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Novelties in Dermatology
Contact Dermatitis Due to Dimethyl Fumarate
Dermatitis de contacto por dimetilfumarato
J.F. Silvestrea,
Autor para correspondencia
silvestre_jfr@gva.es

Corresponding author.
, P. Mercaderb, A.M. Giménez-Arnauc
a Sección de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain
b Sección de Dermatología, Hospital General Universitario Morales Meseguer, Murcia, Spain
c Servicio de Dermatología, Hospital del Mar (IMAS), Barcelona, Spain
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    "titulo" => "Contact Dermatitis Due to Dimethyl Fumarate"
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        "titulo" => "Dermatitis de contacto por dimetilfumarato"
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            2 => "Contact urticaria"
            3 => "Patch test"
            4 => "Shoe"
            5 => "Sofa"
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            0 => "Dimetilfumarato"
            1 => "Dermatitis de contacto"
            2 => "Urticaria de contacto"
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        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Dimethyl fumarate is a fumaric acid ester&#46; It has been used for some years to treat psoriasis and also as a preservative in desiccant sachets in the transport of furniture and footwear&#46; Its irritant properties and sensitizing potential in contact with the skin were recently highlighted when it was implicated as the causative agent in 2 epidemics of severe acute eczema&#58; sofa dermatitis in northern Europe and shoe dermatitis in Spain&#46; The present article aims to guide dermatologists in the diagnosis and management of patients allergic to dimethyl fumarate&#46; We review the clinical manifestations&#44; results of patch tests&#44; possible cross-reactions&#44; and sources of exposure to dimethyl fumarate responsible for these skin reactions&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El dimetilfumarato es un &#233;ster del &#225;cido fum&#225;rico que se utiliza desde hace a&#241;os para el tratamiento de la psoriasis&#59; adem&#225;s se emplea como conservante en bolsitas antihumedad para garantizar el transporte de muebles y calzado&#46; Su capacidad irritante en contacto con la piel y su alta capacidad sensibilizante han quedado demostradas recientemente tras haber sido implicado como agente causal en dos epidemias de eccema agudo grave&#58; por un lado&#44; la &#171;dermatitis del sof&#225;&#187; en el norte de Europa&#44; y por otro lado&#44; una epidemia de dermatitis por calzado en Espa&#241;a&#46; El presente art&#237;culo pretende orientar a los dermat&#243;logos en el diagn&#243;stico y tratamiento de los pacientes al&#233;rgicos al dimetilfumarato&#46; Repasamos las manifestaciones cl&#237;nicas&#44; los resultados de las pruebas epicut&#225;neas&#44; las reacciones cruzadas existentes y las fuentes de exposici&#243;n de dimetilfumarato que inducen estas dermatitis&#46;</p>"
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