Novelties in dermatology
Lipid Nutrition and the Epidermal Barrier: The Connection Between Immune-Mediated Inflammatory Diseases and Peroxisome Proliferator-Activated Receptors, a New Therapeutic Target in Psoriasis and Atopic Dermatitis
Barrera epidérmica y nutrición lipídica. La conexión PPAR e inmunopatología inflamatoria como nuevas dianas de tratamiento en dermatitis atópica y psoriasis
V.G. Villarrubiaa,
, S. Vidal-Asensib, V. Pérez-Bañascoc, J. Cuevas-Santosd, R. Cisterna-Cáncere
Autor para correspondencia
a Departamento de I+D+i, Inmunología, Bioaveda, Jaén, Spain
b Servicio de Dermatología, Hospital Gómez-Ulla, Madrid, Spain
c Servicio de Nefrología, Hospital de Jaén, Jaén, Spain
d Servicio de Patología, Hospital de Guadalajara, Guadalajara, Spain
e Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina, Universidad del País Vasco, Bilbao, Spain
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La conexión PPAR e inmunopatología inflamatoria como nuevas dianas de tratamiento en dermatitis atópica y psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-10-04" "fechaAceptado" => "2010-03-30" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84786" "palabras" => array:6 [ 0 => "Atopic dermatitis" 1 => "Psoriasis" 2 => "Peroxisome proliferator-activated receptors (PPAR)" 3 => "Epidermal barrier" 4 => "Interleukin-10 Interferon-γ" 5 => "Olive oils" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84787" "palabras" => array:6 [ 0 => "Dermatitis atópica" 1 => "Psoriasis" 2 => "PPAR" 3 => "Barrera epidérmica" 4 => "IL-10/IFN-γ" 5 => "Aceites de oliva" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The authors describe peroxisome proliferator-activated receptor (PPAR) transcription factors as connectors between the enzymatic mechanisms of the epidermal barrier and the abnormal immune and inflammatory responses that characterize atopic dermatitis and psoriasis. Also described is a new connection between lipid metabolism and the epidermal barrier. A suggestion that emerges is that atopic dermatitis and psoriasis share at least 2 pathogenic mechanisms-namely, deficient expression of PPAR-α and impaired production of interleukin-10 and interferon-γ-in spite of differences in causes and manifestations. A standardized olive oil formulation with powerful bactericidal and fungicidal effects also has the ability to increase serum levels of these 2 cytokines and regulate serum levels of high-density lipoprotein cholesterol in patients at high risk for inflammatory and cardiovascular disease, suggesting that these may be among the mechanisms responsible for the benefits observed following oral and/or topical administration in patients with atopic dermatitis or psoriasis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los autores describen los factores peroxisome proliferator-activated receptors (PPAR) como conectores entre los mecanismos enzimáticos de la barrera epidérmica (BE) y las alteraciones inmuno/inflamatorias que caracterizan a dermatitis atópica (DA) y psoriasis. Igualmente, se describe una nueva conexión entre el metabolismo lipídico y la BE. El análisis de estos hechos permite sugerir que DA y psoriasis, aunque diferentes en su causalidad y clínica, exhiben al menos dos hechos patogénicos comunes, que se manifiestan por defectos en la expresión de PPAR-α y en la producción de IL-10 e IFN-γ. La capacidad de una formulación magistral de aceites de oliva (FMAO) para aumentar los niveles séricos de ambas citocinas, y regular el colesterol HDL sérico, en pacientes con alto riesgo inflamatorio/cardiovascular, junto a sus potentes efectos bactericidas y fungicidas, sugiere que estos sean algunos de los mecanismos responsables de los positivos efectos observados con la FMAO (oral y/o tópica) en pacientes con DA y psoriasis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:155 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 13 | 9 | 22 |
| 2024 Octubre | 76 | 70 | 146 |
| 2024 Septiembre | 58 | 39 | 97 |
| 2024 Agosto | 85 | 52 | 137 |
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| 2024 Junio | 47 | 27 | 74 |
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| 2024 Marzo | 54 | 29 | 83 |
| 2024 Febrero | 53 | 36 | 89 |
| 2024 Enero | 44 | 43 | 87 |
| 2023 Diciembre | 36 | 28 | 64 |
| 2023 Noviembre | 46 | 34 | 80 |
| 2023 Octubre | 38 | 20 | 58 |
| 2023 Septiembre | 41 | 25 | 66 |
| 2023 Agosto | 29 | 18 | 47 |
| 2023 Julio | 34 | 48 | 82 |
| 2023 Junio | 50 | 32 | 82 |
| 2023 Mayo | 87 | 29 | 116 |
| 2023 Abril | 45 | 27 | 72 |
| 2023 Marzo | 56 | 22 | 78 |
| 2023 Febrero | 33 | 21 | 54 |
| 2023 Enero | 41 | 29 | 70 |
| 2022 Diciembre | 34 | 36 | 70 |
| 2022 Noviembre | 15 | 26 | 41 |
| 2022 Octubre | 17 | 13 | 30 |
| 2022 Septiembre | 12 | 33 | 45 |
| 2022 Agosto | 16 | 35 | 51 |
| 2022 Julio | 19 | 34 | 53 |
| 2022 Junio | 17 | 31 | 48 |
| 2022 Mayo | 42 | 42 | 84 |
| 2022 Abril | 56 | 36 | 92 |
| 2022 Marzo | 57 | 53 | 110 |
| 2022 Febrero | 18 | 26 | 44 |
| 2022 Enero | 40 | 48 | 88 |
| 2021 Diciembre | 62 | 51 | 113 |
| 2021 Noviembre | 47 | 55 | 102 |
| 2021 Octubre | 32 | 55 | 87 |
| 2021 Septiembre | 27 | 50 | 77 |
| 2021 Agosto | 30 | 36 | 66 |
| 2021 Julio | 32 | 35 | 67 |
| 2021 Junio | 22 | 21 | 43 |
| 2021 Mayo | 37 | 28 | 65 |
| 2021 Abril | 74 | 43 | 117 |
| 2021 Marzo | 59 | 16 | 75 |
| 2021 Febrero | 68 | 26 | 94 |
| 2021 Enero | 37 | 14 | 51 |
| 2020 Diciembre | 37 | 14 | 51 |
| 2020 Noviembre | 31 | 25 | 56 |
| 2020 Octubre | 17 | 16 | 33 |
| 2020 Septiembre | 15 | 10 | 25 |
| 2020 Agosto | 34 | 33 | 67 |
| 2020 Julio | 23 | 8 | 31 |
| 2020 Junio | 30 | 28 | 58 |
| 2020 Mayo | 37 | 27 | 64 |
| 2020 Abril | 31 | 22 | 53 |
| 2020 Marzo | 43 | 23 | 66 |
| 2020 Febrero | 5 | 7 | 12 |
| 2020 Enero | 0 | 4 | 4 |
| 2019 Diciembre | 0 | 13 | 13 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 6 | 6 |
| 2019 Septiembre | 0 | 5 | 5 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 24 | 24 |
| 2019 Junio | 0 | 6 | 6 |
| 2019 Mayo | 1 | 51 | 52 |
| 2019 Abril | 0 | 9 | 9 |
| 2019 Marzo | 0 | 9 | 9 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Febrero | 11 | 8 | 19 |
| 2018 Enero | 15 | 4 | 19 |
| 2017 Diciembre | 21 | 7 | 28 |
| 2017 Noviembre | 17 | 6 | 23 |
| 2017 Octubre | 19 | 6 | 25 |
| 2017 Septiembre | 8 | 7 | 15 |
| 2017 Agosto | 20 | 5 | 25 |
| 2017 Julio | 14 | 3 | 17 |
| 2017 Junio | 27 | 9 | 36 |
| 2017 Mayo | 16 | 9 | 25 |
| 2017 Abril | 23 | 7 | 30 |
| 2017 Marzo | 21 | 12 | 33 |
| 2017 Febrero | 17 | 5 | 22 |
| 2017 Enero | 13 | 11 | 24 |
| 2016 Diciembre | 36 | 6 | 42 |
| 2016 Noviembre | 19 | 6 | 25 |
| 2016 Octubre | 18 | 8 | 26 |
| 2016 Septiembre | 30 | 9 | 39 |
| 2016 Agosto | 23 | 5 | 28 |
| 2016 Julio | 26 | 5 | 31 |
| 2016 Junio | 10 | 10 | 20 |
| 2016 Mayo | 8 | 10 | 18 |
| 2016 Abril | 4 | 27 | 31 |
| 2016 Marzo | 6 | 16 | 22 |
| 2016 Febrero | 5 | 19 | 24 |
| 2016 Enero | 8 | 10 | 18 |
| 2015 Diciembre | 9 | 12 | 21 |
| 2015 Noviembre | 8 | 5 | 13 |
| 2015 Octubre | 8 | 3 | 11 |
| 2015 Septiembre | 5 | 5 | 10 |
| 2015 Agosto | 13 | 3 | 16 |
| 2015 Julio | 26 | 5 | 31 |
| 2015 Junio | 49 | 8 | 57 |
| 2015 Mayo | 52 | 14 | 66 |
| 2015 Abril | 42 | 12 | 54 |
| 2015 Marzo | 28 | 11 | 39 |
| 2015 Febrero | 30 | 18 | 48 |
| 2015 Enero | 24 | 10 | 34 |
| 2014 Diciembre | 33 | 5 | 38 |
| 2014 Noviembre | 26 | 10 | 36 |
| 2014 Octubre | 26 | 17 | 43 |
| 2014 Septiembre | 31 | 7 | 38 |
| 2014 Agosto | 33 | 16 | 49 |
| 2014 Julio | 27 | 13 | 40 |
| 2014 Junio | 41 | 15 | 56 |
| 2014 Mayo | 45 | 14 | 59 |
| 2014 Abril | 49 | 12 | 61 |
| 2014 Marzo | 56 | 22 | 78 |
| 2014 Febrero | 37 | 14 | 51 |
| 2014 Enero | 32 | 15 | 47 |
| 2013 Diciembre | 38 | 9 | 47 |
| 2013 Noviembre | 29 | 17 | 46 |
| 2013 Octubre | 23 | 19 | 42 |
| 2013 Septiembre | 33 | 23 | 56 |
| 2013 Agosto | 17 | 19 | 36 |
| 2013 Julio | 29 | 46 | 75 |
| 2013 Junio | 22 | 29 | 51 |
| 2013 Mayo | 18 | 28 | 46 |
| 2013 Abril | 28 | 30 | 58 |
| 2013 Marzo | 40 | 26 | 66 |
| 2013 Febrero | 18 | 14 | 32 |
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