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Case Report
Leishmaniasis and Rheumatoid Nodulosis in a Patient With HIV Infection
Leishmaniasis y Nodulosis Reumatoide en Paciente con Infección por el Virus de la Inmunodeficiencia Humana
I. García-Ríoa,
Autor para correspondencia
irene@aedv.es

Corresponding author.
, E. Daudéna, M. Ballestero-Díeza, J. Fragab, A. García-Díeza
a Departamento de Dermatología, Hospital Universitario de la Princesa, Madrid, Spain
b Departamento de Anatomía Patológica, Hospital Universitario de la Princesa, Madrid, Spain
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        "titulo" => "Leishmaniasis y Nodulosis Reumatoide en Paciente con Infecci&#243;n por el Virus de la Inmunodeficiencia Humana"
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        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We describe the case of a 44-year-old homosexual man diagnosed with HIV infection and visceral leishmaniasis&#46; He presented nodules on the dorsum of the hands&#46; Histological study of one of the nodules revealed necrobiotic palisading granulomas with abundant Leishmania amastigotes within the histiocytes and in the adjacent extracellular space&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Tissue and peripheral blood cultures were positive for Leishmania infantum&#44; zymodeme MON-24&#46; A biopsy of healthy skin did not reveal the presence of Leishmania&#46; A diagnosis of rheumatoid nodulosis with Leishmania was made and treatment was started with intravenous liposomal amphotericin&#44; leading to slight improvement&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">We believe that the presence of the parasite within the nodules was the result of its dissemination during visceral leishmaniasis in an immunocompromised patient with HIV infection&#44; and that the Leishmania did not have an etiological role in the appearance of the nodules&#46; We present the first case of the association between Leishmania and rheumatoid nodulosis&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Describimos el caso de un paciente var&#243;n de 44 a&#241;os&#44; homosexual&#44; infectado por el virus de la inmunodeficiencia humana &#40;VIH&#41; y diagnosticado de leishmaniasis visceral&#46; Cl&#237;nicamente presentaba unos n&#243;dulos en el dorso de las manos&#46; El estudio histol&#243;gico de uno de ellos mostraba granulomas necrobi&#243;ticos en empalizada y abundantes amastigotes de Leishmania dentro de los histiocitos y extracelularmente en la proximidad&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Los cultivos tisulares y de sangre perif&#233;rica fueron positivos para Leishmania infantum&#44; con el an&#225;lisis isoenzim&#225;tico zymodema 24&#46; Una biopsia de piel sana no revel&#243; la presencia de Leishmania&#46; El diagn&#243;stico fue de nodulosis reumatoide con Leishmania&#44; y se inici&#243; tratamiento con anfotericina liposomal intravenosa con leve mejor&#237;a&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Consideramos que la presencia del par&#225;sito en los n&#243;dulos fue producida por la diseminaci&#243;n durante la leishmaniasis visceral&#44; en el contexto de un paciente inmunosuprimido&#44; como en una infecci&#243;n por el VIH&#44; y no tiene un papel etiol&#243;gico en su origen&#46; Es decir&#44; no pensamos que los par&#225;sitos hayan producido los n&#243;dulos&#46; Presentamos el primer caso de asociaci&#243;n entre leishmania y nodulosis reumatoide&#46;</p>"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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