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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma &#40;BCC&#41; is a common malignant tumor and its incidence has risen in recent decades&#46; Research has shown the relationship between ultraviolet &#40;UV&#41; radiation&#44; the skin immune system&#44; and BCC&#46; The role of Langerhans cells &#40;LC&#41; in the immune response to tumors has prompted research into LC density and morphology in response to UV radiation and BCC&#46; However&#44; the data are inconsistent due to differences in research methodology&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To study the density and morphology of LCs in the peritumoral epidermis of BCC using immunohistochemistry and image processing software and compare the results with those from the epidermis overlying the tumor&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Twelve samples from patients with BCC were prepared with a CD1a stain&#46; Areas of epidermis overlying and adjacent to the tumor were defined using light microscopy and the Image J image processing software&#46; The LCs in each area were counted and the cell densities were calculated and compared&#46; Morphological features of LCs were also evaluated in each epidermal area&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The results showed a lower density of LCs in the epidermis overlying the tumor than in the peritumoral epidermis &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; There were also differences in the size&#44; shape&#44; and dendritic pattern of the LCs between the epidermal areas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The lower density and fewer morphological changes of LCs in the epidermis overlying BCC may give rise to alterations in the immune response to BCC&#46; Digital image analysis is a reliable method for the morphometric evaluation of LCs&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El carcinoma basocelular &#40;CBC&#41; es un tumor maligno frecuente y su incidencia ha aumentado en las &#250;ltimas d&#233;cadas&#46; Investigaciones han demostrado la relaci&#243;n entre radiaci&#243;n ultravioleta &#40;RUV&#41;&#44; sistema inmune cut&#225;neo y CBC&#46; La funci&#243;n de las c&#233;lulas de Langerhans &#40;CL&#41; en la respuesta inmuneantitumoral ha motivado la investigaci&#243;n de su densidad y morfolog&#237;a frente a la RUV y al CBC&#46; Sin embargo&#44; los resultados publicados presentan discordancias debido a diferencias en la metodolog&#237;a cient&#237;fica&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar la densidad y morfolog&#237;a de las CL en la epidermis peritumoral comparada con la epidermis supratumoral mediante inmunohistoqu&#237;mica y un programa computacional de im&#225;genes digitales&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Doce casos de CBC fueron te&#241;idos con CD1a&#46; Se utiliz&#243; microscopia &#243;ptica y el programa computacional Image J para calcular las &#225;reas epid&#233;rmicas sobre el tumor y adyacente a &#233;l&#46; Se contabilizaron el n&#250;mero de CL de cada &#225;rea y se determinaron y compararon las densidades celulares&#46; Finalmente&#44; se analiz&#243; la morfolog&#237;a de las CL en ambas &#225;reas epid&#233;rmicas&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los resultados mostraron una menor densidad celular en la epidermis supratumoral respecto a la peritumoral &#40;p &#60; 0&#44;05&#41;&#46; Las CL entre ambas &#225;reas presentaron diferencias en el tama&#241;o&#44; forma celular y patr&#243;n dendr&#237;tico&#46;</p> <span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La menor densidad y alteraciones estructurales de las CL supratumorales podr&#237;an dar lugar a variaciones de la respuesta inmune en el CBC&#46; El uso de tecnolog&#237;a de an&#225;lisis de im&#225;genes digitales ser&#237;a un m&#233;todo fiable en el estudio morfom&#233;trico de las CL&#46;</p>"
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Original article
CD1a+ Langerhans Cells in the Peritumoral Epidermis of Basal Cell Carcinoma
Células de Langerhans CD1a+ en la Epidermis Peritumoral del Carcinoma Basocelular
F. Mardonesa,
Autor para correspondencia
fmardonesv@yahoo.com

Correspondence: Felipe Mardones Valdivieso, Departamento de Dermatología, Hospital Clínico, Universidad de Chile, Santos Dumont, 999, Santiago, Chile.
, V. Zemelmana, I. Sazunicb, C. Moralesb, K. Palmac, M. Vargasd
a Departamento de Dermatología, Hospital Clínico, Universidad de Chile, Santiago, Chile
b Instituto de Anatomía Patológica, Hospital Clínico, Universidad de Chile, Santiago, Chile
c Unidad de Análisis Celular Integral, Centro de Equipamiento y Servicio de Apoyo Tecnológico (CESAT), Facultad de Medicina, Universidad de Chile, Santiago, Chile
d Laboratorio Central de Inmunohistoquímica, S.A., Santiago, Chile
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma &#40;BCC&#41; is a common malignant tumor and its incidence has risen in recent decades&#46; Research has shown the relationship between ultraviolet &#40;UV&#41; radiation&#44; the skin immune system&#44; and BCC&#46; The role of Langerhans cells &#40;LC&#41; in the immune response to tumors has prompted research into LC density and morphology in response to UV radiation and BCC&#46; However&#44; the data are inconsistent due to differences in research methodology&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To study the density and morphology of LCs in the peritumoral epidermis of BCC using immunohistochemistry and image processing software and compare the results with those from the epidermis overlying the tumor&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Twelve samples from patients with BCC were prepared with a CD1a stain&#46; Areas of epidermis overlying and adjacent to the tumor were defined using light microscopy and the Image J image processing software&#46; The LCs in each area were counted and the cell densities were calculated and compared&#46; Morphological features of LCs were also evaluated in each epidermal area&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The results showed a lower density of LCs in the epidermis overlying the tumor than in the peritumoral epidermis &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; There were also differences in the size&#44; shape&#44; and dendritic pattern of the LCs between the epidermal areas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The lower density and fewer morphological changes of LCs in the epidermis overlying BCC may give rise to alterations in the immune response to BCC&#46; Digital image analysis is a reliable method for the morphometric evaluation of LCs&#46;</p>"
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