Review article
Congenital Epidermolysis Bullosa: A Review
Epidermólisis Ampollosa Congénita : Revisión del Tema
C. Siañez-González, R. Pezoa-Jares, J.C. Salas-Alanis
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salas999@hotmail.com
doctor@juliosalas.com
Correspondence: Otomí #206, Colonia Azteca. Cd. Guadalupe. Nuevo León, 67150 Mexico.
doctor@juliosalas.com
Correspondence: Otomí #206, Colonia Azteca. Cd. Guadalupe. Nuevo León, 67150 Mexico.
Escuela de Medicina del Instituto Tecnológico y de Estudios Superiores de Monterrey, Nuevo León, Mexico
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"apellidos" => "Salas-Alanis" "email" => array:2 [ 0 => "salas999@hotmail.com" 1 => "doctor@juliosalas.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Escuela de Medicina del Instituto Tecnológico y de Estudios Superiores de Monterrey, Nuevo León, Mexico" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Otomí #206, Colonia Azteca. Cd. Guadalupe. Nuevo León, 67150 Mexico." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Epidermólisis Ampollosa Congénita : Revisión del Tema" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-04-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84626" "palabras" => array:3 [ 0 => "epidermolysis bullosa" 1 => "molecular biology" 2 => "treatment" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84625" "palabras" => array:3 [ 0 => "epidermólisis ampollosa" 1 => "biología molecular" 2 => "tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Epidermolysis bullosa is a group of hereditary diseases affecting 1 in 17 000 live births worldwide. It consists of blistering of the skin and mucous membranes in response to minimal trauma. The disorder seriously affects the patient's quality of life. Diagnosis is based on immunofluorescence mapping and electron microscopy. Treatment is symptomatic, although new cellular and molecular therapies are currently under investigation. This review covers aspects of the molecular biology, clinical presentation, diagnosis, and treatment of epidermolysis bullosa relevant to improving the care for affected patients.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La epidermólisis ampollosa (EA) engloba un grupo de enfermedades hereditarias que afectan a uno de cada 17.000 nacidos vivos en el mundo. Consiste en la formación de ampollas ante el menor traumatismo que afectan a la piel y a las mucosas. Esta enfermedad empeora seriamente la calidad de vida. El diagnóstico se realiza principalmente por mapeo por inmunofluorescencia y microscopía electrónica. El tratamiento es sintomático, aunque se están investigando nuevas terapias celulares y moleculares. Esta revisión presentará información relevante sobre la biología molecular, la sintomatología clínica, el diagnóstico y el tratamiento de la EA, con la clara intención de proporcionar un mejor cuidado a los pacientes que padecen esta enfermedad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa in Mexico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Uitto" 1 => "L. Pulkkinen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2000" "volumen" => "39" "paginaInicial" => "433" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10944087" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510709019245" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Las epidermólisis bullosas distróficas en México: 2470insG representa la mutación más común en 21 familias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.C. Salas-Alanis" 1 => "J.A. McGrath" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gac Med Mex" "fecha" => "2006" "volumen" => "142" "paginaInicial" => "29" "paginaFinal" => "34" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16548289" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa: from fundamental molecular biology to clinical therapies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Featherstone" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.jid.5700731" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2007" "volumen" => "127" "paginaInicial" => "256" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17228301" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Las epidermólisis bullosas. El proyecto DebRA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.C. Salas-Alanis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Cutan Iber Lat Am" "fecha" => "2007" "volumen" => "35" "paginaInicial" => "165" "paginaFinal" => "166" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The classification of inherited epidermolysis bullosa (EB): Report of the Third International Consensus Meeting on Diagnosis and Classification of EB" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Fine" 1 => "R.A. Eady" 2 => "E.A. Bauer" 3 => "J.W. Bauer" 4 => "L. Bruckner-Tuderman" 5 => "A. Heagerty" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2008.02.004" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2008" "volumen" => "58" "paginaInicial" => "931" "paginaFinal" => "950" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18374450" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What's new in blistering disorders?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Chaudhari" 1 => "M.P. Marinkovich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Allergy Asthma Rep" "fecha" => "2007" "volumen" => "7" "paginaInicial" => "255" "paginaFinal" => "263" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17547846" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Habif TP. Vesicular and bullous diseases. In: Hodgson S, Cook L, editors. Clinical Dermatology: a color guide to diagnosis and therapy. St. Louis: Mosby; 2004. (consulted: 05-09-2008). Available at: <a class="elsevierStyleInterRef" href="http://0-www.mdconsult.com.millenium.itesm.mx/das/book/body/109310392-2/0/1195/0.html">http://0-www.mdconsult.com.millenium.itesm.mx/das/book/body/109310392-2/0/1195/0.html</a>" ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa: a case study in transport, treatment, and care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W. Price-Douglas" 1 => "B. Diehl-Svrjcek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ANC.0000304967.46708.ea" "Revista" => array:6 [ "tituloSerie" => "Adv Neonatal Care" "fecha" => "2007" "volumen" => "7" "paginaInicial" => "289" "paginaFinal" => "294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18097210" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular basis of inherited skin-blistering disorders, and therapeutic implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Aumailley" 1 => "C. Has" 2 => "L. Tunggal" 3 => "L. Bruckner-Tuderman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S1462399406000196" "Revista" => array:6 [ "tituloSerie" => "Expert Rev Mol Med" "fecha" => "2006" "volumen" => "8" "paginaInicial" => "1" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17178008" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal basement membrane: its molecular organization and blistering disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Masunaga" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/03008200600584157" "Revista" => array:6 [ "tituloSerie" => "Connect Tissue Res" "fecha" => "2006" "volumen" => "47" "paginaInicial" => "55" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16754511" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progress in epidermolysis bullosa: from eponyms to molecular genetic classification" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Uitto" 1 => "G. Richard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2004.09.015" "Revista" => array:7 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "33" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15708287" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1542356510011882" "estado" => "S300" "issn" => "15423565" ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Target proteins in inherited and acquired blistering skin disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Fassihi" 1 => "T. Wong" 2 => "V. Wessagowit" 3 => "J.A. McGrath" 4 => "J.E. Mellerio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2006.02065.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2006" "volumen" => "31" "paginaInicial" => "252" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16487105" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Avances biomoleculares en los trastornos epidérmicos hereditarios" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Hernández-Martín" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "203" "paginaFinal" => "216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476370" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin lesions in the neonate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.D. Conlon" 1 => "B.A. Drolet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.pcl.2004.03.015" "Revista" => array:6 [ "tituloSerie" => "Pediatr Clin North Am" "fecha" => "2004" "volumen" => "51" "paginaInicial" => "863" "paginaFinal" => "888" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15275979" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutation analysis of the entire keratin 5 and 14 genes in patients with epidermolysis bullosa simples and identification of novel mutations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.H. Schuilenga-Hut" 1 => "P. Vlies" 2 => "M.F. Jonkman" 3 => "E. Waanders" 4 => "C.H. Buys" 5 => "H. Scheffer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/humu.9124" "Revista" => array:5 [ "tituloSerie" => "Hum Mutat" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12655565" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic abnormalities and clinical classification of epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Mitsuhashi" 1 => "I. Hashimoto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00403-002-0369-0" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol Res" "fecha" => "2003" "volumen" => "295" "paginaInicial" => "S29" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12677430" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa: the expanding mutation database" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Uitto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.0022-202X.2004.23333.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2004" "volumen" => "123" "paginaInicial" => "xii" "paginaFinal" => "xiii" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15373798" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatopathology and molecular genetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Bergman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.12.008" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2008" "volumen" => "58" "paginaInicial" => "452" "paginaFinal" => "457" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18280342" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The biomolecular and ultrastructural basis of epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Solovan" 1 => "M. Ciolan" 2 => "L. Olariu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Dermatovenerol Alp Panonica Adriat" "fecha" => "2005" "volumen" => "14" "paginaInicial" => "127" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16435041" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basic science of epidermolysis bullosa and diagnostic and molecular characterization: proceedings of the 2nd International Symposium on Epidermolysis Bullosa. Santiago, Chile, 2005" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.G. Pfendner" 1 => "A. Bruckner" 2 => "P. Conget" 3 => "J. Mellerio" 4 => "F. Palisson" 5 => "A.W. Lucky" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2007.03307.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "781" "paginaFinal" => "794" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17651158" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The molecular basis of dystrophic epidermolysis bullosa in Mexico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. Salas-Alanis" 1 => "M. Amaya-Guerra" 2 => "J.A. McGrath" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2000" "volumen" => "39" "paginaInicial" => "436" "paginaFinal" => "442" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10944088" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Marinkovich MP. Epidermolysis bullosa. eMedicine [Internet series]; 2007 (consulted on 01-09-2008). Available at: <a class="elsevierStyleInterRef" href="http://www.emedicine.com/derm/topic124.htm">http://www.emedicine.com/derm/topic124.htm</a>" ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa: identification and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.T. Trent" 1 => "R.S. Kirsner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Adv Skin Wound Care" "fecha" => "2003" "volumen" => "16" "paginaInicial" => "284" "paginaFinal" => "290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14652513" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508502764093" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Causespecific risks of childhood death in inherited epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.D. Fine" 1 => "L.B. Johnson" 2 => "M. Weiner" 3 => "C. Suchindran" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr" "fecha" => "2008" "volumen" => "152" "paginaInicial" => "276" "paginaFinal" => "280" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa simplex" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.F. Okulicz" 1 => "N.I. Kihiczak" 2 => "C.K. Janniger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cutis" "fecha" => "2002" "volumen" => "70" "paginaInicial" => "19" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12184667" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508508004551" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In this issue: The complexities of epidermolysis bullosa “simplex”" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.S. Paller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2003.22143.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2004" "volumen" => "122" "paginaInicial" => "vi" "paginaFinal" => "vii" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14962116" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa simplex: localized (Weber-Cockayne type)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. De Kanter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Nurs" "fecha" => "2004" "volumen" => "16" "paginaInicial" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15690931" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.F. Jonkman" 1 => "A.M. Pasmooij" 2 => "S.G. Pasmans" 3 => "M.P. van den Berg" 4 => "H.J. Ter Horst" 5 => "A. Timmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/496901" "Revista" => array:7 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "2005" "volumen" => "77" "paginaInicial" => "653" "paginaFinal" => "660" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16175511" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510710016652" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histopathological and ultrastructural study of ectodermal dysplasia/skin fragility syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Bergman" 1 => "E. Sprecher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2005" "volumen" => "27" "paginaInicial" => "333" "paginaFinal" => "338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16121056" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A usual frameshift and delayed termination codon mutation in keratin 5 causes a novel type of epidermolysis bullosa simplex with migratory circinate erythema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.H. Gu" 1 => "S.C. Kim" 2 => "Y. Ichiki" 3 => "J. Park" 4 => "M. Nagai" 5 => "Y. Kitajima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2003.12424.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2003" "volumen" => "121" "paginaInicial" => "482" "paginaFinal" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12925204" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Herlitz junctional epidermolysis bullosa presenting at birth with anonychia: a case report and review of H-JEB" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Parsapour" 1 => "M.D. Reep" 2 => "L. Mohammed" 3 => "A. Church" 4 => "T. Shwayder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol" "fecha" => "2001" "volumen" => "18" "paginaInicial" => "217" "paginaFinal" => "222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11438002" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment decision-making for patients with the Herlitz subtype of junctional epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.G. Yan" 1 => "J.J. Paris" 2 => "J. Ahluwalia" 3 => "A.T. Lane" 4 => "A.L. Bruckner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.jp.7211694" "Revista" => array:6 [ "tituloSerie" => "J Perinatol" "fecha" => "2007" "volumen" => "27" "paginaInicial" => "307" "paginaFinal" => "311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17363907" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What syndrome is this? Laryngo-onycho-cutaneous syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.C. Kim" 1 => "M.G. Liang" 2 => "E. Pfendner" 3 => "V.E. Kimonis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1525-1470.2007.00408.x" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol" "fecha" => "2007" "volumen" => "24" "paginaInicial" => "306" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17542886" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dystrophic epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.B. Das" 1 => "S. Sahoo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.jp.7211019" "Revista" => array:6 [ "tituloSerie" => "J Perinatol" "fecha" => "2004" "volumen" => "24" "paginaInicial" => "41" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14726937" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Pourreyron" 1 => "G. Cox" 2 => "X. Mao" 3 => "A. Volz" 4 => "N. Baksh" 5 => "T. Wong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Invest Dermatol" "fecha" => "2007" "volumen" => "127" "paginaInicial" => "2438" "paginaFinal" => "2444" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kindler surprise: mutations in a novel actin-associated protein cause Kindler syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.J. White" 1 => "W.H. McLean" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdermsci.2004.12.026" "Revista" => array:6 [ "tituloSerie" => "J Dermatol Sci" "fecha" => "2005" "volumen" => "38" "paginaInicial" => "169" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15927810" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Pfendner EG, Lucky AW. Dystrophic epidermolysis bullosa. GeneReviews [Internet series] 2007 (consulted: 01-09-2008). Available at: <a class="elsevierStyleInterRef" href="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi%3Fbook=gene%26part=EAd">http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene∂=EAd</a>" ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Japanese guidelines for diagnosis and treatment of junctional and dystrophic epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Tamai" 1 => "I. Hashimoto" 2 => "K. Hanada" 3 => "S. Ikeda" 4 => "S. Imamura" 5 => "H. Ogawa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00403-002-0379-y" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol Res" "fecha" => "2003" "volumen" => "295" "paginaInicial" => "S24" "paginaFinal" => "S28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12677429" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A retrospective analysis of tissuefixed immunoreactants from skin biopsies maintained in Michel's medium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.A. Vaughan Jones" 1 => "J.C. Salas-Alanís" 2 => "J.A. McGrath" 3 => "I. Palmer" 4 => "B.S. Bhogal" 5 => "M.M. Black" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "1994" "volumen" => "189" "paginaInicial" => "131" "paginaFinal" => "132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8049555" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Globalization of DNA-based prenatal diagnosis for recessive dystrophic epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Wessagowit" 1 => "A. Chunharas" 2 => "D. Wattanasirichaigoon" 3 => "J.A. McGrath" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2230.2007.02510.x" "Revista" => array:7 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2007" "volumen" => "32" "paginaInicial" => "687" "paginaFinal" => "689" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17868393" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510708023511" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prenatal diagnosis for severe inherited skin disorders: 25 years’ experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Fassihi" 1 => "R.A. Eady" 2 => "J.E. Mellerio" 3 => "G.H. Ashton" 4 => "P.J. Dopping-Hepenstal" 5 => "J.E. Denyer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2005.07012.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "154" "paginaInicial" => "106" "paginaFinal" => "113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16403102" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medical management of epidermolysis bullosa: proceedings of the 2nd International Symposium on Epidermolysis Bullosa, Santiago, Chile, 2005" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Mellerio" 1 => "M. Weiner" 2 => "J.E. Denyer" 3 => "E.I. Pillay" 4 => "A.W. Lucky" 5 => "A. Bruckner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2007.03316.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "795" "paginaFinal" => "800" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17651159" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical management of epidermolysis bullosa: proceedings of the 2nd International Symposium on Epidermolysis Bullosa, Santiago, Chile, 2005" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.G. Azizkhan" 1 => "J.E. Denyer" 2 => "J.E. Mellerio" 3 => "R. González" 4 => "M. Bacigalupo" 5 => "A. Kantor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2007.03313.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "801" "paginaFinal" => "808" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17651160" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychosocial aspects of epidermolysis bullosa: proceedings of the 2nd International Symposium on Epidermolysis Bullosa, Santiago, Chile, 2005" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.W. Lucky" 1 => "E. Pfendner" 2 => "E. Pillay" 3 => "J. Paskel" 4 => "M. Weiner" 5 => "F. Palisson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2007.03311.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "809" "paginaFinal" => "814" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17651161" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical management of epidermolysis bullosa: the importance of a multidisciplinary management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Farhi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2007.03310.x" "Revista" => array:7 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "815" "paginaFinal" => "816" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17651162" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510711001234" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anaesthesia for children with epidermolysis bullosa: a review of 20 years’ experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Iohom" 1 => "B. Lyons" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur J Anaesthesiol" "fecha" => "2001" "volumen" => "18" "paginaInicial" => "745" "paginaFinal" => "754" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11580781" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673600032050" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa: the challenges of wound care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Schober-Flores" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Nurs" "fecha" => "2003" "volumen" => "15" "paginaInicial" => "135" "paginaFinal" => "144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12751349" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Major surgery and anesthetic technique in epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Kömürcü" 1 => "F. Bilgin" 2 => "E. Kurt" 3 => "A.S. Atesalp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mil Med" "fecha" => "2004" "volumen" => "169" "paginaInicial" => "125" "paginaFinal" => "127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15040633" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa: management principles for the neonate, infant, and young child" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Schachner" 1 => "A. Feiner" 2 => "S. Camisulli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Nurs" "fecha" => "2005" "volumen" => "7" "paginaInicial" => "56" "paginaFinal" => "59" "itemHostRev" => array:3 [ "pii" => "S0016510711017846" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conducta clínica en un caso de epidermólisis ampollosa distrófica recesiva" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.B. Medina Quiñónez" 1 => "T. Marchini de Oliveira" 2 => "L. Aires Cándido" 3 => "M.A.A.M. Machado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr (Asunción)" "fecha" => "2003" "volumen" => "30" "paginaInicial" => "39" "paginaFinal" => "43" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manifestaciones orales de la epidermólisis bullosa en el niño" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Vargas" 1 => "L. Palomer" 2 => "F. Palisson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Chil Pediatr" "fecha" => "2005" "volumen" => "76" "paginaInicial" => "612" "paginaFinal" => "616" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tracheolaryngeal complications of inherited epidermolysis bullosa: cumulative experience of the national epidermolysis bullosa registry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.D. Fine" 1 => "L.B. Johnson" 2 => "M. Weiner" 3 => "C. Suchindran" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MLG.0b013e318093ed8e" "Revista" => array:6 [ "tituloSerie" => "Laryngoscope" "fecha" => "2007" "volumen" => "117" "paginaInicial" => "1652" "paginaFinal" => "1660" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17762793" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastrointestinal complications of inherited epidermolysis bullosa: cumulative experience of the National Epidermolysis Bullosa Registry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.D. Fine" 1 => "L.B. Johnson" 2 => "M. Weiner" 3 => "C. Suchindran" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0b013e31812f5667" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2008" "volumen" => "46" "paginaInicial" => "147" "paginaFinal" => "158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18223373" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anesthesia and pain management for pediatric patients with dystrophic epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y.C. Lin" 1 => "B. Golianu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jclinane.2005.11.004" "Revista" => array:7 [ "tituloSerie" => "J Clin Anesth" "fecha" => "2006" "volumen" => "18" "paginaInicial" => "268" "paginaFinal" => "271" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16797428" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510708028198" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genitourinary complications of epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Srinivasin" 1 => "L.S. Palmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urology.2007.06.639" "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "2007" "volumen" => "70" "paginaInicial" => "179.e5" "paginaFinal" => "179.e6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17991543" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging of the esophagus in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.A. Fordham" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rcl.2005.01.001" "Revista" => array:6 [ "tituloSerie" => "Radiol Clin North Am" "fecha" => "2005" "volumen" => "43" "paginaInicial" => "283" "paginaFinal" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15737370" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudosyndactyly and musculoskeletal contractures in inherited epidermolysis bullosa: experience of the National Epidermolysis Bullosa Registry, 1986-2002" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Fine" 1 => "L.B. Johnson" 2 => "M. Weiner" 3 => "A. Stein" 4 => "S. Cash" 5 => "J. Deleoz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Hand Surg (Br)" "fecha" => "2005" "volumen" => "30" "paginaInicial" => "14" "paginaFinal" => "22" ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The IVth International Symposium on Epidermolysis Bullosa, Santiago, Chile, 27-29 September 2007" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.W. Lucky" 1 => "F. Palisson" 2 => "J.E. Mellerio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdermsci.2007.11.004" "Revista" => array:6 [ "tituloSerie" => "J Dermatol Sci" "fecha" => "2008" "volumen" => "49" "paginaInicial" => "178" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18093805" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genitourinary complications of inherited epidermolysis bullosa: experience of the national epidermylosis bullosa registry and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Fine" 1 => "L.B. Johnson" 2 => "M. Weiner" 3 => "A. Stein" 4 => "S. Cash" 5 => "J. DeLeoz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2004" "volumen" => "172" "paginaInicial" => "2040" "paginaFinal" => "2044" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15540785" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Portz M, Stroup L. U of M Sets Course For Cure of Fatal Childhood Skin Disease. University of Minnesota Academia Health Center [Internet]; 2008 (consulted: 03-09-2008). Available at: <a class="elsevierStyleInterRef" href="http://www.ahc.umn.edu/news/releases/EA/index.htm">http://www.ahc.umn.edu/news/releases/EA/index.htm</a>" ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Wagner JE. Combination chemotherapy followed by donor stem cell transplant in treating young patients with epidermolysis bullosa at high risk of developing squamous cell skin cancer. ClinicalTrials.gov [Internet]; 2008 (consulted: 03-09-2008). Available at: <a class="elsevierStyleInterRef" href="http://clinicaltrials.gov/ct2/show/NCT00478244">http://clinicaltrials.gov/ct2/show/NCT00478244</a>" ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa: directions for future research and new challenges for treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Sawamura" 1 => "J.R. McMillan" 2 => "M. Akiyama" 3 => "H. Shimizu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00403-002-0370-7" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol Res" "fecha" => "2003" "volumen" => "295" "paginaInicial" => "S34" "paginaFinal" => "S42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12677431" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Wong" 1 => "L. Gammon" 2 => "L. Liu" 3 => "J.E. Mellerio" 4 => "P.JC. Dopping-Hepenstal" 5 => "J. Pacy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/jid.2008.78" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2008" "volumen" => "128" "paginaInicial" => "2179" "paginaFinal" => "2189" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18385758" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene therapy approaches for epidermolysis bullosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Ferrari" 1 => "G. Pellegrini" 2 => "F. Mavilio" 3 => "M. De Luca" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2004.07.017" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "430" "paginaFinal" => "436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16023940" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene therapy for autosomal dominant disorders of keratin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.S. Lewin" 1 => "P.M. Glazer" 2 => "L.M. Milstone" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1087-0024.2005.10207.x" "Revista" => array:6 [ "tituloSerie" => "J Investig Dermatol Symp Proc" "fecha" => "2005" "volumen" => "10" "paginaInicial" => "47" "paginaFinal" => "61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16250209" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Mavilio" 1 => "G. Pellegrini" 2 => "S. Ferrari" 3 => "F. Di Nunzio" 4 => "E. Di Iorio" 5 => "A. Recchia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nm1504" "Revista" => array:7 [ "tituloSerie" => "Nat Med" "fecha" => "2006" "volumen" => "12" "paginaInicial" => "1397" "paginaFinal" => "1402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17115047" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510709022354" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000010/v1_201304241509/S1578219009705542/v1_201304241509/en/main.assets" "Apartado" => array:4 [ "identificador" => "6224" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000010/v1_201304241509/S1578219009705542/v1_201304241509/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009705542?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 27 | 36 |
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| 2023 Noviembre | 77 | 153 | 230 |
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| 2023 Septiembre | 49 | 136 | 185 |
| 2023 Agosto | 36 | 164 | 200 |
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| 2023 Marzo | 39 | 144 | 183 |
| 2023 Febrero | 38 | 141 | 179 |
| 2023 Enero | 58 | 120 | 178 |
| 2022 Diciembre | 66 | 116 | 182 |
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| 2022 Marzo | 97 | 153 | 250 |
| 2022 Febrero | 51 | 131 | 182 |
| 2022 Enero | 81 | 145 | 226 |
| 2021 Diciembre | 53 | 183 | 236 |
| 2021 Noviembre | 45 | 140 | 185 |
| 2021 Octubre | 74 | 137 | 211 |
| 2021 Septiembre | 49 | 105 | 154 |
| 2021 Agosto | 44 | 96 | 140 |
| 2021 Julio | 45 | 99 | 144 |
| 2021 Junio | 42 | 120 | 162 |
| 2021 Mayo | 38 | 85 | 123 |
| 2021 Abril | 123 | 197 | 320 |
| 2021 Marzo | 74 | 63 | 137 |
| 2021 Febrero | 64 | 76 | 140 |
| 2021 Enero | 56 | 42 | 98 |
| 2020 Diciembre | 48 | 61 | 109 |
| 2020 Noviembre | 59 | 49 | 108 |
| 2020 Octubre | 72 | 31 | 103 |
| 2020 Septiembre | 53 | 31 | 84 |
| 2020 Agosto | 41 | 34 | 75 |
| 2020 Julio | 38 | 25 | 63 |
| 2020 Junio | 35 | 55 | 90 |
| 2020 Mayo | 47 | 39 | 86 |
| 2020 Abril | 50 | 29 | 79 |
| 2020 Marzo | 29 | 45 | 74 |
| 2020 Febrero | 3 | 26 | 29 |
| 2020 Enero | 0 | 22 | 22 |
| 2019 Diciembre | 0 | 14 | 14 |
| 2019 Noviembre | 0 | 10 | 10 |
| 2019 Octubre | 0 | 6 | 6 |
| 2019 Septiembre | 0 | 17 | 17 |
| 2019 Agosto | 0 | 11 | 11 |
| 2019 Julio | 0 | 31 | 31 |
| 2019 Junio | 0 | 37 | 37 |
| 2019 Mayo | 2 | 100 | 102 |
| 2019 Abril | 0 | 50 | 50 |
| 2019 Marzo | 0 | 17 | 17 |
| 2019 Febrero | 0 | 15 | 15 |
| 2019 Enero | 0 | 1 | 1 |
| 2018 Diciembre | 0 | 5 | 5 |
| 2018 Septiembre | 0 | 27 | 27 |
| 2018 Agosto | 0 | 43 | 43 |
| 2018 Julio | 0 | 26 | 26 |
| 2018 Junio | 0 | 14 | 14 |
| 2018 Mayo | 0 | 41 | 41 |
| 2018 Abril | 0 | 45 | 45 |
| 2018 Marzo | 2 | 62 | 64 |
| 2018 Febrero | 28 | 59 | 87 |
| 2018 Enero | 31 | 64 | 95 |
| 2017 Diciembre | 20 | 46 | 66 |
| 2017 Noviembre | 23 | 65 | 88 |
| 2017 Octubre | 23 | 84 | 107 |
| 2017 Septiembre | 24 | 69 | 93 |
| 2017 Agosto | 32 | 47 | 79 |
| 2017 Julio | 24 | 55 | 79 |
| 2017 Junio | 37 | 92 | 129 |
| 2017 Mayo | 34 | 56 | 90 |
| 2017 Abril | 33 | 49 | 82 |
| 2017 Marzo | 38 | 78 | 116 |
| 2017 Febrero | 13 | 66 | 79 |
| 2017 Enero | 13 | 51 | 64 |
| 2016 Diciembre | 37 | 43 | 80 |
| 2016 Noviembre | 22 | 66 | 88 |
| 2016 Octubre | 35 | 83 | 118 |
| 2016 Septiembre | 51 | 70 | 121 |
| 2016 Agosto | 49 | 41 | 90 |
| 2016 Julio | 31 | 38 | 69 |
| 2016 Junio | 12 | 27 | 39 |
| 2016 Mayo | 6 | 30 | 36 |
| 2016 Abril | 4 | 31 | 35 |
| 2016 Marzo | 5 | 33 | 38 |
| 2016 Febrero | 10 | 1 | 11 |
| 2016 Enero | 7 | 29 | 36 |
| 2015 Diciembre | 5 | 28 | 33 |
| 2015 Noviembre | 11 | 46 | 57 |
| 2015 Octubre | 3 | 38 | 41 |
| 2015 Septiembre | 7 | 22 | 29 |
| 2015 Agosto | 18 | 18 | 36 |
| 2015 Julio | 41 | 26 | 67 |
| 2015 Junio | 24 | 26 | 50 |
| 2015 Mayo | 70 | 52 | 122 |
| 2015 Abril | 26 | 49 | 75 |
| 2015 Marzo | 29 | 43 | 72 |
| 2015 Febrero | 28 | 40 | 68 |
| 2015 Enero | 30 | 42 | 72 |
| 2014 Diciembre | 40 | 29 | 69 |
| 2014 Noviembre | 23 | 46 | 69 |
| 2014 Octubre | 30 | 54 | 84 |
| 2014 Septiembre | 29 | 23 | 52 |
| 2014 Agosto | 39 | 27 | 66 |
| 2014 Julio | 36 | 18 | 54 |
| 2014 Junio | 42 | 13 | 55 |
| 2014 Mayo | 42 | 20 | 62 |
| 2014 Abril | 38 | 15 | 53 |
| 2014 Marzo | 54 | 49 | 103 |
| 2014 Febrero | 37 | 44 | 81 |
| 2014 Enero | 42 | 50 | 92 |
| 2013 Diciembre | 34 | 33 | 67 |
| 2013 Noviembre | 26 | 50 | 76 |
| 2013 Octubre | 28 | 62 | 90 |
| 2013 Septiembre | 25 | 77 | 102 |
| 2013 Agosto | 33 | 142 | 175 |
| 2013 Julio | 53 | 65 | 118 |
| 2013 Junio | 29 | 69 | 98 |
| 2013 Mayo | 25 | 99 | 124 |
| 2013 Abril | 33 | 68 | 101 |
| 2013 Marzo | 31 | 53 | 84 |
| 2013 Febrero | 18 | 20 | 38 |
| 2013 Enero | 2 | 4 | 6 |
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