Original article
Immunization and Bacterial Pathogens in the Oropharynx as Risk Factors for Alopecia Areata
Inmunizaciones y bacterias patógenas en la faringe como factores de riesgo para alopecia areata
M.A. Morales-Sánchez
, M.A. Domínguez-Gómez, F. Jurado-Santa Cruz, M.L. Peralta-Pedrero
Autor para correspondencia
Centro Dermatológico Dr. Ladislao de la Pascua, Mexico City, Mexico
Leído
6113
Vecesse ha leído el artículo
2629
Total PDF
3484
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1578219010706673" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70667-3" "estado" => "S300" "fechaPublicacion" => "2010-06-01" "aid" => "70667" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2010;101:437-43" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2614 "formatos" => array:3 [ "EPUB" => 41 "HTML" => 1660 "PDF" => 913 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219010706685" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70668-5" "estado" => "S300" "fechaPublicacion" => "2010-06-01" "aid" => "70668" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2010;101:444-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2324 "formatos" => array:3 [ "EPUB" => 42 "HTML" => 1452 "PDF" => 830 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Cutaneous Collagenous Vasculopathy: A Case Report and Review of the Literature" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "444" "paginaFinal" => "447" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vasculopatía colágena cutánea: aportación de un caso y revisión de la literatura" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Monteagudo, J. Pérez-Valcárcel, A. Ramírez-Santos, M. Cabanillas, Ó. Suárez-Amor" "autores" => array:5 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "Monteagudo" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Pérez-Valcárcel" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Ramírez-Santos" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Cabanillas" ] 4 => array:2 [ "nombre" => "Ó." "apellidos" => "Suárez-Amor" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706685?idApp=UINPBA000044" "url" => "/15782190/0000010100000005/v1_201304241523/S1578219010706685/v1_201304241523/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219010706661" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70666-1" "estado" => "S300" "fechaPublicacion" => "2010-06-01" "aid" => "70666" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2010;101:428-36" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1914 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1240 "PDF" => 630 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Sentinel Lymph Node Biopsy in Patients With Melanoma" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "428" "paginaFinal" => "436" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La técnica del ganglio centinela en pacientes con melanoma" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Tomás-Mallebrera, R. Rojo-España, A. Marquina-Vila, N. Gimeno-Clemente, M.M. Morales-Suárez-Varela" "autores" => array:5 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Tomás-Mallebrera" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Rojo-España" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Marquina-Vila" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Gimeno-Clemente" ] 4 => array:2 [ "nombre" => "M.M." "apellidos" => "Morales-Suárez-Varela" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706661?idApp=UINPBA000044" "url" => "/15782190/0000010100000005/v1_201304241523/S1578219010706661/v1_201304241523/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Immunization and Bacterial Pathogens in the Oropharynx as Risk Factors for Alopecia Areata" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "437" "paginaFinal" => "443" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.A. Morales-Sánchez, M.A. Domínguez-Gómez, F. Jurado-Santa Cruz, M.L. Peralta-Pedrero" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M.A." "apellidos" => "Morales-Sánchez" "email" => array:1 [ 0 => "marthams@prodigy.net.mx" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Domínguez-Gómez" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Jurado-Santa Cruz" ] 3 => array:2 [ "nombre" => "M.L." "apellidos" => "Peralta-Pedrero" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Centro Dermatológico Dr. Ladislao de la Pascua, Mexico City, Mexico" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Inmunizaciones y bacterias patógenas en la faringe como factores de riesgo para alopecia areata" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-06-15" "fechaAceptado" => "2009-12-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84772" "palabras" => array:5 [ 0 => "Alopecia areata" 1 => "Immunization" 2 => "Bacterial colonization" 3 => "Pharynx" 4 => "<span class="elsevierStyleItalic">Streptococcus pyogenes</span> carriage" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84773" "palabras" => array:4 [ 0 => "Alopecia areata" 1 => "Inmunizaciones" 2 => "Bacterias en la faringe" 3 => "Estado de portador de <span class="elsevierStyleItalic">S. pyogenes</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Alopecia areata is an autoimmune inflammatory disease affecting the hair follicles. Researchers are currently interested in whether the presence of bacterial pathogens and/or a history of immunization can trigger an autoimmune response in patients who are genetically predisposed.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">This study aimed to determine whether there is an association between the development of alopecia areata and throat carriage of bacterial pathogens or a history of immunization.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Sixty-five men and women with alopecia areata and 65 control patients with other skin diseases were studied at the Dr Ladislao de la Pascua Dermatology Clinic between September 2008 and February 2009. The patients ranged in age from 18 to 59 years. Patients with scalp diseases were excluded from the control group. In all cases, the patient was questioned about immunizations received in the previous 6 months, and a throat swab was cultured.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A history of immunization (odds ratio [OR], 3.3; 1.6% confidence interval [CI], 1.6-6.7; <span class="elsevierStyleItalic">P</span>=.001), the presence of bacterial pathogens in the oropharynx (OR, 2.6; 95% CI, 1.1-6.2; <span class="elsevierStyleItalic">P</span>=.033), and being a carrier of Streptococcus pyogenes (OR, 2.1; 95% CI, 1.7-2.5; <span class="elsevierStyleItalic">P</span>=.042) were risk factors for alopecia areata. <span class="elsevierStyleItalic">Klebsiella pneumoniae, S pyogenes, Pseudomonas aeruginosa, Streptococcus pneumoniae, Serratia marcescens</span> and <span class="elsevierStyleItalic">Escherichia coli</span> were isolated from cultures.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">This is the first study to show an association between alopecia areata and throat carriage of bacterial pathogens or history of immunization, as risk factors for development of the disease. Given the characteristics of our study population, the association appears valid for patients with less than 25% hair loss and a course of disease under 1 year.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La alopecia areata es una enfermedad inflamatoria autoinmune que afecta al pelo. Actualmente se estudia si las bacterias patógenas y las inmunizaciones son inductores de la respuesta autoinmune en pacientes con susceptibilidad genética.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio fue determinar si las bacterias patógenas en la faringe y el antecedente de haber recibido inmunizaciones están asociados a la enfermedad.</p> <span class="elsevierStyleSectionTitle">Materiales y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">En el Centro Dermatológico «Dr. Ladislao de la Pascua», desde septiembre de 2008 a febrero de 2009, se estudiaron 65 pacientes con alopecia areata y 65 controles con otras dermatosis, excluyendo las del cuero cabelludo. Se incluyeron pacientes de 18 a 59 años de edad y de ambos sexos. A todos se les interrogó sobre inmunizaciones recibidas 6 meses antes y se les realizó un cultivo de exudado faríngeo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Haber recibido inmunizaciones, la presencia de bacterias patógenas en la faringe y ser portador de <span class="elsevierStyleItalic">S. pyogenes</span> se comportaron como factores de riesgo para la alopecia areata, con una razón de probabilidades de 3,3 (IC 95% 1,6-6,7; p = 0,001), 2,6 (IC 95%: 1,1-6,2; p = 0,033) y 2,1 (IC 95% 1,7-2,5; p = 0,042), respectivamente. Las bacterias aisladas fueron <span class="elsevierStyleItalic">Klebiella penumoniae, Streptococcus pyogenes, Pseudomonas aeruginosa, Streptococcus pneumoniae, Serratia marcescens</span> y <span class="elsevierStyleItalic">Escherichia coli</span>.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Este es el primer estudio que apoya los hallazgos de estado de portador de bacterias patógenas en la faringe y la aplicación de inmunizaciones como factores de riesgo para desarrollar alopecia areata. Por las características de nuestra población, esta asociación es válida para los pacientes con menos del 25% de pérdida de pelo y con una evolución inferior a un año.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is alopecia areata an autoimmune disease?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.A. Randall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2001" "volumen" => "9297" "paginaInicial" => "1922" "paginaFinal" => "1924" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alopecia areata: a tissue specific autoimmune disease of the hair follicle" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Gilhar" 1 => "R.S. Kalish" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Autoimmunity Rev" "fecha" => "2006" "volumen" => "5" "paginaInicial" => "64" "paginaFinal" => "69" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.H. Safavi" 1 => "S.A. Muller" 2 => "A.N. Moshell" 3 => "R.J. Melton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0025-6196(11)63913-X" "Revista" => array:6 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "1995" "volumen" => "70" "paginaInicial" => "628" "paginaFinal" => "633" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7791384" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphocytes, neuropeptides, and genes involved in alopecia areata" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Gilhar" 1 => "R. Paus" 2 => "R.S. Kalish" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI31942" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "2007" "volumen" => "117" "paginaInicial" => "2019" "paginaFinal" => "2027" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17671634" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.W. Colombe" 1 => "C.D. Lou" 2 => "V.H. Price" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Invest Dermatol Symposium Proc" "fecha" => "1999" "volumen" => "4" "paginaInicial" => "216" "paginaFinal" => "219" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alopecia areata, stress and psychiatric disorders: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. García-Hernández" 1 => "S. Ruiz-Doblado" 2 => "A. Rodríguez-Pichardo" 3 => "F. Camacho" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "1999" "volumen" => "26" "paginaInicial" => "625" "paginaFinal" => "632" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10554427" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of infections in the pathogenesis of autoimmune diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Samarkos" 1 => "G. Vaiopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Drug Targets Inflamm Allergy" "fecha" => "2005" "volumen" => "4" "paginaInicial" => "99" "paginaFinal" => "103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15720242" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular mimicry: Structural camouflage of proteins and nucleic acids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.A. Tsonis" 1 => "B. Dwivedi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bbamcr.2007.11.001" "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "2008" "volumen" => "1783" "paginaInicial" => "177" "paginaFinal" => "187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18068679" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms for the induction of autoimmunity by infectious agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.W. Wucherpfennig" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI14235" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "2001" "volumen" => "108" "paginaInicial" => "1097" "paginaFinal" => "1104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11602615" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alopecia areata and cytomegalovirus infection in twins: Genes versus environment?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Jackow" 1 => "D. Pharm" 2 => "N. Buffer" 3 => "M. Hordinsky" 4 => "J. Nelson" 5 => "J. Tarrand" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1998" "volumen" => "38" "paginaInicial" => "418" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9520023" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Murine cytomegalovirus is not associated with alopecia areata in C3H/HeJ mice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.J. McElwee" 1 => "D. Boggess" 2 => "B. Burgett" 3 => "R. Bates" 4 => "H.G. Bedigan" 5 => "J.P. Sundberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.1998.00207.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "1998" "volumen" => "110" "paginaInicial" => "986" "paginaFinal" => "987" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9620311" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of cytomegalovirus replication in alopecia areata pathogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Ofidani" 1 => "P. Amerio" 2 => "M.L. Bernardino" 3 => "C. Feliciani" 4 => "G. Bossi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Med Surg" "fecha" => "2000" "volumen" => "4" "paginaInicial" => "63" "paginaFinal" => "65" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11179926" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Onset of alopecia areata alter Epstein-Barr virus infectious mononucleosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.A. Rodríguez" 1 => "M. Duvic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2008.02.005" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2008" "volumen" => "59" "paginaInicial" => "137" "paginaFinal" => "139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18329131" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "There is no relationship between hepatitis C virus and alopecia areata" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Z. Jadali" 1 => "O. Mansouri" 2 => "F. Jadali" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2006" "volumen" => "16" "paginaInicial" => "94" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16491522" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "No increased prevalence of Helicobacter pylori in patients with alopecia areata" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Rigopoulos" 1 => "A. Katsambas" 2 => "A. Karalexis" 3 => "G. Papatheodorou" 4 => "T. Rokkas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2002" "volumen" => "46" "paginaInicial" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11756964" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bacterial superantigens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Proft" 1 => "J.D. Fraser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Immunol" "fecha" => "2003" "volumen" => "133" "paginaInicial" => "299" "paginaFinal" => "306" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12930353" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia de portación asintomática del estreptococo beta hemolítico del grupo A" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Giannelli" 1 => "G.R. Posse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Argent Pediatr" "fecha" => "2007" "volumen" => "105" "paginaInicial" => "221" "paginaFinal" => "224" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic pharyngeal carriage of group A streptococci" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.R. Tanz" 1 => "S.T. Shulman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.inf.0000255328.19808.be" "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "2007" "volumen" => "26" "paginaInicial" => "175" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17259882" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharyngeal carriage of group A streptococci in school children in Chennai" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.A. Lloyd" 1 => "S.E. Jacob" 2 => "T. Menon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Indian J Med Res" "fecha" => "2006" "volumen" => "124" "paginaInicial" => "195" "paginaFinal" => "198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17015934" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and treatment of streptococcal pharyngitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.A. Choby" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Fam Physician" "fecha" => "2009" "volumen" => "79" "paginaInicial" => "383" "paginaFinal" => "390" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19275067" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Defining and dealing with carriers of group A streptococci" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.E. Pichichero" 1 => "J.R. Casey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Contemporary Pediatr" "fecha" => "2003" "volumen" => "20" "paginaInicial" => "46" "paginaFinal" => "56" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Flora normal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.F. Brooks" 1 => "J.S. Butel" 2 => "S.A. Morse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Microbiología médica de Jawetz, Melnick y Adelberg" "paginaInicial" => "218" "paginaFinal" => "219" "edicion" => "16 ed." "serieFecha" => "1998" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vacunación en el adulto" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.A. Gómez-Samano" 1 => "R.A. Bourlon-Cuéllar" 2 => "M.T. Bourlon" 3 => "O.F. Coronel-Ayala" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Int Mex" "fecha" => "2007" "volumen" => "23" "paginaInicial" => "408" "paginaFinal" => "414" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alopecia areata investigational assessment guidelines-Part II" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.A. Olsen" 1 => "M.K. Hordinsky" 2 => "V.H. Price" 3 => "J.L. Roberts" 4 => "J. Shapiro" 5 => "D. Canfield" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2003.09.032" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2004" "volumen" => "51" "paginaInicial" => "440" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15337988" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multivariate analysis in alopecia areata: risk factors and validity of clinical forms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.J. García-Hernández" 1 => "A. Rodríguez-Pichardo" 2 => "F. Camacho" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1999" "volumen" => "135" "paginaInicial" => "998" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10456364" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A clinical study of alopecia areata in Mexico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.A. Guzmán-Sánchez" 1 => "G.D. Villanueva-Qintero" 2 => "N.A. Alfaro" 3 => "A. McMichel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2007.03378.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "1310" "paginaFinal" => "1312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18173533" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Profile of alopecia areata in northern India" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V.K. Sharma" 1 => "G. Dawn" 2 => "B. Kumar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "22" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8838924" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alopecia areata: a long term follow-up study of 191 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Tosti" 1 => "S. Bellavista" 2 => "M. Iorizzo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2006.05.008" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2006" "volumen" => "55" "paginaInicial" => "438" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16908349" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Magnúsdóttir BT, Jónsson JS, Kristinsson KG. Algengi <span class="elsevierStyleItalic">Streptococcus pyogenes</span> og methisillín ónæmra <span class="elsevierStyleItalic">Staphylococcus aureus</span> í hálsi heilbrigðra barna í Garðabæ Laeknabladid. 2008; 94:447-51." ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic plaque psoriasis: streptococcus pyogenes throat carriage rate and therapeutic response to oral antibiotics in comparison with oral methotrexate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Raza" 1 => "M. Usman" 2 => "A. Hameed" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "12.2007/JCPSP.717720" "Revista" => array:6 [ "tituloSerie" => "J Coll Physicians Surg Pak" "fecha" => "2007" "volumen" => "17" "paginaInicial" => "717" "paginaFinal" => "720" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18182134" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hair loss after routine immunizations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.P. Wise" 1 => "K.P. Kiminyo" 2 => "M.E. Salive" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1997" "volumen" => "278" "paginaInicial" => "1176" "paginaFinal" => "1178" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9326478" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination as an additional player in the mosaic of autoimmunity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Schoenfeld" 1 => "A. Aharon-Maor" 2 => "Y. Sherer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "181" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10812488" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination and autoimmunity-“vaccinosis”: a dangerous liaison?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Schoenfeld" 1 => "A. Aron-Maor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Autoimmunity" "fecha" => "2000" "volumen" => "14" "paginaInicial" => "1" "paginaFinal" => "10" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case-control study of serious autoimmune adverse events following hepatitis B immunization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.A. Geier" 1 => "M.R. Geier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Autoimmunity" "fecha" => "2005" "volumen" => "38" "paginaInicial" => "295" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16206512" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P. Sundberg" 1 => "K.A. Silva" 2 => "W. Zhang" 3 => "B.A. Sundberg" 4 => "K. Edwards" 5 => "L.E. King" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "ESVD ACVD" "fecha" => "2009" "volumen" => "20" "paginaInicial" => "99" "paginaFinal" => "104" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000005/v1_201304241523/S1578219010706673/v1_201304241523/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000005/v1_201304241523/S1578219010706673/v1_201304241523/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706673?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 12 | 17 |
| 2024 Octubre | 63 | 54 | 117 |
| 2024 Septiembre | 63 | 29 | 92 |
| 2024 Agosto | 109 | 66 | 175 |
| 2024 Julio | 60 | 33 | 93 |
| 2024 Junio | 65 | 37 | 102 |
| 2024 Mayo | 63 | 39 | 102 |
| 2024 Abril | 44 | 24 | 68 |
| 2024 Marzo | 58 | 36 | 94 |
| 2024 Febrero | 45 | 38 | 83 |
| 2024 Enero | 49 | 31 | 80 |
| 2023 Diciembre | 47 | 29 | 76 |
| 2023 Noviembre | 47 | 29 | 76 |
| 2023 Octubre | 55 | 37 | 92 |
| 2023 Septiembre | 50 | 40 | 90 |
| 2023 Agosto | 28 | 18 | 46 |
| 2023 Julio | 50 | 49 | 99 |
| 2023 Junio | 41 | 24 | 65 |
| 2023 Mayo | 31 | 29 | 60 |
| 2023 Abril | 20 | 21 | 41 |
| 2023 Marzo | 25 | 21 | 46 |
| 2023 Febrero | 27 | 19 | 46 |
| 2023 Enero | 29 | 24 | 53 |
| 2022 Diciembre | 37 | 34 | 71 |
| 2022 Noviembre | 15 | 27 | 42 |
| 2022 Octubre | 15 | 15 | 30 |
| 2022 Septiembre | 20 | 32 | 52 |
| 2022 Agosto | 17 | 27 | 44 |
| 2022 Julio | 16 | 30 | 46 |
| 2022 Junio | 13 | 37 | 50 |
| 2022 Mayo | 22 | 31 | 53 |
| 2022 Abril | 32 | 25 | 57 |
| 2022 Marzo | 17 | 51 | 68 |
| 2022 Febrero | 28 | 24 | 52 |
| 2022 Enero | 18 | 31 | 49 |
| 2021 Diciembre | 18 | 43 | 61 |
| 2021 Noviembre | 26 | 44 | 70 |
| 2021 Octubre | 23 | 56 | 79 |
| 2021 Septiembre | 22 | 49 | 71 |
| 2021 Agosto | 11 | 28 | 39 |
| 2021 Julio | 15 | 33 | 48 |
| 2021 Junio | 17 | 23 | 40 |
| 2021 Mayo | 16 | 28 | 44 |
| 2021 Abril | 34 | 48 | 82 |
| 2021 Marzo | 41 | 24 | 65 |
| 2021 Febrero | 63 | 32 | 95 |
| 2021 Enero | 40 | 23 | 63 |
| 2020 Diciembre | 23 | 13 | 36 |
| 2020 Noviembre | 18 | 28 | 46 |
| 2020 Octubre | 21 | 16 | 37 |
| 2020 Septiembre | 15 | 10 | 25 |
| 2020 Agosto | 20 | 17 | 37 |
| 2020 Julio | 16 | 18 | 34 |
| 2020 Junio | 18 | 20 | 38 |
| 2020 Mayo | 16 | 15 | 31 |
| 2020 Abril | 9 | 20 | 29 |
| 2020 Marzo | 18 | 24 | 42 |
| 2020 Febrero | 0 | 1 | 1 |
| 2020 Enero | 0 | 4 | 4 |
| 2019 Diciembre | 0 | 6 | 6 |
| 2019 Noviembre | 0 | 5 | 5 |
| 2019 Octubre | 0 | 13 | 13 |
| 2019 Septiembre | 0 | 5 | 5 |
| 2019 Agosto | 0 | 6 | 6 |
| 2019 Julio | 0 | 13 | 13 |
| 2019 Junio | 0 | 3 | 3 |
| 2019 Mayo | 0 | 39 | 39 |
| 2019 Abril | 0 | 9 | 9 |
| 2019 Marzo | 0 | 6 | 6 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Mayo | 0 | 7 | 7 |
| 2018 Abril | 0 | 3 | 3 |
| 2018 Marzo | 1 | 2 | 3 |
| 2018 Febrero | 13 | 3 | 16 |
| 2018 Enero | 11 | 3 | 14 |
| 2017 Diciembre | 18 | 12 | 30 |
| 2017 Noviembre | 17 | 6 | 23 |
| 2017 Octubre | 23 | 6 | 29 |
| 2017 Septiembre | 28 | 8 | 36 |
| 2017 Agosto | 38 | 8 | 46 |
| 2017 Julio | 25 | 2 | 27 |
| 2017 Junio | 37 | 20 | 57 |
| 2017 Mayo | 44 | 18 | 62 |
| 2017 Abril | 44 | 22 | 66 |
| 2017 Marzo | 49 | 33 | 82 |
| 2017 Febrero | 26 | 6 | 32 |
| 2017 Enero | 15 | 9 | 24 |
| 2016 Diciembre | 24 | 14 | 38 |
| 2016 Noviembre | 17 | 17 | 34 |
| 2016 Octubre | 29 | 34 | 63 |
| 2016 Septiembre | 34 | 8 | 42 |
| 2016 Agosto | 35 | 9 | 44 |
| 2016 Julio | 24 | 6 | 30 |
| 2016 Junio | 10 | 8 | 18 |
| 2016 Mayo | 8 | 10 | 18 |
| 2016 Abril | 7 | 7 | 14 |
| 2016 Marzo | 4 | 5 | 9 |
| 2016 Febrero | 6 | 1 | 7 |
| 2016 Enero | 5 | 2 | 7 |
| 2015 Diciembre | 15 | 1 | 16 |
| 2015 Noviembre | 3 | 1 | 4 |
| 2015 Octubre | 7 | 1 | 8 |
| 2015 Septiembre | 4 | 4 | 8 |
| 2015 Agosto | 24 | 2 | 26 |
| 2015 Julio | 34 | 3 | 37 |
| 2015 Junio | 30 | 9 | 39 |
| 2015 Mayo | 57 | 15 | 72 |
| 2015 Abril | 38 | 10 | 48 |
| 2015 Marzo | 69 | 12 | 81 |
| 2015 Febrero | 23 | 13 | 36 |
| 2015 Enero | 29 | 12 | 41 |
| 2014 Diciembre | 26 | 18 | 44 |
| 2014 Noviembre | 21 | 23 | 44 |
| 2014 Octubre | 27 | 34 | 61 |
| 2014 Septiembre | 24 | 19 | 43 |
| 2014 Agosto | 27 | 13 | 40 |
| 2014 Julio | 36 | 20 | 56 |
| 2014 Junio | 38 | 12 | 50 |
| 2014 Mayo | 40 | 10 | 50 |
| 2014 Abril | 40 | 7 | 47 |
| 2014 Marzo | 50 | 19 | 69 |
| 2014 Febrero | 42 | 20 | 62 |
| 2014 Enero | 33 | 13 | 46 |
| 2013 Diciembre | 29 | 10 | 39 |
| 2013 Noviembre | 28 | 19 | 47 |
| 2013 Octubre | 25 | 15 | 40 |
| 2013 Septiembre | 40 | 22 | 62 |
| 2013 Agosto | 30 | 17 | 47 |
| 2013 Julio | 35 | 23 | 58 |
| 2013 Junio | 36 | 26 | 62 |
| 2013 Mayo | 25 | 25 | 50 |
| 2013 Abril | 31 | 28 | 59 |
| 2013 Marzo | 35 | 21 | 56 |
| 2013 Febrero | 17 | 14 | 31 |
Mostrar todo
