Spanish Evidence-Based Guidelines on the Treatment of Moderate to Severe Psoriasis with Biologic Agents

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It is associated with a marked decline in quality of life. A wide range of treatments are currently available, although surveys conducted before the advent of biologic agents reflected a strong degree of dissatisfaction with the treatments then available. Extensive scientific evidence has been gathered on the safety of biologic agents, and this has led to a review of the role of systemic treatment in general and has allowed new therapeutic goals and strategies to be contemplated in patients with moderate to severe psoriasis. In this new situation, there is a need for Spanish guidelines on the treatment of moderate to severe psoriasis with biologic agents, drafted by consensus among specialists and ratified by the Spanish Psoriasis Group of the Spanish Academy of Dermatology and Venereology (AEDV). These guidelines should be evidence-based with regard to the pharmacologic characteristics, mechanism of action, administration route and regimen, efficacy, contraindications, adverse effects, and cost estimates of biologic agents approved for the treatment of moderate to severe psoriasis in Spain." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La psoriasis vulgar es una enfermedad cutánea inflamatoria, de curso habitualmente crónico, que afecta a un 1-2% de la población en los países occidentales industrializados, y produce una reducción marcada de la calidad de vida de los pacientes. Pese a la diversidad de tratamientos disponibles, las encuestas efectuadas antes del advenimiento de los agentes biológicos demuestran un alto grado de insatisfacción con respecto a los tratamientos disponibles. Se ha acumulado abundante evidencia científica con respecto a la eficacia y seguridad de los agentes biológicos, que ha llevado a revisar el papel del tratamiento sistémico en general y ha permitido contemplar nuevos objetivos y estrategias terapéuticas en los pacientes con psoriasis moderada a grave. En este contexto nuevo se hace necesario establecer, de forma consensuada por especialistas expertos y ratificada por los integrantes del Grupo Español de Psoriasis de la Academia Española de Dermatología y Venereología (AEDV), unas directrices para el tratamiento de la psoriasis moderada a grave con agentes biológicos, que incluyan información basada en la evidencia científica disponible acerca de las características farmacológicas, mecanismo de acción, vía y pautas de administración, eficacia, contraindicaciones, efectos adversos y estimaciones del coste de los agentes biológicos aprobados para el tratamiento de la psoriasis moderada a grave en España" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:120 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Estadísticas

Consensus statement

Spanish Evidence-Based Guidelines on the Treatment of Moderate to Severe Psoriasis with Biologic Agents

Directrices Españolas Basadas en la Evidencia Para el Tratamiento de la Psorias is Moderada a Grave Cona Gentes Biológicos

L. Puiga,

Autor para correspondencia

lpuig@santpau.cat

Correspondence: Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Maria Claret, 167, 08025 Barcelona, Spain.

, J.M. Carrascosab, E. Daudénc, J.L. Sánchez-Carazod, C. Ferrándizb, M. Sánchez-Regañae, M. García-Bustinduyf, X. Bordasg, J.C. Morenoh, J.M. Hernanzi, S. Laguardaj, V. García-Patosk, for the Spanish Psoriasis Group of the Spanish Academy of Dermatology and Venereology

a Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona

b Servicio de Dermatología. Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona

c Servicio de Dermatología, Hospital de la Princesa, Madrid

d Servicio de Dermatología, Hospital General de Valencia, Valencia

e Servicio de Dermatología, Hospital Universitari Sagrat Cor, Barcelona

f Servicio de Dermatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife

g Servicio de Dermatología, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona

h Servicio de Dermatología, Hospital Universitario Reina Sofía, Córdoba

i Servicio de Dermatología, Hospital Infanta Leonor, Madrid

j Servicio de Dermatología, Hospital Casa de Salud de Valencia, Valencia

k Servicio de Dermatología, Hospital Universitari Vall d’Hebron, Barcelona, Spain

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Información del artículo

ISSN: 15782190
Idioma original: Inglés

DOI:10.1016/S1578-2190(09)70086-1

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2015 Marzo	33	16	49
2015 Febrero	28	10	38
2015 Enero	29	13	42
2014 Diciembre	39	11	50
2014 Noviembre	31	14	45
2014 Octubre	46	11	57
2014 Septiembre	32	15	47
2014 Agosto	38	18	56
2014 Julio	49	18	67
2014 Junio	34	10	44
2014 Mayo	44	16	60
2014 Abril	58	16	74
2014 Marzo	44	13	57
2014 Febrero	41	23	64
2014 Enero	44	18	62
2013 Diciembre	43	14	57
2013 Noviembre	29	16	45
2013 Octubre	30	17	47
2013 Septiembre	34	23	57
2013 Agosto	30	35	65
2013 Julio	40	29	69
2013 Junio	39	29	68
2013 Mayo	33	15	48
2013 Abril	42	46	88
2013 Marzo	38	30	68
2013 Febrero	42	13	55
2013 Enero	10	6	16

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