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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The incidence of melanoma is currently increasing worldwide&#46; One of the factors influencing disease prognosis is the presence of regional lymph node metastases&#46; Sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease&#46; The aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease prognosis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Sentinel lymph node biopsy was carried out in patients with melanoma of the following characteristics&#58; Breslow thickness &#8805;1mm&#44; Breslow thickness &#60;1mm with ulceration&#44; Clark level IV&#8211;V&#44; or regression&#46; Lymphadenectomy was performed in patients with positive sentinel node biopsy&#46; Data were also collected on the following variables&#58; sex&#44; age&#44; skin phototype&#44; site and type of melanoma&#44; Breslow thickness&#44; Clark level&#44; ulceration&#44; regression&#44; cancer stage at diagnosis&#44; TNM classification&#44; change in cancer stage during follow-up&#44; and death due to melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Positive sentinel node biopsies were recorded in 19&#46;44&#37; of patients&#46; Positive results were associated with the following variables&#58; nodular melanoma &#40;crude odds ratio &#91;ORc&#93; compared with superficial spreading melanoma&#44; 3&#46;44&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;33&#8211;8&#46;90&#41;&#59; Breslow thickness &#62;2&#46;0&#44; for a thickness of 2&#46;1&#8211;4&#46;0 &#40;ORc&#44; 21&#46;12&#59; 95&#37; CI&#44; 2&#46;60&#8211;172&#46;03&#41; and for a thickness &#62;4&#46;0 &#40;ORc&#44; 23&#46;25&#59; 95&#37; CI&#44; 2&#46;44&#8211;221&#46;73&#41;&#59; Clark level IV &#40;ORc&#44; 8&#46;73&#59; 95&#37; CI&#44; 1&#46;03&#8211;74&#46;12&#41;&#59; ulceration &#40;ORc&#44; 4&#46;86&#59; 95&#37; CI&#44; 1&#46;58&#8211;14&#46;90&#41;&#59; T3 &#40;ORc&#44; 4&#46;20&#59; 95&#37; CI&#44; 1&#46;52&#8211;11&#46;63&#41; and T4 &#40;ORc&#44; 4&#46;67&#59; 95&#37; CI&#44; 1&#46;27&#8211;17&#46;15&#41; in the TNM classification&#59; change in cancer stage during follow-up &#40;ORc&#44; 7&#46;20&#59; 95&#37; CI&#44; 2&#46;25&#8211;22&#46;99&#41;&#59; and death due to melanoma &#40;ORc&#44; 8&#46;67&#59; 95&#37; CI&#44; 3&#46;62&#8211;96&#46;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">These results confirm the prognostic importance of sentinel lymph node biopsy&#44; which facilitates identification of patients with a greater tendency towards disease progression and death due to melanoma&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Actualmente existe un aumento mundial de la incidencia de melanoma&#46; Su pron&#243;stico depende entre otros factores de la existencia de met&#225;stasis en los ganglios linf&#225;ticos regionales&#46; La realizaci&#243;n de la biopsia del ganglio centinela persigue la identificaci&#243;n de met&#225;stasis ganglionares subcl&#237;nicas como factor pron&#243;stico de la enfermedad&#46; El presente estudio tiene por objetivo estudiar las diferencias entre los pacientes con melanoma&#44; positivos y negativos a la biopsia del ganglio centinela&#44; y analizar el impacto de esta t&#233;cnica en su pron&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; biopsia del ganglio centinela a los pacientes con melanomas de espesor Breslow &#8805; 1 mm o con Breslow &#60; 1 mm y ulceraci&#243;n&#44; nivel de Clark IV&#8211;V o regresi&#243;n&#46; Aquellos con biopsia positiva fueron sometidos a linfadenectom&#237;a&#46; Adem&#225;s&#44; se recogieron las siguientes variables&#58; sexo&#44; edad&#44; fototipo&#44; localizaci&#243;n y tipo de melanoma&#44; niveles Breslow y Clark&#44; ulceraci&#243;n&#44; regresi&#243;n&#44; estadio inicial&#44; TNM&#44; cambio de estadio y fallecimiento por melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El 19&#44;44&#37; de los pacientes present&#243; ganglios positivos&#46; Esta positividad se present&#243; asociada con el melanoma nodular &#40;odds ratio cruda &#91;ORc&#93;&#58; 3&#44;44&#59; intervalo de confianza al 95&#37; &#91;IC 95&#37;&#93;&#58; 1&#44;33&#8211;8&#44;90&#41; con respecto al melanoma de extensi&#243;n superficial Breslow superior a 2&#44;0 &#40;nivel 2&#44;1&#8211;4&#44;0&#58; ORc&#58; 21&#44;14&#59; IC 95&#37;&#58; 2&#44;60&#8211;172&#44;03&#44; nivel &#62; 4&#44;0&#58; ORc&#58; 23&#44;25&#59; IC 95&#37;&#58; 2&#44;44&#8211;221&#44;73&#41;&#44; nivel Clark IV &#40;ORc&#58; 8&#44;73&#59; IC 95&#37; 1&#44;03&#8211;74&#44;12&#41;&#44; ulceraci&#243;n &#40;ORc&#58; 4&#44;86&#59; IC 95&#37;&#58; 1&#44;58&#8211;14&#44;90&#41;&#44; estadios T3 y T4 &#40;T3&#58; ORc&#58; 4&#44;20&#59; IC 95&#37;&#58; 1&#44;52&#8211;11&#44;63&#59; T4&#58; ORc&#58; 4&#44;67&#59; IC 95&#37; 1&#44;27&#8211;17&#44;15&#41;&#44; cambio de estadio &#40;ORc&#58; 7&#44;20&#59; IC 95&#37;&#58; 2&#44;25&#8211;22&#44;99&#41; y fallecimiento por melanoma &#40;ORc&#58; 8&#44;67&#59; IC 95&#37;&#58; 3&#44;62&#8211;96&#44;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estos resultados confirman la importancia pron&#243;stica de la biopsia del ganglio centinela&#44; que permite identificar a los pacientes con mayor tendencia a la progresi&#243;n de la enfermedad y fallecimiento por melanoma&#46;</p>"
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Original article
Sentinel Lymph Node Biopsy in Patients With Melanoma
La técnica del ganglio centinela en pacientes con melanoma
L. Tomás-Mallebreraa, R. Rojo-Españaa, A. Marquina-Vilaa, N. Gimeno-Clementeb,c, M.M. Morales-Suárez-Varelab,c,d,
Autor para correspondencia
maria.m.morales@uv.es

Corresponding author.
a Servicio de Dermatología, Hospital Universitario Dr. Peset, Valencia, Spain
b CIBER Epidemiología y Salud Pública (CIBERESP), Spain
c Unidad de Salud Pública, Higiene y Sanidad Ambiental, Departamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Toxicología y Medicina Legal, Universidad de Valencia, Spain
d Fundación de la Comunidad Valenciana para la Investigación, Hospital Universitario Dr. Peset, Valencia, Spain
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The incidence of melanoma is currently increasing worldwide&#46; One of the factors influencing disease prognosis is the presence of regional lymph node metastases&#46; Sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease&#46; The aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease prognosis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Sentinel lymph node biopsy was carried out in patients with melanoma of the following characteristics&#58; Breslow thickness &#8805;1mm&#44; Breslow thickness &#60;1mm with ulceration&#44; Clark level IV&#8211;V&#44; or regression&#46; Lymphadenectomy was performed in patients with positive sentinel node biopsy&#46; Data were also collected on the following variables&#58; sex&#44; age&#44; skin phototype&#44; site and type of melanoma&#44; Breslow thickness&#44; Clark level&#44; ulceration&#44; regression&#44; cancer stage at diagnosis&#44; TNM classification&#44; change in cancer stage during follow-up&#44; and death due to melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Positive sentinel node biopsies were recorded in 19&#46;44&#37; of patients&#46; Positive results were associated with the following variables&#58; nodular melanoma &#40;crude odds ratio &#91;ORc&#93; compared with superficial spreading melanoma&#44; 3&#46;44&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;33&#8211;8&#46;90&#41;&#59; Breslow thickness &#62;2&#46;0&#44; for a thickness of 2&#46;1&#8211;4&#46;0 &#40;ORc&#44; 21&#46;12&#59; 95&#37; CI&#44; 2&#46;60&#8211;172&#46;03&#41; and for a thickness &#62;4&#46;0 &#40;ORc&#44; 23&#46;25&#59; 95&#37; CI&#44; 2&#46;44&#8211;221&#46;73&#41;&#59; Clark level IV &#40;ORc&#44; 8&#46;73&#59; 95&#37; CI&#44; 1&#46;03&#8211;74&#46;12&#41;&#59; ulceration &#40;ORc&#44; 4&#46;86&#59; 95&#37; CI&#44; 1&#46;58&#8211;14&#46;90&#41;&#59; T3 &#40;ORc&#44; 4&#46;20&#59; 95&#37; CI&#44; 1&#46;52&#8211;11&#46;63&#41; and T4 &#40;ORc&#44; 4&#46;67&#59; 95&#37; CI&#44; 1&#46;27&#8211;17&#46;15&#41; in the TNM classification&#59; change in cancer stage during follow-up &#40;ORc&#44; 7&#46;20&#59; 95&#37; CI&#44; 2&#46;25&#8211;22&#46;99&#41;&#59; and death due to melanoma &#40;ORc&#44; 8&#46;67&#59; 95&#37; CI&#44; 3&#46;62&#8211;96&#46;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">These results confirm the prognostic importance of sentinel lymph node biopsy&#44; which facilitates identification of patients with a greater tendency towards disease progression and death due to melanoma&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Actualmente existe un aumento mundial de la incidencia de melanoma&#46; Su pron&#243;stico depende entre otros factores de la existencia de met&#225;stasis en los ganglios linf&#225;ticos regionales&#46; La realizaci&#243;n de la biopsia del ganglio centinela persigue la identificaci&#243;n de met&#225;stasis ganglionares subcl&#237;nicas como factor pron&#243;stico de la enfermedad&#46; El presente estudio tiene por objetivo estudiar las diferencias entre los pacientes con melanoma&#44; positivos y negativos a la biopsia del ganglio centinela&#44; y analizar el impacto de esta t&#233;cnica en su pron&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; biopsia del ganglio centinela a los pacientes con melanomas de espesor Breslow &#8805; 1 mm o con Breslow &#60; 1 mm y ulceraci&#243;n&#44; nivel de Clark IV&#8211;V o regresi&#243;n&#46; Aquellos con biopsia positiva fueron sometidos a linfadenectom&#237;a&#46; Adem&#225;s&#44; se recogieron las siguientes variables&#58; sexo&#44; edad&#44; fototipo&#44; localizaci&#243;n y tipo de melanoma&#44; niveles Breslow y Clark&#44; ulceraci&#243;n&#44; regresi&#243;n&#44; estadio inicial&#44; TNM&#44; cambio de estadio y fallecimiento por melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El 19&#44;44&#37; de los pacientes present&#243; ganglios positivos&#46; Esta positividad se present&#243; asociada con el melanoma nodular &#40;odds ratio cruda &#91;ORc&#93;&#58; 3&#44;44&#59; intervalo de confianza al 95&#37; &#91;IC 95&#37;&#93;&#58; 1&#44;33&#8211;8&#44;90&#41; con respecto al melanoma de extensi&#243;n superficial Breslow superior a 2&#44;0 &#40;nivel 2&#44;1&#8211;4&#44;0&#58; ORc&#58; 21&#44;14&#59; IC 95&#37;&#58; 2&#44;60&#8211;172&#44;03&#44; nivel &#62; 4&#44;0&#58; ORc&#58; 23&#44;25&#59; IC 95&#37;&#58; 2&#44;44&#8211;221&#44;73&#41;&#44; nivel Clark IV &#40;ORc&#58; 8&#44;73&#59; IC 95&#37; 1&#44;03&#8211;74&#44;12&#41;&#44; ulceraci&#243;n &#40;ORc&#58; 4&#44;86&#59; IC 95&#37;&#58; 1&#44;58&#8211;14&#44;90&#41;&#44; estadios T3 y T4 &#40;T3&#58; ORc&#58; 4&#44;20&#59; IC 95&#37;&#58; 1&#44;52&#8211;11&#44;63&#59; T4&#58; ORc&#58; 4&#44;67&#59; IC 95&#37; 1&#44;27&#8211;17&#44;15&#41;&#44; cambio de estadio &#40;ORc&#58; 7&#44;20&#59; IC 95&#37;&#58; 2&#44;25&#8211;22&#44;99&#41; y fallecimiento por melanoma &#40;ORc&#58; 8&#44;67&#59; IC 95&#37;&#58; 3&#44;62&#8211;96&#44;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estos resultados confirman la importancia pron&#243;stica de la biopsia del ganglio centinela&#44; que permite identificar a los pacientes con mayor tendencia a la progresi&#243;n de la enfermedad y fallecimiento por melanoma&#46;</p>"
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2023 Julio 28 64 92
2023 Junio 40 35 75
2023 Mayo 36 43 79
2023 Abril 26 22 48
2023 Marzo 36 26 62
2023 Febrero 36 33 69
2023 Enero 27 39 66
2022 Diciembre 39 48 87
2022 Noviembre 18 25 43
2022 Octubre 25 15 40
2022 Septiembre 20 37 57
2022 Agosto 22 43 65
2022 Julio 15 35 50
2022 Junio 24 32 56
2022 Mayo 30 49 79
2022 Abril 37 38 75
2022 Marzo 36 55 91
2022 Febrero 21 32 53
2022 Enero 20 50 70
2021 Diciembre 41 47 88
2021 Noviembre 29 51 80
2021 Octubre 28 56 84
2021 Septiembre 23 57 80
2021 Agosto 30 43 73
2021 Julio 18 35 53
2021 Junio 27 48 75
2021 Mayo 33 39 72
2021 Abril 58 50 108
2021 Marzo 77 37 114
2021 Febrero 62 29 91
2021 Enero 34 26 60
2020 Diciembre 31 15 46
2020 Noviembre 22 36 58
2020 Octubre 20 16 36
2020 Septiembre 20 12 32
2020 Agosto 30 26 56
2020 Julio 28 13 41
2020 Junio 30 33 63
2020 Mayo 20 23 43
2020 Abril 22 30 52
2020 Marzo 18 24 42
2020 Febrero 3 0 3
2020 Enero 0 11 11
2019 Diciembre 0 5 5
2019 Noviembre 0 1 1
2019 Septiembre 0 2 2
2019 Julio 0 1 1
2019 Junio 0 5 5
2019 Mayo 1 41 42
2019 Abril 0 7 7
2019 Marzo 0 5 5
2019 Febrero 0 3 3
2018 Marzo 0 1 1
2018 Febrero 13 4 17
2018 Enero 14 2 16
2017 Diciembre 21 7 28
2017 Noviembre 14 4 18
2017 Octubre 12 3 15
2017 Septiembre 16 4 20
2017 Agosto 25 7 32
2017 Julio 16 3 19
2017 Junio 21 8 29
2017 Mayo 16 6 22
2017 Abril 15 2 17
2017 Marzo 16 4 20
2017 Febrero 14 9 23
2017 Enero 19 1 20
2016 Diciembre 18 14 32
2016 Noviembre 13 7 20
2016 Octubre 9 20 29
2016 Septiembre 16 10 26
2016 Agosto 30 4 34
2016 Julio 25 4 29
2016 Junio 10 0 10
2016 Mayo 8 5 13
2016 Abril 7 0 7
2016 Marzo 10 0 10
2016 Febrero 2 2 4
2016 Enero 7 1 8
2015 Diciembre 10 2 12
2015 Noviembre 4 0 4
2015 Octubre 8 1 9
2015 Septiembre 8 4 12
2015 Agosto 13 4 17
2015 Julio 28 12 40
2015 Junio 28 9 37
2015 Mayo 58 15 73
2015 Abril 36 10 46
2015 Marzo 49 8 57
2015 Febrero 20 6 26
2015 Enero 18 12 30
2014 Diciembre 13 5 18
2014 Noviembre 11 4 15
2014 Octubre 29 13 42
2014 Septiembre 20 7 27
2014 Agosto 30 20 50
2014 Julio 36 25 61
2014 Junio 49 6 55
2014 Mayo 35 16 51
2014 Abril 29 8 37
2014 Marzo 39 21 60
2014 Febrero 19 17 36
2014 Enero 34 12 46
2013 Diciembre 26 11 37
2013 Noviembre 19 13 32
2013 Octubre 20 17 37
2013 Septiembre 31 14 45
2013 Agosto 13 19 32
2013 Julio 23 23 46
2013 Junio 19 22 41
2013 Mayo 14 18 32
2013 Abril 25 15 40
2013 Marzo 27 18 45
2013 Febrero 11 10 21
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