Original Article
Adverse Reactions During Biological Therapy for Psoriasis: Results of a Survey of the Spanish Psoriasis Group
Efectos Adversos Observados Durante la Terapia Biológica en la Psoriasis. Resultados de una Encuesta al Grupo Español de Psoriasis
M. Sánchez-Regañaa,
, E. Dilméa, Ll. Puigb, X. Bordasc, J.M. Carrascosa,d, M. Ferrane, P. Herranzf, M. García-Bustinduyg, J.L. López Estebaranzh, M. Alsinai, M.A. Rodríguezj, M. Riberad, E. Fernández-Lópezk, J.C. Morenol, I. Belinchón Romerom, D. Vidaln
Autor para correspondencia
a Hospital Universitari Sagrat Cor, Barcelona, Spain
b Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
c Hospital Universitari de Bellvitge, Barcelona, Spain
d Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
e Hospital del Mar, Barcelona, Spain
f Hospital Universitario la Paz, Madrid, Spain
g Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
h Fundación Hospital Alcorcón, Madrid, Spain
i Hospital Clínic, Barcelona, Spain
j Hospital de León, León, Spain
k Hospital Universitario de Salamanca, Salamanca, Spain
l Hospital Universitario Reina Sofía, Córdoba, Spain
m Hospital General Universitario de Alicante, Alicante, Spain
n Hospital Dos de Maig, Barcelona, Spain
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Resultados de una Encuesta al Grupo Español de Psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-05" "fechaAceptado" => "2009-08-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84698" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Biologic agents" 2 => "Survey" 3 => "Safety" 4 => "Adverse reactions" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84699" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Biológicos" 2 => "Encuesta" 3 => "Seguridad" 4 => "Efectos adversos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Biologic therapies have been a major breakthrough in the treatment of psoriasis because they are more selective and have a better short-term and medium-term safety profile. There are reliable data to support both the efficacy and the safety of these drugs. However, it is always useful to report the clinical experience of dermatologists who are experts in the use of biologic agents to treat psoriasis, particularly with regard to their safety.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We present the results of a survey administered to the members of Spanish Psoriasis Group and based on a series of questions referring to the clinical safety of these agents. A total of 988 patients treated with efalizumab, infliximab, etanercept, and adalimumab were reported by 15 members of the group.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There was a particularly high proportion of reactions (34%) to infliximab infusions. Blood test abnormalities were detected in 13.25% of patients and infections in 12.24%, with one case of pulmonary tuberculosis. Attention is drawn to the adverse effects profile of efalizumab: de novo arthritis in 5.8% and rebound in 20.9% of patients.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">The safety data provided by our study should be taken into account in view of the large number of patients recruited by dermatologists experienced in the use of this type of therapy.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La terapia biológica ha representado un avance muy importante en el tratamiento de la psoriasis, al tratarse de una generación de fármacos más selectivos y con mejor perfil de seguridad a corto y medio plazo. Existen datos sólidos a favor de la eficacia de cada uno de estos fármacos, así como de su seguridad. A pesar de ello, siempre es útil aportar la experiencia clínica de dermatólogos expertos en el tratamiento de la psoriasis con biológicos, en especial en lo referente a su seguridad.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realizó una encuesta a los miembros del Grupo Español de Psoriasis (GEP) basada en una serie de ítems relativos a aspectos referentes a la seguridad clínica de estos fármacos, cuyos resultados se presentan en este artículo. Un total de 988 pacientes tratados con efalizumab, etanercept, infliximab y adalimumab fueron recogidos por parte de 15 miembros del GEP.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Entre los resultados obtenidos destaca la elevada proporción de reacciones a infliximab (34%). Se observaron alteraciones analíticas en el 13,25% de los pacientes e infecciones en el 12,24%, con un único caso de tuberculosis pulmonar. Es de destacar el perfil de efectos secundarios de efalizumab: artritis <span class="elsevierStyleItalic">de novo</span> en el 5,8% y rebote en el 20,9%.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p class="elsevierStyleSimplePara elsevierViewall">Los datos de seguridad aportados por nuestro trabajo deben tenerse en consideración, habida cuenta del importante número de pacientes reclutados por un grupo de dermatólogos expertos en el manejo de este tipo de fármacos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuevos tratamientos en la psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Ferrándiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2007" "volumen" => "129" "paginaInicial" => "377" "paginaFinal" => "378" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis causes as much disability as other major medical diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.R. Rapp" 1 => "S.R. Feldman" 2 => "M.L. Exum" 3 => "A.B. Fleisxe" 4 => "D.M. Reboussin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "numero" => "3 Pt 1" "paginaInicial" => "401" "paginaFinal" => "407" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10459113" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biological therapies in the systemic management of psoriasis; International Consensus Conference" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Sterry" 1 => "J. Baker" 2 => "W.H. Boehncke" 3 => "J.D. Bos" 4 => "S. Chimenti" 5 => "E. Christophers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2004.06269.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2004" "volumen" => "151" "paginaInicial" => "3" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15548171" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673605673941" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term data in the treatment of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Thaci" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08781.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "159" "numero" => "Suppl 2" "paginaInicial" => "18" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18700911" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia biológica y psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Gamo" 1 => "J.L. López -Estebaranz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2006" "volumen" => "97" "paginaInicial" => "1" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16540046" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Directrices españolas basadas en la evidencia para el tratamiento de la psoriasis moderada a grave con agentes biológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Puig" 1 => "J.M. Carrascosa" 2 => "E. Daudén" 3 => "J.L. Sánchez-Carazo" 4 => "C. Ferrándiz" 5 => "M. Sánchez-Regaña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2009" "volumen" => "100" "paginaInicial" => "386" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19558918" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efalizumab: results of a 3-year continuous dosing study for the long-term control of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Leonardi" 1 => "A. Menter" 2 => "T. Hamilton" 3 => "I. Caro" 4 => "B. Xing" 5 => "A.B. Gottlieb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08548.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "1107" "paginaFinal" => "1116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18373710" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term treatment of plaque psoriasis with efalizumab: an Italian experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Costanzo" 1 => "K. Peris" 2 => "M. Talamonti" 3 => "A. Di Cesare" 4 => "M. Concetta Fargnoli" 5 => "E. Botti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07765.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "17" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17371319" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Greek experience with efalizumab in psoriasis from a University Dermatologic Hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Antoniou" 1 => "I. Stefanaki" 2 => "A. Stratigos" 3 => "G. Avgerinou" 4 => "P. Stavropoulos" 5 => "I. Potouridou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07764.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "12" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17371318" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efalizumab in routine use: a clinical experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Selenko-Gebauer" 1 => "F. Karlhoer" 2 => "G. Stingl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07861.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17488399" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efalizumab in the treatment of chronic plaque psoriasis: experiences from the largest psoriasis treatment centre in Denmark" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Kragballe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07763.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "7" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17371317" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etanercept monotherapy in patients with psoriasis: A summary of safety, based on an integrated multistudy database" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.B. Gottlieb" 1 => "C.L. Leonardi" 2 => "B.S. Goffe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2005.10.053" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2006" "volumen" => "54" "paginaInicial" => "S92" "paginaFinal" => "S100" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16488335" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term safety and efficacy of 50 mg of etanercept twice weekly in patients with psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Tyring" 1 => "K.B. Gorgon" 2 => "Y. Poulin" 3 => "R.G. Langley" 4 => "A.B. Gottlieb" 5 => "M. Dunn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.143.6.719" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2007" "volumen" => "143" "paginaInicial" => "719" "paginaFinal" => "726" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17576937" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparación de la eficacia y seguridad del tratamiento continuo e intermitente con etanercept en pacientes con psoriasis moderada a grave durante 54 semanas: estudio CRYSTEL" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P. Ortonne" 1 => "C. Griffiths" 2 => "E. Daudén" 3 => "R. Strohal" 4 => "D. Robertson" 5 => "R. Pedersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Expert Rev Dermatol" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "657" "paginaFinal" => "666" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Ko" 1 => "A.B. Gottlieb" 2 => "J.F. Kerbleski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol Treat" "fecha" => "2009" "volumen" => "20" "paginaInicial" => "100" "paginaFinal" => "108" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for the long-term treatment of psoriasis with infliximab: a dermatology expert group consensus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Reich" 1 => "C. Griffiths" 2 => "J. Barber" 3 => "S. Chimenti" 4 => "E. Daudén" 5 => "A. Giannetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000149970" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2008" "volumen" => "217" "paginaInicial" => "268" "paginaFinal" => "275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18685261" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reacciones a la infusión de infliximab en pacientes dermatológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Puig" 1 => "E. Sáez" 2 => "M.J. Lozano" 3 => "X. Bordas" 4 => "J.M. Carrascosa" 5 => "F. Gallardo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2009" "volumen" => "100" "paginaInicial" => "103" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19445874" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biologic therapies for psoriasis: practical experience in a UK tertiary referral centre" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.B. Warren" 1 => "B.C. Brown" 2 => "D. Lavery" 3 => "D.M. Ashcroft" 4 => "C.E.M. Griffiths" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08865.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "160" "paginaInicial" => "162" "paginaFinal" => "169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18808412" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety results from the comparative study of adalimumab (HUMIRA) versus methotrexate versus placebo in psoriasis patients (CHAMPION)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.H. Saurat" 1 => "G. Stingl" 2 => "L. Dubertret" 3 => "K. Papp" 4 => "R.G. Langley" 5 => "J.P. Ortonne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08315.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "558" "paginaFinal" => "566" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18047523" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical response to adalimumab treatment in patients with moderate to severe psoriasis: double-blind, randomized controlled trial and open-label extension study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.B. Gordon" 1 => "R.G. Langley" 2 => "C. Leonardi" 3 => "D. Toth" 4 => "M.A. Menter" 5 => "S. Kang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2006.05.027" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2006" "volumen" => "55" "paginaInicial" => "598" "paginaFinal" => "606" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17010738" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000002/v1_201304241515/S1578219010706028/v1_201304241515/en/main.assets" "Apartado" => array:4 [ "identificador" => "6252" "tipo" => "SECCION" "fr" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "fr" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000002/v1_201304241515/S1578219010706028/v1_201304241515/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706028?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 7 | 15 |
| 2024 Octubre | 109 | 43 | 152 |
| 2024 Septiembre | 86 | 17 | 103 |
| 2024 Agosto | 97 | 49 | 146 |
| 2024 Julio | 69 | 30 | 99 |
| 2024 Junio | 57 | 23 | 80 |
| 2024 Mayo | 52 | 22 | 74 |
| 2024 Abril | 51 | 24 | 75 |
| 2024 Marzo | 45 | 39 | 84 |
| 2024 Febrero | 49 | 43 | 92 |
| 2024 Enero | 37 | 39 | 76 |
| 2023 Diciembre | 50 | 29 | 79 |
| 2023 Noviembre | 50 | 25 | 75 |
| 2023 Octubre | 43 | 25 | 68 |
| 2023 Septiembre | 34 | 21 | 55 |
| 2023 Agosto | 27 | 18 | 45 |
| 2023 Julio | 36 | 41 | 77 |
| 2023 Junio | 38 | 19 | 57 |
| 2023 Mayo | 30 | 20 | 50 |
| 2023 Abril | 21 | 20 | 41 |
| 2023 Marzo | 25 | 26 | 51 |
| 2023 Febrero | 25 | 19 | 44 |
| 2023 Enero | 32 | 18 | 50 |
| 2022 Diciembre | 28 | 40 | 68 |
| 2022 Noviembre | 19 | 32 | 51 |
| 2022 Octubre | 18 | 20 | 38 |
| 2022 Septiembre | 20 | 36 | 56 |
| 2022 Agosto | 25 | 27 | 52 |
| 2022 Julio | 11 | 35 | 46 |
| 2022 Junio | 15 | 28 | 43 |
| 2022 Mayo | 28 | 32 | 60 |
| 2022 Abril | 27 | 46 | 73 |
| 2022 Marzo | 34 | 56 | 90 |
| 2022 Febrero | 17 | 29 | 46 |
| 2022 Enero | 25 | 41 | 66 |
| 2021 Diciembre | 20 | 33 | 53 |
| 2021 Noviembre | 27 | 48 | 75 |
| 2021 Octubre | 18 | 51 | 69 |
| 2021 Septiembre | 24 | 50 | 74 |
| 2021 Agosto | 28 | 32 | 60 |
| 2021 Julio | 29 | 34 | 63 |
| 2021 Junio | 28 | 40 | 68 |
| 2021 Mayo | 36 | 28 | 64 |
| 2021 Abril | 42 | 59 | 101 |
| 2021 Marzo | 58 | 31 | 89 |
| 2021 Febrero | 48 | 21 | 69 |
| 2021 Enero | 44 | 18 | 62 |
| 2020 Diciembre | 19 | 16 | 35 |
| 2020 Noviembre | 27 | 19 | 46 |
| 2020 Octubre | 26 | 20 | 46 |
| 2020 Septiembre | 15 | 10 | 25 |
| 2020 Agosto | 35 | 20 | 55 |
| 2020 Julio | 23 | 11 | 34 |
| 2020 Junio | 20 | 22 | 42 |
| 2020 Mayo | 29 | 17 | 46 |
| 2020 Abril | 30 | 20 | 50 |
| 2020 Marzo | 28 | 24 | 52 |
| 2020 Febrero | 0 | 3 | 3 |
| 2020 Enero | 0 | 6 | 6 |
| 2019 Diciembre | 0 | 11 | 11 |
| 2019 Noviembre | 0 | 4 | 4 |
| 2019 Octubre | 0 | 3 | 3 |
| 2019 Septiembre | 0 | 5 | 5 |
| 2019 Agosto | 0 | 5 | 5 |
| 2019 Julio | 0 | 11 | 11 |
| 2019 Junio | 0 | 13 | 13 |
| 2019 Mayo | 0 | 42 | 42 |
| 2019 Abril | 0 | 12 | 12 |
| 2019 Marzo | 0 | 9 | 9 |
| 2019 Febrero | 0 | 5 | 5 |
| 2019 Enero | 1 | 1 | 2 |
| 2018 Diciembre | 0 | 3 | 3 |
| 2018 Noviembre | 0 | 8 | 8 |
| 2018 Septiembre | 1 | 0 | 1 |
| 2018 Mayo | 0 | 1 | 1 |
| 2018 Abril | 0 | 6 | 6 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 8 | 3 | 11 |
| 2018 Enero | 20 | 6 | 26 |
| 2017 Diciembre | 13 | 5 | 18 |
| 2017 Noviembre | 21 | 3 | 24 |
| 2017 Octubre | 26 | 14 | 40 |
| 2017 Septiembre | 15 | 11 | 26 |
| 2017 Agosto | 29 | 5 | 34 |
| 2017 Julio | 26 | 4 | 30 |
| 2017 Junio | 22 | 12 | 34 |
| 2017 Mayo | 19 | 13 | 32 |
| 2017 Abril | 14 | 6 | 20 |
| 2017 Marzo | 18 | 17 | 35 |
| 2017 Febrero | 32 | 11 | 43 |
| 2017 Enero | 17 | 11 | 28 |
| 2016 Diciembre | 45 | 6 | 51 |
| 2016 Noviembre | 24 | 7 | 31 |
| 2016 Octubre | 29 | 14 | 43 |
| 2016 Septiembre | 33 | 12 | 45 |
| 2016 Agosto | 24 | 7 | 31 |
| 2016 Julio | 19 | 8 | 27 |
| 2016 Junio | 20 | 5 | 25 |
| 2016 Mayo | 7 | 4 | 11 |
| 2016 Abril | 4 | 7 | 11 |
| 2016 Marzo | 5 | 9 | 14 |
| 2016 Febrero | 9 | 9 | 18 |
| 2016 Enero | 6 | 1 | 7 |
| 2015 Diciembre | 10 | 0 | 10 |
| 2015 Noviembre | 9 | 1 | 10 |
| 2015 Octubre | 10 | 4 | 14 |
| 2015 Septiembre | 8 | 3 | 11 |
| 2015 Agosto | 13 | 2 | 15 |
| 2015 Julio | 26 | 6 | 32 |
| 2015 Junio | 23 | 3 | 26 |
| 2015 Mayo | 52 | 15 | 67 |
| 2015 Abril | 23 | 8 | 31 |
| 2015 Marzo | 23 | 12 | 35 |
| 2015 Febrero | 19 | 6 | 25 |
| 2015 Enero | 13 | 9 | 22 |
| 2014 Diciembre | 19 | 22 | 41 |
| 2014 Noviembre | 14 | 17 | 31 |
| 2014 Octubre | 36 | 16 | 52 |
| 2014 Septiembre | 26 | 11 | 37 |
| 2014 Agosto | 19 | 14 | 33 |
| 2014 Julio | 30 | 19 | 49 |
| 2014 Junio | 50 | 17 | 67 |
| 2014 Mayo | 42 | 16 | 58 |
| 2014 Abril | 38 | 6 | 44 |
| 2014 Marzo | 46 | 20 | 66 |
| 2014 Febrero | 36 | 10 | 46 |
| 2014 Enero | 42 | 15 | 57 |
| 2013 Diciembre | 36 | 9 | 45 |
| 2013 Noviembre | 33 | 24 | 57 |
| 2013 Octubre | 20 | 17 | 37 |
| 2013 Septiembre | 27 | 20 | 47 |
| 2013 Agosto | 22 | 23 | 45 |
| 2013 Julio | 32 | 24 | 56 |
| 2013 Junio | 28 | 30 | 58 |
| 2013 Mayo | 15 | 22 | 37 |
| 2013 Abril | 13 | 27 | 40 |
| 2013 Marzo | 24 | 36 | 60 |
| 2013 Febrero | 17 | 15 | 32 |
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