Original articles
Experience in the Treatment of Cutaneous In-Transit Melanoma Metastases and Satellitosis With Intralesional Interleukin-2
Esperiencia en el Tratamiento de Satelitosis y Metástasis Cutáneas en Tránsuito de Melanoma con Interleucina 2 Intralesional
L.A. Dehesa, J. Vilar-Alejo, P. Valerón-Almazán, G. Carretero
Autor para correspondencia
gcarher@gobiernodecanarias.org
Correspondence: Servicio de Dermatología. Hospital Universitario de Gran Canaria Dr. Negrín. Barranco de La Ballena, s/n. 35012 Las Palmas de Gran Canaria, Spain.
Correspondence: Servicio de Dermatología. Hospital Universitario de Gran Canaria Dr. Negrín. Barranco de La Ballena, s/n. 35012 Las Palmas de Gran Canaria, Spain.
Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
Leído
7721
Vecesse ha leído el artículo
3804
Total PDF
3917
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1578219009701258" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70125-8" "estado" => "S300" "fechaPublicacion" => "2009-09-01" "aid" => "70125" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:571-85" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3281 "formatos" => array:3 [ "EPUB" => 42 "HTML" => 1720 "PDF" => 1519 ] ] "itemSiguiente" => array:18 [ "pii" => "S157821900970126X" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70126-X" "estado" => "S300" "fechaPublicacion" => "2009-09-01" "aid" => "70126" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:586-95" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2995 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 1964 "PDF" => 988 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Validation of a Spanish Questionnaire to Evaluate Habits, Attitudes, and Understanding of Exposure to Sunlight: “The Beach Questionnaire”" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "586" "paginaFinal" => "595" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Validación de un Cuestionario en Español Sobre Comportamientos, Actitudes y Conocimientos Relacionados con la Exposición Solar: «Cuestionario a pie de Playa»" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. de Troya-Martín, N. Blázquez-Sánchez, F. Rivas-Ruiz, I. Fernández-Canedo, A. Rupérez-Sandoval, J. Pons-Palliser, E. Perea-Millab" "autores" => array:7 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "de Troya-Martín" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Blázquez-Sánchez" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Rivas-Ruiz" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Fernández-Canedo" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Rupérez-Sandoval" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Pons-Palliser" ] 6 => array:2 [ "nombre" => "E." "apellidos" => "Perea-Millab" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821900970126X?idApp=UINPBA000044" "url" => "/15782190/0000010000000007/v1_201304241501/S157821900970126X/v1_201304241501/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009701246" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70124-6" "estado" => "S300" "fechaPublicacion" => "2009-09-01" "aid" => "70124" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:562-70" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3477 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 1744 "PDF" => 1695 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Novelties in dermatology</span>" "titulo" => "Current Panorama in the Diagnosis of Cutaneous Tuberculosis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "562" "paginaFinal" => "570" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Panorama Actual en el Diagnóstico de la Tuberculosis Cutánea" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Almaguer-Chávez, J. Ocampo-Candiani, A. Rendón" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Almaguer-Chávez" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Ocampo-Candiani" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Rendón" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701246?idApp=UINPBA000044" "url" => "/15782190/0000010000000007/v1_201304241501/S1578219009701246/v1_201304241501/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Experience in the Treatment of Cutaneous In-Transit Melanoma Metastases and Satellitosis With Intralesional Interleukin-2" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "571" "paginaFinal" => "585" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L.A. Dehesa, J. Vilar-Alejo, P. Valerón-Almazán, G. Carretero" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L.A." "apellidos" => "Dehesa" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Vilar-Alejo" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Valerón-Almazán" ] 3 => array:4 [ "nombre" => "G." "apellidos" => "Carretero" "email" => array:1 [ 0 => "gcarher@gobiernodecanarias.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología. Hospital Universitario de Gran Canaria Dr. Negrín. Barranco de La Ballena, s/n. 35012 Las Palmas de Gran Canaria, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Esperiencia en el Tratamiento de Satelitosis y Metástasis Cutáneas en Tránsuito de Melanoma con Interleucina 2 Intralesional" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-10-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84538" "palabras" => array:4 [ 0 => "interleukin 2" 1 => "malignant melanoma" 2 => "cutaneous metastasis" 3 => "intralesional therapy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84537" "palabras" => array:4 [ 0 => "interleucina 2" 1 => "melanoma maligno" 2 => "metástasis cutáneas" 3 => "terapia intralesional" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Although metastatic melanoma has a poor prognosis, cutaneous metastases represent a special case given their ready accessibility, making it possible for dermatologists to apply local treatment. We report our experience with intralesional treatment with interleukin (IL) 2 in 7 patients with cutaneous metastases from malignant melanoma.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 244 lesions in 7 patients with satellitosis and/or cutaneous metastases from malignant melanoma were treated with intralesional IL-2 twice a week. The maximum dose in each patient ranged from 3 to 18 million units per session, according to the number and size of lesions.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Complete or partial remission was achieved in almost all lesions (95.9% and 3.7%, respectively). Only 1 lesion (0.4%)—the largest and located subcutaneously—did not respond to intralesional treatment and required alcoholization and subsequent surgical removal to achieve cure. All partial responses occurred in subcutaneous lesions larger than 2 cm. Treatment was well tolerated with only a few mild side effects (grade 1-2).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">IL-2 may be an effective and well-tolerated treatment option in patients with satellitosis and cutaneous metastases from melanoma. Lesions smaller than 2 cm and located in the epidermis or superficial dermis respond better than those larger than 2 cm or located in the subcutaneous cellular tissue. More studies are necessary to establish appropriate doses and regimens.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">A pesar del mal pronóstico del melanoma metastásico, las metástasis cutáneas constituyen un grupo especial por su fácil accesibilidad que lo hace susceptible al abordaje local por parte del dermatólogo. Describimos nuestra experiencia de tratamiento intralesional con interleucina 2 (IL-2) en 7 pacientes con metástasis cutáneas de melanoma maligno.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Un total de 244 lesiones en 7 pacientes con satelitosis y/o metástasis cutáneas de melanoma maligno han sido tratadas con IL-2 intralesional administrada dos veces a la semana. Las dosis máximas por pacientes variaron entre los 3 y 18 millones de unidades/sesión, en función del número y tamaño de las lesiones.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se han obtenido remisiones completas (95,9%) o parciales (3,7%) en la gran mayoría de lesiones tratadas, una sola lesión (0,4%), de localización subcutánea y de mayor tamaño, no respondió al tratamiento intralesional y precisó de alcoholización y posterior extirpación quirúrgica para su resolución. Todas las respuestas parciales se observaron en lesiones de localización subcutánea y mayores de 2 cm. El tratamiento fue bien tolerado, con escasos efectos secundarios de intensidad leve (grado 1-2).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La IL-2 puede ser una buena opción para el tratamiento de pacientes con satelitosis y metástasis cutáneas de melanoma con elevada eficacia y escasos efectos secundarios. Las lesiones menores de 2 cm y localizadas en epidermis o dermis superficial responden mejor que las mayores de 2 cm o localizadas en el tejido celular subcutáneo. Son necesarios más estudios para establecer las dosis y pautas de tratamiento adecuadas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Final Version of the American Joint Committee on Cancer stating system for cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. Balch" 1 => "A.C. Buzaid" 2 => "S.J. Soong" 3 => "M.B. Atkins" 4 => "N. Cascinelli" 5 => "D.G. Coit" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.2001.19.16.3635" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "3635" "paginaFinal" => "3648" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11504745" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An evidence-based staging system for cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. Balch" 1 => "S.J. Soong" 2 => "M.B. Atkins" 3 => "A.C. Buzaid" 4 => "N. Cascinelli" 5 => "D.G. Coit" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CA Cancer J Clin" "fecha" => "2004" "volumen" => "54" "paginaInicial" => "131" "paginaFinal" => "149" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15195788" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase II trial of intralesional therapy with interleukin- 2 in soft-tissue melanoma metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Radny" 1 => "U.M. Caroll" 2 => "J. Bauer" 3 => "T. Paul" 4 => "C. Schlegel" 5 => "T.K. Eigentler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6601320" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "2003" "volumen" => "89" "paginaInicial" => "1620" "paginaFinal" => "1626" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14583759" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Critical analysis of the current American Joint Committee on Cancer staging system for cutaneous melanoma and proposal of a new staging system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.C. Buzaid" 1 => "M.I. Ross" 2 => "C.M. Balch" 3 => "S. Soong" 4 => "W.H. McCarthy" 5 => "L. Tinoco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1997.15.3.1039" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "1039" "paginaFinal" => "1051" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9060544" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Locoregional cutaneous metastasis in patients with therapeutic lymph node dissection for malignant melanoma: risk factors and prognostic impact" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Kretscher" 1 => "K.P. Preufer" 2 => "C. Neumann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "2002" "volumen" => "12" "paginaInicial" => "499" "paginaFinal" => "504" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12394192" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyperthermic isolated limb perfusion with low-dose tumor necrosis factor-alpha and melphalan for bulky in-transit melanoma metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.R. Rossi" 1 => "M. Foletto" 2 => "S. Mocellin" 3 => "P. Pilati" 4 => "M. Lise" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2004" "volumen" => "11" "paginaInicial" => "173" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14761920" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of melanoma intransit metastases confined to the limb" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.M. Eggermont" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Surveys" "fecha" => "1996" "volumen" => "26" "paginaInicial" => "335" "paginaFinal" => "349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8783582" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is there a role for isolated limb perfusion with tumor necrosis factor in patients with melanoma?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.H. De Wilt" 1 => "J.F. Thompson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2004" "volumen" => "11" "paginaInicial" => "119" "paginaFinal" => "121" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14761911" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of repeat isolated limb perfusions with tumor necrosis factor alpha and melphalan for multiple in-transit metastases in patients with prior isolated limb perfusion failure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.J. Grünhagen" 1 => "B. van Etten" 2 => "F. Brunstein" 3 => "W.J. Graveland" 4 => "A.N. van Geel" 5 => "J.H. de Wilt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1245/ASO.2005.03.060" "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2005" "volumen" => "12" "paginaInicial" => "609" "paginaFinal" => "615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15968498" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "One hundred consecutive isolated limb perfusions with TNF-alpha and melphalan in melanoma patients with multiple in-transit metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.J. Grünhagen" 1 => "F. Brusntein" 2 => "W.J. Graveland" 3 => "A.N. van Geel" 4 => "J.H. de Wilt" 5 => "A.M. Eggermont" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "2004" "volumen" => "240" "paginaInicial" => "939" "paginaFinal" => "948" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15570199" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of cutaneous malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.M. Jost" 1 => "S. Jelic" 2 => "G. Purkalne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2005" "volumen" => "16" "numero" => "Suppl 1" "paginaInicial" => "66" "paginaFinal" => "68" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective in vitro growth of T lymphocytes from normal human bone marrows" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.A. Morgan" 1 => "F.W. Ruscett" 2 => "R. Gallo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Science" "fecha" => "1976" "volumen" => "193" "paginaInicial" => "1007" "paginaFinal" => "1008" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/181845" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526010000622" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Structure and expression of a cloned cDNA for human interleukin-2" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Taniguchi" 1 => "H. Matsui" 2 => "T. Fujita" 3 => "C. Takaoka" 4 => "N. Kashima" 5 => "R. Yoshimoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1983" "volumen" => "302" "paginaInicial" => "305" "paginaFinal" => "310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6403867" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.A. Waldmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nri1901" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Immunol" "fecha" => "2006" "volumen" => "6" "paginaInicial" => "595" "paginaFinal" => "601" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16868550" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-2 for the treatment of melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.A. Tarhini" 1 => "S.S. Agarwala" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Investig Drugs" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "1234" "paginaFinal" => "1239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16370388" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inmunología celular y molecular" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.K. Abbas" 1 => "A.H. Lichtman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "2.<span class="elsevierStyleSup">a</span> ed." "fecha" => "2004" "editorial" => "Elsevier España" "editorialLocalizacion" => "Madrid" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of recent findings involving interleukin-2-based cancer therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.W. Eklund" 1 => "T.M. Kuzel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Oncol" "fecha" => "2004" "volumen" => "16" "paginaInicial" => "542" "paginaFinal" => "546" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15627015" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin-2" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.A. Rosemberg" 1 => "J.C. Yang" 2 => "S.L. Topalian" 3 => "D.J. Schwartzentruber" 4 => "J.S. Weber" 5 => "D.R. Parkinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1994" "volumen" => "271" "paginaInicial" => "907" "paginaFinal" => "913" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8120958" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overview of interleukin-2 inhalation therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Huland" 1 => "H. Heinzer" 2 => "H. Huland" 3 => "R. Yung" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer J Sci Am" "fecha" => "2000" "volumen" => "6" "numero" => "Suppl 1" "paginaInicial" => "S104" "paginaFinal" => "S112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10685669" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low-dose recombinant IL-2 induces psychological changes: monitoring by Minnesota Multiphasic Personality Inventory (MMPI)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Pizzi" 1 => "M. Caraglia" 2 => "M. Cianciulli" 3 => "A. Fabbrocini" 4 => "A. Libroia" 5 => "E. Matano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anticancer Res" "fecha" => "2002" "volumen" => "22" "paginaInicial" => "727" "paginaFinal" => "732" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12014643" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Trotti" 1 => "A.D. Colevas" 2 => "A. Setser" 3 => "V. Rusch" 4 => "D. Jaques" 5 => "V. Budach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Semen Radiat Oncol" "fecha" => "2003" "volumen" => "13" "paginaInicial" => "176" "paginaFinal" => "181" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitiligo and cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.U. Schallreuter" 1 => "C. Levenig" 2 => "J. Berger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatologica" "fecha" => "1991" "volumen" => "183" "paginaInicial" => "239" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1809584" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of hypopigmentation in malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.C. Bystryn" 1 => "D. Rigel" 2 => "Rj. Friedman" 3 => "A. Kopf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1987" "volumen" => "123" "paginaInicial" => "1053" "paginaFinal" => "1055" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3631983" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of cutaneous depigmentation in Mexican patients with malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Rodríguez-Cuevas" 1 => "A. López-Chavira" 2 => "G. Zepeda del Río" 3 => "I. Cuadra-García" 4 => "J. Fernández-Díez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Med Res" "fecha" => "1998" "volumen" => "29" "paginaInicial" => "155" "paginaFinal" => "158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9650331" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.A. Rosenberg" 1 => "D.E. White" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunother Emphasis Tumor Immunol" "fecha" => "1996" "volumen" => "19" "paginaInicial" => "81" "paginaFinal" => "84" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8859727" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of autoimmunity during treatment of melanoma with interferon" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Gogas" 1 => "J. Ioannovich" 2 => "U. Dafni" 3 => "C. Stavropoulou-Giokas" 4 => "K. Frangia" 5 => "D. Tsoutsos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa053007" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "354" "paginaInicial" => "709" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16481638" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Direct evidence to support the role of antigen-specific CD8(+) T cells in melanoma-associated vitiligo" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.A. Le Gal" 1 => "M.F. Avril" 2 => "J. Bosq" 3 => "P. Lefebvre" 4 => "J.C. Deschemin" 5 => "M. Andrieu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Invest Dermatol Symp Proc" "fecha" => "2001" "volumen" => "117" "paginaInicial" => "1464" "paginaFinal" => "1470" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhanced survival associated with vitiligo expression during maintenance biotherapy for metastatic melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.D. Boasberg" 1 => "D.S.B. Hoon" 2 => "L.D. Piro" 3 => "M.A. Martin" 4 => "A. Fujimoto" 5 => "T.S. Kristedja" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.jid.5700545" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2006" "volumen" => "126" "paginaInicial" => "2658" "paginaFinal" => "2663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16946711" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Jackaman" 1 => "C.S. Bundell" 2 => "B.F. Kinnear" 3 => "A.M. Smith" 4 => "P. Filion" 5 => "D. van Hagen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Immunol" "fecha" => "2003" "volumen" => "171" "paginaInicial" => "5051" "paginaFinal" => "5063" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with melanoma metastases at cutaneous and subcutaneous sites are highly susceptible to interleukin-2-based therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Chang" 1 => "S.A. Rosenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunother" "fecha" => "2001" "volumen" => "24" "paginaInicial" => "88" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11211152" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High dose inhalation interleukin-2 therapy for lung metastases in patients with malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.H. Enk" 1 => "D. Nashan" 2 => "A. Rubben" 3 => "J. Knop" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer" "fecha" => "2000" "volumen" => "9" "paginaInicial" => "2042" "paginaFinal" => "2046" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alternating chemoimmunotherapy with temozolomide and low-dose interleukin- 2 in patients with metastatic melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.V. Masucci" 1 => "E. Mansson-Brahme" 2 => "B. Ragnarsson-Olding" 3 => "B. Nilsson" 4 => "G. Wagenius" 5 => "J. Hansson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.cmr.0000205019.23612.a1" "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "2006" "volumen" => "16" "paginaInicial" => "357" "paginaFinal" => "363" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16845332" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maintenance biotherapy for metastatic melanoma with interleukin-2 and granulocyte macrophagecolony stimulating factor improves survival for patients responding to induction concurrent biochemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.J. O’Day" 1 => "P.D. Boasberg" 2 => "L. Piro" 3 => "T.S. Kristedja" 4 => "H.J. Wang" 5 => "T.M. Martin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2002" "volumen" => "8" "paginaInicial" => "2775" "paginaFinal" => "2781" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12231516" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFN alpha in patients with metastatic melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.C. De Gast" 1 => "D. Batchelor" 2 => "M.J. Kersten" 3 => "F.A. Vyth-Dreese" 4 => "J. Sein" 5 => "W.F. van de Kasteele" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6600717" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "2003" "volumen" => "88" "paginaInicial" => "175" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12610499" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemotherapy with temozolomide, cisplatin, vinblastine, subcutaneous interleukin-2 and interferon- alpha in patients with metastatic melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. González Cao" 1 => "J. Malvehy" 2 => "R. Martí" 3 => "C. Conill" 4 => "M. Sánchez" 5 => "M. Martin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.cmr.0000195697.58013.b7" "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "2006" "volumen" => "16" "paginaInicial" => "59" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16432457" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase I/II study of topical imiquimod and intralesional interleukin-2 in the treatment of accessible metastases in malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.S. Green" 1 => "A.G. Bodman-Smith" 2 => "A.D. Dalgleish" 3 => "M.D. Fischer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07664.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "337" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17223875" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical imiquimod and intralesional interleukin-2 increase activated lymphocytes and restore the Th1/Th2 balance in patients with metastatic melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.S. Green" 1 => "N. Dalgleish" 2 => "N. Belonwu" 3 => "M.D. Ficher" 4 => "M.D. Bodman-Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08709.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "159" "paginaInicial" => "606" "paginaFinal" => "614" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18616776" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000007/v1_201304241501/S1578219009701258/v1_201304241501/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000007/v1_201304241501/S1578219009701258/v1_201304241501/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701258?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 11 | 20 |
| 2024 Octubre | 71 | 56 | 127 |
| 2024 Septiembre | 77 | 52 | 129 |
| 2024 Agosto | 93 | 79 | 172 |
| 2024 Julio | 81 | 59 | 140 |
| 2024 Junio | 65 | 78 | 143 |
| 2024 Mayo | 46 | 63 | 109 |
| 2024 Abril | 58 | 69 | 127 |
| 2024 Marzo | 74 | 65 | 139 |
| 2024 Febrero | 58 | 55 | 113 |
| 2024 Enero | 59 | 45 | 104 |
| 2023 Diciembre | 74 | 46 | 120 |
| 2023 Noviembre | 58 | 45 | 103 |
| 2023 Octubre | 82 | 60 | 142 |
| 2023 Septiembre | 43 | 38 | 81 |
| 2023 Agosto | 48 | 25 | 73 |
| 2023 Julio | 59 | 87 | 146 |
| 2023 Junio | 61 | 40 | 101 |
| 2023 Mayo | 50 | 59 | 109 |
| 2023 Abril | 34 | 47 | 81 |
| 2023 Marzo | 28 | 56 | 84 |
| 2023 Febrero | 43 | 30 | 73 |
| 2023 Enero | 33 | 38 | 71 |
| 2022 Diciembre | 33 | 35 | 68 |
| 2022 Noviembre | 14 | 37 | 51 |
| 2022 Octubre | 18 | 28 | 46 |
| 2022 Septiembre | 23 | 38 | 61 |
| 2022 Agosto | 12 | 34 | 46 |
| 2022 Julio | 17 | 34 | 51 |
| 2022 Junio | 11 | 21 | 32 |
| 2022 Mayo | 25 | 44 | 69 |
| 2022 Abril | 40 | 53 | 93 |
| 2022 Marzo | 35 | 57 | 92 |
| 2022 Febrero | 22 | 45 | 67 |
| 2022 Enero | 26 | 48 | 74 |
| 2021 Diciembre | 24 | 48 | 72 |
| 2021 Noviembre | 30 | 46 | 76 |
| 2021 Octubre | 38 | 54 | 92 |
| 2021 Septiembre | 27 | 44 | 71 |
| 2021 Agosto | 23 | 35 | 58 |
| 2021 Julio | 15 | 37 | 52 |
| 2021 Junio | 25 | 29 | 54 |
| 2021 Mayo | 21 | 18 | 39 |
| 2021 Abril | 42 | 80 | 122 |
| 2021 Marzo | 39 | 17 | 56 |
| 2021 Febrero | 50 | 25 | 75 |
| 2021 Enero | 30 | 21 | 51 |
| 2020 Diciembre | 41 | 15 | 56 |
| 2020 Noviembre | 28 | 13 | 41 |
| 2020 Octubre | 15 | 11 | 26 |
| 2020 Septiembre | 26 | 16 | 42 |
| 2020 Agosto | 31 | 17 | 48 |
| 2020 Julio | 27 | 13 | 40 |
| 2020 Junio | 20 | 20 | 40 |
| 2020 Mayo | 20 | 18 | 38 |
| 2020 Abril | 25 | 9 | 34 |
| 2020 Marzo | 20 | 21 | 41 |
| 2020 Febrero | 0 | 3 | 3 |
| 2020 Enero | 0 | 8 | 8 |
| 2019 Diciembre | 0 | 9 | 9 |
| 2019 Noviembre | 0 | 2 | 2 |
| 2019 Septiembre | 0 | 5 | 5 |
| 2019 Julio | 0 | 16 | 16 |
| 2019 Junio | 0 | 6 | 6 |
| 2019 Mayo | 0 | 49 | 49 |
| 2019 Abril | 0 | 3 | 3 |
| 2019 Marzo | 0 | 5 | 5 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 15 | 7 | 22 |
| 2018 Enero | 21 | 5 | 26 |
| 2017 Diciembre | 17 | 11 | 28 |
| 2017 Noviembre | 23 | 12 | 35 |
| 2017 Octubre | 16 | 8 | 24 |
| 2017 Septiembre | 19 | 16 | 35 |
| 2017 Agosto | 29 | 15 | 44 |
| 2017 Julio | 31 | 10 | 41 |
| 2017 Junio | 24 | 41 | 65 |
| 2017 Mayo | 21 | 18 | 39 |
| 2017 Abril | 35 | 19 | 54 |
| 2017 Marzo | 46 | 33 | 79 |
| 2017 Febrero | 28 | 22 | 50 |
| 2017 Enero | 29 | 20 | 49 |
| 2016 Diciembre | 41 | 21 | 62 |
| 2016 Noviembre | 14 | 16 | 30 |
| 2016 Octubre | 31 | 22 | 53 |
| 2016 Septiembre | 38 | 21 | 59 |
| 2016 Agosto | 39 | 23 | 62 |
| 2016 Julio | 33 | 19 | 52 |
| 2016 Junio | 13 | 13 | 26 |
| 2016 Mayo | 13 | 19 | 32 |
| 2016 Abril | 7 | 22 | 29 |
| 2016 Marzo | 9 | 25 | 34 |
| 2016 Febrero | 7 | 25 | 32 |
| 2016 Enero | 4 | 26 | 30 |
| 2015 Diciembre | 10 | 21 | 31 |
| 2015 Noviembre | 10 | 1 | 11 |
| 2015 Octubre | 10 | 30 | 40 |
| 2015 Septiembre | 7 | 19 | 26 |
| 2015 Agosto | 14 | 8 | 22 |
| 2015 Julio | 40 | 24 | 64 |
| 2015 Junio | 41 | 39 | 80 |
| 2015 Mayo | 80 | 37 | 117 |
| 2015 Abril | 29 | 29 | 58 |
| 2015 Marzo | 30 | 20 | 50 |
| 2015 Febrero | 24 | 35 | 59 |
| 2015 Enero | 31 | 29 | 60 |
| 2014 Diciembre | 28 | 20 | 48 |
| 2014 Noviembre | 22 | 18 | 40 |
| 2014 Octubre | 27 | 17 | 44 |
| 2014 Septiembre | 33 | 18 | 51 |
| 2014 Agosto | 31 | 26 | 57 |
| 2014 Julio | 43 | 35 | 78 |
| 2014 Junio | 28 | 8 | 36 |
| 2014 Mayo | 45 | 13 | 58 |
| 2014 Abril | 48 | 8 | 56 |
| 2014 Marzo | 49 | 27 | 76 |
| 2014 Febrero | 43 | 26 | 69 |
| 2014 Enero | 37 | 18 | 55 |
| 2013 Diciembre | 36 | 13 | 49 |
| 2013 Noviembre | 30 | 18 | 48 |
| 2013 Octubre | 39 | 30 | 69 |
| 2013 Septiembre | 33 | 29 | 62 |
| 2013 Agosto | 28 | 45 | 73 |
| 2013 Julio | 38 | 91 | 129 |
| 2013 Junio | 27 | 45 | 72 |
| 2013 Mayo | 30 | 42 | 72 |
| 2013 Abril | 29 | 37 | 66 |
| 2013 Marzo | 32 | 28 | 60 |
| 2013 Febrero | 26 | 13 | 39 |
| 2013 Enero | 9 | 3 | 12 |
Mostrar todo
