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        "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p class="elsevierStyleSimplePara elsevierViewall">The relationship between androgenetic alopecia and cardiovascular disease has been studied by some authors in the past&#44; although the results of epidemiological studies have been variable&#46; The objective of this study was to determine the prevalence of metabolic syndrome and carotid arteriosclerosis in patients with early-onset androgenetic alopecia&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Seventy men were studied&#44; 35 with diagnosis of early-onset &#40;before 35 years of age&#41; androgenetic alopecia and 35 control subjects who consulted for other skin conditions&#46; In both groups&#44; the criteria for metabolic syndrome according to the Adult Treatment Panel-III were studied &#40;obesity&#44; triglycerides&#44; high-density lipoprotein cholesterol&#44; systolic and diastolic blood pressure&#44; and blood glucose&#41;&#44; presence of atheromatous plaques&#44; and carotid intima-media thickness using Doppler ultrasonography&#46; Other cardiovascular risk factors&#44; hormones&#44; and acute-phase reactants were also analyzed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Criteria for metabolic syndrome were met by 57&#46;1&#37; of the patients with androgenetic alopecia compared to 14&#46;3&#37; of the controls &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;0001&#41;&#46; Thirty-four percent of the patients with androgenetic alopecia had atheromatous plaques compared to 8&#46;6&#37; of the controls &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;018&#41;&#46; In an independent correlation analysis&#44; abdominal obesity&#44; systolic blood pressure&#44; triglycerides&#44; and blood glucose levels were significantly greater among patients with androgenetic alopecia&#46; Testosterone and sex hormone binding globulin levels were similar in the 2 groups whereas insulin and aldosterone levels were higher in patients with androgenetic alopecia &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The high frequency of metabolic syndrome and carotid atheromatous plaques in patients with androgenetic alopecia suggests cardiovascular screening should be done to enable early detection of individuals at risk and initiation of preventive treatment before cardiovascular disease becomes established</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">La relaci&#243;n entre la alopecia androg&#233;nica &#40;AAG&#41; y la enfermedad cardiovascular ha sido objeto de estudio por parte de algunos autores en las &#250;ltimas d&#233;cadas&#44; y se han obtenido diferentes resultados en los distintos estudios epidemiol&#243;gicos&#46; El objetivo de este trabajo es conocer la prevalencia del s&#237;ndrome metab&#243;lico y de la arteriosclerosis carot&#237;dea en los pacientes con AAG de inicio precoz&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se han estudiado 70 pacientes varones&#44; 35 diagnosticados de AAG de inicio precoz &#40;antes de los 35 a&#241;os&#41; y 35 controles atendidos por otras enfermedades dermatol&#243;gicas&#46; En ambos grupos se estudiaron los criterios de s&#237;ndrome metab&#243;lico que propone la ATP-III &#40;obesidad&#44; trigliceridemia&#44; cHDL&#44; presi&#243;n arterial sist&#243;lica&#44; presi&#243;n arterial diast&#243;lica y glucemia&#41;&#44; la presencia de placa de ateroma y el grosor &#237;ntimamedia carot&#237;deo mediante ecograf&#237;a Doppler&#46; Tambi&#233;n se analizaron otros factores de riesgo cardiovascular&#44; un estudio hormonal y de reactantes de fase aguda&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 57&#44;1&#37; de los pacientes con AAG cumple criterios de s&#237;ndrome metab&#243;lico frente al 14&#44;3&#37; del grupo control &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; El 34&#37; de los pacientes con AAG present&#243; placa de ateroma frente al 8&#44;6&#37; de los controles &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#41;&#46; Los valores de obesidad abdominal&#44; presi&#243;n arterial sist&#243;lica&#44; trigliceridemia y glucemia analizados de forma independiente fueron estad&#237;sticamente superiores en el grupo de pacientes con AAG&#46; Los niveles de testosterona y de la prote&#237;na transportadora de hormonas esteroideas fueron similares en ambos grupos&#59; sin embargo&#44; los niveles de insulina y aldosterona resultaron ser mayores en el grupo de pacientes con AAG &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La elevada frecuencia con la que se presenta el s&#237;ndrome metab&#243;lico y la ateromatosis carot&#237;dea en los pacientes con AAG hace necesario un cribado cardiovascular para detectar precozmente a aquellos individuos en riesgo e iniciar tratamiento preventivo antes de que se establezca la enfermedad cardiovascular&#46;</p>"
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                      "titulo" => "Factors discriminating men with coronary heart disease from healthy controls"
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                        0 => array:2 [
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                          "autores" => array:4 [
                            0 => "S&#46;G&#46; Cotton"
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                        "tituloSerie" => "Br Heart J"
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                        "paginaFinal" => "464"
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                          "etal" => false
                          "autores" => array:6 [
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                            2 => "L&#46; Hiltunen"
                            3 => "J&#46; Jokelainen"
                            4 => "S&#46; Kein&#228;nen- Kiukaanniemi"
                            5 => "S&#46; N&#228;yh&#228;"
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                        "paginaFinal" => "129"
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                            2 => "S&#46;B&#46; Harrap"
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                    ]
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                        "paginaFinal" => "404"
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                            0 => "S&#46;M&#46; Lesko"
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                            2 => "S&#46; Shapiro"
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                        "tituloSerie" => "JAMA"
                        "fecha" => "1993"
                        "volumen" => "269"
                        "paginaInicial" => "998"
                        "paginaFinal" => "1003"
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                        "paginaInicial" => "165"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10647754"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Executive Summary on the Third Report of The National Cholesterol Education Program &#40;NECP&#41; Expert Panel on Detection&#44; Evaluation and Treatment of High Blood Cholesterol in Adults &#40;Adult Treatment Panel III&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46;I&#46; Adult Treatment Panel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2001"
                        "volumen" => "285"
                        "paginaInicial" => "2486"
                        "paginaFinal" => "2497"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11368702"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular risk assessment in the metabolic syndrome&#58; Results from the Prospective Cardiovascular Munster &#40;PROCAM&#41; Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Assmann"
                            1 => "H&#46; Schulte"
                            2 => "U&#46; Seedorf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#41;"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "S11"
                        "paginaFinal" => "S16"
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526011001002"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International Diabetes Federation&#46; Prevalence and cardiovascular disease risk of the metabolic syndrome using National Cholesterol Education Program and International Diabetes Federation definitions in the Korean population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;M&#46; Choi"
                            1 => "S&#46;M&#46; Kim"
                            2 => "Y&#46;E&#46; Kim"
                            3 => "D&#46;S&#46; Choi"
                            4 => "S&#46;H&#46; Baik"
                            5 => "J&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.metabol.2006.12.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "552"
                        "paginaFinal" => "558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17379016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic syndrome&#58; Epidemiology and its risks"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Lameira"
                            1 => "S&#46; Lejeune"
                            2 => "J&#46;J&#46; Mourad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0151-9638(08)70543-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol Venereol"
                        "fecha" => "2008"
                        "volumen" => "135"
                        "paginaInicial" => "S249"
                        "paginaFinal" => "S253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18466792"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of metabolic syndrome in population-based study&#44; Vit&#243;ria&#44; ESBrazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;B&#46; Salaroli"
                            1 => "G&#46;C&#46; Barbosa"
                            2 => "J&#46;G&#46; Mill"
                            3 => "M&#46;C&#46; Molina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Endocrinol Metabol"
                        "fecha" => "2007"
                        "volumen" => "51"
                        "paginaInicial" => "1143"
                        "paginaFinal" => "1152"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18157391"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Capacidad predictiva de los criterios diagn&#243;sticos del s&#237;ndrome metab&#243;lico sobre la resistencia a la insulina y el riesgo coronario"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Mart&#237;nez Candela"
                            1 => "J&#46; Franch Nadal"
                            2 => "J&#46; Romero Ortiz"
                            3 => "C&#46; C&#225;novas Dom&#237;nguez"
                            4 => "A&#46; Gallardo Mart&#237;n"
                            5 => "M&#46;L&#46; L&#243;pez Yepes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2007"
                        "volumen" => "129"
                        "paginaInicial" => "601"
                        "paginaFinal" => "606"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalencia del s&#237;ndrome metab&#243;lico en la provincia de Albacete"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Calbo Mayo"
                            1 => "I&#46; Terrancle de Juan"
                            2 => "P&#46; Fern&#225;ndez Jim&#233;nez"
                            3 => "M&#46;J&#46; Rodr&#237;guez Mart&#237;n"
                            4 => "V&#46; Mart&#237;nez D&#237;az"
                            5 => "Y&#46; Santisteban L&#243;pez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2007"
                        "volumen" => "2072"
                        "paginaInicial" => "64"
                        "paginaFinal" => "68"
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526010000154"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early androgenetic alopecia as a marker of insulin resistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Matilainen"
                            1 => "P&#46; Koskela"
                            2 => "S&#46; Kein&#228;nen-Kiukaanniemi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(00)02763-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2000"
                        "volumen" => "356"
                        "paginaInicial" => "1165"
                        "paginaFinal" => "1166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11030300"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous blood flow in early male pattern baldness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Klemp"
                            1 => "K&#46; Peters"
                            2 => "B&#46; Hansted"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1989"
                        "volumen" => "92"
                        "paginaInicial" => "725"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2715645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transcutaneous PO2 of the scalp in male pattern baldness&#58; A new piece to the puzzle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;E&#46; Goldman"
                            1 => "D&#46;M&#46; Fisher"
                            2 => "S&#46;L&#46; Ringler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1996"
                        "volumen" => "97"
                        "paginaInicial" => "1109"
                        "paginaFinal" => "1116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8628793"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of androgenetic alopecia and hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Ahouansou"
                            1 => "P&#46; Le Toumelin"
                            2 => "B&#46; Crickx"
                            3 => "V&#46; Descamps"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2007.0152"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "paginaInicial" => "220"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17478384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy&#44; premature skin barrier formation&#44; eye abnormalities&#44; and alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Sainte Marie"
                            1 => "A&#46; Toulon"
                            2 => "R&#46; Paus"
                            3 => "E&#46; Maubec"
                            4 => "A&#46; Cherfa"
                            5 => "M&#46; Grossin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2353/ajpath.2007.060991"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "2007"
                        "volumen" => "171"
                        "paginaInicial" => "846"
                        "paginaFinal" => "860"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17675581"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526011001014"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated aldosterone levels in patients with androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Arias-Santiago"
                            1 => "M&#46;T&#46; Guti&#233;rrez-Salmer&#243;n"
                            2 => "L&#46; Castellote-Caballero"
                            3 => "R&#46; Naranjo-Sintes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2009.09293.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "161"
                        "paginaInicial" => "1196"
                        "paginaFinal" => "1198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19519833"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of insulin resistance linked diseases and hair loss in elderly men&#46; Finnish population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Hirsso"
                            1 => "M&#46; Laakso"
                            2 => "V&#46; Matilainen"
                            3 => "L&#46; Hiltunen"
                            4 => "U&#46; Rajala"
                            5 => "J&#46; Jokelainen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cent Eur J Public Health"
                        "fecha" => "2006"
                        "volumen" => "14"
                        "paginaInicial" => "78"
                        "paginaFinal" => "81"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16830609"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early onset of androgenetic alopecia associated with early severe coronary heart disease&#58; A population-based&#44; case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46;A&#46; Matilainen"
                            1 => "P&#46;K&#46; M&#228;kinen"
                            2 => "S&#46;M&#46; Kein&#228;nen-Kiukaanniemi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiovasc Risk"
                        "fecha" => "2001"
                        "volumen" => "8"
                        "paginaInicial" => "147"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11455846"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relative importance of various risk factors for asymptomatic carotid atherosclerosis versus coronary heart disease incidence&#58; The Atherosclerosis Risk in Communities Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;R&#46; Sharrett"
                            1 => "P&#46;D&#46; Sorlie"
                            2 => "L&#46;E&#46; Chambless"
                            3 => "A&#46;R&#46; Folsom"
                            4 => "R&#46;G&#46; Hutchinson"
                            5 => "G&#46; Heiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "149"
                        "paginaInicial" => "843"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10221321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Baldness and myocardial infarction in men&#58; The atherosclerosis risk in communities study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Shahar"
                            1 => "G&#46; Heiss"
                            2 => "W&#46;D&#46; Rosamond"
                            3 => "M&#46; Szklo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/aje/kwm365"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2008"
                        "volumen" => "167"
                        "paginaInicial" => "676"
                        "paginaFinal" => "683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18208984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men&#58; A 6-year follow-up study of 6&#44;226 persons&#58; The Troms&#248; Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;H&#46; Johnsen"
                            1 => "E&#46;B&#46; Mathiesen"
                            2 => "O&#46; Joakimsen"
                            3 => "E&#46; Stensland"
                            4 => "T&#46; Wilsgaard"
                            5 => "M&#46;L&#46; L&#248;chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STROKEAHA.107.487264"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2007"
                        "volumen" => "38"
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                            "web" => "Medline"
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              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is androgenetic alopecia a risk for atherosclerosis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Dogramaci"
                            1 => "D&#46;D&#46; Balci"
                            2 => "A&#46; Balci"
                            3 => "S&#46; Karazincir"
                            4 => "N&#46; Savas"
                            5 => "C&#46; Topaloglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2009.03137.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "673"
                        "paginaFinal" => "677"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19250324"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ecograf&#237;a carot&#237;dea en la evaluaci&#243;n de la ateroesclerosis precl&#237;nica&#46; Distribuci&#243;n de valores de grosor &#237;ntima-media y frecuencia de placas de ateroma en una cohorte comunitaria espa&#241;ola"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Junyent"
                            1 => "R&#46; Gilabert"
                            2 => "I&#46; N&#250;&#241;ez"
                            3 => "E&#46; Corbella"
                            4 => "M&#46; Vela"
                            5 => "D&#46; Zamb&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "770"
                        "paginaFinal" => "774"
                        "itemHostRev" => array:3 [
                          "pii" => "S155252601100104X"
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                          "issn" => "15525260"
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                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "C-reactive protein in healthy subjects&#58; associations with obesity&#44; insulin resistance&#44; and endothelial dysfunction&#58; A potencial role for cytokines originating from adipose tissue&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;S&#46; Yudkin"
                            1 => "C&#46;D&#46; Stehouwer"
                            2 => "J&#46;J&#46; Emeis"
                            3 => "SW&#46; Coppack"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol"
                        "fecha" => "1999"
                        "volumen" => "19"
                        "paginaInicial" => "972"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10195925"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Androgen receptors&#44; 5-alpha-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Fujimoto"
                            1 => "I&#46; Morimoto"
                            2 => "E&#46; Morita"
                            3 => "H&#46; Sugimoto"
                            4 => "Y&#46; Ito"
                            5 => "S&#46; Eto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Steroid Biochem Mol Biol"
                        "fecha" => "1994"
                        "volumen" => "50"
                        "paginaInicial" => "169"
                        "paginaFinal" => "174"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8049146"
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                          ]
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Original Article
Male Androgenetic Alopecia and Cardiovascular Risk Factors: A Case-Control Study
Alopecia androgénica masculina y factores de riesgo cardiovascular: estudio de casos y controles
S. Arias-Santiagoa,
Autor para correspondencia
salvadorarias@hotmail.es

Corresponding author.
, M.T. Gutiérrez-Salmeróna, L. Castellote-Caballerob, A. Buendía-Eismanc, R. Naranjo-Sintesa
a Servicio de Dermatología, Hospital Clínico San Cecilio, Granada, Spain
b Servicio de Radiología, Hospital Clínico San Cecilio, Granada, Spain
c Departamento de Dermatología, Facultad de Medicina, Granada, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p class="elsevierStyleSimplePara elsevierViewall">The relationship between androgenetic alopecia and cardiovascular disease has been studied by some authors in the past&#44; although the results of epidemiological studies have been variable&#46; The objective of this study was to determine the prevalence of metabolic syndrome and carotid arteriosclerosis in patients with early-onset androgenetic alopecia&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Seventy men were studied&#44; 35 with diagnosis of early-onset &#40;before 35 years of age&#41; androgenetic alopecia and 35 control subjects who consulted for other skin conditions&#46; In both groups&#44; the criteria for metabolic syndrome according to the Adult Treatment Panel-III were studied &#40;obesity&#44; triglycerides&#44; high-density lipoprotein cholesterol&#44; systolic and diastolic blood pressure&#44; and blood glucose&#41;&#44; presence of atheromatous plaques&#44; and carotid intima-media thickness using Doppler ultrasonography&#46; Other cardiovascular risk factors&#44; hormones&#44; and acute-phase reactants were also analyzed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Criteria for metabolic syndrome were met by 57&#46;1&#37; of the patients with androgenetic alopecia compared to 14&#46;3&#37; of the controls &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;0001&#41;&#46; Thirty-four percent of the patients with androgenetic alopecia had atheromatous plaques compared to 8&#46;6&#37; of the controls &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;018&#41;&#46; In an independent correlation analysis&#44; abdominal obesity&#44; systolic blood pressure&#44; triglycerides&#44; and blood glucose levels were significantly greater among patients with androgenetic alopecia&#46; Testosterone and sex hormone binding globulin levels were similar in the 2 groups whereas insulin and aldosterone levels were higher in patients with androgenetic alopecia &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The high frequency of metabolic syndrome and carotid atheromatous plaques in patients with androgenetic alopecia suggests cardiovascular screening should be done to enable early detection of individuals at risk and initiation of preventive treatment before cardiovascular disease becomes established</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">La relaci&#243;n entre la alopecia androg&#233;nica &#40;AAG&#41; y la enfermedad cardiovascular ha sido objeto de estudio por parte de algunos autores en las &#250;ltimas d&#233;cadas&#44; y se han obtenido diferentes resultados en los distintos estudios epidemiol&#243;gicos&#46; El objetivo de este trabajo es conocer la prevalencia del s&#237;ndrome metab&#243;lico y de la arteriosclerosis carot&#237;dea en los pacientes con AAG de inicio precoz&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se han estudiado 70 pacientes varones&#44; 35 diagnosticados de AAG de inicio precoz &#40;antes de los 35 a&#241;os&#41; y 35 controles atendidos por otras enfermedades dermatol&#243;gicas&#46; En ambos grupos se estudiaron los criterios de s&#237;ndrome metab&#243;lico que propone la ATP-III &#40;obesidad&#44; trigliceridemia&#44; cHDL&#44; presi&#243;n arterial sist&#243;lica&#44; presi&#243;n arterial diast&#243;lica y glucemia&#41;&#44; la presencia de placa de ateroma y el grosor &#237;ntimamedia carot&#237;deo mediante ecograf&#237;a Doppler&#46; Tambi&#233;n se analizaron otros factores de riesgo cardiovascular&#44; un estudio hormonal y de reactantes de fase aguda&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 57&#44;1&#37; de los pacientes con AAG cumple criterios de s&#237;ndrome metab&#243;lico frente al 14&#44;3&#37; del grupo control &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; El 34&#37; de los pacientes con AAG present&#243; placa de ateroma frente al 8&#44;6&#37; de los controles &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#41;&#46; Los valores de obesidad abdominal&#44; presi&#243;n arterial sist&#243;lica&#44; trigliceridemia y glucemia analizados de forma independiente fueron estad&#237;sticamente superiores en el grupo de pacientes con AAG&#46; Los niveles de testosterona y de la prote&#237;na transportadora de hormonas esteroideas fueron similares en ambos grupos&#59; sin embargo&#44; los niveles de insulina y aldosterona resultaron ser mayores en el grupo de pacientes con AAG &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La elevada frecuencia con la que se presenta el s&#237;ndrome metab&#243;lico y la ateromatosis carot&#237;dea en los pacientes con AAG hace necesario un cribado cardiovascular para detectar precozmente a aquellos individuos en riesgo e iniciar tratamiento preventivo antes de que se establezca la enfermedad cardiovascular&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:27 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors discriminating men with coronary heart disease from healthy controls"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;G&#46; Cotton"
                            1 => "J&#46;M&#46; Nixon"
                            2 => "R&#46;G&#46; Carpenter"
                            3 => "D&#46;W&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br Heart J"
                        "fecha" => "1972"
                        "volumen" => "34"
                        "paginaInicial" => "458"
                        "paginaFinal" => "464"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5031636"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity and low-grade inflammation among young Finnish men with early-onset alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Hirsso"
                            1 => "U&#46; Rajala"
                            2 => "L&#46; Hiltunen"
                            3 => "J&#46; Jokelainen"
                            4 => "S&#46; Kein&#228;nen- Kiukaanniemi"
                            5 => "S&#46; N&#228;yh&#228;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000098570"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2007"
                        "volumen" => "214"
                        "paginaInicial" => "125"
                        "paginaFinal" => "129"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17341860"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Male pattern baldness is not associated with established cardiovascular risk factors in the general population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Ellis"
                            1 => "M&#46; Stebbing"
                            2 => "S&#46;B&#46; Harrap"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Sci"
                        "fecha" => "2001"
                        "volumen" => "100"
                        "paginaInicial" => "401"
                        "paginaFinal" => "404"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11256978"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case-control study of baldness in relation to myocardial infarction in men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Lesko"
                            1 => "L&#46; Rosenberg"
                            2 => "S&#46; Shapiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1993"
                        "volumen" => "269"
                        "paginaInicial" => "998"
                        "paginaFinal" => "1003"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8429606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Male pattern baldness and coronary heart disease&#58; The Physician&#39;s Health Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;A&#46; Lotufo"
                            1 => "C&#46;U&#46; Chae"
                            2 => "U&#46;A&#46; Ajani"
                            3 => "C&#46;H&#46; Hennekens"
                            4 => "J&#46;E&#46; Manson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2000"
                        "volumen" => "160"
                        "paginaInicial" => "165"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10647754"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Executive Summary on the Third Report of The National Cholesterol Education Program &#40;NECP&#41; Expert Panel on Detection&#44; Evaluation and Treatment of High Blood Cholesterol in Adults &#40;Adult Treatment Panel III&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46;I&#46; Adult Treatment Panel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2001"
                        "volumen" => "285"
                        "paginaInicial" => "2486"
                        "paginaFinal" => "2497"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11368702"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular risk assessment in the metabolic syndrome&#58; Results from the Prospective Cardiovascular Munster &#40;PROCAM&#41; Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Assmann"
                            1 => "H&#46; Schulte"
                            2 => "U&#46; Seedorf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#41;"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "S11"
                        "paginaFinal" => "S16"
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526011001002"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International Diabetes Federation&#46; Prevalence and cardiovascular disease risk of the metabolic syndrome using National Cholesterol Education Program and International Diabetes Federation definitions in the Korean population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;M&#46; Choi"
                            1 => "S&#46;M&#46; Kim"
                            2 => "Y&#46;E&#46; Kim"
                            3 => "D&#46;S&#46; Choi"
                            4 => "S&#46;H&#46; Baik"
                            5 => "J&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.metabol.2006.12.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "552"
                        "paginaFinal" => "558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17379016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic syndrome&#58; Epidemiology and its risks"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Lameira"
                            1 => "S&#46; Lejeune"
                            2 => "J&#46;J&#46; Mourad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0151-9638(08)70543-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol Venereol"
                        "fecha" => "2008"
                        "volumen" => "135"
                        "paginaInicial" => "S249"
                        "paginaFinal" => "S253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18466792"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of metabolic syndrome in population-based study&#44; Vit&#243;ria&#44; ESBrazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;B&#46; Salaroli"
                            1 => "G&#46;C&#46; Barbosa"
                            2 => "J&#46;G&#46; Mill"
                            3 => "M&#46;C&#46; Molina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Endocrinol Metabol"
                        "fecha" => "2007"
                        "volumen" => "51"
                        "paginaInicial" => "1143"
                        "paginaFinal" => "1152"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18157391"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Capacidad predictiva de los criterios diagn&#243;sticos del s&#237;ndrome metab&#243;lico sobre la resistencia a la insulina y el riesgo coronario"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Mart&#237;nez Candela"
                            1 => "J&#46; Franch Nadal"
                            2 => "J&#46; Romero Ortiz"
                            3 => "C&#46; C&#225;novas Dom&#237;nguez"
                            4 => "A&#46; Gallardo Mart&#237;n"
                            5 => "M&#46;L&#46; L&#243;pez Yepes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2007"
                        "volumen" => "129"
                        "paginaInicial" => "601"
                        "paginaFinal" => "606"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalencia del s&#237;ndrome metab&#243;lico en la provincia de Albacete"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Calbo Mayo"
                            1 => "I&#46; Terrancle de Juan"
                            2 => "P&#46; Fern&#225;ndez Jim&#233;nez"
                            3 => "M&#46;J&#46; Rodr&#237;guez Mart&#237;n"
                            4 => "V&#46; Mart&#237;nez D&#237;az"
                            5 => "Y&#46; Santisteban L&#243;pez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2007"
                        "volumen" => "2072"
                        "paginaInicial" => "64"
                        "paginaFinal" => "68"
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526010000154"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early androgenetic alopecia as a marker of insulin resistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Matilainen"
                            1 => "P&#46; Koskela"
                            2 => "S&#46; Kein&#228;nen-Kiukaanniemi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(00)02763-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2000"
                        "volumen" => "356"
                        "paginaInicial" => "1165"
                        "paginaFinal" => "1166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11030300"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous blood flow in early male pattern baldness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Klemp"
                            1 => "K&#46; Peters"
                            2 => "B&#46; Hansted"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1989"
                        "volumen" => "92"
                        "paginaInicial" => "725"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2715645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transcutaneous PO2 of the scalp in male pattern baldness&#58; A new piece to the puzzle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;E&#46; Goldman"
                            1 => "D&#46;M&#46; Fisher"
                            2 => "S&#46;L&#46; Ringler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1996"
                        "volumen" => "97"
                        "paginaInicial" => "1109"
                        "paginaFinal" => "1116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8628793"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of androgenetic alopecia and hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Ahouansou"
                            1 => "P&#46; Le Toumelin"
                            2 => "B&#46; Crickx"
                            3 => "V&#46; Descamps"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2007.0152"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "paginaInicial" => "220"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17478384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
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                      "titulo" => "Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy&#44; premature skin barrier formation&#44; eye abnormalities&#44; and alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Sainte Marie"
                            1 => "A&#46; Toulon"
                            2 => "R&#46; Paus"
                            3 => "E&#46; Maubec"
                            4 => "A&#46; Cherfa"
                            5 => "M&#46; Grossin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2353/ajpath.2007.060991"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "2007"
                        "volumen" => "171"
                        "paginaInicial" => "846"
                        "paginaFinal" => "860"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17675581"
                            "web" => "Medline"
                          ]
                        ]
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                          "pii" => "S1552526011001014"
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              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated aldosterone levels in patients with androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Arias-Santiago"
                            1 => "M&#46;T&#46; Guti&#233;rrez-Salmer&#243;n"
                            2 => "L&#46; Castellote-Caballero"
                            3 => "R&#46; Naranjo-Sintes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2009.09293.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "161"
                        "paginaInicial" => "1196"
                        "paginaFinal" => "1198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19519833"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of insulin resistance linked diseases and hair loss in elderly men&#46; Finnish population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Hirsso"
                            1 => "M&#46; Laakso"
                            2 => "V&#46; Matilainen"
                            3 => "L&#46; Hiltunen"
                            4 => "U&#46; Rajala"
                            5 => "J&#46; Jokelainen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cent Eur J Public Health"
                        "fecha" => "2006"
                        "volumen" => "14"
                        "paginaInicial" => "78"
                        "paginaFinal" => "81"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16830609"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early onset of androgenetic alopecia associated with early severe coronary heart disease&#58; A population-based&#44; case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46;A&#46; Matilainen"
                            1 => "P&#46;K&#46; M&#228;kinen"
                            2 => "S&#46;M&#46; Kein&#228;nen-Kiukaanniemi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiovasc Risk"
                        "fecha" => "2001"
                        "volumen" => "8"
                        "paginaInicial" => "147"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11455846"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relative importance of various risk factors for asymptomatic carotid atherosclerosis versus coronary heart disease incidence&#58; The Atherosclerosis Risk in Communities Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;R&#46; Sharrett"
                            1 => "P&#46;D&#46; Sorlie"
                            2 => "L&#46;E&#46; Chambless"
                            3 => "A&#46;R&#46; Folsom"
                            4 => "R&#46;G&#46; Hutchinson"
                            5 => "G&#46; Heiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "149"
                        "paginaInicial" => "843"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10221321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Baldness and myocardial infarction in men&#58; The atherosclerosis risk in communities study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Shahar"
                            1 => "G&#46; Heiss"
                            2 => "W&#46;D&#46; Rosamond"
                            3 => "M&#46; Szklo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/aje/kwm365"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2008"
                        "volumen" => "167"
                        "paginaInicial" => "676"
                        "paginaFinal" => "683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18208984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men&#58; A 6-year follow-up study of 6&#44;226 persons&#58; The Troms&#248; Study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;H&#46; Johnsen"
                            1 => "E&#46;B&#46; Mathiesen"
                            2 => "O&#46; Joakimsen"
                            3 => "E&#46; Stensland"
                            4 => "T&#46; Wilsgaard"
                            5 => "M&#46;L&#46; L&#248;chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/STROKEAHA.107.487264"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2007"
                        "volumen" => "38"
                        "paginaInicial" => "2873"
                        "paginaFinal" => "2880"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17901390"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is androgenetic alopecia a risk for atherosclerosis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Dogramaci"
                            1 => "D&#46;D&#46; Balci"
                            2 => "A&#46; Balci"
                            3 => "S&#46; Karazincir"
                            4 => "N&#46; Savas"
                            5 => "C&#46; Topaloglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2009.03137.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "673"
                        "paginaFinal" => "677"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19250324"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "25&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ecograf&#237;a carot&#237;dea en la evaluaci&#243;n de la ateroesclerosis precl&#237;nica&#46; Distribuci&#243;n de valores de grosor &#237;ntima-media y frecuencia de placas de ateroma en una cohorte comunitaria espa&#241;ola"
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                        0 => array:2 [
                          "etal" => true
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                            0 => "M&#46; Junyent"
                            1 => "R&#46; Gilabert"
                            2 => "I&#46; N&#250;&#241;ez"
                            3 => "E&#46; Corbella"
                            4 => "M&#46; Vela"
                            5 => "D&#46; Zamb&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "770"
                        "paginaFinal" => "774"
                        "itemHostRev" => array:3 [
                          "pii" => "S155252601100104X"
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            25 => array:3 [
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              "etiqueta" => "26&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "C-reactive protein in healthy subjects&#58; associations with obesity&#44; insulin resistance&#44; and endothelial dysfunction&#58; A potencial role for cytokines originating from adipose tissue&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;S&#46; Yudkin"
                            1 => "C&#46;D&#46; Stehouwer"
                            2 => "J&#46;J&#46; Emeis"
                            3 => "SW&#46; Coppack"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol"
                        "fecha" => "1999"
                        "volumen" => "19"
                        "paginaInicial" => "972"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10195925"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Androgen receptors&#44; 5-alpha-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Fujimoto"
                            1 => "I&#46; Morimoto"
                            2 => "E&#46; Morita"
                            3 => "H&#46; Sugimoto"
                            4 => "Y&#46; Ito"
                            5 => "S&#46; Eto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Steroid Biochem Mol Biol"
                        "fecha" => "1994"
                        "volumen" => "50"
                        "paginaInicial" => "169"
                        "paginaFinal" => "174"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8049146"
                            "web" => "Medline"
                          ]
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