Guidelines on the Use of Methotrexate in Psoriasis

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"apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "p" "identificador" => "aff0080" ] ] ] 19 => array:1 [ "colaborador" => "the Psoriasis Group of the Spanish Academy of Dermatology and Venereology" ] ] "afiliaciones" => array:16 [ 0 => array:3 [ "entidad" => "Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Germans Trias i Pujol, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Hospital Universitari de Sabadell, Corporació Parc Taulí, Sabadell, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Hospital Universitario Sagrat Cor, Barcelona, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Hospital Universitario La Princesa, Madrid, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Hospital Clínic, Barcelona, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Hospital Fundación Alcorcón, Madrid, Spain" "etiqueta" => "i" "identificador" => "aff0045" ] 9 => array:3 [ "entidad" => "Hospital Universitario de Bellvitge de Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "j" "identificador" => "aff0050" ] 10 => array:3 [ "entidad" => "Hospital 12 de Octubre, Madrid, Spain" "etiqueta" => "k" "identificador" => "aff0055" ] 11 => array:3 [ "entidad" => "Hospital Universitario de Canarias, Tenerife, Spain" "etiqueta" => "l" "identificador" => "aff0060" ] 12 => array:3 [ "entidad" => "Hospital Son Llàtzer, Palma de Mallorca, Islas Baleares, Spain" "etiqueta" => "m" "identificador" => "aff0065" ] 13 => array:3 [ "entidad" => "Hospital General de Alicante, Alicante, Spain" "etiqueta" => "n" "identificador" => "aff0070" ] 14 => array:3 [ "entidad" => "Hospital General Universitario, Valencia, Spain" "etiqueta" => "o" "identificador" => "aff0075" ] 15 => array:3 [ "entidad" => "Hospital Reina Sofía, Córdoba, Spain" "etiqueta" => "p" "identificador" => "aff0080" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metotrexato: guía de uso en psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-03-29" "fechaAceptado" => "2010-04-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84779" "palabras" => array:4 [ 0 => "Methotrexate" 1 => "Guidelines" 2 => "Treatment" 3 => "Psoriasis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84778" "palabras" => array:4 [ 0 => "Metotrexato" 1 => "Guía" 2 => "Tratamiento" 3 => "Psoriasis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Psoriasis, a chronic multifactorial inflammatory disease that develops in genetically predisposed individuals, affects approximately 1.5% of the Spanish population. This disease has a negative impact on patients’ quality of life, and long-term therapy is often required to control the symptoms. In addition to the classical systemic treatments (methotrexate, acitretin, cyclosporine, and ultraviolet light), the group of drugs known as biologics (etanercept, infliximab, adalimumab, and ustekinumab) provides the dermatologist with an expanded therapeutic armamentarium, thereby improving the likelihood of controlling psoriasis in patients with severe and/or extensive disease. Methotrexate, a classic antipsoriatic drug, is still very useful either as single-drug therapy or in combination with other systemic drugs, particularly as a rescue therapy or combined with biologics. This article aims to establish the role of methotrexate in the treatment of psoriasis. We considered it of interest to develop guidelines for using methotrexate in the management of psoriasis with a view to ensuring the safe and proper use of this drug in the management of psoriasis. This document was developed by consensus among members of the Psoriasis Group of the Spanish Academy of Dermatology and Venereology." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La psoriasis es una enfermedad inflamatoria crónica, de predisposición genética y origen multifactorial, que afecta aproximadamente al 1,5% de la población española, repercutiendo negativamente de forma importante en la calidad de vida de los pacientes, los cuales requieren frecuentemente tratamientos de larga duración, para controlar sus síntomas. Los tratamientos sistémicos clásicos (metotrexato, acitetrino, ciclosporina, luz ultravioleta), junto con las denominadas terapias biológicas (etanercept, infliximab, adalimumab, ustekinumab), permiten al dermatólogo disponer de un arsenal terapéutico más amplio y disponer, por lo tanto, de mayores posibilidades de control de pacientes con psoriasis severa y/o extensa. El metotrexato, un fármaco clásico en la terapia antipsoriásica, sigue siendo de gran utilidad tanto en monoterapia como asociado a otros fármacos sistémicos, en especial como rescate o combinación con los biológicos. El objetivo de este artículo es establecer el papel del metotrexato en el tratamiento de la psoriasis. Por ello hemos creído de interés elaborar una guía de uso de metotrexato en psoriasis, consensuada entre varios componentes del Grupo de Psoriasis de la Academia Española de Dermatología y Venereología, que facilite la utilización segura y precisa de este fármaco en el manejo de pacientes con psoriasis." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:79 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic suppression of tissue reactivity. II. 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methotrexate for psoriasis in the era of biological therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2008.02976.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2008" "volumen" => "33" "paginaInicial" => "551" "paginaFinal" => "554" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000007/v1_201304241526/S157821901070682X/v1_201304241526/en/main.assets" "Apartado" => array:4 [ "identificador" => "6244" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Consensus statement" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000007/v1_201304241526/S157821901070682X/v1_201304241526/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901070682X?idApp=UINPBA000044"]

Estadísticas

Consensus statement

Guidelines on the Use of Methotrexate in Psoriasis

Metotrexato: guía de uso en psoriasis

G. Carreteroa,

Autor para correspondencia

gcarrete@aedv.es

Corresponding author.

, L. Puigb, L. Dehesaa, J.M. Carrascosac, M. Riberad, M. Sánchez-Regañae, E. Daudénf, D. Vidalg, M. Alsinah, C. Muñoz-Santosh, J.L. López-Estebaranzi, J. Notarioj, C. Ferrandizc, F. Vanaclochak, M. García-Bustinduyl, R. Tabernerm, I. Belinchónn, J. Sánchez-Carazoo, J.C. Morenop, the Psoriasis Group of the Spanish Academy of Dermatology and Venereology

a Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain

b Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

c Hospital Germans Trias i Pujol, Barcelona, Spain

d Hospital Universitari de Sabadell, Corporació Parc Taulí, Sabadell, Spain

e Hospital Universitario Sagrat Cor, Barcelona, Spain

f Hospital Universitario La Princesa, Madrid, Spain

g Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain

h Hospital Clínic, Barcelona, Spain

i Hospital Fundación Alcorcón, Madrid, Spain

j Hospital Universitario de Bellvitge de Hospitalet de Llobregat, Barcelona, Spain

k Hospital 12 de Octubre, Madrid, Spain

l Hospital Universitario de Canarias, Tenerife, Spain

m Hospital Son Llàtzer, Palma de Mallorca, Islas Baleares, Spain

n Hospital General de Alicante, Alicante, Spain

o Hospital General Universitario, Valencia, Spain

p Hospital Reina Sofía, Córdoba, Spain

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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Psoriasis&#44; a chronic multifactorial inflammatory disease that develops in genetically predisposed individuals&#44; affects approximately 1&#46;5&#37; of the Spanish population&#46; This disease has a negative impact on patients&#8217; quality of life&#44; and long-term therapy is often required to control the symptoms&#46; In addition to the classical systemic treatments &#40;methotrexate&#44; acitretin&#44; cyclosporine&#44; and ultraviolet light&#41;&#44; the group of drugs known as biologics &#40;etanercept&#44; infliximab&#44; adalimumab&#44; and ustekinumab&#41; provides the dermatologist with an expanded therapeutic armamentarium&#44; thereby improving the likelihood of controlling psoriasis in patients with severe and&#47;or extensive disease&#46; Methotrexate&#44; a classic antipsoriatic drug&#44; is still very useful either as single-drug therapy or in combination with other systemic drugs&#44; particularly as a rescue therapy or combined with biologics&#46; This article aims to establish the role of methotrexate in the treatment of psoriasis&#46; We considered it of interest to develop guidelines for using methotrexate in the management of psoriasis with a view to ensuring the safe and proper use of this drug in the management of psoriasis&#46; This document was developed by consensus among members of the Psoriasis Group of the Spanish Academy of Dermatology and Venereology&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La psoriasis es una enfermedad inflamatoria cr&#243;nica&#44; de predisposici&#243;n gen&#233;tica y origen multifactorial&#44; que afecta aproximadamente al 1&#44;5&#37; de la poblaci&#243;n espa&#241;ola&#44; repercutiendo negativamente de forma importante en la calidad de vida de los pacientes&#44; los cuales requieren frecuentemente tratamientos de larga duraci&#243;n&#44; para controlar sus s&#237;ntomas&#46; Los tratamientos sist&#233;micos cl&#225;sicos &#40;metotrexato&#44; acitetrino&#44; ciclosporina&#44; luz ultravioleta&#41;&#44; junto con las denominadas terapias biol&#243;gicas &#40;etanercept&#44; infliximab&#44; adalimumab&#44; ustekinumab&#41;&#44; permiten al dermat&#243;logo disponer de un arsenal terap&#233;utico m&#225;s amplio y disponer&#44; por lo tanto&#44; de mayores posibilidades de control de pacientes con psoriasis severa y&#47;o extensa&#46; El metotrexato&#44; un f&#225;rmaco cl&#225;sico en la terapia antipsori&#225;sica&#44; sigue siendo de gran utilidad tanto en monoterapia como asociado a otros f&#225;rmacos sist&#233;micos&#44; en especial como rescate o combinaci&#243;n con los biol&#243;gicos&#46; El objetivo de este art&#237;culo es establecer el papel del metotrexato en el tratamiento de la psoriasis&#46; Por ello hemos cre&#237;do de inter&#233;s elaborar una gu&#237;a de uso de metotrexato en psoriasis&#44; consensuada entre varios componentes del Grupo de Psoriasis de la Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a&#44; que facilite la utilizaci&#243;n segura y precisa de este f&#225;rmaco en el manejo de pacientes con psoriasis&#46;</p>"
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Información del artículo

ISSN: 15782190
Idioma original: Inglés

DOI:10.1016/S1578-2190(10)70682-X

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2016 Noviembre	24	6	30
2016 Octubre	26	11	37
2016 Septiembre	50	18	68
2016 Agosto	30	3	33
2016 Julio	30	11	41
2016 Junio	11	12	23
2016 Mayo	10	11	21
2016 Abril	9	1	10
2016 Marzo	6	1	7
2016 Febrero	6	1	7
2016 Enero	7	0	7
2015 Diciembre	9	0	9
2015 Noviembre	8	11	19
2015 Octubre	6	1	7
2015 Septiembre	10	1	11
2015 Agosto	13	1	14
2015 Julio	33	1	34
2015 Junio	37	21	58
2015 Mayo	62	23	85
2015 Abril	40	24	64
2015 Marzo	24	24	48
2015 Febrero	27	26	53
2015 Enero	31	23	54
2014 Diciembre	51	21	72
2014 Noviembre	33	25	58
2014 Octubre	39	34	73
2014 Septiembre	35	33	68
2014 Agosto	42	17	59
2014 Julio	47	23	70
2014 Junio	51	21	72
2014 Mayo	56	21	77
2014 Abril	57	14	71
2014 Marzo	55	32	87
2014 Febrero	37	22	59
2014 Enero	34	23	57
2013 Diciembre	42	18	60
2013 Noviembre	39	28	67
2013 Octubre	34	41	75
2013 Septiembre	25	30	55
2013 Agosto	29	46	75
2013 Julio	44	55	99
2013 Junio	26	56	82
2013 Mayo	35	49	84
2013 Abril	41	70	111
2013 Marzo	34	44	78
2013 Febrero	24	19	43

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