Estadísticas

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      "titulo" => "Facial Papules and Intestinal Lipomatosis"
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          "titulo" => "Pápulas faciales y lipomatosis intestinal"
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          "autoresLista" => "M. Gutiérrez-Pascual, F.J. Vicente-Martín, F.J. Salamanca Santamaría, J.L. López-Estebaranz"
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    "pii" => "S1578219010708386"
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    "doi" => "10.1016/S1578-2190(10)70838-6"
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    "cita" => "Actas Dermosifiliogr. 2010;101:534-41"
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      "titulo" => "Clinical Research Publication by Spanish Dermatologists Over Time and in Comparison With Other Research Groups in 2008"
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          "titulo" => "Evolución de la investigación clínica publicada por los dermatólogos españoles y comparación con otros grupos en 2008"
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          "autoresLista" => "B. Aranegui, I. García-Doval, A. García-Cruz"
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              "apellidos" => "García-Doval"
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    "titulo" => "Leonine Facies in Carcinoid Syndrome"
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        "autoresLista" => "M. Yuste, A. Romo, G. Nieto, P. Unamuno"
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            "apellidos" => "Yuste"
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            "apellidos" => "Romo"
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        "titulo" => "Facies leonina en el s&#237;ndrome carcinoide"
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    "fechaRecibido" => "2009-09-29"
    "fechaAceptado" => "2010-02-08"
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            0 => "Carcinoid syndrome"
            1 => "Leonine facies"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Carcinoid syndrome is a rare disorder caused when elevated levels of vasoactive substances secreted by a carcinoid tumor fail to be metabolized by the liver&#46; This can occur for a variety of reasons including metastatic invasion of the organ&#46; Carcinoid syndrome results in elevated levels of 5-hydroxyindoleacetic acid in the urine&#46; Clinical manifestations include&#58; flushing&#44; diarrhea&#44; bronchospasm&#44; and heart failure&#46; We describe a patient with carcinoid syndrome and hepatic metastases&#44; in whom the key symptom of persistent facial edema resulted in conspicuous leonine facies&#59; there was a partial response to treatment with oral isotretinoin and intramuscular lanreotide&#46; Differential diagnosis was made with other conditions causing facial edema&#46; A review is performed of the various skin manifestations of carcinoid syndrome&#44; highlighting their role in the early diagnosis and treatment of the disorder&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome carcinoide es un proceso infrecuente que se produce por la presencia en el organismo de niveles elevados de sustancias vasoactivas secretadas por un tumor carcinoide y no metabolizadas por el h&#237;gado&#44; debido a diversas circunstancias&#44; entre ellas la invasi&#243;n metast&#225;sica del mismo&#46; Se traduce en una elevaci&#243;n del 5-hidroxi-indolac&#233;tico en orina&#46; Cl&#237;nicamente cursa con s&#237;ntomas cut&#225;neos &#40;episodios de rubefacci&#243;n-<span class="elsevierStyleItalic">flushing</span>&#41;&#44; digestivos &#40;diarrea&#41;&#44; respiratorios &#40;broncoespasmo&#41; y cardiovasculares &#40;insuficiencia cardiaca&#41;&#46; Describimos el caso de un paciente con s&#237;ndrome carcinoide con met&#225;stasis hep&#225;ticas cuyo s&#237;ntoma gu&#237;a fue el edema facial&#44; que se hizo persistente otorg&#225;ndole una facies leonina muy llamativa&#44; que respondi&#243; parcialmente al tratamiento con isotretino&#237;na por v&#237;a oral y lanre&#243;tida intramuscular&#46; Realizamos diagn&#243;stico diferencial con otros cuadros que cursan con edema facial y revisamos las diversas manifestaciones cut&#225;neas que pueden surgir en el s&#237;ndrome carcinoide&#44; destacando su importancia para realizar un diagn&#243;stico y tratamiento precoces del proceso&#46;</p>"
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