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Numerous histiocytes were also found among the lymphocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Immunohistochemistry showed the cells to be strongly positive for CD3&#44; CD4&#44; and CD5&#46; Furthermore&#44; staining was focally positive for CD8&#44; CD20&#44; and CD68&#44; but negative for CD7 and CD30&#46; The analysis of T-cell clonality using PCR for the T-cell receptor gamma &#40;TCRG&#41; gene showed monoclonal rearrangement&#46; On the basis of these data we established a diagnosis of primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Further tests included an analysis of lymphocyte populations and immunoglobulin levels&#44; computed tomography of the neck&#44; thorax&#44; abdomen&#44; and pelvis&#44; and bone-marrow biopsy&#46; All results were normal or negative&#46; The lesion underwent a rapid spontaneous reduction in size and was completely flat after 6 weeks of follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The area of residual hyperpigmentation was not infiltrated or hard to the touch&#46; The patient subsequently underwent local radiation therapy using a 6-MeV electron beam&#44; with a total dose of 4000 cGy administered at a dosage of 200 cGy per day&#46; He remained asymptomatic at 7 months &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma is a rare disease and accounts for just 2&#37; of all primary cutaneous lymphomas&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Clinical presentation is usually as a solitary plaque or tumor&#44; typically located on the face&#44; neck&#44; or upper torso&#59; it is asymptomatic and fast-growing&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;6</span></a> Spontaneous total remission of the lesions&#44; as occurred with our patient&#44; has been previously reported in only 1 case&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Histology reveals dense nodular or diffuse dermal infiltrates that tend to infiltrate the subcutaneous tissue&#46; Focal epidermotropism is a possible finding and means that a diagnosis of mycosis fungoides should always be considered&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;6&#44;7</span></a> By definition&#44; there is a predominance of CD4&#43; small- to medium-sized pleomorphic lymphocytes&#44; although up to 30&#37; of large pleomorphic lymphocytes may be found&#46; Cases where a higher percentage of large cells is found should be classified as peripheral T-cell lymphoma&#44; not otherwise specified&#46; Mixed inflammatory infiltrates have also been reported&#44; consisting of histiocytes&#44; B cells&#44; plasma cells&#44; and&#44; in some cases&#44; CD8&#43; T cells and eosinophils&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;8&#44;9</span></a> TCRG analysis shows monoclonal rearrangement in 60&#37; to 70&#37; of cases&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The differential diagnosis should principally include benign lymphoid proliferations &#40;T-cell pseudolymphoma&#44; pseudolymphomatous folliculitis&#44; papules&#44; nodules&#44; and solitary lymphoid tumors&#41; and mycosis fungoides in its unilesional and granulomatous forms&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In our case&#44; the rapid&#44; self-limiting course&#44; together with the fact that the patient had previously been treated with allopurinol&#44; led to an initial diagnosis of T-cell pseudolymphoma&#46; The subsequent pathology report made it possible to establish the diagnosis of primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The prognosis in these lymphomas is generally very favorable&#44; particularly in cases of solitary lesions&#44; and 5-year survival is around 80&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;5</span></a> These cases of localized disease are usually treated with surgical excision or local radiation therapy&#44; and more aggressive treatments such as chemotherapy are not required&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3&#44;6&#44;8</span></a> However&#44; careful monitoring with regular follow-up visits is recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The usually painless course and the clinical and histologic similarity that this type of lymphoma may bear to other cutaneous lymphoid infiltrates has led some authors to suggest the term <span class="elsevierStyleItalic">lymphocyte proliferations of uncertain significance</span> to refer to cases&#44; without forcing a diagnosis&#44; where it is not possible to determine whether the process is benign or malignant&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion&#44; we present an unusual case of primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma with spontaneous remission&#46; Because the clinical&#44; histologic&#44; and immunohistochemical characteristics of this type of lymphoma may coincide with those of other cutaneous lymphoid infiltrates&#44; a careful study is required to reach a diagnosis&#46; Dermatologists and pathologists should be aware of this entity in order to avoid unnecessary aggressive treatments&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Messeguer F&#44; et al&#46; Linfoma cut&#225;neo primario de c&#233;lulas T pleom&#243;rficas de peque&#241;o y mediano CD4&#43;&#58; a prop&#243;sito de un caso con resoluci&#243;n espont&#225;nea&#46; Actas Dermosifiliogr&#46;2011&#59;102&#58;636-8&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Brownish-red skin tumor on the left cheek&#44; with a smooth&#44; shiny surface&#46; B&#44; Complete remission of the lesion 6 weeks later&#44; showing residual hyperpigmentation and a depressed central area corresponding to the biopsy site&#46;</p>"
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Case and research letter
Primary Cutaneous CD4+ Small- to Medium-Sized Pleomorphic T-Cell Lymphoma: Report of a Case With Spontaneous Resolution
Linfoma cutáneo primario de células T pleomórficas de pequeño y mediano tamaño CD4+: a propósito de un caso con resolución espontánea
F. Messeguera,
Autor para correspondencia
francescmb@comv.es

Corresponding author.
, E. Gimenob, A. Agusti-Mejiasc, J. San Juand
a Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
b Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, Spain
c Servicio de Dermatología del Hospital General Universitario de Valencia
d Servicio de Anatomía Patológica, Hospital Arnau de Vilanova, Valencia, Spain
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The only relevant information in the patient&#39;s past history was that he had taken allopurinol for 3 months to treat asymptomatic hyperuricemia&#46; He had interrupted this medication 3 days before visiting our department&#46; Physical examination revealed an oval&#44; dome-shaped erythematous tumor measuring 3 x 4<span class="elsevierStyleHsp" style=""></span>cm on the left cheek&#46; The tumor had well-defined borders and a shiny surface and was indurated on palpation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A biopsy of the lesion was taken for histopathology study&#46; The low-magnification view showed that the epidermis was not involved and revealed a dense cellular infiltrate occupying the entire thickness of the dermis and reaching the subcutaneous tissue&#46; The neoplastic infiltrate consisted predominantly of small- to medium-sized lymphocytes with moderate pleomorphism and mild atypia&#46; Numerous histiocytes were also found among the lymphocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Immunohistochemistry showed the cells to be strongly positive for CD3&#44; CD4&#44; and CD5&#46; Furthermore&#44; staining was focally positive for CD8&#44; CD20&#44; and CD68&#44; but negative for CD7 and CD30&#46; The analysis of T-cell clonality using PCR for the T-cell receptor gamma &#40;TCRG&#41; gene showed monoclonal rearrangement&#46; On the basis of these data we established a diagnosis of primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Further tests included an analysis of lymphocyte populations and immunoglobulin levels&#44; computed tomography of the neck&#44; thorax&#44; abdomen&#44; and pelvis&#44; and bone-marrow biopsy&#46; All results were normal or negative&#46; The lesion underwent a rapid spontaneous reduction in size and was completely flat after 6 weeks of follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The area of residual hyperpigmentation was not infiltrated or hard to the touch&#46; The patient subsequently underwent local radiation therapy using a 6-MeV electron beam&#44; with a total dose of 4000 cGy administered at a dosage of 200 cGy per day&#46; He remained asymptomatic at 7 months &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma is a rare disease and accounts for just 2&#37; of all primary cutaneous lymphomas&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Clinical presentation is usually as a solitary plaque or tumor&#44; typically located on the face&#44; neck&#44; or upper torso&#59; it is asymptomatic and fast-growing&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;6</span></a> Spontaneous total remission of the lesions&#44; as occurred with our patient&#44; has been previously reported in only 1 case&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Histology reveals dense nodular or diffuse dermal infiltrates that tend to infiltrate the subcutaneous tissue&#46; Focal epidermotropism is a possible finding and means that a diagnosis of mycosis fungoides should always be considered&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#44;6&#44;7</span></a> By definition&#44; there is a predominance of CD4&#43; small- to medium-sized pleomorphic lymphocytes&#44; although up to 30&#37; of large pleomorphic lymphocytes may be found&#46; Cases where a higher percentage of large cells is found should be classified as peripheral T-cell lymphoma&#44; not otherwise specified&#46; Mixed inflammatory infiltrates have also been reported&#44; consisting of histiocytes&#44; B cells&#44; plasma cells&#44; and&#44; in some cases&#44; CD8&#43; T cells and eosinophils&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;8&#44;9</span></a> TCRG analysis shows monoclonal rearrangement in 60&#37; to 70&#37; of cases&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The differential diagnosis should principally include benign lymphoid proliferations &#40;T-cell pseudolymphoma&#44; pseudolymphomatous folliculitis&#44; papules&#44; nodules&#44; and solitary lymphoid tumors&#41; and mycosis fungoides in its unilesional and granulomatous forms&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In our case&#44; the rapid&#44; self-limiting course&#44; together with the fact that the patient had previously been treated with allopurinol&#44; led to an initial diagnosis of T-cell pseudolymphoma&#46; The subsequent pathology report made it possible to establish the diagnosis of primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The prognosis in these lymphomas is generally very favorable&#44; particularly in cases of solitary lesions&#44; and 5-year survival is around 80&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;5</span></a> These cases of localized disease are usually treated with surgical excision or local radiation therapy&#44; and more aggressive treatments such as chemotherapy are not required&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3&#44;6&#44;8</span></a> However&#44; careful monitoring with regular follow-up visits is recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The usually painless course and the clinical and histologic similarity that this type of lymphoma may bear to other cutaneous lymphoid infiltrates has led some authors to suggest the term <span class="elsevierStyleItalic">lymphocyte proliferations of uncertain significance</span> to refer to cases&#44; without forcing a diagnosis&#44; where it is not possible to determine whether the process is benign or malignant&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion&#44; we present an unusual case of primary cutaneous CD4&#43; small- to medium-sized pleomorphic T-cell lymphoma with spontaneous remission&#46; Because the clinical&#44; histologic&#44; and immunohistochemical characteristics of this type of lymphoma may coincide with those of other cutaneous lymphoid infiltrates&#44; a careful study is required to reach a diagnosis&#46; Dermatologists and pathologists should be aware of this entity in order to avoid unnecessary aggressive treatments&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Messeguer F&#44; et al&#46; Linfoma cut&#225;neo primario de c&#233;lulas T pleom&#243;rficas de peque&#241;o y mediano CD4&#43;&#58; a prop&#243;sito de un caso con resoluci&#243;n espont&#225;nea&#46; Actas Dermosifiliogr&#46;2011&#59;102&#58;636-8&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Brownish-red skin tumor on the left cheek&#44; with a smooth&#44; shiny surface&#46; B&#44; Complete remission of the lesion 6 weeks later&#44; showing residual hyperpigmentation and a depressed central area corresponding to the biopsy site&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dense dermal infiltrate consisting of small- and medium-sized pleomorphic lymphocytes and histiocytes &#40;hematoxylin&#8211;eosin&#44; original magnification x250&#41;&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A and B&#44; Strongly positive staining for CD4 in almost the entire sample &#40;original magnifications x20 and x100&#41;&#46; C&#44; The histiocytes were positive for immune staining with CD68 &#40;original magnification x100&#41;&#46;</p>"
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