Review article
Histopathology of the More Common Viral Skin Infections
Histopatología de las infecciones víricas cutáneas más frecuentes
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Giménez-Arnau" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Silvestre" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Mercader" ] 2 => array:2 [ "nombre" => "A.M." "apellidos" => "Giménez-Arnau" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706193?idApp=UINPBA000044" "url" => "/15782190/0000010100000003/v1_201304241518/S1578219010706193/v1_201304241518/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S157821901070617X" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70617-X" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "70617" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Actas Dermosifiliogr. 2010;101:197-200" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2499 "formatos" => array:3 [ "EPUB" => 40 "HTML" => 1361 "PDF" => 1098 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>" "titulo" => "Antioxidants in Photoprotection: Do They Really Work?" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "197" "paginaFinal" => "200" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Antioxidantes en fotoprotección, ¿realmente funcionan?" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.V. De Gálvez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M.V." "apellidos" => "De Gálvez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901070617X?idApp=UINPBA000044" "url" => "/15782190/0000010100000003/v1_201304241518/S157821901070617X/v1_201304241518/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Histopathology of the More Common Viral Skin Infections" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "216" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L. Requena, C. Requena" "autores" => array:2 [ 0 => array:4 [ "nombre" => "L." "apellidos" => "Requena" "email" => array:1 [ 0 => "lrequena@fjd.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Requena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Histopatología de las infecciones víricas cutáneas más frecuentes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-18" "fechaAceptado" => "2009-07-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84732" "palabras" => array:7 [ 0 => "Histopathology" 1 => "Viral infections" 2 => "Skin" 3 => "Herpesvirus" 4 => "Cytomegalovirus" 5 => "Papillomavirus" 6 => "Parapoxvirus" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84733" "palabras" => array:7 [ 0 => "Histopatología" 1 => "Infecciones víricas" 2 => "Piel" 3 => "Herpes virus" 4 => "Citomegalovirus" 5 => "Papilomavirus" 6 => "Parapoxvirus" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We describe the histopathological characteristics of viral skin infections. Herpes simplex virus and varicella-zoster virus produce an intraepidermal vesicle with variable degrees of epithelial necrosis. Typical findings include keratinocytes with ballooned nuclei with a ground-glass appearance and giant multinucleated keratinocytes. In the endothelial cells of the dermal blood vessels, cytomegalovirus produces large eosinophilic nuclear inclusions surrounded by a clear halo. Human herpes virus 8 is etiologically associated with Kaposi sarcoma. In its early stages, this tumor contains blood vessels with a fine endothelium passing through the dermal collagen bundles. In the plaque and nodular stages, the vessel lumens are more clearly visible and there is a progressive increase in the number of neoplastic spindle cells with a low degree of pleomorphism and atypia, and occasional mitoses. The infiltrate is made up of lymphocytes and plasma cells. Contagious ecthyma and milker's nodule give rise to an acanthotic epidermis with ballooned keratinocytes containing eosinophilic cytoplasmic viral inclusions. Molluscum contagiosum shows lobules of epithelium that open onto the epidermal surface and characteristic inclusion bodies. Acanthosis, papillomatosis, and hyperkeratosis are observed in common warts, with confluence of the epidermal ridges in the center of the lesion and koilocytes.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">En este trabajo describimos las características histopatológicas de las infecciones víricas cutáneas. El herpes simple y el virus varicela-zóster producen una vesícula intraepidérmica con grados variables de necrosis epitelial. Son característicos los queratinocitos con núcleos balonizados con aspecto de vidrio esmerilado y los queratinocitos gigantes multinucleados. El citomegalovirus produce grandes inclusiones nucleares eosinófilas rodeadas de un halo claro en los endotelios de los vasos dérmicos. El herpes virus tipo 8 se relaciona etiológicamente con el sarcoma de Kaposi, que en sus fases iniciales muestra luces vasculares de endotelios finos disecando los haces de colágeno dérmicos. En las fases en placa y nodular las luces vasculares son más visibles, aumenta progresivamente el número de células fusiformes tumorales con discreto grado de atipia y pleomorfismo y algunas mitosis. El infiltrado se compone de linfocitos y células plasmáticas. El orf y el nódulo de los ordeñadores inducen una epidermis acantósica con queratinocitos balonizados que contienen inclusiones víricas citoplasmáticas eosinófilas. El molusco contagioso muestra lóbulos de epitelio abiertos a la superficie epidérmica con característicos cuerpos de inclusión. En las verrugas vulgares aparece acantosis, papilomatosis e hiperqueratosis, con confluencia de las crestas epidérmicas hacia el centro de la lesión y coilocitos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:103 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The histopathologic evolution of recurrent herpes simplex labialis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.C. Huff" 1 => "G.G. Krueger" 2 => "J.C. Overall" 3 => "J. Copeland" 4 => "S.L. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 6 | 15 |
| 2024 Octubre | 111 | 55 | 166 |
| 2024 Septiembre | 110 | 59 | 169 |
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| 2024 Enero | 63 | 39 | 102 |
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| 2023 Noviembre | 84 | 44 | 128 |
| 2023 Octubre | 81 | 44 | 125 |
| 2023 Septiembre | 79 | 34 | 113 |
| 2023 Agosto | 53 | 27 | 80 |
| 2023 Julio | 53 | 55 | 108 |
| 2023 Junio | 72 | 54 | 126 |
| 2023 Mayo | 43 | 35 | 78 |
| 2023 Abril | 36 | 41 | 77 |
| 2023 Marzo | 40 | 46 | 86 |
| 2023 Febrero | 36 | 32 | 68 |
| 2023 Enero | 33 | 37 | 70 |
| 2022 Diciembre | 41 | 52 | 93 |
| 2022 Noviembre | 25 | 42 | 67 |
| 2022 Octubre | 20 | 22 | 42 |
| 2022 Septiembre | 24 | 46 | 70 |
| 2022 Agosto | 20 | 43 | 63 |
| 2022 Julio | 26 | 34 | 60 |
| 2022 Junio | 35 | 39 | 74 |
| 2022 Mayo | 89 | 47 | 136 |
| 2022 Abril | 64 | 50 | 114 |
| 2022 Marzo | 49 | 52 | 101 |
| 2022 Febrero | 71 | 46 | 117 |
| 2022 Enero | 52 | 56 | 108 |
| 2021 Diciembre | 36 | 43 | 79 |
| 2021 Noviembre | 54 | 46 | 100 |
| 2021 Octubre | 54 | 53 | 107 |
| 2021 Septiembre | 44 | 55 | 99 |
| 2021 Agosto | 67 | 40 | 107 |
| 2021 Julio | 45 | 39 | 84 |
| 2021 Junio | 46 | 30 | 76 |
| 2021 Mayo | 38 | 35 | 73 |
| 2021 Abril | 110 | 52 | 162 |
| 2021 Marzo | 90 | 27 | 117 |
| 2021 Febrero | 76 | 48 | 124 |
| 2021 Enero | 44 | 22 | 66 |
| 2020 Diciembre | 45 | 20 | 65 |
| 2020 Noviembre | 38 | 23 | 61 |
| 2020 Octubre | 23 | 10 | 33 |
| 2020 Septiembre | 28 | 11 | 39 |
| 2020 Agosto | 41 | 19 | 60 |
| 2020 Julio | 31 | 11 | 42 |
| 2020 Junio | 42 | 29 | 71 |
| 2020 Mayo | 44 | 26 | 70 |
| 2020 Abril | 30 | 21 | 51 |
| 2020 Marzo | 33 | 23 | 56 |
| 2020 Febrero | 5 | 5 | 10 |
| 2020 Enero | 0 | 7 | 7 |
| 2019 Diciembre | 0 | 11 | 11 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 0 | 4 | 4 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 8 | 8 |
| 2019 Junio | 0 | 14 | 14 |
| 2019 Mayo | 0 | 53 | 53 |
| 2019 Abril | 0 | 47 | 47 |
| 2019 Marzo | 0 | 16 | 16 |
| 2019 Febrero | 0 | 13 | 13 |
| 2019 Enero | 0 | 8 | 8 |
| 2018 Abril | 1 | 0 | 1 |
| 2018 Marzo | 7 | 0 | 7 |
| 2018 Febrero | 35 | 4 | 39 |
| 2018 Enero | 26 | 3 | 29 |
| 2017 Diciembre | 36 | 5 | 41 |
| 2017 Noviembre | 45 | 4 | 49 |
| 2017 Octubre | 40 | 3 | 43 |
| 2017 Septiembre | 34 | 10 | 44 |
| 2017 Agosto | 56 | 13 | 69 |
| 2017 Julio | 60 | 7 | 67 |
| 2017 Junio | 58 | 19 | 77 |
| 2017 Mayo | 73 | 12 | 85 |
| 2017 Abril | 48 | 10 | 58 |
| 2017 Marzo | 51 | 37 | 88 |
| 2017 Febrero | 53 | 14 | 67 |
| 2017 Enero | 31 | 7 | 38 |
| 2016 Diciembre | 54 | 15 | 69 |
| 2016 Noviembre | 47 | 23 | 70 |
| 2016 Octubre | 47 | 26 | 73 |
| 2016 Septiembre | 64 | 32 | 96 |
| 2016 Agosto | 63 | 16 | 79 |
| 2016 Julio | 30 | 20 | 50 |
| 2016 Junio | 12 | 21 | 33 |
| 2016 Mayo | 9 | 24 | 33 |
| 2016 Abril | 2 | 5 | 7 |
| 2016 Marzo | 6 | 7 | 13 |
| 2016 Febrero | 2 | 10 | 12 |
| 2016 Enero | 8 | 8 | 16 |
| 2015 Diciembre | 10 | 7 | 17 |
| 2015 Noviembre | 14 | 9 | 23 |
| 2015 Octubre | 2 | 1 | 3 |
| 2015 Septiembre | 5 | 2 | 7 |
| 2015 Agosto | 10 | 7 | 17 |
| 2015 Julio | 52 | 54 | 106 |
| 2015 Junio | 44 | 33 | 77 |
| 2015 Mayo | 92 | 37 | 129 |
| 2015 Abril | 43 | 26 | 69 |
| 2015 Marzo | 51 | 25 | 76 |
| 2015 Febrero | 67 | 23 | 90 |
| 2015 Enero | 45 | 30 | 75 |
| 2014 Diciembre | 62 | 26 | 88 |
| 2014 Noviembre | 41 | 19 | 60 |
| 2014 Octubre | 46 | 35 | 81 |
| 2014 Septiembre | 50 | 21 | 71 |
| 2014 Agosto | 45 | 18 | 63 |
| 2014 Julio | 65 | 20 | 85 |
| 2014 Junio | 51 | 14 | 65 |
| 2014 Mayo | 58 | 19 | 77 |
| 2014 Abril | 62 | 20 | 82 |
| 2014 Marzo | 71 | 30 | 101 |
| 2014 Febrero | 40 | 14 | 54 |
| 2014 Enero | 51 | 26 | 77 |
| 2013 Diciembre | 49 | 17 | 66 |
| 2013 Noviembre | 24 | 23 | 47 |
| 2013 Octubre | 31 | 24 | 55 |
| 2013 Septiembre | 48 | 43 | 91 |
| 2013 Agosto | 37 | 37 | 74 |
| 2013 Julio | 40 | 45 | 85 |
| 2013 Junio | 25 | 25 | 50 |
| 2013 Mayo | 42 | 16 | 58 |
| 2013 Abril | 36 | 28 | 64 |
| 2013 Marzo | 28 | 22 | 50 |
| 2013 Febrero | 27 | 17 | 44 |
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