Case and Research Letters
Esomeprazole-Induced Subacute Cutaneous Lupus Erythematosus
Lupus eritematoso cutáneo subagudo inducido por esomeprazol
Leído
11524
Vecesse ha leído el artículo
3007
Total PDF
8517
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S1578219011000618" "issn" => "15782190" "doi" => "10.1016/j.adengl.2010.09.007" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "378" "copyright" => "Elsevier España, S.L. and AEDV" "copyrightAnyo" => "2010" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2011;102:638-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5102 "formatos" => array:3 [ "EPUB" => 51 "HTML" => 4105 "PDF" => 946 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731011001621" "issn" => "00017310" "doi" => "10.1016/j.ad.2010.09.018" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "378" "copyright" => "Elsevier España, S.L. y AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2011;102:638-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6166 "formatos" => array:3 [ "EPUB" => 2 "HTML" => 4636 "PDF" => 1528 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Lupus eritematoso cutáneo subagudo inducido por esomeprazol" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "638" "paginaFinal" => "640" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Esomeprazole-Induced Subacute Cutaneous Lupus Erythematosus" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 960 "Ancho" => 720 "Tamanyo" => 178566 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hiperqueratosis, degeneración vacuolar de la capa basal, discreta exocitosis linfocitaria y la presencia de queratinocitos necróticos. A nivel dérmico infiltrado inflamatorio perivascular superficial. HEx20.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Alcántara-González, M.T. Truchuelo-Díez, C. González-García, P. Jaén Olasolo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Alcántara-González" ] 1 => array:2 [ "nombre" => "M.T." "apellidos" => "Truchuelo-Díez" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "González-García" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Jaén Olasolo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219011000618" "doi" => "10.1016/j.adengl.2010.09.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000618?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001621?idApp=UINPBA000044" "url" => "/00017310/0000010200000008/v1_201304241336/S0001731011001621/v1_201304241336/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S157821901100062X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2010.12.007" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "379" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2011;102:640-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5399 "formatos" => array:3 [ "EPUB" => 49 "HTML" => 4461 "PDF" => 889 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and research letters</span>" "titulo" => "Posttraumatic Eosinophilic Fasciitis: Diagnostic Usefulness of Magnetic Resonance Imaging" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "640" "paginaFinal" => "642" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fascitis eosinofílica asociada a traumatismo: utilidad diagnóstica de la resonancia magnética" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 535 "Ancho" => 952 "Tamanyo" => 48988 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance imaging of the lower limbs. Axial short TI inversion recovery images. The muscle fascia is thickened and shows an increased signal intensity (arrows).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Armengot-Carbó, M. Velasco-Pastor, P. Navarro-Conde, E. Gimeno-Carpio" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Armengot-Carbó" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Velasco-Pastor" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Navarro-Conde" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Gimeno-Carpio" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731011001633" "doi" => "10.1016/j.ad.2010.12.016" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001633?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901100062X?idApp=UINPBA000044" "url" => "/15782190/0000010200000008/v1_201304241234/S157821901100062X/v1_201304241234/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219011000643" "issn" => "15782190" "doi" => "10.1016/j.adengl.2010.10.009" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "381" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2011;102:636-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6787 "formatos" => array:3 [ "EPUB" => 46 "HTML" => 5816 "PDF" => 925 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and research letter</span>" "titulo" => "Primary Cutaneous CD4+ Small- to Medium-Sized Pleomorphic T-Cell Lymphoma: Report of a Case With Spontaneous Resolution" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "636" "paginaFinal" => "638" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfoma cutáneo primario de células T pleomórficas de pequeño y mediano tamaño CD4+: a propósito de un caso con resolución espontánea" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 714 "Ancho" => 952 "Tamanyo" => 273488 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dense dermal infiltrate consisting of small- and medium-sized pleomorphic lymphocytes and histiocytes (hematoxylin–eosin, original magnification x250).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Messeguer, E. Gimeno, A. Agusti-Mejias, J. San Juan" "autores" => array:4 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Messeguer" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Gimeno" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Agusti-Mejias" ] 3 => array:2 [ "nombre" => "J. San" "apellidos" => "Juan" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731011001657" "doi" => "10.1016/j.ad.2010.10.023" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001657?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000643?idApp=UINPBA000044" "url" => "/15782190/0000010200000008/v1_201304241234/S1578219011000643/v1_201304241234/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Esomeprazole-Induced Subacute Cutaneous Lupus Erythematosus" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "638" "paginaFinal" => "640" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Alcántara-González, M.T. Truchuelo-Díez, C. González-García, P. Jaén Olasolo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Alcántara-González" "email" => array:1 [ 0 => "raistlin_majere_19@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.T." "apellidos" => "Truchuelo-Díez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "González-García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Jaén Olasolo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lupus eritematoso cutáneo subagudo inducido por esomeprazol" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 960 "Ancho" => 721 "Tamanyo" => 168727 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hyperkeratosis, vacuolar degeneration of the basal layer, discrete lymphocytic exocytosis, and presence of necrotic keratinocytes. Note the superficial perivascular inflammatory infiltrate in the dermis (hematoxylin-eosin, original magnification ×20).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 74-year-old woman with a history of hypertension, diabetes mellitus, dyslipidemia, spondyloarthritis, and idiopathic thrombocytopenic purpura for which she had undergone splenectomy 5 years previously. She was being followed up by her rheumatologist for joint pain of inflammatory origin with low titers of rheumatoid factor and was taking lorazepam, ranitidine, domperidone, indapamide, AM3, and ursodeoxycholic acid. She attended our clinic with a pruritic disorder that had begun a week earlier and took the form of well-defined discretely desquamative erythematous papules on her back and, to a lesser extent, on her chest, thighs, and proximal upper arms. She had no blisters or mucosal lesions. These signs first appeared during winter, and the patient reported no previous sun exposure. Of interest, she reported starting esomeprazole and a vitamin complex (B<span class="elsevierStyleInf">1</span>, B<span class="elsevierStyleInf">6</span>, and B<span class="elsevierStyleInf">12</span>) 3 weeks before the lesions first appeared. A biopsy specimen of one of the lesions was obtained, and the patient was prescribed mometasone cream twice daily. Esomeprazole and the vitamin supplement were withdrawn.</p><p id="par0010" class="elsevierStylePara elsevierViewall">At 3 weeks, the lesions had progressed to confluent annular erythematous-violaceous plaques on the above-mentioned sites (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a>). The biopsy revealed hyperkeratosis in the epidermis, epidermal atrophy, degeneration of the basal layer, lymphocytic exocytosis, spongiosis, and occasional necrotic keratinocytes. A superficial perivascular lymphohistiocytic inflammatory infiltrate was observed in the dermis (<a class="elsevierStyleCrossRef" href="#fig0010">fig. 2</a>). Based on clinical and microscopy findings, the patient was diagnosed with subacute cutaneous lupus erythematosus (SCLE).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The results of a complete blood count and routine biochemistry were unremarkable. The immunology workup revealed positive titers for antinuclear antibody (1/160), anti-SSA/Ro antibody, and anti-SSB/La antibody. These results had also been positive in laboratory studies performed 2 years previously in the rheumatology department.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Based on a suspected diagnosis of SCLE induced or exacerbated by esomeprazole, treatment with a topical corticosteroid was continued and the culprit medication was withdrawn. The lesions had completely resolved 8 weeks after the interruption of esomeprazole.</p><p id="par0025" class="elsevierStylePara elsevierViewall">SCLE is a well-defined subtype of lupus erythematosus characterized by annular or psoriasiform lesions, limited systemic involvement, and the presence of circulating anti-SSA/Ro antibody.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> An association has been described between SCLE and various drugs, including thiazides, statins, calcium channel antagonists, phenytoin, griseofulvin, tumor necrosis factor antagonists, terbinafine,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–5</span></a> and, recently, proton pump inhibitors such as omeprazole, lansoprazole, and pantoprazole.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–8</span></a> Esomeprazole is the S enantiomer of omeprazole and is used to treat gastroesophageal reflux disease. It came onto the market in Spain in 2002.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Unlike drug-induced systemic lupus erythematosus, which usually involves positive antihistone antibody titers, drug-induced SCLE is generally associated with positive anti-SSA/Ro antibody titers, but not with positive antihistone antibody titers. In some cases, these titers become negative once the culprit agent is withdrawn.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In the case we present, it is striking that anti-SSA/Ro and anti-SSB/La antibody titers were previously positive and that this finding was maintained after onset of the skin symptoms. Four of the 8 previously reported cases of SCLE induced by proton pump inhibitors presented positive antinuclear antibody titers before the onset of cutaneous symptoms; however, it is unknown whether anti-SSA/Ro or anti-SSB/La antibody titers were positive. No analytical results were available for the remaining 4 patients (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–8</span></a> These findings point to a predisposition to SCLE, which was triggered by proton pump inhibitors. The pathogenic mechanism responsible for the formation of antibodies is unknown. It has been postulated that binding of the drug to proteins could trigger the immune response through a hapten-type mechanism, leading to formation of antibodies.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The suspect medication must be withdrawn in order to achieve resolution of the symptoms; topical or oral corticosteroids can be used as coadjuvant therapy to speed up recovery. Without withdrawal of the medication, cure is not possible, as shown in previous cases where lesions persisted despite treatment with oral corticosteroids or hydroxychloroquine.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Our patient was taking a vitamin complex concomitantly with esomeprazole; however, this medication seems a highly unlikely culprit, since there have been no previous reports of cases of lupus erythematosus caused by this agent. Nor can we rule out an episode of idiopathic SCLE, although the apparently clear temporal relationship with the medication and the absence of previous sun exposure and of other characteristic symptoms do not seem to support this possibility as a first option.</p><p id="par0050" class="elsevierStylePara elsevierViewall">To conclude, we present the first case of SCLE induced by esomeprazole. Similarly, we observed positive anti-SSA/Ro and anti-SSB/La antibody titers before the onset of symptoms, suggesting the need for individual predisposition before the condition can develop.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Alcántara-González J, et al. Lupues eritematoso cutáneo subagudo inducido por esomeprazol. Actas Dermosifiliogr. 2011;102:640-2.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 721 "Ancho" => 961 "Tamanyo" => 87437 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Confluent, ring-shaped erythematous-violaceous plaques on the back.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 960 "Ancho" => 721 "Tamanyo" => 168727 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hyperkeratosis, vacuolar degeneration of the basal layer, discrete lymphocytic exocytosis, and presence of necrotic keratinocytes. Note the superficial perivascular inflammatory infiltrate in the dermis (hematoxylin-eosin, original magnification ×20).</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviations</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">ANA antinuclear antibody; dsDNA double-stranded anti-DNA antibody; histone antihistone antibody; NA not available; RF rheumatoid factor; SSA anti-Ro/SSA antibody; SSB anti-La/SSB antibody.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Author \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Medication \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Latency \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Previous Serology Results \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Serology During Symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Outcome After Withdrawal \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bracke et al<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> (2005) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lansoprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA+, histone− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution in 3 wk \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bracke et al<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> (2005) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lansoprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA+, FR+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution in 1 mo \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dam et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> (2008) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lansoprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, dsDNA− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA+, SSB−, dsDNA−, histone−, RF+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution in 12 wk \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dam et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> (2008) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Omeprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, dsDNA+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, dsDNA−, histone− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution in 4 wk \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dam et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> (2008) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pantoprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4-8 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, dsDNA− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA−, SSB−, dsDNA−, RF+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Active until death in 2001 (not withdrawn) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dam et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> (2008) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lansoprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA+, SSB−, dsDNA+, histone−, RF+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Active until death in 2000 (not withdrawn) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dam et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> (2008) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pantoprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA−, SSA+, SSB−, histone− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution in 4 wk \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mankia et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> (2010) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Omeprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA+, SSB−, dsDNA+, histone− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution in 1 mo \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Present case \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Woman \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Esomeprazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA+, SSB+, RF+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA+, SSA+, SSB+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resolution in 8 wk \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab181819.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Previous Cases and Characteristics of Patients With Subacute Cutaneous Lupus Erythematosus Induced by Proton Pump Inhibitors.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lupus eritematoso cutáneo subagudo inducido por fármacos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Martín" 1 => "D. Ramón" 2 => "C. Monteagudo" 3 => "B. Llombart" 4 => "A. Castelló" 5 => "I. Molina" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2004" "volumen" => "95" "paginaInicial" => "117" "paginaFinal" => "119" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced subacute cutaneous lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.P. Callen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0961203310370349" "Revista" => array:6 [ "tituloSerie" => "Lupus" "fecha" => "2010" "volumen" => "19" "paginaInicial" => "1107" "paginaFinal" => "1111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20693204" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced lupus: an update on its dermatologic aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.V. Marzano" 1 => "P. Vezzoli" 2 => "C. Crosti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0961203309106176" "Revista" => array:6 [ "tituloSerie" => "Lupus" "fecha" => "2009" "volumen" => "18" "paginaInicial" => "935" "paginaFinal" => "940" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762393" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced cutaneous lupus erythematosus, a distinct syndrome that is frequently unrecognized" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.P. Callen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mjd.2001.116583" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2001" "volumen" => "45" "paginaInicial" => "315" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11464200" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced, Ro /SSA-positive cutaneous lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Srivastava" 1 => "A. Rencic" 2 => "G. Diglio" 3 => "H. Santana" 4 => "P. Bonitz" 5 => "R. Watson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2003" "volumen" => "139" "paginaInicial" => "45" "paginaFinal" => "49" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12533163" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subacute cutaneous lupus erythematosus induced or exacerbated by proton pump inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Dam" 1 => "A. Bygum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-0335" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2008" "volumen" => "88" "paginaInicial" => "87" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18176768" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lansoprazole-induced subacute cutaneous lupus erythematosus: two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Bracke" 1 => "T. Nijsten" 2 => "J. Vandermaesen" 3 => "L. Meuleman" 4 => "J. Lambert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00015550510026668" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2005" "volumen" => "85" "paginaInicial" => "353" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16191862" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Omeprazole-induced subacute cutaneous lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.K. Mankia" 1 => "E. Rytina" 2 => "N.P. Burrows" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Exp Dermato" "fecha" => "2010" "volumen" => "35" "paginaInicial" => "e1" "paginaFinal" => "e2" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esomeprazole: a review of its use in the management of gastric acid-related diseases in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. McKeage" 1 => "S.K. Blick" 2 => "J.D. Croxtall" 3 => "K.A. Lyseng-Williamson" 4 => "G.M. Keating" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drugs" "fecha" => "2008" "volumen" => "68" "paginaInicial" => "1571" "paginaFinal" => "1607" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18627213" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010200000008/v1_201304241234/S1578219011000618/v1_201304241234/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000008/v1_201304241234/S1578219011000618/v1_201304241234/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000618?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 7 | 12 | 19 |
| 2024 Octubre | 89 | 51 | 140 |
| 2024 Septiembre | 97 | 63 | 160 |
| 2024 Agosto | 131 | 63 | 194 |
| 2024 Julio | 92 | 56 | 148 |
| 2024 Junio | 103 | 66 | 169 |
| 2024 Mayo | 88 | 57 | 145 |
| 2024 Abril | 69 | 32 | 101 |
| 2024 Marzo | 99 | 43 | 142 |
| 2024 Febrero | 64 | 38 | 102 |
| 2024 Enero | 76 | 38 | 114 |
| 2023 Diciembre | 75 | 26 | 101 |
| 2023 Noviembre | 88 | 38 | 126 |
| 2023 Octubre | 69 | 36 | 105 |
| 2023 Septiembre | 77 | 43 | 120 |
| 2023 Agosto | 52 | 28 | 80 |
| 2023 Julio | 77 | 44 | 121 |
| 2023 Junio | 77 | 18 | 95 |
| 2023 Mayo | 110 | 24 | 134 |
| 2023 Abril | 79 | 35 | 114 |
| 2023 Marzo | 70 | 39 | 109 |
| 2023 Febrero | 74 | 25 | 99 |
| 2023 Enero | 67 | 24 | 91 |
| 2022 Diciembre | 110 | 45 | 155 |
| 2022 Noviembre | 57 | 34 | 91 |
| 2022 Octubre | 62 | 27 | 89 |
| 2022 Septiembre | 55 | 37 | 92 |
| 2022 Agosto | 48 | 34 | 82 |
| 2022 Julio | 66 | 40 | 106 |
| 2022 Junio | 69 | 27 | 96 |
| 2022 Mayo | 127 | 36 | 163 |
| 2022 Abril | 131 | 44 | 175 |
| 2022 Marzo | 113 | 53 | 166 |
| 2022 Febrero | 113 | 25 | 138 |
| 2022 Enero | 138 | 57 | 195 |
| 2021 Diciembre | 94 | 42 | 136 |
| 2021 Noviembre | 110 | 40 | 150 |
| 2021 Octubre | 97 | 46 | 143 |
| 2021 Septiembre | 110 | 41 | 151 |
| 2021 Agosto | 131 | 31 | 162 |
| 2021 Julio | 74 | 35 | 109 |
| 2021 Junio | 101 | 35 | 136 |
| 2021 Mayo | 87 | 48 | 135 |
| 2021 Abril | 136 | 98 | 234 |
| 2021 Marzo | 86 | 19 | 105 |
| 2021 Febrero | 70 | 33 | 103 |
| 2021 Enero | 56 | 23 | 79 |
| 2020 Diciembre | 46 | 21 | 67 |
| 2020 Noviembre | 31 | 19 | 50 |
| 2020 Octubre | 17 | 8 | 25 |
| 2020 Septiembre | 52 | 17 | 69 |
| 2020 Agosto | 29 | 22 | 51 |
| 2020 Julio | 20 | 21 | 41 |
| 2020 Junio | 31 | 30 | 61 |
| 2020 Mayo | 34 | 14 | 48 |
| 2020 Abril | 29 | 30 | 59 |
| 2020 Marzo | 47 | 25 | 72 |
| 2020 Febrero | 6 | 7 | 13 |
| 2019 Diciembre | 4 | 5 | 9 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 2 | 2 |
| 2019 Septiembre | 6 | 8 | 14 |
| 2019 Agosto | 0 | 10 | 10 |
| 2019 Julio | 0 | 10 | 10 |
| 2019 Junio | 0 | 22 | 22 |
| 2019 Mayo | 3 | 19 | 22 |
| 2019 Abril | 0 | 25 | 25 |
| 2019 Marzo | 0 | 10 | 10 |
| 2019 Febrero | 3 | 3 | 6 |
| 2019 Enero | 1 | 2 | 3 |
| 2018 Diciembre | 0 | 2 | 2 |
| 2018 Noviembre | 2 | 3 | 5 |
| 2018 Septiembre | 4 | 1 | 5 |
| 2018 Agosto | 0 | 5 | 5 |
| 2018 Julio | 0 | 1 | 1 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Mayo | 0 | 5 | 5 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 5 | 5 | 10 |
| 2018 Febrero | 58 | 2 | 60 |
| 2018 Enero | 77 | 13 | 90 |
| 2017 Diciembre | 87 | 9 | 96 |
| 2017 Noviembre | 64 | 8 | 72 |
| 2017 Octubre | 77 | 18 | 95 |
| 2017 Septiembre | 70 | 21 | 91 |
| 2017 Agosto | 117 | 10 | 127 |
| 2017 Julio | 93 | 6 | 99 |
| 2017 Junio | 105 | 17 | 122 |
| 2017 Mayo | 98 | 10 | 108 |
| 2017 Abril | 95 | 19 | 114 |
| 2017 Marzo | 93 | 31 | 124 |
| 2017 Febrero | 66 | 15 | 81 |
| 2017 Enero | 64 | 9 | 73 |
| 2016 Diciembre | 111 | 10 | 121 |
| 2016 Noviembre | 137 | 12 | 149 |
| 2016 Octubre | 144 | 20 | 164 |
| 2016 Septiembre | 216 | 20 | 236 |
| 2016 Agosto | 130 | 18 | 148 |
| 2016 Julio | 65 | 9 | 74 |
| 2016 Junio | 14 | 10 | 24 |
| 2016 Mayo | 16 | 4 | 20 |
| 2016 Abril | 5 | 10 | 15 |
| 2016 Marzo | 11 | 3 | 14 |
| 2016 Febrero | 6 | 1 | 7 |
| 2016 Enero | 12 | 2 | 14 |
| 2015 Diciembre | 11 | 2 | 13 |
| 2015 Noviembre | 21 | 2 | 23 |
| 2015 Octubre | 24 | 4 | 28 |
| 2015 Septiembre | 23 | 2 | 25 |
| 2015 Agosto | 22 | 6 | 28 |
| 2015 Julio | 108 | 12 | 120 |
| 2015 Junio | 87 | 12 | 99 |
| 2015 Mayo | 104 | 17 | 121 |
| 2015 Abril | 104 | 15 | 119 |
| 2015 Marzo | 76 | 13 | 89 |
| 2015 Febrero | 60 | 11 | 71 |
| 2015 Enero | 88 | 11 | 99 |
| 2014 Diciembre | 96 | 7 | 103 |
| 2014 Noviembre | 65 | 12 | 77 |
| 2014 Octubre | 84 | 16 | 100 |
| 2014 Septiembre | 58 | 15 | 73 |
| 2014 Agosto | 68 | 11 | 79 |
| 2014 Julio | 77 | 20 | 97 |
| 2014 Junio | 98 | 11 | 109 |
| 2014 Mayo | 100 | 23 | 123 |
| 2014 Abril | 79 | 11 | 90 |
| 2014 Marzo | 112 | 24 | 136 |
| 2014 Febrero | 67 | 22 | 89 |
| 2014 Enero | 62 | 16 | 78 |
| 2013 Diciembre | 71 | 15 | 86 |
| 2013 Noviembre | 44 | 14 | 58 |
| 2013 Octubre | 36 | 16 | 52 |
| 2013 Septiembre | 20 | 8 | 28 |
| 2013 Agosto | 13 | 10 | 23 |
| 2013 Julio | 7 | 14 | 21 |
| 2013 Junio | 18 | 16 | 34 |
| 2013 Mayo | 20 | 19 | 39 |
| 2013 Abril | 13 | 21 | 34 |
| 2013 Marzo | 23 | 24 | 47 |
| 2013 Febrero | 28 | 7 | 35 |
| 2013 Enero | 36 | 13 | 49 |
| 2012 Diciembre | 16 | 12 | 28 |
| 2012 Noviembre | 1 | 6 | 7 |
| 2012 Octubre | 5 | 4 | 9 |
Mostrar todo
