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Quinacrine in the Treatment of Cutaneous Lupus Erythematosus: Practical Aspects and a Case Series
Aspectos Prácticos de la Quinacrina Como Tratamiento del Lupus Eritematoso Cutáneo: Serie de Casos
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Zaragoza, A. Pérez, J.L. Sánchez, V. Oliver, L. Martínez, V. Alegre" "autores" => array:6 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Zaragoza" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Pérez" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Oliver" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Martínez" ] 5 => array:2 [ "nombre" => "V." "apellidos" => "Alegre" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010705795?idApp=UINPBA000044" "url" => "/15782190/0000010100000001/v1_201304241512/S1578219010705795/v1_201304241512/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Quinacrine in the Treatment of Cutaneous Lupus Erythematosus: Practical Aspects and a Case Series" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "54" "paginaFinal" => "58" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "B. González-Sixto, I. García-Doval, R. Oliveira, C. Posada, M.A. García-Cruz, M. Cruces" "autores" => array:6 [ 0 => array:4 [ "nombre" => "B." "apellidos" => "González-Sixto" "email" => array:1 [ 0 => "bgonsix@aedv.esn" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "García-Doval" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "R." "apellidos" => "Oliveira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Posada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "M.A." "apellidos" => "García-Cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "M." "apellidos" => "Cruces" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Enfermedades Autoinmunes, Servicio de Dermatología, Complejo Hospitalario de Pontevedra, Pontevedra, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Farmacia, Complejo Hospitalario de Pontevedra, Pontevedra, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aspectos Prácticos de la Quinacrina Como Tratamiento del Lupus Eritematoso Cutáneo: Serie de Casos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-12-17" "fechaAceptado" => "2009-07-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84666" "palabras" => array:4 [ 0 => "Cutaneous lupus erythematosus" 1 => "Antimalarials" 2 => "Quinacrine" 3 => "Adverse effect" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84667" "palabras" => array:4 [ 0 => "Lupus eritematoso cutáneo" 1 => "Antimaláricos" 2 => "Quinacrina" 3 => "Efecto secundario" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Hydroxychloroquine and chloroquine are antimalarials used as first-line treatment of cutaneous lupus. Quinacrine is not often employed by Spanish physicians due to a lack of information about its use and the fact that it is not marketed in Spain. It is effective in monotherapy or in combination therapy with other antimalarials. One of the advantages of quinacrine over chloroquine and hydroxychloroquine is that it does not appear to cause retinal toxicity.</p><p class="elsevierStyleSimplePara elsevierViewall">Quinacrine is used as second-line therapy in patients with pre-existing eye problems that contraindicate treatment with chloroquine or hydroxychloroquine (after evaluation of which drug has the better risk-benefit relationship), and in combination therapy with other antimalarials in patients with resistance or only a partial response to chloroquine or hydroxychloroquine.</p><p class="elsevierStyleSimplePara elsevierViewall">We report 8 cases of patients with cutaneous lupus who received treatment with quinacrine in monotherapy or in combination with other antimalarials. Lesions resolved in 5 patients and improved in 3. Therapy had to be withdrawn in 1 patient due to an exacerbation of his psoriasis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Los antimaláricos de primera elección en el tratamiento del lupus cutáneo son la hidroxicloroquina (hydroxychloroquine) y la cloroquina (chloroquine). La quinacrina (Qn) se emplea poco, fundamentalmente por la ausencia de información sobre su utilización y por no estar comercializada en España. Es eficaz en combinación con otros antimaláricos y en monoterapia. La quinacrine parece carecer de toxicidad retiniana y ésta es una de sus ventajas sobre la chloroquine y la hydroxychloroquine.</p><p class="elsevierStyleSimplePara elsevierViewall">Se utiliza cuando existen alteraciones oculares previas al tratamiento que contraindican el uso de otros antimaláricos (al valorar la opción con mejor relación riesgo-beneficio), y en tratamiento combinado con otros antimaláricos en pacientes resistentes o parcialmente respondedores a chloroquine o hydroxychloroquine.</p><p class="elsevierStyleSimplePara elsevierViewall">Presentamos una serie de 8 casos de pacientes con lupus cutáneo que han recibido tratamiento con quinacrine en monoterapia o combinada con otros antimaláricos, se obtuvo resolución de las lesiones en 5 pacientes y mejoría de éstas en 3 pacientes. En uno de los pacientes fue necesario suspender el tratamiento por la aparición de un brote de psoriasis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of lupus erythematosus with mepacrine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Page" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1951" "volumen" => "2" "paginaInicial" => "755" "paginaFinal" => "758" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2571008" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lupus erythematosus treated with a combination of quinacrine, hydroxychloroquine and chloroquine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. Tye" 1 => "H. White" 2 => "B. Appel" 3 => "H.B. Ansell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM195901082600203" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1959" "volumen" => "260" "paginaInicial" => "63" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13613503" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New concepts in antimalarial use and mode of action in dermatology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Kalia" 1 => "J.P. Dutz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1529-8019.2007.00131.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Ther" "fecha" => "2007" "volumen" => "20" "paginaInicial" => "160" "paginaFinal" => "174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17970883" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bull's-eye maculopathy associated with quinacrine therapy for malaria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.J. Browning" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ajo.2003.08.047" "Revista" => array:6 [ "tituloSerie" => "Am J Ophthalmol" "fecha" => "2004" "volumen" => "137" "paginaInicial" => "577" "paginaFinal" => "579" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15013892" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ocular toxicity of antimalarial drugs. Long-term follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.E. Carr" 1 => "P. Henkind" 2 => "N. Rothfield" 3 => "I.M. Siegel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Ophthalmol" "fecha" => "1968" "volumen" => "66" "paginaInicial" => "738" "paginaFinal" => "744" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5729592" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antimalarial agents and lupus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.J. Wallace" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheum Dis Clin North Am" "fecha" => "1994" "volumen" => "20" "paginaInicial" => "243" "paginaFinal" => "263" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8153401" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of quinacrine (Atabrine) in rheumatic diseases: A reexamination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.J. Wallace" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "1989" "volumen" => "18" "paginaInicial" => "282" "paginaFinal" => "296" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2658071" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510711019754" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chloroquine-quinacrine association in resistant cutaneous lupus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Lipsker" 1 => "J.C. Piette" 2 => "P. Cacoub" 3 => "P. Godeau" 4 => "C. Frances" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "1995" "volumen" => "190" "paginaInicial" => "257" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7599397" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association of the two antimalarials chloroquine and quinacrine for treatment-resistant chronic and subacute cutaneous lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Feldmann" 1 => "D. Salomon" 2 => "J.H. Saurat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "1994" "volumen" => "189" "paginaInicial" => "425" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7873836" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The benefit of combining hydroxychloroquine with quinacrine in the treatment of SLE patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. T oubi" 1 => "I. Rosner" 2 => "M. Rozenbaum" 3 => "A. Kessel" 4 => "T.D. Golan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lupus" "fecha" => "2000" "volumen" => "9" "paginaInicial" => "92" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10787004" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current treatment of cutaneous lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Werth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Online J" "fecha" => "2001" "volumen" => "7" "paginaInicial" => "2" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12165218" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lupus panniculitis treated by a combination therapy of hydroxychloroquine and quinacrine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.S. Chung" 1 => "S.K. Hann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Dermatol" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "569" "paginaFinal" => "572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9350102" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S001651070803424X" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000001/v1_201304241512/S1578219010705801/v1_201304241512/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000001/v1_201304241512/S1578219010705801/v1_201304241512/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010705801?idApp=UINPBA000044" ]
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| 2021 Septiembre | 28 | 44 | 72 |
| 2021 Agosto | 24 | 23 | 47 |
| 2021 Julio | 27 | 31 | 58 |
| 2021 Junio | 29 | 31 | 60 |
| 2021 Mayo | 21 | 27 | 48 |
| 2021 Abril | 52 | 45 | 97 |
| 2021 Marzo | 53 | 34 | 87 |
| 2021 Febrero | 78 | 32 | 110 |
| 2021 Enero | 40 | 16 | 56 |
| 2020 Diciembre | 31 | 10 | 41 |
| 2020 Noviembre | 32 | 20 | 52 |
| 2020 Octubre | 44 | 20 | 64 |
| 2020 Septiembre | 27 | 19 | 46 |
| 2020 Agosto | 17 | 27 | 44 |
| 2020 Julio | 29 | 12 | 41 |
| 2020 Junio | 25 | 24 | 49 |
| 2020 Mayo | 42 | 25 | 67 |
| 2020 Abril | 26 | 17 | 43 |
| 2020 Marzo | 13 | 18 | 31 |
| 2020 Febrero | 4 | 15 | 19 |
| 2020 Enero | 0 | 4 | 4 |
| 2019 Diciembre | 0 | 9 | 9 |
| 2019 Noviembre | 0 | 5 | 5 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Julio | 0 | 6 | 6 |
| 2019 Junio | 0 | 11 | 11 |
| 2019 Mayo | 1 | 51 | 52 |
| 2019 Marzo | 0 | 3 | 3 |
| 2019 Febrero | 0 | 2 | 2 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 13 | 6 | 19 |
| 2018 Enero | 20 | 4 | 24 |
| 2017 Diciembre | 20 | 8 | 28 |
| 2017 Noviembre | 18 | 5 | 23 |
| 2017 Octubre | 14 | 4 | 18 |
| 2017 Septiembre | 38 | 6 | 44 |
| 2017 Agosto | 52 | 9 | 61 |
| 2017 Julio | 30 | 4 | 34 |
| 2017 Junio | 26 | 14 | 40 |
| 2017 Mayo | 13 | 9 | 22 |
| 2017 Abril | 16 | 8 | 24 |
| 2017 Marzo | 16 | 12 | 28 |
| 2017 Febrero | 13 | 8 | 21 |
| 2017 Enero | 14 | 6 | 20 |
| 2016 Diciembre | 23 | 15 | 38 |
| 2016 Noviembre | 26 | 8 | 34 |
| 2016 Octubre | 27 | 12 | 39 |
| 2016 Septiembre | 29 | 14 | 43 |
| 2016 Agosto | 35 | 10 | 45 |
| 2016 Julio | 38 | 9 | 47 |
| 2016 Junio | 6 | 12 | 18 |
| 2016 Mayo | 9 | 10 | 19 |
| 2016 Abril | 4 | 0 | 4 |
| 2016 Marzo | 2 | 1 | 3 |
| 2016 Febrero | 9 | 3 | 12 |
| 2016 Enero | 12 | 2 | 14 |
| 2015 Diciembre | 10 | 0 | 10 |
| 2015 Noviembre | 12 | 2 | 14 |
| 2015 Octubre | 8 | 11 | 19 |
| 2015 Septiembre | 2 | 3 | 5 |
| 2015 Agosto | 9 | 4 | 13 |
| 2015 Julio | 29 | 26 | 55 |
| 2015 Junio | 37 | 11 | 48 |
| 2015 Mayo | 71 | 25 | 96 |
| 2015 Abril | 42 | 29 | 71 |
| 2015 Marzo | 31 | 32 | 63 |
| 2015 Febrero | 41 | 18 | 59 |
| 2015 Enero | 35 | 16 | 51 |
| 2014 Diciembre | 27 | 13 | 40 |
| 2014 Noviembre | 27 | 18 | 45 |
| 2014 Octubre | 33 | 19 | 52 |
| 2014 Septiembre | 28 | 19 | 47 |
| 2014 Agosto | 28 | 24 | 52 |
| 2014 Julio | 39 | 22 | 61 |
| 2014 Junio | 26 | 11 | 37 |
| 2014 Mayo | 41 | 15 | 56 |
| 2014 Abril | 31 | 12 | 43 |
| 2014 Marzo | 47 | 22 | 69 |
| 2014 Febrero | 28 | 14 | 42 |
| 2014 Enero | 33 | 23 | 56 |
| 2013 Diciembre | 31 | 15 | 46 |
| 2013 Noviembre | 26 | 25 | 51 |
| 2013 Octubre | 23 | 29 | 52 |
| 2013 Septiembre | 31 | 22 | 53 |
| 2013 Agosto | 19 | 28 | 47 |
| 2013 Julio | 39 | 31 | 70 |
| 2013 Junio | 23 | 36 | 59 |
| 2013 Mayo | 18 | 31 | 49 |
| 2013 Abril | 25 | 32 | 57 |
| 2013 Marzo | 26 | 34 | 60 |
| 2013 Febrero | 11 | 13 | 24 |
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