Original articles
Clear Cells in Cutaneous Squamous Cell Carcinoma
Las Células Claras en el Carcinoma Espinocelular Cutáneo
R. Corbalán-Véleza,
, J.A. Ruiz-Maciab, C. Brufauc, J.M. López-Lozanod, E. Martínez-Barbae, F.J. Carapetod
Autor para correspondencia
raulcorb@gmail.com
Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
a Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca Murcia, Spain
b Servicio de Anatomía Patológica, Hospital Vega Baja, Orihuela, Alicante, Spain
c Servicio de Dermatología, Hospital General Reina Sofía, Murcia, Spain
d Servicio de Medicina Preventiva, Hospital Vega Baja, Orihuela, Alicante, Spain
e Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Arrixaca Murcia, Spain
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Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Las Células Claras en el Carcinoma Espinocelular Cutáneo" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84456" "palabras" => array:4 [ 0 => "clear cells" 1 => "squamous cell carcinoma" 2 => "skin" 3 => "dermatopathology" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84455" "palabras" => array:4 [ 0 => "células claras" 1 => "carcinoma espinocelular" 2 => "piel" 3 => "dermatopatología" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Although few cases of squamous cell carcinoma (SCC) with clear cells have been published, we believe that these cells are often present in SCC.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 249 SCCs, analyzing a number of clinical and histological variables. Various immunohistochemical techniques (immunoperoxidase method) were used to determine whether adnexal differentiation was present.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There were 96 SCCs with a proportion of clear cells of over 25%. Advanced or established SCCs and SCCs associated with Bowen disease contained a larger proportion of clear cells. We defined 2 histological patterns: a) clear cells around the keratin pearls of SCCs arising from pre-existing actinic keratosis and with indirect signs of human papilloma virus infection in hair follicles; and b) clear cells that simulate adnexal differentiation in lesions arising on pre-existing Bowen disease lesions. There were also 19 carcinomas with true adnexal differentiation.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p class="elsevierStyleSimplePara elsevierViewall">Clear cells are frequently observed in SCC, though large numbers of clear cells are present only in certain SCCs. The appearance of clear cells in SCCs is progressive and they are only present in more advanced SCC. The presence of clear cells is suggestive of adnexal differentiation; however, in the majority of cases, their presence is due to infiltration of normal adnexal structures by the cells of pagetoid Bowen disease. True adnexal differentiation exists only in a small percentage of cases (7.6% in our study). The histological pattern described as clear cells around keratin pearls practically rules out this differentiation.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Se han publicado pocos casos de carcinoma espinocelular (CE) de células claras, aunque creemos que es frecuente observar células claras en los CE.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado 249 CE. Analizamos distintas variables clínicas e histológicas. Hemos usado diversas técnicas de inmunohistoquímica (método de inmunoperoxidasa) para valorar si existía diferenciación anexial.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Observamos 96 CE con más de un 25% de células claras. Existe más cantidad de células claras en los CE desarrollados o «no incipientes» y en los derivados de enfermedad de Bowen (EB). Describimos dos patrones histológicos: a) células claras alrededor de las perlas córneas del CE, que se asocia a la existencia de queratosis actínica como lesión previa y a signos indirectos de virus del papiloma humano (VPH) en infundíbulos pilosos, y b) células claras que simulan diferenciación anexial, relacionado con EB como lesión previa. También hemos encontrado 19 carcinomas con verdadera diferenciación anexial.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Es frecuente observar células claras en los CE, aunque solo algunos presentan una gran cantidad. El desarrollo de células claras en los CE sería progresivo y solo aparecería en los CE más desarrollados. Cuando se observan células claras en los CE, se tiende a pensar que existe diferenciación anexial, sin embargo, en la mayoría de casos se trataría solo de EB de células claras que infiltra estructuras anexiales normales. En un pequeño porcentaje de casos (7,6% en nuestro estudio) sí existe verdadera diferenciación anexial. Por otra parte, el patrón histológico descrito como células claras alrededor de perlas córneas prácticamente nos descartaría dicha diferenciación.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This study was awarded the 2007-2008 August C. Stiefel Research Prize.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
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| 2022 Septiembre | 19 | 50 | 69 |
| 2022 Agosto | 22 | 49 | 71 |
| 2022 Julio | 17 | 35 | 52 |
| 2022 Junio | 25 | 29 | 54 |
| 2022 Mayo | 25 | 57 | 82 |
| 2022 Abril | 52 | 51 | 103 |
| 2022 Marzo | 37 | 69 | 106 |
| 2022 Febrero | 19 | 33 | 52 |
| 2022 Enero | 42 | 40 | 82 |
| 2021 Diciembre | 29 | 44 | 73 |
| 2021 Noviembre | 42 | 51 | 93 |
| 2021 Octubre | 55 | 50 | 105 |
| 2021 Septiembre | 42 | 46 | 88 |
| 2021 Agosto | 28 | 30 | 58 |
| 2021 Julio | 29 | 39 | 68 |
| 2021 Junio | 32 | 32 | 64 |
| 2021 Mayo | 25 | 40 | 65 |
| 2021 Abril | 44 | 68 | 112 |
| 2021 Marzo | 55 | 43 | 98 |
| 2021 Febrero | 56 | 39 | 95 |
| 2021 Enero | 25 | 22 | 47 |
| 2020 Diciembre | 36 | 22 | 58 |
| 2020 Noviembre | 23 | 21 | 44 |
| 2020 Octubre | 17 | 30 | 47 |
| 2020 Septiembre | 20 | 21 | 41 |
| 2020 Agosto | 26 | 32 | 58 |
| 2020 Julio | 15 | 6 | 21 |
| 2020 Junio | 18 | 28 | 46 |
| 2020 Mayo | 29 | 20 | 49 |
| 2020 Abril | 24 | 17 | 41 |
| 2020 Marzo | 44 | 21 | 65 |
| 2020 Febrero | 4 | 8 | 12 |
| 2020 Enero | 0 | 3 | 3 |
| 2019 Diciembre | 0 | 11 | 11 |
| 2019 Noviembre | 0 | 6 | 6 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 0 | 6 | 6 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 15 | 15 |
| 2019 Junio | 0 | 32 | 32 |
| 2019 Mayo | 1 | 90 | 91 |
| 2019 Abril | 0 | 53 | 53 |
| 2019 Marzo | 0 | 9 | 9 |
| 2019 Febrero | 0 | 22 | 22 |
| 2019 Enero | 0 | 15 | 15 |
| 2018 Diciembre | 0 | 4 | 4 |
| 2018 Noviembre | 0 | 6 | 6 |
| 2018 Septiembre | 0 | 7 | 7 |
| 2018 Agosto | 0 | 27 | 27 |
| 2018 Julio | 0 | 12 | 12 |
| 2018 Junio | 0 | 15 | 15 |
| 2018 Mayo | 0 | 14 | 14 |
| 2018 Abril | 0 | 27 | 27 |
| 2018 Marzo | 0 | 24 | 24 |
| 2018 Febrero | 11 | 9 | 20 |
| 2018 Enero | 14 | 24 | 38 |
| 2017 Diciembre | 14 | 21 | 35 |
| 2017 Noviembre | 13 | 36 | 49 |
| 2017 Octubre | 12 | 23 | 35 |
| 2017 Septiembre | 9 | 17 | 26 |
| 2017 Agosto | 22 | 21 | 43 |
| 2017 Julio | 23 | 21 | 44 |
| 2017 Junio | 28 | 34 | 62 |
| 2017 Mayo | 25 | 36 | 61 |
| 2017 Abril | 24 | 19 | 43 |
| 2017 Marzo | 14 | 34 | 48 |
| 2017 Febrero | 13 | 30 | 43 |
| 2017 Enero | 9 | 10 | 19 |
| 2016 Diciembre | 29 | 14 | 43 |
| 2016 Noviembre | 27 | 12 | 39 |
| 2016 Octubre | 31 | 16 | 47 |
| 2016 Septiembre | 41 | 19 | 60 |
| 2016 Agosto | 23 | 6 | 29 |
| 2016 Julio | 19 | 5 | 24 |
| 2016 Junio | 9 | 8 | 17 |
| 2016 Mayo | 6 | 7 | 13 |
| 2016 Abril | 6 | 4 | 10 |
| 2016 Marzo | 4 | 1 | 5 |
| 2016 Febrero | 8 | 8 | 16 |
| 2016 Enero | 10 | 8 | 18 |
| 2015 Diciembre | 6 | 6 | 12 |
| 2015 Noviembre | 11 | 8 | 19 |
| 2015 Octubre | 9 | 12 | 21 |
| 2015 Septiembre | 9 | 4 | 13 |
| 2015 Agosto | 17 | 2 | 19 |
| 2015 Julio | 39 | 15 | 54 |
| 2015 Junio | 37 | 10 | 47 |
| 2015 Mayo | 48 | 22 | 70 |
| 2015 Abril | 37 | 24 | 61 |
| 2015 Marzo | 29 | 26 | 55 |
| 2015 Febrero | 18 | 21 | 39 |
| 2015 Enero | 20 | 30 | 50 |
| 2014 Diciembre | 29 | 25 | 54 |
| 2014 Noviembre | 14 | 18 | 32 |
| 2014 Octubre | 27 | 28 | 55 |
| 2014 Septiembre | 33 | 21 | 54 |
| 2014 Agosto | 28 | 19 | 47 |
| 2014 Julio | 44 | 27 | 71 |
| 2014 Junio | 46 | 15 | 61 |
| 2014 Mayo | 47 | 17 | 64 |
| 2014 Abril | 54 | 9 | 63 |
| 2014 Marzo | 51 | 22 | 73 |
| 2014 Febrero | 44 | 13 | 57 |
| 2014 Enero | 33 | 22 | 55 |
| 2013 Diciembre | 45 | 13 | 58 |
| 2013 Noviembre | 30 | 25 | 55 |
| 2013 Octubre | 23 | 22 | 45 |
| 2013 Septiembre | 27 | 18 | 45 |
| 2013 Agosto | 25 | 20 | 45 |
| 2013 Julio | 41 | 31 | 72 |
| 2013 Junio | 26 | 21 | 47 |
| 2013 Mayo | 20 | 18 | 38 |
| 2013 Abril | 18 | 23 | 41 |
| 2013 Marzo | 29 | 23 | 52 |
| 2013 Febrero | 32 | 20 | 52 |
| 2013 Enero | 8 | 3 | 11 |
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