Practical dermatology
Oral Leukoplakia: Clinical, Histopathologic, and Molecular Features and Therapeutic Approach
La Leucoplasia Oral: Definición de Parámetros Clínicos, Histopatológicos y Moleculares y Actitud Terapéutica
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Of note among the range of lesions covered by this broad area of knowledge is oral leukoplakia—the most common precancerous lesion and the most problematic in terms of both diagnosis and therapeutic management.</p><p class="elsevierStyleSimplePara elsevierViewall">In addition to defining leukoplakia, this review also establishes a differential diagnosis with the other most important oral diseases and analyzes the different clinical, histologic, and molecular features that can provide an indication of the risk of malignant transformation. Finally, a therapeutic algorithm is presented to help us optimize clinical management of the disease.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Actualmente existe un incremento del número de casos de patología oral en los servicios de Dermatología. Dentro de las diversas lesiones que forman parte de esta amplia área de conocimiento destacamos la leucoplasia oral, por ser la lesión mucosa precancerosa más frecuente y la que mayores problemas origina tanto en su diagnóstico como en su manejo terapéutico. En esta revisión, además de definir la leucoplasia, establecemos un diagnóstico diferencial con el resto de las patologías orales más importantes y analizamos los diversos parámetros clínicos, histológicos y moleculares que definen el riesgo de transformación maligna de esta patología. Finalmente se establece un algoritmo terapéutico que nos ayuda a optimizar su manejo clínico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:90 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 22 | 28 |
| 2024 Octubre | 60 | 219 | 279 |
| 2024 Septiembre | 86 | 233 | 319 |
| 2024 Agosto | 128 | 223 | 351 |
| 2024 Julio | 79 | 231 | 310 |
| 2024 Junio | 93 | 236 | 329 |
| 2024 Mayo | 86 | 351 | 437 |
| 2024 Abril | 64 | 174 | 238 |
| 2024 Marzo | 64 | 196 | 260 |
| 2024 Febrero | 60 | 248 | 308 |
| 2024 Enero | 59 | 245 | 304 |
| 2023 Diciembre | 67 | 253 | 320 |
| 2023 Noviembre | 68 | 372 | 440 |
| 2023 Octubre | 51 | 272 | 323 |
| 2023 Septiembre | 52 | 266 | 318 |
| 2023 Agosto | 47 | 161 | 208 |
| 2023 Julio | 69 | 211 | 280 |
| 2023 Junio | 65 | 190 | 255 |
| 2023 Mayo | 65 | 199 | 264 |
| 2023 Abril | 29 | 126 | 155 |
| 2023 Marzo | 23 | 111 | 134 |
| 2023 Febrero | 21 | 104 | 125 |
| 2023 Enero | 30 | 116 | 146 |
| 2022 Diciembre | 35 | 121 | 156 |
| 2022 Noviembre | 16 | 83 | 99 |
| 2022 Octubre | 16 | 107 | 123 |
| 2022 Septiembre | 24 | 120 | 144 |
| 2022 Agosto | 11 | 79 | 90 |
| 2022 Julio | 14 | 81 | 95 |
| 2022 Junio | 10 | 101 | 111 |
| 2022 Mayo | 28 | 108 | 136 |
| 2022 Abril | 32 | 190 | 222 |
| 2022 Marzo | 32 | 178 | 210 |
| 2022 Febrero | 26 | 129 | 155 |
| 2022 Enero | 27 | 111 | 138 |
| 2021 Diciembre | 29 | 87 | 116 |
| 2021 Noviembre | 48 | 101 | 149 |
| 2021 Octubre | 35 | 110 | 145 |
| 2021 Septiembre | 36 | 94 | 130 |
| 2021 Agosto | 34 | 68 | 102 |
| 2021 Julio | 28 | 78 | 106 |
| 2021 Junio | 36 | 71 | 107 |
| 2021 Mayo | 33 | 42 | 75 |
| 2021 Abril | 50 | 99 | 149 |
| 2021 Marzo | 62 | 42 | 104 |
| 2021 Febrero | 59 | 39 | 98 |
| 2021 Enero | 36 | 33 | 69 |
| 2020 Diciembre | 21 | 26 | 47 |
| 2020 Noviembre | 16 | 23 | 39 |
| 2020 Octubre | 29 | 23 | 52 |
| 2020 Septiembre | 15 | 27 | 42 |
| 2020 Agosto | 18 | 25 | 43 |
| 2020 Julio | 21 | 23 | 44 |
| 2020 Junio | 23 | 47 | 70 |
| 2020 Mayo | 18 | 34 | 52 |
| 2020 Abril | 23 | 30 | 53 |
| 2020 Marzo | 21 | 26 | 47 |
| 2020 Febrero | 0 | 5 | 5 |
| 2020 Enero | 1 | 4 | 5 |
| 2019 Diciembre | 0 | 15 | 15 |
| 2019 Noviembre | 0 | 6 | 6 |
| 2019 Octubre | 0 | 7 | 7 |
| 2019 Septiembre | 0 | 14 | 14 |
| 2019 Agosto | 0 | 10 | 10 |
| 2019 Julio | 0 | 9 | 9 |
| 2019 Junio | 0 | 8 | 8 |
| 2019 Mayo | 0 | 51 | 51 |
| 2019 Abril | 0 | 17 | 17 |
| 2019 Marzo | 0 | 7 | 7 |
| 2019 Febrero | 0 | 3 | 3 |
| 2019 Enero | 0 | 2 | 2 |
| 2018 Noviembre | 0 | 2 | 2 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Junio | 0 | 2 | 2 |
| 2018 Mayo | 0 | 6 | 6 |
| 2018 Abril | 0 | 83 | 83 |
| 2018 Marzo | 3 | 28 | 31 |
| 2018 Febrero | 28 | 111 | 139 |
| 2018 Enero | 27 | 130 | 157 |
| 2017 Diciembre | 39 | 182 | 221 |
| 2017 Noviembre | 40 | 181 | 221 |
| 2017 Octubre | 25 | 162 | 187 |
| 2017 Septiembre | 32 | 98 | 130 |
| 2017 Agosto | 48 | 113 | 161 |
| 2017 Julio | 41 | 164 | 205 |
| 2017 Junio | 49 | 178 | 227 |
| 2017 Mayo | 57 | 182 | 239 |
| 2017 Abril | 38 | 140 | 178 |
| 2017 Marzo | 54 | 199 | 253 |
| 2017 Febrero | 29 | 194 | 223 |
| 2017 Enero | 24 | 125 | 149 |
| 2016 Diciembre | 37 | 213 | 250 |
| 2016 Noviembre | 40 | 199 | 239 |
| 2016 Octubre | 51 | 172 | 223 |
| 2016 Septiembre | 76 | 240 | 316 |
| 2016 Agosto | 127 | 128 | 255 |
| 2016 Julio | 48 | 107 | 155 |
| 2016 Junio | 13 | 79 | 92 |
| 2016 Mayo | 11 | 96 | 107 |
| 2016 Abril | 8 | 1 | 9 |
| 2016 Marzo | 2 | 13 | 15 |
| 2016 Febrero | 4 | 11 | 15 |
| 2016 Enero | 10 | 11 | 21 |
| 2015 Diciembre | 6 | 10 | 16 |
| 2015 Noviembre | 14 | 6 | 20 |
| 2015 Octubre | 10 | 5 | 15 |
| 2015 Septiembre | 10 | 7 | 17 |
| 2015 Agosto | 9 | 1 | 10 |
| 2015 Julio | 51 | 185 | 236 |
| 2015 Junio | 62 | 89 | 151 |
| 2015 Mayo | 97 | 112 | 209 |
| 2015 Abril | 64 | 163 | 227 |
| 2015 Marzo | 42 | 230 | 272 |
| 2015 Febrero | 49 | 235 | 284 |
| 2015 Enero | 46 | 183 | 229 |
| 2014 Diciembre | 58 | 203 | 261 |
| 2014 Noviembre | 39 | 181 | 220 |
| 2014 Octubre | 71 | 173 | 244 |
| 2014 Septiembre | 77 | 118 | 195 |
| 2014 Agosto | 67 | 135 | 202 |
| 2014 Julio | 71 | 102 | 173 |
| 2014 Junio | 68 | 78 | 146 |
| 2014 Mayo | 60 | 68 | 128 |
| 2014 Abril | 74 | 15 | 89 |
| 2014 Marzo | 78 | 33 | 111 |
| 2014 Febrero | 77 | 41 | 118 |
| 2014 Enero | 51 | 31 | 82 |
| 2013 Diciembre | 50 | 30 | 80 |
| 2013 Noviembre | 50 | 33 | 83 |
| 2013 Octubre | 41 | 62 | 103 |
| 2013 Septiembre | 41 | 68 | 109 |
| 2013 Agosto | 38 | 80 | 118 |
| 2013 Julio | 48 | 78 | 126 |
| 2013 Junio | 39 | 69 | 108 |
| 2013 Mayo | 48 | 91 | 139 |
| 2013 Abril | 42 | 87 | 129 |
| 2013 Marzo | 36 | 83 | 119 |
| 2013 Febrero | 33 | 56 | 89 |
| 2013 Enero | 8 | 5 | 13 |
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