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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mohs micrographic surgery &#40;MMS&#41; is the treatment of choice for high-risk facial basal cell carcinoma &#40;BCC&#41; as it offers the greatest chance of cure with maximum preservation of healthy tissue&#46; Its use in Spanish public health care hospitals is still limited&#44; however&#44; due to the controversy surrounding its cost&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the cost of MMS with fresh tissue to treat high-risk facial BCC and compare this to the estimated cost of conventional surgery in a Spanish public hospital&#46; A secondary objective was to identify cost-optimization strategies for MMS&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study of a consecutive series of patients with high-risk facial BCC who underwent MMS at the Department of Dermatology at Hospital Costa del Sol in Malaga&#44; Spain between July 2006 and December 2007&#46; We performed a descriptive analysis of the clinical characteristics of the patients and surgical factors&#46; We calculated the total and mean cost of MMS and compared the results to the estimated costs of conventional surgery using patients as their own controls&#46; Differences were analyzed according to tumor site and size&#44; histologic subtype&#44; and recurrence&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Seventy-nine patients &#40;mean age&#44; 62 years&#41; with 81 high-risk facial BCCs&#44; 97&#46;5&#37; of which were primary tumors&#44; underwent MMS&#46; The most common tumor site was the nose &#40;57&#37;&#41; followed by the orbital region &#40;25&#37;&#41;&#46; Histology showed that 64&#37; of the tumors were infiltrative or micronodular carcinomas&#46; Tumor-free margins were achieved in all patients&#44; with no more than 2 stages required in 88&#37; of the cases&#46; The most common surgical reconstruction techniques were direct closure &#40;21&#37;&#41; and closure with a local skin flap or graft &#40;71&#37;&#41;&#59; the corresponding estimates for conventional surgery were 2&#37; and 89&#37;&#44; respectively&#46; The total and mean cost of MMS was &#8364;106 129&#46;07 and &#8364;1325&#46;80&#44; respectively &#40;compared to &#8364;97700 and &#8364;1208&#46;70 for conventional surgery&#41;&#46; The difference in mean costs between MMS and conventional surgery was not significant &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;534&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">MMS is a viable&#44; effective technique that does not generate significantly higher costs than conventional surgery in selected patients with high-risk facial BCC&#46; Certain technical and organizational strategies could contribute to optimizing the cost of MMS&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La cirug&#237;a microgr&#225;fica de Mohs constituye el tratamiento de elecci&#243;n del carcinoma basocelular de alto riesgo&#44; pues ofrece la mayor garant&#237;a de curaci&#243;n con la m&#225;xima preservaci&#243;n de tejido sano&#46; Sin embargo&#44; su implementaci&#243;n en hospitales del &#225;mbito sanitario p&#250;blico espa&#241;oles es minoritaria hasta la fecha&#44; debido a que el coste econ&#243;mico de esta t&#233;cnica contin&#250;a siendo motivo de controversia&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar los costes de la cirug&#237;a microgr&#225;fica de Mohs en fresco &#40;CMF&#41; en el tratamiento del carcinoma basocelular facial de alto riesgo &#40;CBFR&#41; frente al coste te&#243;rico mediante cirug&#237;a convencional &#40;CC&#41;&#44; en un centro hospitalario del &#225;mbito sanitario p&#250;blico espa&#241;ol&#46; Identificar estrategias de optimizaci&#243;n de costes en este tipo de cirug&#237;a&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal de una serie consecutiva de pacientes con CBFR intervenidos mediante CMF en el Servicio de Dermatolog&#237;a del Hospital Costa del Sol desde julio 2006 a diciembre 2007&#46; Se realiz&#243; un an&#225;lisis descriptivo de las caracter&#237;sticas cl&#237;nicas de la serie y aspectos quir&#250;rgicos&#46; Se realiz&#243; un estudio de costes &#40;coste total y coste medio&#41; de la CMF y se compararon con los costes te&#243;ricos de la CC&#44; utilizando cada paciente como su propio control&#46; Se analizaron las diferencias por localizaci&#243;n&#44; tama&#241;o del tumor&#44; histolog&#237;a y recurrencia&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se intervinieron con CMF 79 pacientes con 81 CBFR &#40;edad media &#61; 62 a&#241;os&#41;&#46; El 97&#44;5&#37; fueron tumores primarios&#46; La localizaci&#243;n m&#225;s frecuente fue la pir&#225;mide nasal &#40;57&#37;&#41; seguida de la regi&#243;n orbitaria &#40;25&#37;&#41;&#46; El 64&#37; correspondieron a tipos histol&#243;gicos infiltrativo y micronodular&#46; La ex&#233;resis tumoral mediante CMF se concluy&#243; en todos los casos con m&#225;rgenes libres&#44; requiri&#233;ndose en el 88&#37; &#250;nicamente uno o dos estadios&#46; Las t&#233;cnicas de reconstrucci&#243;n quir&#250;rgica m&#225;s empleadas fueron el cierre directo y colgajo local &#40;21 y 71&#37; de los casos respectivamente en la CMF&#44; frente al 2 y 89&#37; en la CC&#41;&#46; El coste total y coste medio de la CMF fue de 106&#46;129&#44;07 y 1&#46;325&#44;8 euros respectivamente &#40;frente a 97&#46;770 y 1&#46;208&#44;7 euros de la CC&#41;&#46; La diferencia de costes entre ambos procedimientos no fue significativa &#40;p &#61; 0&#44;534&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">LA CMF es una t&#233;cnica factible&#44; eficaz y que genera costes que no son significativamente superiores a los de la CC en pacientes seleccionados con CBFR&#46; Algunas estrategias t&#233;cnicas y organizativas pueden contribuir a la optimizaci&#243;n de costes de esta cirug&#237;a&#46;</p>"
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Original article
Cost Analysis of Mohs Micrographic Surgery in High-Risk Facial Basal Cell Carcinoma
Análisis de costes de la cirugía micrográfica de Mohs en el carcinoma basocelular facial de alto riesgo
N. Blázquez-Sáncheza,b,
Autor para correspondencia
nuriaderm1@gmail.com

Corresponding author.
, M. de Troya-Martína,b, M. Frieyro-Eliceguia, R. Fúnez-Liébanac, L. Martín-Márquezd, F. Rivas-Ruize
a Servicio de Dermatología, Empresa Pública Hospital Costa del Sol, Marbella, Málaga, Spain
b CIBER Epidemiología y Salud Pública (CIBERESP), Empresa Pública Hospital Costa del Sol, Marbella, Málaga, Spain
c Laboratorio de Anatomía Patológica, Empresa Pública Hospital Costa del Sol, Marbella, Málaga, Spain
d Departamento de Económico, Empresa Pública Hospital Costa del Sol, Marbella, Málaga, Spain
e Unidad de Investigación, Empresa Pública Hospital Costa del Sol, Marbella, Málaga, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mohs micrographic surgery &#40;MMS&#41; is the treatment of choice for high-risk facial basal cell carcinoma &#40;BCC&#41; as it offers the greatest chance of cure with maximum preservation of healthy tissue&#46; Its use in Spanish public health care hospitals is still limited&#44; however&#44; due to the controversy surrounding its cost&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the cost of MMS with fresh tissue to treat high-risk facial BCC and compare this to the estimated cost of conventional surgery in a Spanish public hospital&#46; A secondary objective was to identify cost-optimization strategies for MMS&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study of a consecutive series of patients with high-risk facial BCC who underwent MMS at the Department of Dermatology at Hospital Costa del Sol in Malaga&#44; Spain between July 2006 and December 2007&#46; We performed a descriptive analysis of the clinical characteristics of the patients and surgical factors&#46; We calculated the total and mean cost of MMS and compared the results to the estimated costs of conventional surgery using patients as their own controls&#46; Differences were analyzed according to tumor site and size&#44; histologic subtype&#44; and recurrence&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Seventy-nine patients &#40;mean age&#44; 62 years&#41; with 81 high-risk facial BCCs&#44; 97&#46;5&#37; of which were primary tumors&#44; underwent MMS&#46; The most common tumor site was the nose &#40;57&#37;&#41; followed by the orbital region &#40;25&#37;&#41;&#46; Histology showed that 64&#37; of the tumors were infiltrative or micronodular carcinomas&#46; Tumor-free margins were achieved in all patients&#44; with no more than 2 stages required in 88&#37; of the cases&#46; The most common surgical reconstruction techniques were direct closure &#40;21&#37;&#41; and closure with a local skin flap or graft &#40;71&#37;&#41;&#59; the corresponding estimates for conventional surgery were 2&#37; and 89&#37;&#44; respectively&#46; The total and mean cost of MMS was &#8364;106 129&#46;07 and &#8364;1325&#46;80&#44; respectively &#40;compared to &#8364;97700 and &#8364;1208&#46;70 for conventional surgery&#41;&#46; The difference in mean costs between MMS and conventional surgery was not significant &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;534&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">MMS is a viable&#44; effective technique that does not generate significantly higher costs than conventional surgery in selected patients with high-risk facial BCC&#46; Certain technical and organizational strategies could contribute to optimizing the cost of MMS&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La cirug&#237;a microgr&#225;fica de Mohs constituye el tratamiento de elecci&#243;n del carcinoma basocelular de alto riesgo&#44; pues ofrece la mayor garant&#237;a de curaci&#243;n con la m&#225;xima preservaci&#243;n de tejido sano&#46; Sin embargo&#44; su implementaci&#243;n en hospitales del &#225;mbito sanitario p&#250;blico espa&#241;oles es minoritaria hasta la fecha&#44; debido a que el coste econ&#243;mico de esta t&#233;cnica contin&#250;a siendo motivo de controversia&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar los costes de la cirug&#237;a microgr&#225;fica de Mohs en fresco &#40;CMF&#41; en el tratamiento del carcinoma basocelular facial de alto riesgo &#40;CBFR&#41; frente al coste te&#243;rico mediante cirug&#237;a convencional &#40;CC&#41;&#44; en un centro hospitalario del &#225;mbito sanitario p&#250;blico espa&#241;ol&#46; Identificar estrategias de optimizaci&#243;n de costes en este tipo de cirug&#237;a&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal de una serie consecutiva de pacientes con CBFR intervenidos mediante CMF en el Servicio de Dermatolog&#237;a del Hospital Costa del Sol desde julio 2006 a diciembre 2007&#46; Se realiz&#243; un an&#225;lisis descriptivo de las caracter&#237;sticas cl&#237;nicas de la serie y aspectos quir&#250;rgicos&#46; Se realiz&#243; un estudio de costes &#40;coste total y coste medio&#41; de la CMF y se compararon con los costes te&#243;ricos de la CC&#44; utilizando cada paciente como su propio control&#46; Se analizaron las diferencias por localizaci&#243;n&#44; tama&#241;o del tumor&#44; histolog&#237;a y recurrencia&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se intervinieron con CMF 79 pacientes con 81 CBFR &#40;edad media &#61; 62 a&#241;os&#41;&#46; El 97&#44;5&#37; fueron tumores primarios&#46; La localizaci&#243;n m&#225;s frecuente fue la pir&#225;mide nasal &#40;57&#37;&#41; seguida de la regi&#243;n orbitaria &#40;25&#37;&#41;&#46; El 64&#37; correspondieron a tipos histol&#243;gicos infiltrativo y micronodular&#46; La ex&#233;resis tumoral mediante CMF se concluy&#243; en todos los casos con m&#225;rgenes libres&#44; requiri&#233;ndose en el 88&#37; &#250;nicamente uno o dos estadios&#46; Las t&#233;cnicas de reconstrucci&#243;n quir&#250;rgica m&#225;s empleadas fueron el cierre directo y colgajo local &#40;21 y 71&#37; de los casos respectivamente en la CMF&#44; frente al 2 y 89&#37; en la CC&#41;&#46; El coste total y coste medio de la CMF fue de 106&#46;129&#44;07 y 1&#46;325&#44;8 euros respectivamente &#40;frente a 97&#46;770 y 1&#46;208&#44;7 euros de la CC&#41;&#46; La diferencia de costes entre ambos procedimientos no fue significativa &#40;p &#61; 0&#44;534&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">LA CMF es una t&#233;cnica factible&#44; eficaz y que genera costes que no son significativamente superiores a los de la CC en pacientes seleccionados con CBFR&#46; Algunas estrategias t&#233;cnicas y organizativas pueden contribuir a la optimizaci&#243;n de costes de esta cirug&#237;a&#46;</p>"
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