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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">This consensus statement on the management of primary cutaneous melanoma that we present here was based on selection&#44; discussion&#44; review&#44; and comparison of recent literature &#40;including national and international guidelines&#41;&#46; The protocols for the diagnosis&#44; treatment&#44; and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered&#46; The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time&#46; As such&#44; the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients&#44; and neither can it nor should it be used for this purpose&#46; Professionals reading the statement should not therefore consider it binding on their practice&#44; and in no case can this text be used to guarantee or seek responsibility for a given medical opinion&#46; The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor&#44; which&#44; in comparison with other types of cancer&#44; we believe does not receive sufficient attention in Spain&#46; In addition&#44; the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological&#44; clinical&#44; and basic applied research projects on the subject of malignant melanoma in our society&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El documento de consenso respecto al manejo del melanoma primario de la piel&#44; que detallamos a continuaci&#243;n&#44; nace de la puesta en com&#250;n&#44; aceptaci&#243;n&#44; revisi&#243;n y confrontaci&#243;n con la literatura reciente &#40;incluyendo gu&#237;as cl&#237;nicas nacionales e internacionales&#41;&#44; as&#237; como de los protocolos de diagn&#243;stico&#44; seguimiento y tratamiento consensuados en los diferentes centros hospitalarios de toda Catalu&#241;a y Baleares pertenecientes a la Xarxa de Centres de Melanoma de Catalunya i Balears&#46; El objetivo principal de este documento es exponer de forma conjunta el manejo habitual del paciente con melanoma que actualmente se realiza en nuestro medio&#46; Sin embargo&#44; este documento no pretende&#44; ni puede&#44; por lo que tampoco debiera ser usado como un protocolo de obligado cumplimiento por los profesionales que atendemos a este grupo de enfermos&#46; En este sentido&#44; cabe mencionar que la consulta de este documento por parte del profesional no es vinculante para su acci&#243;n&#44; y en ning&#250;n caso este texto podr&#225; ser utilizado para garantizar o buscar responsabilidades del juicio m&#233;dico concreto&#46; El grupo de dermat&#243;logos que firman dicho documento se form&#243; hace ahora tres a&#241;os&#44; con la intenci&#243;n de dar a conocer a nuestras autoridades la importancia de este complejo tumor&#44; que en nuestro pa&#237;s creemos que se encuentra err&#243;neamente infravalorada con respecto a otros tipo de c&#225;ncer&#46; Adem&#225;s&#44; fruto de las reuniones peri&#243;dicas del grupo&#44; han surgido tambi&#233;n interesantes propuestas de colaboraci&#243;n en distintos proyectos de investigaci&#243;n epidemiol&#243;gica&#44; cl&#237;nica y b&#225;sica aplicada en torno al melanoma maligno en nuestra sociedad&#46;</p>"
      ]
    ]
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      "titulo" => "References"
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        0 => array:1 [
          "bibliografiaReferencia" => array:119 [
            0 => array:3 [
              "identificador" => "bib1"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "fecha" => "1998"
                        "volumen" => "134"
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                    ]
                  ]
                ]
              ]
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              "identificador" => "bib2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is dermoscopy useful for the diagnosis of melanoma&#63; Results of a meta-analysis using techniques adapted to the evaluation of the diagnostic tests"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                    ]
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                ]
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            ]
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              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanomas that failed dermoscopic detection&#58; a combined clinicodermoscopic approach for not missing melanoma"
                      "autores" => array:1 [
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:7 [
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                        "fecha" => "2007"
                        "volumen" => "33"
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                ]
              ]
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            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follow up of melanocytic skin lesions with digital dermoscopy"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "297"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
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              "etiqueta" => "5&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma in the 21st century&#44; part 1&#58; epidemiology&#44; risk factors&#44; screening&#44; prevention&#44; and diagnosis"
                      "autores" => array:1 [
                        0 => array:3 [ …3]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4065/82.3.364"
                      "Revista" => array:6 [
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                        "fecha" => "2007"
                        "volumen" => "82"
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                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
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                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra041245"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "998"
                        "paginaFinal" => "1012"
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              ]
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            6 => array:3 [
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              "etiqueta" => "7&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Evidence-based and interdisciplinary consensus-based German guidelines&#58; systemic medical treatment of melanoma in the adjuvant and palliative setting"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CMR.0b013e3282f702bf"
                      "Revista" => array:6 [
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                        "fecha" => "2008"
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                    ]
                  ]
                ]
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            ]
            7 => array:3 [
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              "etiqueta" => "8&#46;"
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                ]
              ]
            ]
            8 => array:3 [
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                  "referenciaCompleta" => "Australian CancerNetwork&#46; Melanoma Guidelines Revision Working Party&#46; Clinical Practice Guidelines for the Management of Melanoma in Australia and New Zealand&#46; Cancer Council Australia and Australian Cancer Network&#44; Sydney and New Zealand Guidelines Group&#44; Wellington &#40;2008&#41;&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.cancer.org.au/">www&#46;cancer&#46;org&#46;au</a>&#46;"
                ]
              ]
            ]
            9 => array:3 [
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              "etiqueta" => "10&#46;"
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                0 => array:1 [
                  "referenciaCompleta" => "Gu&#237;a de Prevenci&#243;n y Tratamiento del Melanoma Cut&#225;neo de la Comunidad Valenciana&#44; Valencia &#40;2006&#41;&#46; Available from&#58; <a class="elsevierStyleInterRef" href="http://www.biblioteca.sp.san.gva.es/">www&#46;biblioteca&#46;sp&#46;san&#46;gva&#46;es</a>&#46;"
                ]
              ]
            ]
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                      "autores" => array:1 [
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                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
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                        "fecha" => "1999"
                        "volumen" => "36"
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                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A melanoma-associated germline mutation in exon 1&#946; inactivates p14ARF"
                      "autores" => array:1 [
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.onc.1204728"
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                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
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                      "titulo" => "Melanoma Genetics Consortium &#40;GenoMEL&#41;&#46; High-risk melanoma susceptibility genes and pancreatic cancer&#44; neural system tumors&#44; and uveal melanoma across GenoMEL"
                      "autores" => array:1 [
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                      ]
                    ]
                  ]
                  "host" => array:1 [
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                  "contribucion" => array:1 [
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                    ]
                  ]
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              ]
            ]
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                      "autores" => array:1 [
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                    ]
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Consensus Statement
Initial Evaluation, Diagnosis, Staging, Treatment, and Follow-up of Patients with Primary Cutaneous Malignant Melanoma. Consensus Statement of the Network of Catalan and Balearic Melanoma Centers
Valoración inicial, diagnóstico, estadificación, tratamiento y seguimiento de los pacientes con melanoma maligno primario de la piel. Documento de consenso de la “Xarxa de Centres de Melanoma de Catalunya i Balears”
C. Mangasa,
Autor para correspondencia
cris_mangas@yahoo.es

Corresponding author.
, C. Paradeloa, S. Puigb, F. Gallardoc, J. Marcovald, A. Azone, R. Bartralotf, S. Belg, X. Bigatàh, N. Curcói, J. Dalmauj, L.J. del Pozok, C. Ferrándiza, M. Formigónl, A. Gonzálezm, M. Justn, A. Llambricho, E. Llistosellap, J. Malvehyq, R.M. Martír..., M.E. Noguéss, R. Pedragosat, V. Rocamorau, M. Sàbatv, M. SalleraswVer más
a Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
b Unitat de Melanoma, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain
c Hospital del Mar, IMIM, Barcelona, Spain
d Hospital Universitari de Bellvitge, Barcelona, Spain
e Hospital Sant Joan de Reus, Reus, Barcelona, Spain
f Hospital Vall d’Hebron, Barcelona, Spain
g Hospital Comarcal d’Amposta, Amposta, Tarragona, Spain
h Hospital de Mataró, Mataró, Barcelona, Spain
i Hospital Mútua de Terrassa, Terrassa, Barcelona, Spain
j Hospital Santa Creu i Sant Pau, Barcelona, Spain
k Hospital Universitari Son Dureta, Palma de Mallorca, Spain
l Consorci Sanitari de Terrassa, Terrassa, Barcelona, Spain
m Consorci Sanitari Integral, L’Hospitalet de Llobregat, Barcelona, Spain
n Hospital de Figueres, Figueres, Girona, Spain
o Hospital Son Llàtzer, Palma de Mallorca, Spain
p Hospital Universitari Dr. Josep Trueta, Girona, Spain
q Hospital Clínic i Provincial de Barcelona, Barcelona, Spain
r Hospital Universitari Arnau de Vilanova, Lleida, Spain
s Hospital d’Igualada, Igualada, Barcelona, Spain
t Hospital Plató, Barcelona, Spain
u Hospital de Manacor, Manacor, Mallorca, Spain
v Hospital ParcTaulí, Sabadell, Barcelona, Spain
w Hospital Sagrat Cor, Barcelona, Spain
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        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">This consensus statement on the management of primary cutaneous melanoma that we present here was based on selection&#44; discussion&#44; review&#44; and comparison of recent literature &#40;including national and international guidelines&#41;&#46; The protocols for the diagnosis&#44; treatment&#44; and follow-up used in the hospital centers throughout Catalonia and the Balearic Isles belonging to the Network of Catalan and Balearic Melanoma Centers were also considered&#46; The main objective of this statement was to present the overall management of melanoma patients typically used in our region at the present time&#46; As such&#44; the statement was not designed to be an obligatory protocol for health professionals caring for this group of patients&#44; and neither can it nor should it be used for this purpose&#46; Professionals reading the statement should not therefore consider it binding on their practice&#44; and in no case can this text be used to guarantee or seek responsibility for a given medical opinion&#46; The group of dermatologists who have signed this statement was created 3 years ago with the aim of making our authorities aware of the importance of this complex tumor&#44; which&#44; in comparison with other types of cancer&#44; we believe does not receive sufficient attention in Spain&#46; In addition&#44; the regular meetings of the group have produced interesting proposals for collaboration in various epidemiological&#44; clinical&#44; and basic applied research projects on the subject of malignant melanoma in our society&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El documento de consenso respecto al manejo del melanoma primario de la piel&#44; que detallamos a continuaci&#243;n&#44; nace de la puesta en com&#250;n&#44; aceptaci&#243;n&#44; revisi&#243;n y confrontaci&#243;n con la literatura reciente &#40;incluyendo gu&#237;as cl&#237;nicas nacionales e internacionales&#41;&#44; as&#237; como de los protocolos de diagn&#243;stico&#44; seguimiento y tratamiento consensuados en los diferentes centros hospitalarios de toda Catalu&#241;a y Baleares pertenecientes a la Xarxa de Centres de Melanoma de Catalunya i Balears&#46; El objetivo principal de este documento es exponer de forma conjunta el manejo habitual del paciente con melanoma que actualmente se realiza en nuestro medio&#46; Sin embargo&#44; este documento no pretende&#44; ni puede&#44; por lo que tampoco debiera ser usado como un protocolo de obligado cumplimiento por los profesionales que atendemos a este grupo de enfermos&#46; En este sentido&#44; cabe mencionar que la consulta de este documento por parte del profesional no es vinculante para su acci&#243;n&#44; y en ning&#250;n caso este texto podr&#225; ser utilizado para garantizar o buscar responsabilidades del juicio m&#233;dico concreto&#46; El grupo de dermat&#243;logos que firman dicho documento se form&#243; hace ahora tres a&#241;os&#44; con la intenci&#243;n de dar a conocer a nuestras autoridades la importancia de este complejo tumor&#44; que en nuestro pa&#237;s creemos que se encuentra err&#243;neamente infravalorada con respecto a otros tipo de c&#225;ncer&#46; Adem&#225;s&#44; fruto de las reuniones peri&#243;dicas del grupo&#44; han surgido tambi&#233;n interesantes propuestas de colaboraci&#243;n en distintos proyectos de investigaci&#243;n epidemiol&#243;gica&#44; cl&#237;nica y b&#225;sica aplicada en torno al melanoma maligno en nuestra sociedad&#46;</p>"
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                    0 => array:2 [
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                        0 => array:2 [ …2]
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                      "titulo" => "CDKN2A mutations in Spanish cutaneous malignant melanoma families and patients with multiple melanomas and other neoplasia"
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                    0 => array:2 [
                      "titulo" => "A melanoma-associated germline mutation in exon 1&#946; inactivates p14ARF"
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ISSN: 15782190
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