Original Article
Plaque-Phase Mycosis Fungoides Treated with Photodynamic Therapy: Results from 12 Patients
Micosis fungoide en fase de placas tratada con terapia fotodinámica: resultados en 12 pacientes
M. Fernández-Guarino
, A. Harto, B. Pérez-García, C. Montull, E. De Las Heras, P. Jaén
Autor para correspondencia
Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, Spain
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Guerra-Tapia, L. Puig-Sanz, J. Conejo Mir, J. Toribio-Pérez, C. Iglesias, I. Zsolt" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Guerra-Tapia" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Puig-Sanz" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Conejo Mir" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Toribio-Pérez" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Iglesias" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Zsolt" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707162?idApp=UINPBA000044" "url" => "/15782190/0000010100000009/v1_201304241531/S1578219010707162/v1_201304241531/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Plaque-Phase Mycosis Fungoides Treated with Photodynamic Therapy: Results from 12 Patients" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "785" "paginaFinal" => "791" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Fernández-Guarino, A. Harto, B. Pérez-García, C. Montull, E. De Las Heras, P. Jaén" "autores" => array:6 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Fernández-Guarino" "email" => array:1 [ 0 => "montsefdez@msn.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Harto" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Pérez-García" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Montull" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "De Las Heras" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Jaén" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Micosis fungoide en fase de placas tratada con terapia fotodinámica: resultados en 12 pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-02-07" "fechaAceptado" => "2010-06-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84807" "palabras" => array:3 [ 0 => "Mycosis fungoides" 1 => "Photodynamic therapy" 2 => "Methyl aminolevulinate" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84806" "palabras" => array:3 [ 0 => "Micosis fungoide" 1 => "Terapia fotodinámica" 2 => "Metilaminolevulínico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Recent years have seen an increase in the off-label use of photodynamic therapy for the treatment of a variety of skin diseases. Plaque-phase mycosis fungoides is among the most promising possibilities for the use of this treatment.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the treatment of plaque-phase mycosis fungoides with photodynamic therapy and compare the results obtained using fluorescence photography.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We performed a prospective, descriptive, observational study. Twelve patients with 24 lesions were treated with topical methyl aminolevulinate (MAL) under an occlusive dressing for 3 hours, followed by 8 minutes of red light (630 nm, 37 J/ cm<span class="elsevierStyleSup">2</span>; Aktilite).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Six patients had a complete response, 5 a partial response, and 1 did not respond to treatment. A mean of 5.7 sessions was applied and no side effects were reported. Treatment tolerance was excellent.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Photodynamic therapy with MAL appears to be a good treatment option for patients with plaque-phase mycosis fungoides with a small number of lesions.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La terapia fotodinámica (TFD) está siendo desarrollada en los últimos años en dermatosis diferentes de las aprobadas para su uso. Entre todas ellas, la micosis fungoide (MF) en estadio de placas es una de las más prometedoras.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar los resultados en el tratamiento de la MF en placas con TFD y correlacionarlos con la fotografía de fluorescencia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Llevamos a cabo un estudio prospectivo, descriptivo y observacional. Se seleccionaron un total de 12 pacientes con 24 lesiones que fueron tratados con metilaminolevulinato (MAL) tópico ocluido tres horas y luz roja (630 nm, 37 J/cm<span class="elsevierStyleSup">2</span>, 8 min, Aktilite<span class="elsevierStyleSup">®</span>).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Un total de 6 pacientes obtuvo respuesta completa, 5 pacientes alcanzaron respuesta parcial y uno no respondió al tratamiento. La media de sesiones aplicadas fue de 5,7 y no se recopilaron efectos secundarios. La tolerancia fue excelente.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La TFD con MAL parece una buena alternativa terapéutica para los pacientes con MF en placas con escaso número de lesiones.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Otras indicaciones dermatológicas del ALAPDT" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.M. Welch" 1 => "K. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 10 | 11 | 21 |
| 2024 Octubre | 50 | 48 | 98 |
| 2024 Septiembre | 63 | 25 | 88 |
| 2024 Agosto | 70 | 65 | 135 |
| 2024 Julio | 56 | 33 | 89 |
| 2024 Junio | 58 | 20 | 78 |
| 2024 Mayo | 44 | 23 | 67 |
| 2024 Abril | 54 | 27 | 81 |
| 2024 Marzo | 49 | 33 | 82 |
| 2024 Febrero | 53 | 38 | 91 |
| 2024 Enero | 43 | 40 | 83 |
| 2023 Diciembre | 49 | 24 | 73 |
| 2023 Noviembre | 51 | 41 | 92 |
| 2023 Octubre | 41 | 28 | 69 |
| 2023 Septiembre | 38 | 26 | 64 |
| 2023 Agosto | 21 | 21 | 42 |
| 2023 Julio | 36 | 40 | 76 |
| 2023 Junio | 54 | 23 | 77 |
| 2023 Mayo | 49 | 21 | 70 |
| 2023 Abril | 36 | 25 | 61 |
| 2023 Marzo | 25 | 28 | 53 |
| 2023 Febrero | 23 | 25 | 48 |
| 2023 Enero | 32 | 37 | 69 |
| 2022 Diciembre | 37 | 40 | 77 |
| 2022 Noviembre | 18 | 22 | 40 |
| 2022 Octubre | 15 | 15 | 30 |
| 2022 Septiembre | 16 | 49 | 65 |
| 2022 Agosto | 16 | 55 | 71 |
| 2022 Julio | 15 | 26 | 41 |
| 2022 Junio | 14 | 27 | 41 |
| 2022 Mayo | 21 | 41 | 62 |
| 2022 Abril | 28 | 43 | 71 |
| 2022 Marzo | 34 | 56 | 90 |
| 2022 Febrero | 22 | 21 | 43 |
| 2022 Enero | 27 | 49 | 76 |
| 2021 Diciembre | 27 | 47 | 74 |
| 2021 Noviembre | 32 | 53 | 85 |
| 2021 Octubre | 23 | 57 | 80 |
| 2021 Septiembre | 18 | 50 | 68 |
| 2021 Agosto | 15 | 30 | 45 |
| 2021 Julio | 17 | 41 | 58 |
| 2021 Junio | 14 | 27 | 41 |
| 2021 Mayo | 25 | 23 | 48 |
| 2021 Abril | 33 | 44 | 77 |
| 2021 Marzo | 34 | 23 | 57 |
| 2021 Febrero | 47 | 25 | 72 |
| 2021 Enero | 38 | 25 | 63 |
| 2020 Diciembre | 17 | 18 | 35 |
| 2020 Noviembre | 33 | 20 | 53 |
| 2020 Octubre | 14 | 12 | 26 |
| 2020 Septiembre | 7 | 7 | 14 |
| 2020 Agosto | 31 | 27 | 58 |
| 2020 Julio | 10 | 9 | 19 |
| 2020 Junio | 22 | 26 | 48 |
| 2020 Mayo | 25 | 18 | 43 |
| 2020 Abril | 30 | 27 | 57 |
| 2020 Marzo | 21 | 21 | 42 |
| 2020 Febrero | 0 | 2 | 2 |
| 2020 Enero | 0 | 2 | 2 |
| 2019 Diciembre | 0 | 12 | 12 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Octubre | 0 | 7 | 7 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 4 | 4 |
| 2019 Junio | 0 | 1 | 1 |
| 2019 Mayo | 0 | 36 | 36 |
| 2019 Abril | 0 | 9 | 9 |
| 2019 Marzo | 0 | 5 | 5 |
| 2019 Febrero | 0 | 1 | 1 |
| 2018 Diciembre | 0 | 2 | 2 |
| 2018 Octubre | 0 | 3 | 3 |
| 2018 Marzo | 1 | 1 | 2 |
| 2018 Febrero | 17 | 2 | 19 |
| 2018 Enero | 9 | 6 | 15 |
| 2017 Diciembre | 14 | 7 | 21 |
| 2017 Noviembre | 13 | 1 | 14 |
| 2017 Octubre | 10 | 6 | 16 |
| 2017 Septiembre | 13 | 3 | 16 |
| 2017 Agosto | 11 | 4 | 15 |
| 2017 Julio | 12 | 3 | 15 |
| 2017 Junio | 17 | 5 | 22 |
| 2017 Mayo | 13 | 5 | 18 |
| 2017 Abril | 13 | 7 | 20 |
| 2017 Marzo | 10 | 5 | 15 |
| 2017 Febrero | 12 | 7 | 19 |
| 2017 Enero | 11 | 5 | 16 |
| 2016 Diciembre | 20 | 7 | 27 |
| 2016 Noviembre | 25 | 1 | 26 |
| 2016 Octubre | 39 | 12 | 51 |
| 2016 Septiembre | 30 | 5 | 35 |
| 2016 Agosto | 26 | 6 | 32 |
| 2016 Julio | 25 | 4 | 29 |
| 2016 Junio | 6 | 6 | 12 |
| 2016 Mayo | 3 | 0 | 3 |
| 2016 Abril | 4 | 1 | 5 |
| 2016 Marzo | 3 | 1 | 4 |
| 2016 Febrero | 7 | 7 | 14 |
| 2016 Enero | 8 | 0 | 8 |
| 2015 Diciembre | 13 | 0 | 13 |
| 2015 Noviembre | 14 | 0 | 14 |
| 2015 Octubre | 5 | 6 | 11 |
| 2015 Septiembre | 1 | 3 | 4 |
| 2015 Agosto | 17 | 3 | 20 |
| 2015 Julio | 21 | 3 | 24 |
| 2015 Junio | 25 | 2 | 27 |
| 2015 Mayo | 50 | 9 | 59 |
| 2015 Abril | 28 | 5 | 33 |
| 2015 Marzo | 29 | 3 | 32 |
| 2015 Febrero | 33 | 6 | 39 |
| 2015 Enero | 23 | 6 | 29 |
| 2014 Diciembre | 17 | 14 | 31 |
| 2014 Noviembre | 18 | 12 | 30 |
| 2014 Octubre | 27 | 14 | 41 |
| 2014 Septiembre | 13 | 12 | 25 |
| 2014 Agosto | 29 | 12 | 41 |
| 2014 Julio | 38 | 20 | 58 |
| 2014 Junio | 23 | 11 | 34 |
| 2014 Mayo | 33 | 15 | 48 |
| 2014 Abril | 21 | 9 | 30 |
| 2014 Marzo | 24 | 18 | 42 |
| 2014 Febrero | 17 | 16 | 33 |
| 2014 Enero | 25 | 14 | 39 |
| 2013 Diciembre | 24 | 8 | 32 |
| 2013 Noviembre | 24 | 14 | 38 |
| 2013 Octubre | 25 | 19 | 44 |
| 2013 Septiembre | 24 | 19 | 43 |
| 2013 Agosto | 18 | 17 | 35 |
| 2013 Julio | 35 | 26 | 61 |
| 2013 Junio | 15 | 17 | 32 |
| 2013 Mayo | 24 | 18 | 42 |
| 2013 Abril | 25 | 19 | 44 |
| 2013 Marzo | 27 | 36 | 63 |
| 2013 Febrero | 12 | 12 | 24 |
| 2013 Enero | 2 | 1 | 3 |
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