Original articles
Clinical-Pathological Features of Cutaneous Melanomas Diagnosed in a Mediterranean Tertiary Hospital Between 1990 and 2004: A Comparison Between Sexes and Age Groups and Analysis of Long-Term Outcomes
Características Clínico-Patológicas de los Melanomas Cutáneos Diagnosticados en un Hospital Terciario Mediterráneo Entre 1990 y 2004: Comparación Entre Sexos, por Grupos de Edad y Evolución a lo Largo del Tiempo
D.M. Arranz-Sáncheza,
, Á. Pizarrob, J.L. Valencia-Delfac, M. Villeta-Lópezc, M.J. González-Beatod, M. Mayor-Arenalb, M. Casado-Jiménezb
Autor para correspondencia
dulcem.arranz@salud.madrid.org
Correspondence: Unidad de Dermatología, Hospital Infanta Sofía, Paseo de Europa, 34, 28702 San Sebastián de los Reyes, Madrid, Spain.
Correspondence: Unidad de Dermatología, Hospital Infanta Sofía, Paseo de Europa, 34, 28702 San Sebastián de los Reyes, Madrid, Spain.
a Unidad de Dermatología, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain
c Escuela Universitaria de Estadística, Universidad Complutense de Madrid, Spain
d Departamento de Anatomía Patológica, Hospital Universitario La Paz, Madrid, Spain
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Early diagnosis continues to be essential for effective treatment. Our objective was to analyze cutaneous malignant melanomas diagnosed over a 15-year period in a tertiary hospital for trends towards earlier diagnosis and to identify subgroups with poorer prognosis.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis of primary cutaneous melanomas analyzed in the pathology department of Hospital La Paz, Madrid, Spain, between 1990 and 2004.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In total, 526 melanomas were diagnosed. The mean (SD) Breslow thickness was 2.63 (4.84) mm and the median thickness was 0.98 mm (range, 0-65 mm). The mean size (widest point) was 16.59 (12.11) mm. The most common histological type was surface-spreading melanoma and the most common site was the trunk. Melanomas detected in men were generally larger and thicker than in women (<span class="elsevierStyleItalic">P</span>=.05). Individuals aged over 60 years consulted for significantly thicker and larger tumors than younger individuals. The incidence of malignant melanomas has increased steadily over the years whereas the mean Breslow thickness and size have decreased.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Diagnosis of melanoma in Spain is made increasingly earlier, although locally advanced tumors are still sometimes seen in men and in individuals aged over 60 years.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">En las últimas décadas está aumentando la incidencia de melanoma maligno (MM) y el diagnóstico precoz sigue siendo esencial para conseguir su curación. Nuestro objetivo fue analizar los MM cutáneos diagnosticados durante 15 años en un hospital terciario para comprobar si existe una tendencia favorable hacia un diagnóstico cada vez más precoz e intentar identificar grupos de población con MM de peor pronóstico.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Análisis retrospectivo de los melanomas cutáneos primarios analizados en el Departamento de Anatomía Patológica del Hospital La Paz entre 1990 y 2004.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron en total 526 melanomas. El espesor medio de Breslow fue de 2,63 mm (desviación estándar [DE] 4,84) y la mediana de 0,98 mm (0-65 mm); el tamaño medio (diámetro mayor) fue de 16,59 mm (DE 12,11); el tipo histológico más frecuente fue el melanoma de extensión superficial y la localización más habitual el tronco. Los melanomas detectados en varones tendieron a ser más grandes y de mayor espesor (p =0,05) que los de las mujeres. Los mayores de 60 años consultaron con tumores significativamente más gruesos y de mayor diámetro que los pacientes más jóvenes. A lo largo de estos años, ha aumentado progresivamente el número de MM, pero han disminuido el Breslow medio y el tamaño.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El diagnóstico del melanoma en nuestro medio es cada vez más precoz, pero los varones y los mayores de 60 años en ocasiones aún consultan con tumores localmente avanzados.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 7 | 16 |
| 2024 Octubre | 63 | 33 | 96 |
| 2024 Septiembre | 50 | 14 | 64 |
| 2024 Agosto | 77 | 48 | 125 |
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| 2024 Marzo | 49 | 29 | 78 |
| 2024 Febrero | 61 | 38 | 99 |
| 2024 Enero | 51 | 39 | 90 |
| 2023 Diciembre | 36 | 36 | 72 |
| 2023 Noviembre | 56 | 45 | 101 |
| 2023 Octubre | 38 | 26 | 64 |
| 2023 Septiembre | 40 | 23 | 63 |
| 2023 Agosto | 27 | 24 | 51 |
| 2023 Julio | 45 | 60 | 105 |
| 2023 Junio | 47 | 26 | 73 |
| 2023 Mayo | 42 | 19 | 61 |
| 2023 Abril | 24 | 21 | 45 |
| 2023 Marzo | 30 | 28 | 58 |
| 2023 Febrero | 21 | 19 | 40 |
| 2023 Enero | 33 | 27 | 60 |
| 2022 Diciembre | 40 | 47 | 87 |
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| 2022 Octubre | 23 | 28 | 51 |
| 2022 Septiembre | 21 | 53 | 74 |
| 2022 Agosto | 23 | 35 | 58 |
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| 2022 Mayo | 21 | 47 | 68 |
| 2022 Abril | 29 | 38 | 67 |
| 2022 Marzo | 39 | 58 | 97 |
| 2022 Febrero | 22 | 27 | 49 |
| 2022 Enero | 29 | 46 | 75 |
| 2021 Diciembre | 30 | 42 | 72 |
| 2021 Noviembre | 19 | 52 | 71 |
| 2021 Octubre | 29 | 45 | 74 |
| 2021 Septiembre | 19 | 38 | 57 |
| 2021 Agosto | 14 | 20 | 34 |
| 2021 Julio | 18 | 27 | 45 |
| 2021 Junio | 12 | 22 | 34 |
| 2021 Mayo | 14 | 21 | 35 |
| 2021 Abril | 26 | 27 | 53 |
| 2021 Marzo | 37 | 9 | 46 |
| 2021 Febrero | 31 | 22 | 53 |
| 2021 Enero | 20 | 9 | 29 |
| 2020 Diciembre | 26 | 10 | 36 |
| 2020 Noviembre | 20 | 22 | 42 |
| 2020 Octubre | 7 | 8 | 15 |
| 2020 Septiembre | 20 | 14 | 34 |
| 2020 Agosto | 20 | 15 | 35 |
| 2020 Julio | 20 | 5 | 25 |
| 2020 Junio | 16 | 21 | 37 |
| 2020 Mayo | 24 | 12 | 36 |
| 2020 Abril | 16 | 14 | 30 |
| 2020 Marzo | 18 | 13 | 31 |
| 2020 Febrero | 1 | 7 | 8 |
| 2019 Diciembre | 0 | 7 | 7 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Junio | 0 | 1 | 1 |
| 2019 Mayo | 0 | 35 | 35 |
| 2019 Abril | 0 | 1 | 1 |
| 2019 Marzo | 0 | 2 | 2 |
| 2019 Febrero | 0 | 5 | 5 |
| 2018 Diciembre | 0 | 2 | 2 |
| 2018 Octubre | 0 | 2 | 2 |
| 2018 Febrero | 29 | 2 | 31 |
| 2018 Enero | 27 | 4 | 31 |
| 2017 Diciembre | 33 | 7 | 40 |
| 2017 Noviembre | 16 | 2 | 18 |
| 2017 Octubre | 13 | 5 | 18 |
| 2017 Septiembre | 19 | 1 | 20 |
| 2017 Agosto | 26 | 6 | 32 |
| 2017 Julio | 23 | 3 | 26 |
| 2017 Junio | 30 | 13 | 43 |
| 2017 Mayo | 26 | 6 | 32 |
| 2017 Abril | 22 | 7 | 29 |
| 2017 Marzo | 26 | 8 | 34 |
| 2017 Febrero | 26 | 6 | 32 |
| 2017 Enero | 11 | 5 | 16 |
| 2016 Diciembre | 42 | 8 | 50 |
| 2016 Noviembre | 30 | 12 | 42 |
| 2016 Octubre | 24 | 18 | 42 |
| 2016 Septiembre | 33 | 1 | 34 |
| 2016 Agosto | 28 | 2 | 30 |
| 2016 Julio | 29 | 0 | 29 |
| 2016 Junio | 13 | 6 | 19 |
| 2016 Mayo | 10 | 1 | 11 |
| 2016 Abril | 11 | 6 | 17 |
| 2016 Marzo | 7 | 7 | 14 |
| 2016 Febrero | 8 | 8 | 16 |
| 2016 Enero | 7 | 10 | 17 |
| 2015 Diciembre | 6 | 5 | 11 |
| 2015 Noviembre | 12 | 9 | 21 |
| 2015 Octubre | 6 | 3 | 9 |
| 2015 Septiembre | 7 | 2 | 9 |
| 2015 Agosto | 17 | 6 | 23 |
| 2015 Julio | 38 | 3 | 41 |
| 2015 Junio | 32 | 12 | 44 |
| 2015 Mayo | 83 | 15 | 98 |
| 2015 Abril | 30 | 13 | 43 |
| 2015 Marzo | 21 | 17 | 38 |
| 2015 Febrero | 54 | 15 | 69 |
| 2015 Enero | 27 | 26 | 53 |
| 2014 Diciembre | 32 | 5 | 37 |
| 2014 Noviembre | 13 | 6 | 19 |
| 2014 Octubre | 27 | 8 | 35 |
| 2014 Septiembre | 21 | 8 | 29 |
| 2014 Agosto | 29 | 17 | 46 |
| 2014 Julio | 37 | 16 | 53 |
| 2014 Junio | 34 | 10 | 44 |
| 2014 Mayo | 31 | 9 | 40 |
| 2014 Abril | 39 | 15 | 54 |
| 2014 Marzo | 37 | 15 | 52 |
| 2014 Febrero | 47 | 6 | 53 |
| 2014 Enero | 32 | 11 | 43 |
| 2013 Diciembre | 33 | 12 | 45 |
| 2013 Noviembre | 28 | 12 | 40 |
| 2013 Octubre | 29 | 15 | 44 |
| 2013 Septiembre | 35 | 15 | 50 |
| 2013 Agosto | 24 | 14 | 38 |
| 2013 Julio | 45 | 40 | 85 |
| 2013 Junio | 25 | 13 | 38 |
| 2013 Mayo | 21 | 13 | 34 |
| 2013 Abril | 19 | 15 | 34 |
| 2013 Marzo | 31 | 17 | 48 |
| 2013 Febrero | 28 | 8 | 36 |
| 2013 Enero | 7 | 3 | 10 |
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