre | 60 | 37 | 97 |
2021 Agosto | 34 | 36 | 70 |
2021 Julio | 34 | 45 | 79 |
2021 Junio | 40 | 31 | 71 |
2021 Mayo | 36 | 44 | 80 |
2021 Abril | 73 | 78 | 151 |
2021 Marzo | 86 | 38 | 124 |
2021 Febrero | 48 | 27 | 75 |
2021 Enero | 37 | 23 | 60 |
2020 Diciembre | 39 | 15 | 54 |
2020 Noviembre | 23 | 34 | 57 |
2020 Octubre | 33 | 16 | 49 |
2020 Septiembre | 37 | 18 | 55 |
2020 Agosto | 24 | 17 | 41 |
2020 Julio | 26 | 19 | 45 |
2020 Junio | 39 | 34 | 73 |
2020 Mayo | 29 | 21 | 50 |
2020 Abril | 37 | 26 | 63 |
2020 Marzo | 41 | 26 | 67 |
2020 Febrero | 6 | 4 | 10 |
2020 Enero | 0 | 7 | 7 |
2019 Diciembre | 4 | 6 | 10 |
2019 Noviembre | 0 | 3 | 3 |
2019 Octubre | 1 | 1 | 2 |
2019 Septiembre | 6 | 5 | 11 |
2019 Julio | 0 | 12 | 12 |
2019 Junio | 1 | 8 | 9 |
2019 Mayo | 3 | 20 | 23 |
2019 Abril | 3 | 7 | 10 |
2019 Marzo | 0 | 9 | 9 |
2019 Febrero | 2 | 1 | 3 |
2018 Diciembre | 2 | 0 | 2 |
2018 Noviembre | 2 | 0 | 2 |
2018 Octubre | 1 | 0 | 1 |
2018 Septiembre | 3 | 0 | 3 |
2018 Agosto | 0 | 10 | 10 |
2018 Julio | 0 | 5 | 5 |
2018 Junio | 0 | 1 | 1 |
2018 Mayo | 0 | 8 | 8 |
2018 Abril | 0 | 4 | 4 |
2018 Marzo | 1 | 4 | 5 |
2018 Febrero | 38 | 1 | 39 |
2018 Enero | 48 | 9 | 57 |
2017 Diciembre | 48 | 11 | 59 |
2017 Noviembre | 51 | 11 | 62 |
2017 Octubre | 43 | 10 | 53 |
2017 Septiembre | 42 | 13 | 55 |
2017 Agosto | 67 | 14 | 81 |
2017 Julio | 68 | 9 | 77 |
2017 Junio | 78 | 25 | 103 |
2017 Mayo | 62 | 18 | 80 |
2017 Abril | 61 | 8 | 69 |
2017 Marzo | 58 | 9 | 67 |
2017 Febrero | 47 | 13 | 60 |
2017 Enero | 35 | 10 | 45 |
2016 Diciembre | 60 | 7 | 67 |
2016 Noviembre | 74 | 12 | 86 |
2016 Octubre | 90 | 13 | 103 |
2016 Septiembre | 60 | 11 | 71 |
2016 Agosto | 89 | 13 | 102 |
2016 Julio | 58 | 11 | 69 |
2016 Junio | 11 | 4 | 15 |
2016 Mayo | 8 | 9 | 17 |
2016 Abril | 8 | 12 | 20 |
2016 Marzo | 9 | 1 | 10 |
2016 Febrero | 10 | 12 | 22 |
2016 Enero | 6 | 2 | 8 |
2015 Diciembre | 8 | 1 | 9 |
2015 Noviembre | 15 | 3 | 18 |
2015 Octubre | 9 | 4 | 13 |
2015 Septiembre | 18 | 6 | 24 |
2015 Agosto | 11 | 5 | 16 |
2015 Julio | 41 | 7 | 48 |
2015 Junio | 64 | 4 | 68 |
2015 Mayo | 92 | 14 | 106 |
2015 Abril | 77 | 6 | 83 |
2015 Marzo | 58 | 8 | 66 |
2015 Febrero | 39 | 1 | 40 |
2015 Enero | 40 | 5 | 45 |
2014 Diciembre | 78 | 10 | 88 |
2014 Noviembre | 35 | 6 | 41 |
2014 Octubre | 70 | 18 | 88 |
2014 Septiembre | 44 | 15 | 59 |
2014 Agosto | 49 | 9 | 58 |
2014 Julio | 57 | 19 | 76 |
2014 Junio | 86 | 19 | 105 |
2014 Mayo | 98 | 17 | 115 |
2014 Abril | 106 | 13 | 119 |
2014 Marzo | 82 | 51 | 133 |
2014 Febrero | 61 | 21 | 82 |
2014 Enero | 92 | 18 | 110 |
2013 Diciembre | 67 | 28 | 95 |
2013 Noviembre | 64 | 26 | 90 |
2013 Octubre | 57 | 33 | 90 |
2013 Septiembre | 19 | 17 | 36 |
2013 Agosto | 17 | 27 | 44 |
2013 Julio | 14 | 43 | 57 |
2013 Junio | 13 | 39 | 52 |
2013 Mayo | 20 | 17 | 37 |
2013 Abril | 27 | 28 | 55 |
2013 Marzo | 32 | 12 | 44 |
2013 Febrero | 69 | 4 | 73 |
2013 Enero | 55 | 10 | 65 |
2012 Diciembre | 24 | 4 | 28 |
2012 Noviembre | 1 | 9 | 10 |
2012 Octubre | 0 | 1 | 1 |
2012 Agosto | 0 | 1 | 1 |