Multiple Primary Melanoma | Actas Dermo-Sifiliográficas

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Gómez-Mateo, S.P. Ávalos-Peralta, J.J. Ríos-Martín, A.M. Carrizosa-Esquivel, R. González-Cámpora, F. Camacho-Martínez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Gómez-Mateo" ] 1 => array:2 [ "nombre" => "S.P." "apellidos" => "Ávalos-Peralta" ] 2 => array:2 [ "nombre" => "J.J." "apellidos" => "Ríos-Martín" ] 3 => array:2 [ "nombre" => "A.M." "apellidos" => "Carrizosa-Esquivel" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "González-Cámpora" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Camacho-Martínez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700885?idApp=UINPBA000044" "url" => "/15782190/0000010000000005/v1_201304241456/S1578219009700885/v1_201304241456/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009700861" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70086-1" "estado" => "S300" "fechaPublicacion" => "2009-06-01" "aid" => "70086" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:386-413" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2988 "formatos" => array:3 [ "EPUB" => 32 "HTML" => 1986 "PDF" => 970 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Consensus statement" "titulo" => "Spanish Evidence-Based Guidelines on the Treatment of Moderate to Severe Psoriasis with Biologic Agents" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "386" "paginaFinal" => "413" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Directrices Españolas Basadas en la Evidencia Para el Tratamiento de la Psorias is Moderada a Grave Cona Gentes Biológicos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Puig, J.M. Carrascosa, E. Daudén, J.L. Sánchez-Carazo, C. Ferrándiz, M. Sánchez-Regaña, M. García-Bustinduy, X. Bordas, J.C. Moreno, J.M. Hernanz, S. Laguarda, V. García-Patos" "autores" => array:13 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Puig" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Carrascosa" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Daudén" ] 3 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez-Carazo" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Ferrándiz" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Sánchez-Regaña" ] 6 => array:2 [ "nombre" => "M." "apellidos" => "García-Bustinduy" ] 7 => array:2 [ "nombre" => "X." "apellidos" => "Bordas" ] 8 => array:2 [ "nombre" => "J.C." "apellidos" => "Moreno" ] 9 => array:2 [ "nombre" => "J.M." "apellidos" => "Hernanz" ] 10 => array:2 [ "nombre" => "S." "apellidos" => "Laguarda" ] 11 => array:2 [ "nombre" => "V." "apellidos" => "García-Patos" ] 12 => array:1 [ "colaborador" => "for the Spanish Psoriasis Group of the Spanish Academy of Dermatology and Venereology" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700861?idApp=UINPBA000044" "url" => "/15782190/0000010000000005/v1_201304241456/S1578219009700861/v1_201304241456/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "Original articles" "titulo" => "Multiple Primary Melanoma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "414" "paginaFinal" => "419" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.R. Ferreres, A. Moreno, J. Marcoval" "autores" => array:3 [ 0 => array:4 [ "nombre" => "J.R." "apellidos" => "Ferreres" "email" => array:1 [ 0 => "joseramonferreresriera@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Moreno" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "1" "identificador" => "fn1" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Marcoval" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital de Bellvitge, C/ Feixa Llarga, s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanoma Primario Múltiple" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-09-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84492" "palabras" => array:4 [ 0 => "multiple" 1 => "melanoma" 2 => "Mediterranean" 3 => "Spain" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84491" "palabras" => array:4 [ 0 => "múltiple" 1 => "melanoma" 2 => "mediterránea" 3 => "España" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "IntroductionThe risk of multiple melanoma is estimated to be between 1% and 8%, with the majority of studies being carried out on North American populations. Our objective was to determine the risk and the clinical-pathological features of multiple primary melanoma in a Spanish Mediterranean population. Material and methodsWe performed a retrospective study of the medical records and the database of the Melanoma Unit of Hospital de Bellvitge, Barcelona, Spain, between 1988 and 2005. ResultsWe found 25 cases of multiple primary melanoma among 934 patients studied, representing a risk of 2.6% in our population of melanoma patients. In 50% of cases, the second melanoma appeared during the first year of follow-up. These subsequent lesions occurred at a different site from the initial lesion in 58% of cases. In the majority of cases, lesions in a single patient showed similar cytological and architectural features. However, we did observe marked interindividual variability in the histology of multiple primary melanomas. ConclusionAlthough the risk of a second melanoma in our population appears to be lower than in North American populations, it is not negligible. Melanoma patients must therefore be followed up for life, not only for the risk of metastases but also for the risk of a new primary tumor. Complete examination of the skin must be performed at each visit." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "IntroducciónEl riesgo de melanoma múltiple se cifra aproximadamente entre un 1 y un 8%. La mayoría de los estudios se basan en población anglosajona. Nuestro objetivo es determinar el riesgo y las características clínicas e histológicas de los melanomas múltiples en una población mediterránea. Material y métodosHemos realizado un estudio retrospectivo a partir de las historias clínicas y la base de datos de la Unidad de Melanoma del Hospital de Bellvitge (Barcelona) de los pacientes con melanoma diagnosticados entre 1988 y 2005. ResultadosHemos encontrado 25 pacientes con melanoma primario múltiple de entre los 934 pacientes estudiados, siendo el riesgo del 2,6% para nuestra población de pacientes con melanoma. El 50% de segundos melanomas aparecieron dentro del primer año de seguimiento. En el 58% de los casos el siguiente melanoma apareció en un área distinta al anterior. En la mayoría de los casos las características histológicas se mantuvieron, por lo que se refiere a la citología y el tipo de distribución arquitectural en los distintos melanomas de un mismo paciente. No observamos similitud histológica y sí una gran variabilidad interindividual de los melanomas primarios múltiples de distintos pacientes. ConclusiónAunque en la población mediterránea el riesgo de padecer un segundo melanoma parece ser menor que en los anglosajones, éste no es despreciable. Por dicho motivo, los pacientes con melanoma deben ser seguidos de por vida no sólo por el riesgo de metástasis, sino por el de aparición de otros nuevos primarios, debiéndose de explorar todo el tegumento cutáneo en cada visita." ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "Although Dr Abelardo Moreno passed away during the preparation of this manuscript, he was involved in the histologic evaluation of the multiple melanomas analyzed and in the drafting of the manuscript until the very last moment." "identificador" => "fn1" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Original articles

Multiple Primary Melanoma

Melanoma Primario Múltiple

J.R. Ferreresa,

Autor para correspondencia

joseramonferreresriera@yahoo.es

Correspondence: Servicio de Dermatología, Hospital de Bellvitge, C/ Feixa Llarga, s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain.

, A. Morenob,1, J. Marcovala

a Servicio de Dermatología, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain

b Servicio de Anatomía Patológica, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain

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            0 => "multiple"
            1 => "melanoma"
            2 => "Mediterranean"
            3 => "Spain"
          ]
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          "titulo" => "Palabras clave"
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            0 => "m&#250;ltiple"
            1 => "melanoma"
            2 => "mediterr&#225;nea"
            3 => "Espa&#241;a"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">The risk of multiple melanoma is estimated to be between 1&#37; and 8&#37;&#44; with the majority of studies being carried out on North American populations&#46; Our objective was to determine the risk and the clinical-pathological features of multiple primary melanoma in a Spanish Mediterranean population&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective study of the medical records and the database of the Melanoma Unit of Hospital de Bellvitge&#44; Barcelona&#44; Spain&#44; between 1988 and 2005&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We found 25 cases of multiple primary melanoma among 934 patients studied&#44; representing a risk of 2&#46;6&#37; in our population of melanoma patients&#46; In 50&#37; of cases&#44; the second melanoma appeared during the first year of follow-up&#46; These subsequent lesions occurred at a different site from the initial lesion in 58&#37; of cases&#46; In the majority of cases&#44; lesions in a single patient showed similar cytological and architectural features&#46; However&#44; we did observe marked interindividual variability in the histology of multiple primary melanomas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Although the risk of a second melanoma in our population appears to be lower than in North American populations&#44; it is not negligible&#46; Melanoma patients must therefore be followed up for life&#44; not only for the risk of metastases but also for the risk of a new primary tumor&#46; Complete examination of the skin must be performed at each visit&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El riesgo de melanoma m&#250;ltiple se cifra aproximadamente entre un 1 y un 8&#37;&#46; La mayor&#237;a de los estudios se basan en poblaci&#243;n anglosajona&#46; Nuestro objetivo es determinar el riesgo y las caracter&#237;sticas cl&#237;nicas e histol&#243;gicas de los melanomas m&#250;ltiples en una poblaci&#243;n mediterr&#225;nea&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado un estudio retrospectivo a partir de las historias cl&#237;nicas y la base de datos de la Unidad de Melanoma del Hospital de Bellvitge &#40;Barcelona&#41; de los pacientes con melanoma diagnosticados entre 1988 y 2005&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos encontrado 25 pacientes con melanoma primario m&#250;ltiple de entre los 934 pacientes estudiados&#44; siendo el riesgo del 2&#44;6&#37; para nuestra poblaci&#243;n de pacientes con melanoma&#46; El 50&#37; de segundos melanomas aparecieron dentro del primer a&#241;o de seguimiento&#46; En el 58&#37; de los casos el siguiente melanoma apareci&#243; en un &#225;rea distinta al anterior&#46; En la mayor&#237;a de los casos las caracter&#237;sticas histol&#243;gicas se mantuvieron&#44; por lo que se refiere a la citolog&#237;a y el tipo de distribuci&#243;n arquitectural en los distintos melanomas de un mismo paciente&#46; No observamos similitud histol&#243;gica y s&#237; una gran variabilidad interindividual de los melanomas primarios m&#250;ltiples de distintos pacientes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque en la poblaci&#243;n mediterr&#225;nea el riesgo de padecer un segundo melanoma parece ser menor que en los anglosajones&#44; &#233;ste no es despreciable&#46; Por dicho motivo&#44; los pacientes con melanoma deben ser seguidos de por vida no s&#243;lo por el riesgo de met&#225;stasis&#44; sino por el de aparici&#243;n de otros nuevos primarios&#44; debi&#233;ndose de explorar todo el tegumento cut&#225;neo en cada visita&#46;</p>"
      ]
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      0 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara">Although Dr Abelardo Moreno passed away during the preparation of this manuscript&#44; he was involved in the histologic evaluation of the multiple melanomas analyzed and in the drafting of the manuscript until the very last moment&#46;</p>"
        "identificador" => "fn1"
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    ]
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      "titulo" => "References"
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        0 => array:1 [
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib1"
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            1 => array:3 [
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            2 => array:3 [
              "identificador" => "bib3"
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                            0 => "B&#46; P&#233;rez-Su&#225;rez"
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                          "etal" => true
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                            0 => "Y&#46; Gilaberte Calzada"
                            1 => "M&#46;P&#46; Teruel Melero"
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              "etiqueta" => "7&#46;"
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                      "titulo" => "Propuesta de protocolo para elinforme histol&#243;gico del tumor primario de los pacientes con un melanoma cut&#225;neo del Grupo de Trabajo para el Melanoma Cut&#225;neo de la Comunidad Valenciana"
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                          "etal" => true
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                            0 => "E&#46; Nagore"
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                      "autores" => array:1 [
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                          "etal" => false
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                            0 => "P&#46; L&#225;zaro Ocha&#237;ta"
                            1 => "A&#46; Bittini Copano"
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            ]
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                        0 => array:2 [
                          "etal" => false
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                          ]
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                      ]
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                  ]
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                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46;M&#46; Johnson"
                            1 => "J&#46;W&#46; Smith 2nd"
                            2 => "B&#46;R&#46; Nelson"
                            3 => "A&#46; Chang"
                          ]
                        ]
                      ]
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                        ]
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                ]
              ]
            ]
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                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "J&#46; Malvehy"
                            2 => "C&#46; Badenas"
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                          ]
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                      ]
                    ]
                  ]
                ]
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            ]
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Información del artículo

ISSN: 15782190
Idioma original: Inglés

DOI:10.1016/S1578-2190(09)70087-3

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