Case reports
Multiple Painful, Treatment-Resistant Leg Ulcers Associated With Dermatomyositis-Like Lesions Over the Interphalangeal Joints Induced by Hydroxyurea
Úlceras Dolorosas Múltiples en la Pierna Resistentes al Tratamiento Asociadas a Lesiones Dermatomiositis-like en las Articulaciones Interfalángicas de las Manos: Hidroxiurea Como Agente Causal
A. Martorell-Calatayud
, C. Requena, E. Nagore-Enguídanos, C. Guillén-Barona
Autor para correspondencia
antmarto@hotmail.com
Correspondence: C/ San José de la Montaña n.° 14, puerta 11, 46008 Valencia, Spain.
Correspondence: C/ San José de la Montaña n.° 14, puerta 11, 46008 Valencia, Spain.
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
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Blasco, P. Lázaro, C. Ferrándiz, A. García-Díez, J. Liso" "autores" => array:5 [ 0 => array:2 [ "nombre" => "A.J." "apellidos" => "Blasco" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Lázaro" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Ferrándiz" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "García-Díez" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Liso" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701751?idApp=UINPBA000044" "url" => "/15782190/0000010000000009/v1_201304241507/S1578219009701751/v1_201304241507/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Multiple Painful, Treatment-Resistant Leg Ulcers Associated With Dermatomyositis-Like Lesions Over the Interphalangeal Joints Induced by Hydroxyurea" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "804" "paginaFinal" => "807" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Martorell-Calatayud, C. Requena, E. Nagore-Enguídanos, C. Guillén-Barona" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Martorell-Calatayud" "email" => array:1 [ 0 => "antmarto@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Requena" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Nagore-Enguídanos" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Guillén-Barona" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: C/ San José de la Montaña n.° 14, puerta 11, 46008 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Úlceras Dolorosas Múltiples en la Pierna Resistentes al Tratamiento Asociadas a Lesiones Dermatomiositis-like en las Articulaciones Interfalángicas de las Manos: Hidroxiurea Como Agente Causal" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-03-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84583" "palabras" => array:3 [ 0 => "hydroxyurea" 1 => "leg ulcer" 2 => "dermatomyositis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84584" "palabras" => array:3 [ 0 => "hidroxiurea" 1 => "úlcera en pierna" 2 => "dermatomiositis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The onset of a dermatomyositis-like rash and persistent skin ulcers during long-term treatment with hydroxyurea is a very rare event that has not been fully described in the literature.</p><p class="elsevierStyleSimplePara elsevierViewall">The fact that these lesions have a typical clinical presentation and course, and that complete resolution can only be achieved by immediate withdrawal of the drug, means that dermatologists should be aware of this condition in order to avoid a delay in diagnosis.</p><p class="elsevierStyleSimplePara elsevierViewall">We present the case of a 76-year-old woman who developed a dermatomyositis-like eruption associated with chronic ulcers on the lower limbs during long-term treatment with hydroxyurea.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El desarrollo de una erupción dermatomiositis-like y de úlceras cutáneas de evolución tórpida, en el contexto de un tratamiento mantenido a largo plazo con hidroxiurea, es un fenómeno muy infrecuente y parcialmente descrito en la literatura.</p><p class="elsevierStyleSimplePara elsevierViewall">El hecho de que las características clínicas y evolutivas de este tipo de lesiones son típicas y que su resolución completa sólo se alcanza mediante la suspensión inmediata del tratamiento, hace necesario que el dermatólogo conozca este cuadro, con el fin de evitar el retraso diagnóstico.</p><p class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de una paciente de 76 años que desarrolló una erupción dermatomiositis-like junto a un proceso ulcerativo crónico en los miembros inferiores en el contexto de un tratamiento con hidroxiurea mantenido a largo plazo.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2022 Octubre | 16 | 19 | 35 |
| 2022 Septiembre | 16 | 51 | 67 |
| 2022 Agosto | 14 | 32 | 46 |
| 2022 Julio | 13 | 34 | 47 |
| 2022 Junio | 17 | 42 | 59 |
| 2022 Mayo | 22 | 50 | 72 |
| 2022 Abril | 33 | 34 | 67 |
| 2022 Marzo | 22 | 54 | 76 |
| 2022 Febrero | 17 | 36 | 53 |
| 2022 Enero | 32 | 63 | 95 |
| 2021 Diciembre | 19 | 54 | 73 |
| 2021 Noviembre | 30 | 65 | 95 |
| 2021 Octubre | 32 | 53 | 85 |
| 2021 Septiembre | 12 | 36 | 48 |
| 2021 Agosto | 14 | 31 | 45 |
| 2021 Julio | 22 | 40 | 62 |
| 2021 Junio | 16 | 28 | 44 |
| 2021 Mayo | 16 | 29 | 45 |
| 2021 Abril | 36 | 71 | 107 |
| 2021 Marzo | 32 | 12 | 44 |
| 2021 Febrero | 48 | 31 | 79 |
| 2021 Enero | 29 | 17 | 46 |
| 2020 Diciembre | 30 | 13 | 43 |
| 2020 Noviembre | 35 | 21 | 56 |
| 2020 Octubre | 17 | 10 | 27 |
| 2020 Septiembre | 24 | 16 | 40 |
| 2020 Agosto | 26 | 11 | 37 |
| 2020 Julio | 10 | 12 | 22 |
| 2020 Junio | 28 | 21 | 49 |
| 2020 Mayo | 15 | 26 | 41 |
| 2020 Abril | 18 | 12 | 30 |
| 2020 Marzo | 34 | 18 | 52 |
| 2020 Febrero | 4 | 2 | 6 |
| 2020 Enero | 0 | 6 | 6 |
| 2019 Diciembre | 0 | 6 | 6 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 3 | 3 |
| 2019 Septiembre | 0 | 4 | 4 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Junio | 0 | 3 | 3 |
| 2019 Mayo | 1 | 63 | 64 |
| 2019 Marzo | 0 | 6 | 6 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Febrero | 14 | 4 | 18 |
| 2018 Enero | 15 | 3 | 18 |
| 2017 Diciembre | 11 | 11 | 22 |
| 2017 Noviembre | 18 | 4 | 22 |
| 2017 Octubre | 12 | 3 | 15 |
| 2017 Septiembre | 12 | 3 | 15 |
| 2017 Agosto | 21 | 5 | 26 |
| 2017 Julio | 20 | 3 | 23 |
| 2017 Junio | 22 | 12 | 34 |
| 2017 Mayo | 10 | 8 | 18 |
| 2017 Abril | 23 | 13 | 36 |
| 2017 Marzo | 20 | 3 | 23 |
| 2017 Febrero | 12 | 6 | 18 |
| 2017 Enero | 9 | 7 | 16 |
| 2016 Diciembre | 26 | 10 | 36 |
| 2016 Noviembre | 21 | 4 | 25 |
| 2016 Octubre | 26 | 11 | 37 |
| 2016 Septiembre | 30 | 9 | 39 |
| 2016 Agosto | 29 | 1 | 30 |
| 2016 Julio | 28 | 4 | 32 |
| 2016 Junio | 14 | 4 | 18 |
| 2016 Mayo | 6 | 5 | 11 |
| 2016 Abril | 7 | 4 | 11 |
| 2016 Marzo | 6 | 7 | 13 |
| 2016 Febrero | 10 | 3 | 13 |
| 2016 Enero | 3 | 0 | 3 |
| 2015 Diciembre | 7 | 1 | 8 |
| 2015 Noviembre | 14 | 1 | 15 |
| 2015 Octubre | 2 | 3 | 5 |
| 2015 Septiembre | 6 | 3 | 9 |
| 2015 Agosto | 10 | 5 | 15 |
| 2015 Julio | 37 | 11 | 48 |
| 2015 Junio | 20 | 2 | 22 |
| 2015 Mayo | 70 | 22 | 92 |
| 2015 Abril | 31 | 9 | 40 |
| 2015 Marzo | 40 | 13 | 53 |
| 2015 Febrero | 36 | 16 | 52 |
| 2015 Enero | 27 | 28 | 55 |
| 2014 Diciembre | 21 | 19 | 40 |
| 2014 Noviembre | 23 | 16 | 39 |
| 2014 Octubre | 25 | 24 | 49 |
| 2014 Septiembre | 18 | 26 | 44 |
| 2014 Agosto | 29 | 13 | 42 |
| 2014 Julio | 43 | 28 | 71 |
| 2014 Junio | 49 | 9 | 58 |
| 2014 Mayo | 53 | 9 | 62 |
| 2014 Abril | 29 | 13 | 42 |
| 2014 Marzo | 46 | 22 | 68 |
| 2014 Febrero | 28 | 22 | 50 |
| 2014 Enero | 42 | 13 | 55 |
| 2013 Diciembre | 36 | 14 | 50 |
| 2013 Noviembre | 32 | 23 | 55 |
| 2013 Octubre | 33 | 22 | 55 |
| 2013 Septiembre | 36 | 25 | 61 |
| 2013 Agosto | 16 | 26 | 42 |
| 2013 Julio | 30 | 52 | 82 |
| 2013 Junio | 29 | 27 | 56 |
| 2013 Mayo | 28 | 25 | 53 |
| 2013 Abril | 32 | 31 | 63 |
| 2013 Marzo | 37 | 21 | 58 |
| 2013 Febrero | 27 | 17 | 44 |
| 2013 Enero | 8 | 3 | 11 |
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