Correspondence: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo, 46, 28007 Madrid, Spain.
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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:476-85" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2285 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 1606 "PDF" => 646 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Clinical-Pathological Features of Cutaneous Melanomas Diagnosed in a Mediterranean Tertiary Hospital Between 1990 and 2004: A Comparison Between Sexes and Age Groups and Analysis of Long-Term Outcomes" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "476" "paginaFinal" => "485" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características Clínico-Patológicas de los Melanomas Cutáneos Diagnosticados en un Hospital Terciario Mediterráneo Entre 1990 y 2004: Comparación Entre Sexos, por Grupos de Edad y Evolución a lo Largo del Tiempo" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D.M. Arranz-Sánchez, Á. Pizarro, J.L. Valencia-Delfa, M. Villeta-López, M.J. González-Beato, M. Mayor-Arenal, M. Casado-Jiménez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "D.M." "apellidos" => "Arranz-Sánchez" ] 1 => array:2 [ "nombre" => "Á." "apellidos" => "Pizarro" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Valencia-Delfa" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Villeta-López" ] 4 => array:2 [ "nombre" => "M.J." "apellidos" => "González-Beato" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Mayor-Arenal" ] 6 => array:2 [ "nombre" => "M." "apellidos" => "Casado-Jiménez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701040?idApp=UINPBA000044" "url" => "/15782190/0000010000000006/v1_201304241459/S1578219009701040/v1_201304241459/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Sentinel Node Biopsy as a Prognostic Factor in Cutaneous Melanoma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "486" "paginaFinal" => "492" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.A. Avilés-Izquierdo, P. Lázaro-Ochaita" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J.A." "apellidos" => "Avilés-Izquierdo" "email" => array:1 [ 0 => "dermaviles@yahoo.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Lázaro-Ochaita" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo, 46, 28007 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Biopsia del Ganglio Centinela como Factor Pronóstico en el Melanoma Cutáneo" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-11-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84521" "palabras" => array:4 [ 0 => "melanoma" 1 => "sentinel node biopsy" 2 => "epidemiology" 3 => "survival" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84522" "palabras" => array:4 [ 0 => "melanoma" 1 => "ganglio centinela" 2 => "epidemiología" 3 => "supervivencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of sentinel node biopsy (SNB) is to identify subclinical lymph node metastases using a procedure with minimal morbidity, establish more accurate staging in patients with melanoma, determine prognosis, and choose the most suitable treatment in each patient.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze the outcomes of SNB in patients with cutaneous melanoma, and the impact of this procedure on survival.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Information was gathered retrospectively on all patients in whom this procedure was performed at Hospital General Universitario Gregorio Marañón, Madrid, Spain, over an 11-year period (1997-2007). Descriptive epidemiological analysis of the variables and survival analysis were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Sentinel node invasion by melanoma was present in 42 of 238 patients (17.6%). Tumor thickness and nodular melanomas were associated with the presence of lymph node micrometastases. There were no differences in overall survival, but disease-free survival was significantly lower in patients with a positive SNB, who also had a higher melanoma-related mortality.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Detection of lymph node micrometastases by sentinel node biopsy is a marker of tumor aggressiveness and an important prognostic factor in melanoma patients. Information from SNB permits better staging and determines the diagnostic and therapeutic approach in these patients.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La biopsia del ganglio centinela (BGC) persigue la identificación de metástasis ganglionares subclínicas con una morbilidad mínima, una estadificación más precisa de los pacientes con melanoma, estimar el pronóstico de estos pacientes y adoptar el tratamiento más adecuado en cada caso.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Analizar los resultados obtenidos con esta técnica en pacientes con melanoma cutáneo y el impacto de la misma en su supervivencia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se obtuvieron de forma retrospectiva los datos referentes a todos los pacientes a los que se les realizó esta técnica en el Hospital General Universitario Gregorio Marañón de Madrid durante 11 años (1997-2007). Se realizó un estudio epidemiológico descriptivo y un estudio analítico del impacto en la supervivencia.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En 42 de 238 casos (17,6%) se encontró afectación del ganglio centinela por melanoma. El espesor tumoral y el tipo histológico nodular se asociaron a la presencia de micrometástasis ganglionares. Aunque el resultado del ganglio centinela no se asoció con una mayor supervivencia global, el tiempo libre de enfermedad fue significativamente inferior en los pacientes con ganglio centinela positivo, que además presentaron una mayor tasa de mortalidad por melanoma.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La detección de micrometástasis ganglionares gracias a la BGC supone un marcador de agresividad y un importante factor pronóstico en los pacientes con melanoma. La información que nos aporta esta técnica nos permite una mejor estadificación, determinando la actitud diagnóstica y terapéutica a seguir en estos pacientes.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Gershenwald" 1 => "W. Thompson" 2 => "P.F. Mansfield" 3 => "J.E. Lee" 4 => "M.I. Colome" 5 => "C.H. 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año/Mes | Html | Total | |
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2024 Noviembre | 6 | 9 | 15 |
2024 Octubre | 56 | 42 | 98 |
2024 Septiembre | 48 | 34 | 82 |
2024 Agosto | 69 | 54 | 123 |
2024 Julio | 52 | 44 | 96 |
2024 Junio | 55 | 40 | 95 |
2024 Mayo | 46 | 42 | 88 |
2024 Abril | 46 | 30 | 76 |
2024 Marzo | 46 | 48 | 94 |
2024 Febrero | 50 | 41 | 91 |
2024 Enero | 41 | 43 | 84 |
2023 Diciembre | 46 | 29 | 75 |
2023 Noviembre | 47 | 40 | 87 |
2023 Octubre | 31 | 32 | 63 |
2023 Septiembre | 37 | 23 | 60 |
2023 Agosto | 25 | 22 | 47 |
2023 Julio | 42 | 56 | 98 |
2023 Junio | 41 | 25 | 66 |
2023 Mayo | 35 | 22 | 57 |
2023 Abril | 14 | 8 | 22 |
2023 Marzo | 22 | 26 | 48 |
2023 Febrero | 19 | 30 | 49 |
2023 Enero | 26 | 40 | 66 |
2022 Diciembre | 28 | 46 | 74 |
2022 Noviembre | 15 | 31 | 46 |
2022 Octubre | 13 | 35 | 48 |
2022 Septiembre | 11 | 46 | 57 |
2022 Agosto | 14 | 32 | 46 |
2022 Julio | 16 | 32 | 48 |
2022 Junio | 12 | 24 | 36 |
2022 Mayo | 21 | 29 | 50 |
2022 Abril | 29 | 48 | 77 |
2022 Marzo | 30 | 65 | 95 |
2022 Febrero | 17 | 29 | 46 |
2022 Enero | 19 | 39 | 58 |
2021 Diciembre | 13 | 40 | 53 |
2021 Noviembre | 30 | 40 | 70 |
2021 Octubre | 22 | 55 | 77 |
2021 Septiembre | 14 | 32 | 46 |
2021 Agosto | 8 | 24 | 32 |
2021 Julio | 14 | 29 | 43 |
2021 Junio | 12 | 31 | 43 |
2021 Mayo | 12 | 13 | 25 |
2021 Abril | 19 | 39 | 58 |
2021 Marzo | 53 | 16 | 69 |
2021 Febrero | 25 | 26 | 51 |
2021 Enero | 21 | 16 | 37 |
2020 Diciembre | 32 | 12 | 44 |
2020 Noviembre | 24 | 11 | 35 |
2020 Octubre | 13 | 14 | 27 |
2020 Septiembre | 34 | 8 | 42 |
2020 Agosto | 13 | 13 | 26 |
2020 Julio | 21 | 15 | 36 |
2020 Junio | 17 | 14 | 31 |
2020 Mayo | 11 | 19 | 30 |
2020 Abril | 39 | 13 | 52 |
2020 Marzo | 13 | 11 | 24 |
2020 Febrero | 0 | 6 | 6 |
2020 Enero | 0 | 6 | 6 |
2019 Diciembre | 0 | 7 | 7 |
2019 Septiembre | 0 | 1 | 1 |
2019 Junio | 0 | 2 | 2 |
2019 Mayo | 1 | 44 | 45 |
2019 Marzo | 0 | 7 | 7 |
2019 Febrero | 0 | 5 | 5 |
2018 Noviembre | 0 | 1 | 1 |
2018 Octubre | 0 | 1 | 1 |
2018 Junio | 0 | 1 | 1 |
2018 Febrero | 9 | 3 | 12 |
2018 Enero | 16 | 3 | 19 |
2017 Diciembre | 17 | 5 | 22 |
2017 Noviembre | 14 | 2 | 16 |
2017 Octubre | 12 | 4 | 16 |
2017 Septiembre | 19 | 3 | 22 |
2017 Agosto | 23 | 7 | 30 |
2017 Julio | 23 | 3 | 26 |
2017 Junio | 31 | 6 | 37 |
2017 Mayo | 27 | 4 | 31 |
2017 Abril | 23 | 7 | 30 |
2017 Marzo | 24 | 5 | 29 |
2017 Febrero | 11 | 5 | 16 |
2017 Enero | 9 | 9 | 18 |
2016 Diciembre | 21 | 9 | 30 |
2016 Noviembre | 27 | 6 | 33 |
2016 Octubre | 25 | 15 | 40 |
2016 Septiembre | 28 | 5 | 33 |
2016 Agosto | 24 | 4 | 28 |
2016 Julio | 18 | 4 | 22 |
2016 Junio | 13 | 5 | 18 |
2016 Mayo | 6 | 6 | 12 |
2016 Abril | 9 | 23 | 32 |
2016 Marzo | 5 | 2 | 7 |
2016 Febrero | 6 | 2 | 8 |
2016 Enero | 7 | 1 | 8 |
2015 Diciembre | 9 | 0 | 9 |
2015 Noviembre | 10 | 1 | 11 |
2015 Octubre | 7 | 3 | 10 |
2015 Septiembre | 3 | 3 | 6 |
2015 Agosto | 12 | 4 | 16 |
2015 Julio | 43 | 5 | 48 |
2015 Junio | 42 | 6 | 48 |
2015 Mayo | 60 | 20 | 80 |
2015 Abril | 33 | 7 | 40 |
2015 Marzo | 22 | 10 | 32 |
2015 Febrero | 29 | 11 | 40 |
2015 Enero | 31 | 16 | 47 |
2014 Diciembre | 16 | 4 | 20 |
2014 Noviembre | 16 | 11 | 27 |
2014 Octubre | 34 | 10 | 44 |
2014 Septiembre | 32 | 11 | 43 |
2014 Agosto | 34 | 22 | 56 |
2014 Julio | 49 | 17 | 66 |
2014 Junio | 41 | 10 | 51 |
2014 Mayo | 31 | 17 | 48 |
2014 Abril | 37 | 11 | 48 |
2014 Marzo | 39 | 19 | 58 |
2014 Febrero | 23 | 14 | 37 |
2014 Enero | 28 | 12 | 40 |
2013 Diciembre | 26 | 7 | 33 |
2013 Noviembre | 32 | 16 | 48 |
2013 Octubre | 25 | 10 | 35 |
2013 Septiembre | 44 | 16 | 60 |
2013 Agosto | 30 | 37 | 67 |
2013 Julio | 62 | 29 | 91 |
2013 Junio | 28 | 38 | 66 |
2013 Mayo | 27 | 18 | 45 |
2013 Abril | 43 | 33 | 76 |
2013 Marzo | 40 | 26 | 66 |
2013 Febrero | 29 | 11 | 40 |
2013 Enero | 7 | 3 | 10 |