Controversies in dermatology
Problems in Defining Melanoma Regression and Prognostic Implication
Regresión en el Melanoma: Problemas en su Definición e Implicación Pronóstica
Leído
18151
Vecesse ha leído el artículo
13094
Total PDF
5057
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1578219009701714" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70171-4" "estado" => "S300" "fechaPublicacion" => "2009-11-01" "aid" => "70171" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:759-66" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7103 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1725 "PDF" => 5334 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009701726" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70172-6" "estado" => "S300" "fechaPublicacion" => "2009-11-01" "aid" => "70172" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:767-79" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2751 "formatos" => array:3 [ "EPUB" => 39 "HTML" => 1463 "PDF" => 1249 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>" "titulo" => "Study and Treatment of Locally Advanced Melanoma" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "767" "paginaFinal" => "779" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanoma Localmente Avanzado. Estudio y Tratamiento" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Moreno-Ramírez, L. de la Cruz, L. Ferrándiz, F.M. Camacho" "autores" => array:4 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Moreno-Ramírez" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "de la Cruz" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Ferrándiz" ] 3 => array:2 [ "nombre" => "F.M." "apellidos" => "Camacho" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701726?idApp=UINPBA000044" "url" => "/15782190/0000010000000009/v1_201304241507/S1578219009701726/v1_201304241507/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009701702" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70170-2" "estado" => "S300" "fechaPublicacion" => "2009-11-01" "aid" => "70170" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:756-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2072 "formatos" => array:3 [ "EPUB" => 36 "HTML" => 1233 "PDF" => 803 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actas 1909-2009</span>" "titulo" => "Infectious Nature Of Leprosy by Juan De Azua" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "756" "paginaFinal" => "758" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Contagiosidad de la Lepra, por Juan de Azúa" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Terencio de las Aguas" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Terencio de las Aguas" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701702?idApp=UINPBA000044" "url" => "/15782190/0000010000000009/v1_201304241507/S1578219009701702/v1_201304241507/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Controversies in dermatology</span>" "titulo" => "Problems in Defining Melanoma Regression and Prognostic Implication" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "759" "paginaFinal" => "766" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Requena, R. Botella-Estrada, V. Traves, E. Nagore, S. Almenar, C. Guillén" "autores" => array:6 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Requena" "email" => array:1 [ 0 => "celiareq@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Botella-Estrada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Traves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Nagore" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "S." "apellidos" => "Almenar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "C." "apellidos" => "Guillén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología. Instituto Valenciano de Oncología. C/ Profesor Beltrán Báguena, n.° 8. 46009 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Regresión en el Melanoma: Problemas en su Definición e Implicación Pronóstica" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-03-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84593" "palabras" => array:5 [ 0 => "melanoma" 1 => "regression" 2 => "prognosis" 3 => "sentinel lymph node" 4 => "metastasis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84594" "palabras" => array:5 [ 0 => "melanoma" 1 => "regresión" 2 => "pronóstico" 3 => "ganglio centinela" 4 => "metástasis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Between 10% and 35% of all melanomas show histological regression. That is, there is an area within the melanoma where the tumor retreats or disappears to be progressively replaced by fibrosis with presence of melanophages and variable degrees of inflammation, and increased vascularity. Such regression is generally considered an indicator of poor prognosis in melanoma, although a number of studies contradict this affirmation.</p><p class="elsevierStyleSimplePara elsevierViewall">In this review, we summarize the leading articles about the influence of regression on melanoma prognosis. The results of these studies are very inconsistent, and so the prognostic significance of regression is somewhat controversial. We believe that some of these differences can be explained by differing criteria for regression and so we propose clear histological criteria to define early and sustained regression.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Entre un 10 y un 35% de todos los melanomas presentan regresión histológica, es decir, un área en el seno del melanoma en el que el tumor disminuye o desaparece y es sustituido progresivamente por fibrosis, con cantidades variables de melanófagos, inflamación y neovascularización. Aunque mayoritariamente se considera la presencia de regresión como un factor de mal pronóstico en el melanoma, existen varios trabajos que contradicen esta idea. En esta revisión resumimos los principales artículos publicados sobre la influencia de la regresión en el pronóstico del melanoma y encontramos resultados muy dispares, de modo que el significado pronóstico de la regresión en el melanoma es, a la vista de los trabajos publicados, cuando menos controvertido. Pensamos que parte de las diferencias encontradas se pueden deber a la disparidad en cuanto a los criterios utilizados para definir la regresión, y por ello proponemos unos criterios histológicos que aclaren los conceptos de regresión temprana y establecida.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological regression in primary cutaneous melanoma: recognition, prevalence and significance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Blessing" 1 => "K.M. McLaren" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "1992" "volumen" => "20" "paginaInicial" => "315" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1577409" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumour regression predicts higher risk of sentinel node involvement in thin cutaneous melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Oláh" 1 => "R. Gyulai" 2 => "I. Korom" 3 => "E. Varga" 4 => "A. Dobozy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "149" "paginaInicial" => "662" "paginaFinal" => "663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14511013" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic significance of histologic regression in cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Brogelli" 1 => "U.M. Reali" 2 => "S. Moretti" 3 => "C. Urso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "1992" "volumen" => "2" "paginaInicial" => "87" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1643435" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The significance of inflammation and regression in melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.G. Cook" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Virchows Arch A Pathol Anat Histopathol" "fecha" => "1992" "volumen" => "420" "paginaInicial" => "113" "paginaFinal" => "115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1549899" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypothesis: a role for telomere crisis in spontaneous regression of melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.C. Bastian" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.139.5.667" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2003" "volumen" => "139" "paginaInicial" => "667" "paginaFinal" => "668" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12756110" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunocytochemical analysis of the cellular infiltrate in primary regressing and non-regressing malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.J. Tefany" 1 => "R.S. Barnetson" 2 => "G.M. Halliday" 3 => "S.W. McCarthy" 4 => "W.H. McCarthy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "1991" "volumen" => "97" "paginaInicial" => "197" "paginaFinal" => "202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1712819" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Gershenwald" 1 => "W. Thompson" 2 => "P.F. Mansfield" 3 => "J.E. Lee" 4 => "M.I. Colome" 5 => "C.H. Tseng" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1999.17.3.976" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "976" "paginaFinal" => "983" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10071292" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors analysis of17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. Balch" 1 => "S.J. Soong" 2 => "J.E. Gershenwald" 3 => "J.F. Thompson" 4 => "D.S. Reintgen" 5 => "N. Cascinelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J ClinOncol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "3622" "paginaFinal" => "3634" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation study between the status of sentinel lymph node(s) and the clinicopathological data of primary melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Botella-Estrada" 1 => "E. Nagore" 2 => "L. Hueso" 3 => "J. Giménez" 4 => "S. Almenar" 5 => "C Guillén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "First World Meeting of Interdisciplinary Melanoma/Skin Cancer Centers" "conferencia" => "Barcelona, Spain: September" "serieFecha" => "2007" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous melanoma with regression does not require a lower threshold for sentinel lymph node biopsy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.T. Morris" 1 => "K.J. Busam" 2 => "S. Bero" 3 => "A. Patel" 4 => "M.S. Brady" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1245/s10434-007-9675-2" "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2008" "volumen" => "15" "paginaInicial" => "316" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18004626" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Partial regression of primary cutaneous melanoma: is there an association with sub-clinical sentinel lymph node metastasis?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Fontaine" 1 => "W. Parkhill" 2 => "W. Greer" 3 => "N. Walsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2003" "volumen" => "25" "paginaInicial" => "371" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14501285" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The correlation of regression in primary melanoma with sentinel lymph node status" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Kaur" 1 => "R.J. Thomas" 2 => "N. Desai" 3 => "M.A. Green" 4 => "D. Lovell" 5 => "B.W. Powell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jcp.2007.049411" "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "2008" "volumen" => "61" "paginaInicial" => "297" "paginaFinal" => "300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17675538" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The regressing thin malignant melanoma: a distinctive lesion with metastatic potential" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.A. Gromet" 1 => "W.L. Epstein" 2 => "M.S. Blois" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1978" "volumen" => "42" "paginaInicial" => "2282" "paginaFinal" => "2292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/719608" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological characteristics of metastasizing thin melanomas: a case-control study of 43 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Guitart" 1 => "L. Lowe" 2 => "M. Piepkorn" 3 => "V.G. Prieto" 4 => "M.S. Rabkin" 5 => "S.G. Ronan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2002" "volumen" => "138" "paginaInicial" => "603" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12020220" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "“Thin” malignant melanoma: risk factors and clinical management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.L. Slingluff Jr" 1 => "H.F. Seigler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Plast Surg" "fecha" => "1992" "volumen" => "28" "paginaInicial" => "89" "paginaFinal" => "94" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1642416" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thin malignant melanomas with regression and metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.G. Ronan" 1 => "A.M. Eng" 2 => "H.A. Briele" 3 => "N.N. Shioura" 4 => "T.K. Das Gupta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1987" "volumen" => "123" "paginaInicial" => "1326" "paginaFinal" => "1330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3662564" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Model predicting survival in stage I melanoma based on tumor progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.H. Clark Jr" 1 => "D.E. Elder" 2 => "D. Guerry 4th" 3 => "L.E. Braitman" 4 => "B.J. Trock" 5 => "D. Schultz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "1989" "volumen" => "81" "paginaInicial" => "1893" "paginaFinal" => "1904" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2593166" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thin malignant melanomas (less than 1.5 mm) with metastasis: a histological study and survival analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Blessing" 1 => "K.M. McLaren" 2 => "A. McLean" 3 => "P. Davidson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "1990" "volumen" => "17" "paginaInicial" => "389" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2076865" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regression in malignant melanoma. A histologic feature without independent prognostic significance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.W. Kelly" 1 => "R.W. Sagebiel" 2 => "M.S. Blois" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1985" "volumen" => "56" "paginaInicial" => "2287" "paginaFinal" => "2291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4052972" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognosis in patients with thin malignant melanoma: influence of regression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V.J. McGovern" 1 => "H.M. Shaw" 2 => "G.W. Milton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "1983" "volumen" => "7" "paginaInicial" => "673" "paginaFinal" => "680" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6629343" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histologic features of tumors and the female superiority in survival from malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.M. Shaw" 1 => "V.J. McGovern" 2 => "G.W. Milton" 3 => "G.A. Farago" 4 => "W.H. McCarthy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1980" "volumen" => "45" "paginaInicial" => "1604" "paginaFinal" => "1608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7370919" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biologic behavior of thin malignant melanomas with regressive changes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.R. Paladugu" 1 => "R.H. Yonemoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "1983" "volumen" => "118" "paginaInicial" => "41" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6848075" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regression in thin malignant melanoma. Microscopic diagnosis and prognostic importance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.H. Cooper" 1 => "H.J. Wanebo" 2 => "R.W. Hagar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1985" "volumen" => "121" "paginaInicial" => "1127" "paginaFinal" => "1131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4037837" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features of superficial spreading melanomas with zones of regression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.M. Czarnetzki" 1 => "M. Denter" 2 => "E.B. Brocker" 3 => "P. Rumke" 4 => "V. Krieg" 5 => "F. Vakilzadeh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cancer Res Clin Oncol" "fecha" => "1984" "volumen" => "107" "paginaInicial" => "225" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6736111" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "On the prognostic importance of white depressed areas in the primary lesion of superficial spreading melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.I. McLean" 1 => "R.A. Lew" 2 => "A.J. Sober" 3 => "M.C. Mihm Jr" 4 => "T.B. Fitzpatrick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1979" "volumen" => "43" "paginaInicial" => "157" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/761159" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A study of thin (< 1.5 mm) malignant melanomas with poor prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.G. Park" 1 => "K. Blessing" 2 => "K.M. McLaren" 3 => "A.C. Watson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Plast Surg" "fecha" => "1993" "volumen" => "46" "paginaInicial" => "607" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8252271" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histologic regression in malignant melanoma: an interobserver concordance study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Kang" 1 => "R.L. Barnhill" 2 => "M.C. Mihm Jr" 3 => "A.J. Sober" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1993" "volumen" => "20" "paginaInicial" => "126" "paginaFinal" => "129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8320356" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological diagnosis of nevi and melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Massi" 1 => "P. LeBoit" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2004" "editorial" => "Steinkopff Verlag Darmstadt" "editorialLocalizacion" => "Germany" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.G. Clemente" 1 => "M.C. Mihm Jr" 2 => "R. Bufalino" 3 => "S. Zurrida" 4 => "P. Collini" 5 => "N. Cascinelli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1996" "volumen" => "77" "paginaInicial" => "1303" "paginaFinal" => "1310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8608507" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance: could it be related to a different cytokine microenvironment?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Moretti" 1 => "A. Spallanzani" 2 => "C. Pinzi" 3 => "F. Prignano" 4 => "P. Fabbri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2006.00616.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2007" "volumen" => "34" "paginaInicial" => "301" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17381800" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000009/v1_201304241507/S1578219009701714/v1_201304241507/en/main.assets" "Apartado" => array:4 [ "identificador" => "6176" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Controversies in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000009/v1_201304241507/S1578219009701714/v1_201304241507/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701714?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 7 | 10 | 17 |
| 2024 Octubre | 91 | 93 | 184 |
| 2024 Septiembre | 103 | 107 | 210 |
| 2024 Agosto | 167 | 94 | 261 |
| 2024 Julio | 178 | 109 | 287 |
| 2024 Junio | 126 | 96 | 222 |
| 2024 Mayo | 103 | 88 | 191 |
| 2024 Abril | 72 | 76 | 148 |
| 2024 Marzo | 143 | 117 | 260 |
| 2024 Febrero | 106 | 103 | 209 |
| 2024 Enero | 97 | 156 | 253 |
| 2023 Diciembre | 91 | 133 | 224 |
| 2023 Noviembre | 80 | 197 | 277 |
| 2023 Octubre | 81 | 143 | 224 |
| 2023 Septiembre | 57 | 152 | 209 |
| 2023 Agosto | 42 | 123 | 165 |
| 2023 Julio | 53 | 159 | 212 |
| 2023 Junio | 61 | 124 | 185 |
| 2023 Mayo | 49 | 159 | 208 |
| 2023 Abril | 35 | 125 | 160 |
| 2023 Marzo | 32 | 126 | 158 |
| 2023 Febrero | 43 | 117 | 160 |
| 2023 Enero | 44 | 138 | 182 |
| 2022 Diciembre | 61 | 119 | 180 |
| 2022 Noviembre | 27 | 110 | 137 |
| 2022 Octubre | 42 | 110 | 152 |
| 2022 Septiembre | 53 | 132 | 185 |
| 2022 Agosto | 27 | 141 | 168 |
| 2022 Julio | 40 | 153 | 193 |
| 2022 Junio | 29 | 166 | 195 |
| 2022 Mayo | 72 | 179 | 251 |
| 2022 Abril | 85 | 101 | 186 |
| 2022 Marzo | 77 | 144 | 221 |
| 2022 Febrero | 30 | 122 | 152 |
| 2022 Enero | 49 | 288 | 337 |
| 2021 Diciembre | 45 | 186 | 231 |
| 2021 Noviembre | 42 | 214 | 256 |
| 2021 Octubre | 56 | 213 | 269 |
| 2021 Septiembre | 43 | 163 | 206 |
| 2021 Agosto | 46 | 176 | 222 |
| 2021 Julio | 37 | 176 | 213 |
| 2021 Junio | 43 | 190 | 233 |
| 2021 Mayo | 26 | 212 | 238 |
| 2021 Abril | 94 | 365 | 459 |
| 2021 Marzo | 64 | 242 | 306 |
| 2021 Febrero | 53 | 158 | 211 |
| 2021 Enero | 43 | 144 | 187 |
| 2020 Diciembre | 47 | 149 | 196 |
| 2020 Noviembre | 31 | 108 | 139 |
| 2020 Octubre | 44 | 116 | 160 |
| 2020 Septiembre | 36 | 60 | 96 |
| 2020 Agosto | 29 | 94 | 123 |
| 2020 Julio | 12 | 54 | 66 |
| 2020 Junio | 34 | 74 | 108 |
| 2020 Mayo | 22 | 49 | 71 |
| 2020 Abril | 18 | 48 | 66 |
| 2020 Marzo | 12 | 45 | 57 |
| 2020 Febrero | 2 | 26 | 28 |
| 2020 Enero | 0 | 31 | 31 |
| 2019 Diciembre | 0 | 33 | 33 |
| 2019 Noviembre | 0 | 21 | 21 |
| 2019 Octubre | 0 | 24 | 24 |
| 2019 Septiembre | 0 | 35 | 35 |
| 2019 Agosto | 0 | 23 | 23 |
| 2019 Julio | 0 | 31 | 31 |
| 2019 Junio | 0 | 32 | 32 |
| 2019 Mayo | 2 | 82 | 84 |
| 2019 Abril | 0 | 69 | 69 |
| 2019 Marzo | 0 | 11 | 11 |
| 2019 Febrero | 0 | 17 | 17 |
| 2019 Enero | 0 | 8 | 8 |
| 2018 Diciembre | 0 | 15 | 15 |
| 2018 Noviembre | 1 | 4 | 5 |
| 2018 Septiembre | 0 | 9 | 9 |
| 2018 Agosto | 0 | 35 | 35 |
| 2018 Julio | 0 | 25 | 25 |
| 2018 Junio | 0 | 26 | 26 |
| 2018 Mayo | 0 | 37 | 37 |
| 2018 Abril | 0 | 31 | 31 |
| 2018 Marzo | 1 | 40 | 41 |
| 2018 Febrero | 19 | 102 | 121 |
| 2018 Enero | 14 | 126 | 140 |
| 2017 Diciembre | 25 | 85 | 110 |
| 2017 Noviembre | 25 | 139 | 164 |
| 2017 Octubre | 21 | 132 | 153 |
| 2017 Septiembre | 26 | 142 | 168 |
| 2017 Agosto | 20 | 111 | 131 |
| 2017 Julio | 12 | 122 | 134 |
| 2017 Junio | 23 | 158 | 181 |
| 2017 Mayo | 22 | 115 | 137 |
| 2017 Abril | 22 | 100 | 122 |
| 2017 Marzo | 21 | 133 | 154 |
| 2017 Febrero | 17 | 130 | 147 |
| 2017 Enero | 27 | 97 | 124 |
| 2016 Diciembre | 44 | 101 | 145 |
| 2016 Noviembre | 29 | 117 | 146 |
| 2016 Octubre | 25 | 146 | 171 |
| 2016 Septiembre | 36 | 151 | 187 |
| 2016 Agosto | 107 | 123 | 230 |
| 2016 Julio | 61 | 78 | 139 |
| 2016 Junio | 12 | 54 | 66 |
| 2016 Mayo | 7 | 36 | 43 |
| 2016 Abril | 7 | 1 | 8 |
| 2016 Marzo | 6 | 2 | 8 |
| 2016 Febrero | 6 | 37 | 43 |
| 2016 Enero | 11 | 26 | 37 |
| 2015 Diciembre | 11 | 2 | 13 |
| 2015 Noviembre | 10 | 2 | 12 |
| 2015 Octubre | 7 | 33 | 40 |
| 2015 Septiembre | 6 | 1 | 7 |
| 2015 Agosto | 7 | 20 | 27 |
| 2015 Julio | 31 | 52 | 83 |
| 2015 Junio | 34 | 71 | 105 |
| 2015 Mayo | 58 | 67 | 125 |
| 2015 Abril | 29 | 55 | 84 |
| 2015 Marzo | 25 | 67 | 92 |
| 2015 Febrero | 21 | 56 | 77 |
| 2015 Enero | 26 | 43 | 69 |
| 2014 Diciembre | 28 | 41 | 69 |
| 2014 Noviembre | 17 | 28 | 45 |
| 2014 Octubre | 27 | 40 | 67 |
| 2014 Septiembre | 35 | 30 | 65 |
| 2014 Agosto | 51 | 28 | 79 |
| 2014 Julio | 38 | 35 | 73 |
| 2014 Junio | 47 | 12 | 59 |
| 2014 Mayo | 46 | 19 | 65 |
| 2014 Abril | 44 | 12 | 56 |
| 2014 Marzo | 52 | 81 | 133 |
| 2014 Febrero | 25 | 101 | 126 |
| 2014 Enero | 42 | 111 | 153 |
| 2013 Diciembre | 28 | 71 | 99 |
| 2013 Noviembre | 31 | 105 | 136 |
| 2013 Octubre | 33 | 91 | 124 |
| 2013 Septiembre | 32 | 120 | 152 |
| 2013 Agosto | 34 | 182 | 216 |
| 2013 Julio | 34 | 214 | 248 |
| 2013 Junio | 24 | 131 | 155 |
| 2013 Mayo | 29 | 63 | 92 |
| 2013 Abril | 40 | 72 | 112 |
| 2013 Marzo | 42 | 40 | 82 |
| 2013 Febrero | 25 | 20 | 45 |
| 2013 Enero | 7 | 3 | 10 |
Mostrar todo
