Correspondence: Felipe Mardones Valdivieso, Departamento de Dermatología, Hospital Clínico, Universidad de Chile, Santos Dumont, 999, Santiago, Chile.
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Research has shown the relationship between ultraviolet (UV) radiation, the skin immune system, and BCC. The role of Langerhans cells (LC) in the immune response to tumors has prompted research into LC density and morphology in response to UV radiation and BCC. However, the data are inconsistent due to differences in research methodology.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To study the density and morphology of LCs in the peritumoral epidermis of BCC using immunohistochemistry and image processing software and compare the results with those from the epidermis overlying the tumor.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Twelve samples from patients with BCC were prepared with a CD1a stain. Areas of epidermis overlying and adjacent to the tumor were defined using light microscopy and the Image J image processing software. The LCs in each area were counted and the cell densities were calculated and compared. Morphological features of LCs were also evaluated in each epidermal area.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The results showed a lower density of LCs in the epidermis overlying the tumor than in the peritumoral epidermis (P<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). There were also differences in the size, shape, and dendritic pattern of the LCs between the epidermal areas.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The lower density and fewer morphological changes of LCs in the epidermis overlying BCC may give rise to alterations in the immune response to BCC. Digital image analysis is a reliable method for the morphometric evaluation of LCs.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El carcinoma basocelular (CBC) es un tumor maligno frecuente y su incidencia ha aumentado en las últimas décadas. Investigaciones han demostrado la relación entre radiación ultravioleta (RUV), sistema inmune cutáneo y CBC. La función de las células de Langerhans (CL) en la respuesta inmuneantitumoral ha motivado la investigación de su densidad y morfología frente a la RUV y al CBC. Sin embargo, los resultados publicados presentan discordancias debido a diferencias en la metodología científica.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar la densidad y morfología de las CL en la epidermis peritumoral comparada con la epidermis supratumoral mediante inmunohistoquímica y un programa computacional de imágenes digitales.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Doce casos de CBC fueron teñidos con CD1a. Se utilizó microscopia óptica y el programa computacional Image J para calcular las áreas epidérmicas sobre el tumor y adyacente a él. Se contabilizaron el número de CL de cada área y se determinaron y compararon las densidades celulares. Finalmente, se analizó la morfología de las CL en ambas áreas epidérmicas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los resultados mostraron una menor densidad celular en la epidermis supratumoral respecto a la peritumoral (p < 0,05). Las CL entre ambas áreas presentaron diferencias en el tamaño, forma celular y patrón dendrítico.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p class="elsevierStyleSimplePara elsevierViewall">La menor densidad y alteraciones estructurales de las CL supratumorales podrían dar lugar a variaciones de la respuesta inmune en el CBC. El uso de tecnología de análisis de imágenes digitales sería un método fiable en el estudio morfométrico de las CL.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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año/Mes | Html | Total | |
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2024 Noviembre | 6 | 14 | 20 |
2024 Octubre | 68 | 51 | 119 |
2024 Septiembre | 60 | 37 | 97 |
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2024 Abril | 56 | 26 | 82 |
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2024 Febrero | 57 | 38 | 95 |
2024 Enero | 44 | 47 | 91 |
2023 Diciembre | 53 | 22 | 75 |
2023 Noviembre | 53 | 39 | 92 |
2023 Octubre | 42 | 31 | 73 |
2023 Septiembre | 75 | 27 | 102 |
2023 Agosto | 23 | 32 | 55 |
2023 Julio | 26 | 57 | 83 |
2023 Junio | 44 | 41 | 85 |
2023 Mayo | 38 | 36 | 74 |
2023 Abril | 25 | 21 | 46 |
2023 Marzo | 21 | 24 | 45 |
2023 Febrero | 27 | 21 | 48 |
2023 Enero | 25 | 45 | 70 |
2022 Diciembre | 33 | 38 | 71 |
2022 Noviembre | 11 | 26 | 37 |
2022 Octubre | 19 | 30 | 49 |
2022 Septiembre | 20 | 40 | 60 |
2022 Agosto | 14 | 37 | 51 |
2022 Julio | 15 | 30 | 45 |
2022 Junio | 13 | 27 | 40 |
2022 Mayo | 24 | 57 | 81 |
2022 Abril | 23 | 28 | 51 |
2022 Marzo | 37 | 58 | 95 |
2022 Febrero | 22 | 29 | 51 |
2022 Enero | 48 | 57 | 105 |
2021 Diciembre | 68 | 49 | 117 |
2021 Noviembre | 60 | 57 | 117 |
2021 Octubre | 65 | 49 | 114 |
2021 Septiembre | 37 | 45 | 82 |
2021 Agosto | 41 | 29 | 70 |
2021 Julio | 25 | 39 | 64 |
2021 Junio | 17 | 32 | 49 |
2021 Mayo | 23 | 30 | 53 |
2021 Abril | 45 | 80 | 125 |
2021 Marzo | 54 | 16 | 70 |
2021 Febrero | 61 | 21 | 82 |
2021 Enero | 39 | 13 | 52 |
2020 Diciembre | 42 | 24 | 66 |
2020 Noviembre | 12 | 21 | 33 |
2020 Octubre | 26 | 12 | 38 |
2020 Septiembre | 37 | 10 | 47 |
2020 Agosto | 12 | 14 | 26 |
2020 Julio | 10 | 6 | 16 |
2020 Junio | 32 | 19 | 51 |
2020 Mayo | 33 | 24 | 57 |
2020 Abril | 15 | 23 | 38 |
2020 Marzo | 34 | 19 | 53 |
2020 Febrero | 1 | 5 | 6 |
2020 Enero | 0 | 4 | 4 |
2019 Diciembre | 0 | 14 | 14 |
2019 Noviembre | 0 | 11 | 11 |
2019 Octubre | 0 | 5 | 5 |
2019 Septiembre | 0 | 2 | 2 |
2019 Agosto | 0 | 5 | 5 |
2019 Julio | 0 | 8 | 8 |
2019 Junio | 0 | 7 | 7 |
2019 Mayo | 0 | 46 | 46 |
2019 Abril | 0 | 9 | 9 |
2019 Marzo | 0 | 7 | 7 |
2019 Febrero | 0 | 5 | 5 |
2018 Diciembre | 0 | 5 | 5 |
2018 Febrero | 18 | 3 | 21 |
2018 Enero | 27 | 4 | 31 |
2017 Diciembre | 23 | 9 | 32 |
2017 Noviembre | 32 | 3 | 35 |
2017 Octubre | 20 | 7 | 27 |
2017 Septiembre | 24 | 6 | 30 |
2017 Agosto | 39 | 15 | 54 |
2017 Julio | 19 | 9 | 28 |
2017 Junio | 45 | 13 | 58 |
2017 Mayo | 44 | 8 | 52 |
2017 Abril | 24 | 12 | 36 |
2017 Marzo | 30 | 22 | 52 |
2017 Febrero | 30 | 9 | 39 |
2017 Enero | 16 | 6 | 22 |
2016 Diciembre | 44 | 8 | 52 |
2016 Noviembre | 54 | 9 | 63 |
2016 Octubre | 35 | 15 | 50 |
2016 Septiembre | 52 | 18 | 70 |
2016 Agosto | 51 | 4 | 55 |
2016 Julio | 43 | 4 | 47 |
2016 Junio | 18 | 9 | 27 |
2016 Mayo | 10 | 6 | 16 |
2016 Abril | 20 | 12 | 32 |
2016 Marzo | 14 | 7 | 21 |
2016 Febrero | 9 | 12 | 21 |
2016 Enero | 6 | 8 | 14 |
2015 Diciembre | 12 | 6 | 18 |
2015 Noviembre | 17 | 10 | 27 |
2015 Octubre | 14 | 8 | 22 |
2015 Septiembre | 24 | 8 | 32 |
2015 Agosto | 20 | 3 | 23 |
2015 Julio | 61 | 6 | 67 |
2015 Junio | 38 | 7 | 45 |
2015 Mayo | 86 | 16 | 102 |
2015 Abril | 48 | 11 | 59 |
2015 Marzo | 32 | 11 | 43 |
2015 Febrero | 22 | 11 | 33 |
2015 Enero | 35 | 14 | 49 |
2014 Diciembre | 30 | 15 | 45 |
2014 Noviembre | 22 | 7 | 29 |
2014 Octubre | 32 | 12 | 44 |
2014 Septiembre | 28 | 8 | 36 |
2014 Agosto | 40 | 24 | 64 |
2014 Julio | 46 | 19 | 65 |
2014 Junio | 51 | 10 | 61 |
2014 Mayo | 54 | 16 | 70 |
2014 Abril | 55 | 15 | 70 |
2014 Marzo | 69 | 13 | 82 |
2014 Febrero | 54 | 14 | 68 |
2014 Enero | 54 | 14 | 68 |
2013 Diciembre | 42 | 15 | 57 |
2013 Noviembre | 29 | 14 | 43 |
2013 Octubre | 29 | 17 | 46 |
2013 Septiembre | 30 | 17 | 47 |
2013 Agosto | 20 | 13 | 33 |
2013 Julio | 28 | 24 | 52 |
2013 Junio | 30 | 13 | 43 |
2013 Mayo | 28 | 9 | 37 |
2013 Abril | 23 | 22 | 45 |
2013 Marzo | 33 | 20 | 53 |
2013 Febrero | 26 | 15 | 41 |
2013 Enero | 8 | 3 | 11 |