Original
ATP-binding Cassette Transporter ABCB5 Gene is Expressed with Variability in Malignant Melanoma
Expresión variable del gen ABCB5 de las transportadoras de casetes de unión a ATP en el melanoma maligno
I. Vásquez-Moctezumaa, M.A. Meraz-Ríosb, C.G. Villanueva-Lópeza, M. Magañac, R. Martínez-Maciasd, D.J. Sánchez-Gonzáleze, F. García-Sierraf, N.E. Herrera-Gonzáleza,
Autor para correspondencia
a Escuela Superior de Medicina, Instituto Politécnico Nacional, México DF, México
b Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México DF, México
c Hospital General de México, Universidad Nacional Autónoma de México (UNAM), México DF, México
d Unidad de Oncología, Hospital General de México, México DF, México
e Escuela Médico Militar, Universidad de Falcan (UDEFA), México DF, México
f Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México DF, México
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Incidence of melanoma varies according to geographic region and genetic background. Epidemiological studies indicate that acral melanoma (AM) is among the most common melanomas in the Mexican population. While extensive studies have identified genes associated with melanoma, little is known about the genes involved in the pathogenesis of AM.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To compare the gene expression patterns between primary melanoma and normal skin.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We used 10 samples of fresh acral melanomas and normal skin for the study of differential gene expression and 22 samples of melanoma for <span class="elsevierStyleItalic">in situ</span> hybridization.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We first identified a gene that was present in a sample of AM and absent in normal skin. DNA sequencing of this differentially expressed gene revealed that it corresponded to ABCB5, a gene recently implicated in the regulation of progenitor cell fusion. Furthermore, we detected ABCB5 expression in other melanoma specimens by RT-PCR. We showed that nine out of ten melanomas were positive for ABCB5 while only one melanoma and normal skin samples were negative. All ABCB5 expressing melanomas had variable gene expression according to <span class="elsevierStyleItalic">in situ</span> hybridization studies, suggesting that the ABCB5 gene may be differentially regulated by individual melanomas.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The ABCB5 gene may be related to the properties of chemoresistance and aggressiveness of melanoma. The high expression found in samples of acral melanoma may provide more insight on the pathogenesis of this common type of melanoma in the Mexican population, frequently associated with poor prognosis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El melanoma es una neoplasia maligna que presenta una elevada mortalidad y un alto riesgo de desarrollar metástasis. La incidencia de esta enfermedad varía en función de la región geográfica y el trasfondo genético. Estudios epidemiológicos indican que el melanoma acral es uno de los más comunes en la población mexicana. Hay una gran cantidad de estudios sobre genes asociados al melanoma, sin embargo, se sabe muy poco de los genes que se relacionan con el melanoma acral.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Comparar el patrón de expresión génica entre melanomas acrales primarios y piel sana.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se utilizaron muestras en fresco de 10 lesiones de melanoma acral y piel sana para el estudio de expresión diferencial de genes y 22 muestras de melanoma para la hibridación <span class="elsevierStyleItalic">in situ.</span></p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Identificamos un gen que estaba presente en una muestra de melanoma acral y ausente en la piel normal. La secuenciación de este gen reveló que correspondía al gen ABCB5, recientemente implicado en la regulación de la fusión de células progenitoras. Al realizar RT-PCR de otros melanomas se detectó la expresión de este gen: 9 de 10 melanomas fueron positivos para ABCB5. Todos los melanomas tuvieron una expresión variable de ABCB5 detectado por hibridación <span class="elsevierStyleItalic">in situ,</span> lo cual sugiere que el gen puede ser regulado diferencialmente en melanomas individuales.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El gen ABCB5 podría estar relacionado con las propiedades de resistencia a la quimioterapia y la agresividad del melanoma. La elevada expresión encontrada en las muestras de melanoma acral podría ayudar a la mejor comprensión de la patogenia de esta forma frecuente de melanoma en la población mexicana, que se asocia generalmente con un peor pronóstico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Lens" 1 => "M. 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| 2024 Agosto | 122 | 75 | 197 |
| 2024 Julio | 67 | 59 | 126 |
| 2024 Junio | 70 | 39 | 109 |
| 2024 Mayo | 61 | 35 | 96 |
| 2024 Abril | 63 | 37 | 100 |
| 2024 Marzo | 52 | 41 | 93 |
| 2024 Febrero | 53 | 41 | 94 |
| 2024 Enero | 44 | 45 | 89 |
| 2023 Diciembre | 52 | 38 | 90 |
| 2023 Noviembre | 43 | 31 | 74 |
| 2023 Octubre | 75 | 46 | 121 |
| 2023 Septiembre | 38 | 30 | 68 |
| 2023 Agosto | 31 | 29 | 60 |
| 2023 Julio | 40 | 53 | 93 |
| 2023 Junio | 37 | 26 | 63 |
| 2023 Mayo | 31 | 23 | 54 |
| 2023 Abril | 27 | 32 | 59 |
| 2023 Marzo | 22 | 57 | 79 |
| 2023 Febrero | 20 | 53 | 73 |
| 2023 Enero | 34 | 39 | 73 |
| 2022 Diciembre | 31 | 52 | 83 |
| 2022 Noviembre | 16 | 38 | 54 |
| 2022 Octubre | 17 | 19 | 36 |
| 2022 Septiembre | 14 | 39 | 53 |
| 2022 Agosto | 19 | 33 | 52 |
| 2022 Julio | 17 | 31 | 48 |
| 2022 Junio | 19 | 28 | 47 |
| 2022 Mayo | 19 | 42 | 61 |
| 2022 Abril | 36 | 48 | 84 |
| 2022 Marzo | 39 | 53 | 92 |
| 2022 Febrero | 23 | 27 | 50 |
| 2022 Enero | 22 | 41 | 63 |
| 2021 Diciembre | 25 | 46 | 71 |
| 2021 Noviembre | 27 | 53 | 80 |
| 2021 Octubre | 37 | 51 | 88 |
| 2021 Septiembre | 23 | 54 | 77 |
| 2021 Agosto | 30 | 37 | 67 |
| 2021 Julio | 24 | 35 | 59 |
| 2021 Junio | 17 | 27 | 44 |
| 2021 Mayo | 29 | 30 | 59 |
| 2021 Abril | 56 | 47 | 103 |
| 2021 Marzo | 83 | 33 | 116 |
| 2021 Febrero | 57 | 23 | 80 |
| 2021 Enero | 27 | 15 | 42 |
| 2020 Diciembre | 20 | 16 | 36 |
| 2020 Noviembre | 20 | 25 | 45 |
| 2020 Octubre | 16 | 5 | 21 |
| 2020 Septiembre | 30 | 14 | 44 |
| 2020 Agosto | 27 | 21 | 48 |
| 2020 Julio | 19 | 13 | 32 |
| 2020 Junio | 24 | 20 | 44 |
| 2020 Mayo | 40 | 20 | 60 |
| 2020 Abril | 22 | 23 | 45 |
| 2020 Marzo | 16 | 16 | 32 |
| 2020 Febrero | 2 | 3 | 5 |
| 2020 Enero | 0 | 4 | 4 |
| 2019 Diciembre | 0 | 10 | 10 |
| 2019 Noviembre | 0 | 2 | 2 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 0 | 3 | 3 |
| 2019 Agosto | 0 | 3 | 3 |
| 2019 Julio | 0 | 7 | 7 |
| 2019 Junio | 0 | 7 | 7 |
| 2019 Mayo | 0 | 43 | 43 |
| 2019 Abril | 0 | 11 | 11 |
| 2019 Marzo | 0 | 7 | 7 |
| 2019 Febrero | 0 | 10 | 10 |
| 2019 Enero | 0 | 1 | 1 |
| 2018 Diciembre | 0 | 7 | 7 |
| 2018 Septiembre | 0 | 2 | 2 |
| 2018 Agosto | 0 | 11 | 11 |
| 2018 Julio | 0 | 5 | 5 |
| 2018 Junio | 0 | 6 | 6 |
| 2018 Mayo | 0 | 3 | 3 |
| 2018 Abril | 0 | 3 | 3 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 11 | 5 | 16 |
| 2018 Enero | 16 | 8 | 24 |
| 2017 Diciembre | 15 | 7 | 22 |
| 2017 Noviembre | 12 | 7 | 19 |
| 2017 Octubre | 13 | 10 | 23 |
| 2017 Septiembre | 12 | 3 | 15 |
| 2017 Agosto | 22 | 8 | 30 |
| 2017 Julio | 12 | 17 | 29 |
| 2017 Junio | 24 | 20 | 44 |
| 2017 Mayo | 19 | 10 | 29 |
| 2017 Abril | 21 | 8 | 29 |
| 2017 Marzo | 15 | 30 | 45 |
| 2017 Febrero | 20 | 8 | 28 |
| 2017 Enero | 9 | 10 | 19 |
| 2016 Diciembre | 30 | 14 | 44 |
| 2016 Noviembre | 26 | 11 | 37 |
| 2016 Octubre | 20 | 6 | 26 |
| 2016 Septiembre | 22 | 6 | 28 |
| 2016 Agosto | 19 | 10 | 29 |
| 2016 Julio | 18 | 4 | 22 |
| 2016 Junio | 14 | 4 | 18 |
| 2016 Mayo | 6 | 5 | 11 |
| 2016 Abril | 12 | 8 | 20 |
| 2016 Marzo | 5 | 7 | 12 |
| 2016 Febrero | 10 | 7 | 17 |
| 2016 Enero | 13 | 3 | 16 |
| 2015 Diciembre | 11 | 1 | 12 |
| 2015 Noviembre | 9 | 6 | 15 |
| 2015 Octubre | 15 | 8 | 23 |
| 2015 Septiembre | 18 | 2 | 20 |
| 2015 Agosto | 12 | 2 | 14 |
| 2015 Julio | 21 | 6 | 27 |
| 2015 Junio | 11 | 7 | 18 |
| 2015 Mayo | 34 | 9 | 43 |
| 2015 Abril | 24 | 11 | 35 |
| 2015 Marzo | 17 | 7 | 24 |
| 2015 Febrero | 22 | 9 | 31 |
| 2015 Enero | 11 | 11 | 22 |
| 2014 Diciembre | 12 | 19 | 31 |
| 2014 Noviembre | 7 | 16 | 23 |
| 2014 Octubre | 15 | 12 | 27 |
| 2014 Septiembre | 11 | 11 | 22 |
| 2014 Agosto | 13 | 15 | 28 |
| 2014 Julio | 18 | 22 | 40 |
| 2014 Junio | 22 | 11 | 33 |
| 2014 Mayo | 23 | 21 | 44 |
| 2014 Abril | 23 | 9 | 32 |
| 2014 Marzo | 34 | 23 | 57 |
| 2014 Febrero | 20 | 25 | 45 |
| 2014 Enero | 22 | 21 | 43 |
| 2013 Diciembre | 24 | 10 | 34 |
| 2013 Noviembre | 18 | 15 | 33 |
| 2013 Octubre | 10 | 16 | 26 |
| 2013 Septiembre | 20 | 24 | 44 |
| 2013 Agosto | 27 | 23 | 50 |
| 2013 Julio | 19 | 44 | 63 |
| 2013 Junio | 15 | 29 | 44 |
| 2013 Mayo | 21 | 27 | 48 |
| 2013 Abril | 21 | 28 | 49 |
| 2013 Marzo | 23 | 28 | 51 |
| 2013 Febrero | 11 | 19 | 30 |
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