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Case report
Necrobiotic Xanthogranuloma: Efficacy of Surgery in 2 Patients
Necrobiotic Xanthogranuloma: Efficacy of Surgery in 2 Patients
P. Gactoa,
Autor para correspondencia
purigacto@gmail.com

Correspondence: Servicio de Cirugía Plástica, 5.a Planta, Hospital de Rehabilitación y Traumatología, Hospitales Universitarios Virgen del Rocío, Avd. Manuel Siurot, s/n, 41013 Sevilla, Spain.
, F. Barreraa, J.J. Pereyrab, P. Fernández-Ortegaa
a Servicio de Cirugía Plástica, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain
b Servicio de Dermatología, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Necrobiotic xanthogranuloma is a rare disease characterized by indurated nodules and yellowish-red plaques in the dermis or subdermal tissues particularly in the periorbital region&#59; the lesions are often ulcerated&#46; This disease is frequently associated with hematological disorders such as monoclonal gammopathy and lymphoproliferative disorders&#46; Its pathogenesis is unknown and the small number of cases makes long-term studies difficult&#46; We present 2 cases of periorbital lesions in which the biopsies established a diagnosis of necrobiotic xanthogranuloma&#46; Both patients were treated with corticosteroids and cyclophosphamide&#44; with no improvement&#46; The lesions were excised and the periorbital regions were reconstructed with skin grafts&#46; After 1 year of follow-up there are no signs of recurrence&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El xantogranuloma necrobi&#243;tico es una enfermedad poco frecuente que se caracteriza por la presencia de n&#243;dulos indurados y placas rojo-amarillentas en los tejidos d&#233;rmicos o subd&#233;rmicos&#44; a menudo ulceradas&#44; que asientan preferentemente en la regi&#243;n periorbitaria&#46; Suele asociarse con alteraciones hematol&#243;gicas como gammapat&#237;a monoclonal y trastornos linfoproliferativos&#46; Su patogenia es desconocida y el escaso n&#250;mero de casos existentes hace dif&#237;cil la publicaci&#243;n de estudios a largo plazo&#46; Presentamos dos casos de lesiones periorbitarias cuyas biopsias establecieron el diagn&#243;stico de xantogranuloma necrobi&#243;tico&#46; Los pacientes se sometieron a tratamiento con corticoides y ciclofosfamida sin mejor&#237;a&#46; Las lesiones fueron tratadas quir&#250;rgicamente mediante escisi&#243;n y reconstrucci&#243;n con injertos de piel&#46; Tras un a&#241;o de seguimiento no hay evidencias de recurrencia de la enfermedad&#46;</p>"
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2024 Marzo 48 41 89
2024 Febrero 51 42 93
2024 Enero 41 43 84
2023 Diciembre 51 41 92
2023 Noviembre 65 42 107
2023 Octubre 44 37 81
2023 Septiembre 28 24 52
2023 Agosto 24 24 48
2023 Julio 43 50 93
2023 Junio 43 28 71
2023 Mayo 40 25 65
2023 Abril 24 17 41
2023 Marzo 19 34 53
2023 Febrero 24 25 49
2023 Enero 35 36 71
2022 Diciembre 33 43 76
2022 Noviembre 13 26 39
2022 Octubre 21 18 39
2022 Septiembre 14 44 58
2022 Agosto 12 33 45
2022 Julio 16 32 48
2022 Junio 8 19 27
2022 Mayo 28 43 71
2022 Abril 37 45 82
2022 Marzo 34 74 108
2022 Febrero 20 31 51
2022 Enero 25 49 74
2021 Diciembre 18 44 62
2021 Noviembre 27 43 70
2021 Octubre 27 55 82
2021 Septiembre 33 46 79
2021 Agosto 19 24 43
2021 Julio 23 30 53
2021 Junio 15 21 36
2021 Mayo 16 18 34
2021 Abril 69 58 127
2021 Marzo 51 17 68
2021 Febrero 56 19 75
2021 Enero 24 14 38
2020 Diciembre 29 5 34
2020 Noviembre 24 14 38
2020 Octubre 7 8 15
2020 Septiembre 21 18 39
2020 Agosto 29 15 44
2020 Julio 12 7 19
2020 Junio 28 26 54
2020 Mayo 13 18 31
2020 Abril 20 16 36
2020 Marzo 20 16 36
2020 Febrero 1 7 8
2020 Enero 0 13 13
2019 Diciembre 0 12 12
2019 Noviembre 0 3 3
2019 Octubre 0 1 1
2019 Septiembre 0 5 5
2019 Agosto 0 3 3
2019 Julio 0 10 10
2019 Junio 0 6 6
2019 Mayo 2 46 48
2019 Abril 0 36 36
2019 Marzo 0 11 11
2019 Febrero 0 8 8
2018 Diciembre 0 2 2
2018 Octubre 0 4 4
2018 Agosto 0 6 6
2018 Julio 0 7 7
2018 Junio 0 1 1
2018 Abril 0 1 1
2018 Marzo 0 5 5
2018 Febrero 6 2 8
2018 Enero 12 6 18
2017 Diciembre 13 11 24
2017 Noviembre 15 5 20
2017 Octubre 10 9 19
2017 Septiembre 12 7 19
2017 Agosto 14 18 32
2017 Julio 9 4 13
2017 Junio 25 16 41
2017 Mayo 14 14 28
2017 Abril 26 10 36
2017 Marzo 26 9 35
2017 Febrero 12 14 26
2017 Enero 15 16 31
2016 Diciembre 16 14 30
2016 Noviembre 12 9 21
2016 Octubre 24 11 35
2016 Septiembre 21 6 27
2016 Agosto 24 9 33
2016 Julio 22 6 28
2016 Junio 14 4 18
2016 Mayo 11 0 11
2016 Abril 9 4 13
2016 Marzo 6 0 6
2016 Febrero 8 2 10
2016 Enero 5 1 6
2015 Diciembre 10 0 10
2015 Noviembre 11 8 19
2015 Octubre 10 6 16
2015 Septiembre 5 5 10
2015 Agosto 14 5 19
2015 Julio 34 8 42
2015 Junio 25 9 34
2015 Mayo 76 14 90
2015 Abril 47 11 58
2015 Marzo 31 7 38
2015 Febrero 21 14 35
2015 Enero 21 18 39
2014 Diciembre 18 6 24
2014 Noviembre 17 4 21
2014 Octubre 32 12 44
2014 Septiembre 30 10 40
2014 Agosto 36 11 47
2014 Julio 45 16 61
2014 Junio 35 14 49
2014 Mayo 55 14 69
2014 Abril 48 13 61
2014 Marzo 49 21 70
2014 Febrero 27 16 43
2014 Enero 32 16 48
2013 Diciembre 46 18 64
2013 Noviembre 33 20 53
2013 Octubre 25 17 42
2013 Septiembre 23 15 38
2013 Agosto 20 18 38
2013 Julio 42 39 81
2013 Junio 20 34 54
2013 Mayo 25 22 47
2013 Abril 33 29 62
2013 Marzo 31 23 54
2013 Febrero 20 9 29
2013 Enero 10 3 13
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