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Lymphomatoid Papulosis in Children: Report of 9 Cases and Review of the Literature
Papulosis linfomatoide en la infancia: presentación de 9 casos y revisión de la literatura
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Aguayo-Leiva, L. Ríos-Buceta, P. Jaén-Olasolo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "I.R." "apellidos" => "Aguayo-Leiva" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Ríos-Buceta" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Jaén-Olasolo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706983?idApp=UINPBA000044" "url" => "/15782190/0000010100000008/v1_201304241529/S1578219010706983/v1_201304241529/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Lymphomatoid Papulosis in Children: Report of 9 Cases and Review of the Literature" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "693" "paginaFinal" => "701" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Martorell-Calatayud, A. Hernández-Martín, I. Colmenero, S. Vañó-Galván, C. López-Obregón, A. Armand, M. Gambra Arzoz, A. Torrelo" "autores" => array:8 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Martorell-Calatayud" "email" => array:1 [ 0 => "antmarto@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Hernández-Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "Colmenero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "S." "apellidos" => "Vañó-Galván" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "López-Obregón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Armand" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "M." "apellidos" => "Gambra Arzoz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 7 => array:3 [ "nombre" => "A." "apellidos" => "Torrelo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Infantil Niño Jesús, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Infantil Niño Jesús, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Pediatría, Hospital Infantil Niño Jesús, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Papulosis linfomatoide en la infancia: presentación de 9 casos y revisión de la literatura" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-07" "fechaAceptado" => "2010-03-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84797" "palabras" => array:3 [ 0 => "Cutaneous T-cell lymphoma" 1 => "Lymphomatoid papulosis" 2 => "Childhood" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84796" "palabras" => array:3 [ 0 => "Linfoma cutáneo de células T" 1 => "Papulosis linfomatoide" 2 => "Infancia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lymphomatoid papulosis is a rare CD30+ T-cell lymphoproliferative disease with an excellent prognosis. It is usually seen in adults and is rare in children. The clinical and pathologic manifestations and the risk of progression to other types of lymphoma are thus not clearly defined in the pediatric age group.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To describe the characteristics of lymphomatoid papulosis in a group of children and perform a review of the literature.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A retrospective study was performed of 9 patients under 18 years of age diagnosed with lymphomatoid papulosis and treated in our department between 1995 and 2009</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The study included 7 boys and 2 girls aged between 2 and 17 years. Lesions compatible with pityriasis lichenoides acuta appeared before the lymphomatoid papulosis in 2 cases and afterwards in 1 case. The lymphomatoid papulosis lesions resolved spontaneously, leaving postinflammatory hyperpigmentation (77%) or hypopigmentation (23%). Scarring occurred in 77% of cases. Histologically, all cases showed features compatible with lymphomatoid papulosis type A. Molecular studies showed monoclonality in all 3 cases in which this technique was performed.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lymphomatoid papulosis is a rare disease in childhood and the manifestations are similar to the adult form. This lymphoproliferative disease, occasionally associated with pityriasis lichenoides acuta, has histological features compatible with a type A or histiocytoid pattern. Progression to other lymphoproliferative disorders during followup is less common in the childhood form than in adults. The frequent association of pityriasis lichenoides acuta and lymphomatoid papulosis observed in our study, and the difficulty distinguishing between these 2 conditions in some cases, suggest that these diseases could be part of a single clinical-pathological spectrum.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La papulosis linfomatoide es un proceso linfoproliferativo de células T CD30+ poco frecuente y de pronóstico excelente que generalmente afecta a adultos y, en menor medida a niños, por lo que tanto el espectro clínico-patológico como el riesgo de progresión a otro tipo de linfoma en el grupo pediátrico no están bien establecidos.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Analizar las características de la papulosis linfomatoide infantil a partir de la descripción de nuevos casos y de la revisión de la literatura.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se realizó un estudio retrospectivo de 9 pacientes menores de 18 años diagnosticados de papulosis linfomatoide atendidos en nuestro servicio entre 1995 y 2009.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 7 niños y 2 niñas de edades entre 2 y 17 años. Las lesiones de papulosis linfomatoide se vieron precedidas en 2 casos y seguidas en 1 de otras compatibles con pitiriasis liquenoide aguda.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">La resolución de las lesiones fue espontánea, dejando hiperpigmentación (77%) o hipopigmentación postinflamatoria (23%) y cicatrices en el 77% de los casos. Histológicamente todos los casos presentaron el patrón tipo A de papulosis linfomatoide. El estudio molecular mostró monoclonalidad en los 3 casos en los que fue realizado.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La papulosis linfomatoide infantil es una entidad rara que se manifiesta clínicamente como la forma adulta. Esta enfermedad linfoproliferativa, que ocasionalmente se asocia a pitiriasis liquenoide aguda, muestra hallazgos histológicos compatibles con el patrón histiocitoide o tipo A. El desarrollo de otros procesos linfoproliferativos malignos en el seguimiento posterior es menos frecuente en la papulosis linfomatoide infantil comparado con la variante adulta. La frecuente asociación de pitiriasis liquenoide y de papulosis linfomatoide encontrada en nuestro análisis, así como la dificultad que supone en algunos casos el diferenciar entre ambos procesos, permiten sugerir que ambas patologías podrían formar parte de un espectro clínico-patológico común.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphomatoid papulosis: A continuing selfhealing eruption, clinically benign-histologically malignant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W.L. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 12 | 6 | 18 |
| 2024 Octubre | 60 | 54 | 114 |
| 2024 Septiembre | 62 | 32 | 94 |
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| 2024 Enero | 42 | 98 | 140 |
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| 2023 Noviembre | 59 | 70 | 129 |
| 2023 Octubre | 56 | 37 | 93 |
| 2023 Septiembre | 44 | 39 | 83 |
| 2023 Agosto | 32 | 36 | 68 |
| 2023 Julio | 65 | 83 | 148 |
| 2023 Junio | 28 | 34 | 62 |
| 2023 Mayo | 37 | 65 | 102 |
| 2023 Abril | 23 | 32 | 55 |
| 2023 Marzo | 27 | 58 | 85 |
| 2023 Febrero | 20 | 61 | 81 |
| 2023 Enero | 27 | 50 | 77 |
| 2022 Diciembre | 29 | 63 | 92 |
| 2022 Noviembre | 18 | 49 | 67 |
| 2022 Octubre | 13 | 31 | 44 |
| 2022 Septiembre | 11 | 49 | 60 |
| 2022 Agosto | 14 | 42 | 56 |
| 2022 Julio | 12 | 39 | 51 |
| 2022 Junio | 10 | 34 | 44 |
| 2022 Mayo | 17 | 49 | 66 |
| 2022 Abril | 22 | 45 | 67 |
| 2022 Marzo | 21 | 69 | 90 |
| 2022 Febrero | 21 | 35 | 56 |
| 2022 Enero | 20 | 44 | 64 |
| 2021 Diciembre | 16 | 46 | 62 |
| 2021 Noviembre | 29 | 44 | 73 |
| 2021 Octubre | 18 | 47 | 65 |
| 2021 Septiembre | 18 | 54 | 72 |
| 2021 Agosto | 27 | 24 | 51 |
| 2021 Julio | 28 | 44 | 72 |
| 2021 Junio | 19 | 26 | 45 |
| 2021 Mayo | 21 | 42 | 63 |
| 2021 Abril | 43 | 48 | 91 |
| 2021 Marzo | 49 | 18 | 67 |
| 2021 Febrero | 40 | 24 | 64 |
| 2021 Enero | 27 | 20 | 47 |
| 2020 Diciembre | 13 | 24 | 37 |
| 2020 Noviembre | 25 | 16 | 41 |
| 2020 Octubre | 32 | 10 | 42 |
| 2020 Septiembre | 23 | 18 | 41 |
| 2020 Agosto | 28 | 22 | 50 |
| 2020 Julio | 18 | 13 | 31 |
| 2020 Junio | 25 | 28 | 53 |
| 2020 Mayo | 28 | 31 | 59 |
| 2020 Abril | 17 | 17 | 34 |
| 2020 Marzo | 27 | 17 | 44 |
| 2020 Febrero | 1 | 2 | 3 |
| 2020 Enero | 0 | 3 | 3 |
| 2019 Diciembre | 0 | 10 | 10 |
| 2019 Noviembre | 1 | 4 | 5 |
| 2019 Octubre | 0 | 1 | 1 |
| 2019 Septiembre | 0 | 4 | 4 |
| 2019 Agosto | 0 | 5 | 5 |
| 2019 Julio | 0 | 6 | 6 |
| 2019 Junio | 0 | 5 | 5 |
| 2019 Mayo | 0 | 38 | 38 |
| 2019 Marzo | 0 | 12 | 12 |
| 2018 Marzo | 4 | 1 | 5 |
| 2018 Febrero | 29 | 4 | 33 |
| 2018 Enero | 14 | 3 | 17 |
| 2017 Diciembre | 35 | 10 | 45 |
| 2017 Noviembre | 17 | 1 | 18 |
| 2017 Octubre | 20 | 4 | 24 |
| 2017 Septiembre | 18 | 5 | 23 |
| 2017 Agosto | 32 | 6 | 38 |
| 2017 Julio | 20 | 5 | 25 |
| 2017 Junio | 14 | 5 | 19 |
| 2017 Mayo | 12 | 8 | 20 |
| 2017 Abril | 16 | 19 | 35 |
| 2017 Marzo | 18 | 8 | 26 |
| 2017 Febrero | 20 | 4 | 24 |
| 2017 Enero | 13 | 4 | 17 |
| 2016 Diciembre | 28 | 4 | 32 |
| 2016 Noviembre | 25 | 4 | 29 |
| 2016 Octubre | 23 | 16 | 39 |
| 2016 Septiembre | 28 | 7 | 35 |
| 2016 Agosto | 36 | 9 | 45 |
| 2016 Julio | 20 | 4 | 24 |
| 2016 Junio | 12 | 9 | 21 |
| 2016 Mayo | 6 | 7 | 13 |
| 2016 Abril | 3 | 3 | 6 |
| 2016 Marzo | 4 | 7 | 11 |
| 2016 Febrero | 7 | 1 | 8 |
| 2016 Enero | 10 | 1 | 11 |
| 2015 Diciembre | 11 | 1 | 12 |
| 2015 Noviembre | 6 | 1 | 7 |
| 2015 Octubre | 6 | 3 | 9 |
| 2015 Septiembre | 2 | 4 | 6 |
| 2015 Agosto | 14 | 4 | 18 |
| 2015 Julio | 22 | 29 | 51 |
| 2015 Junio | 13 | 5 | 18 |
| 2015 Mayo | 54 | 10 | 64 |
| 2015 Abril | 29 | 6 | 35 |
| 2015 Marzo | 32 | 9 | 41 |
| 2015 Febrero | 21 | 11 | 32 |
| 2015 Enero | 17 | 17 | 34 |
| 2014 Diciembre | 14 | 20 | 34 |
| 2014 Noviembre | 16 | 13 | 29 |
| 2014 Octubre | 28 | 15 | 43 |
| 2014 Septiembre | 25 | 13 | 38 |
| 2014 Agosto | 35 | 16 | 51 |
| 2014 Julio | 28 | 12 | 40 |
| 2014 Junio | 34 | 10 | 44 |
| 2014 Mayo | 45 | 13 | 58 |
| 2014 Abril | 35 | 10 | 45 |
| 2014 Marzo | 29 | 14 | 43 |
| 2014 Febrero | 30 | 20 | 50 |
| 2014 Enero | 26 | 18 | 44 |
| 2013 Diciembre | 22 | 18 | 40 |
| 2013 Noviembre | 29 | 20 | 49 |
| 2013 Octubre | 35 | 19 | 54 |
| 2013 Septiembre | 33 | 20 | 53 |
| 2013 Agosto | 23 | 26 | 49 |
| 2013 Julio | 33 | 37 | 70 |
| 2013 Junio | 24 | 21 | 45 |
| 2013 Mayo | 29 | 26 | 55 |
| 2013 Abril | 27 | 22 | 49 |
| 2013 Marzo | 27 | 24 | 51 |
| 2013 Febrero | 13 | 23 | 36 |
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