Original articles
Therapeutic Effectiveness of Psoralen-U V-A Bath Therapy In Psoriasis
Eficacia Terapéutica del Baño-PUVA en Psoriasis
M.T. Rodríguez-Granadosa,
, M.J. Pereira-Rodríguezb, F.L. Vázquez-Vizosoc
Autor para correspondencia
trgranados@mundo-r.com
Correspondence. Servicio de Dermatología. Complejo Hospitalario Universitario de Santiago de Compostela. Facultad de Medicina. Universidad de Compostela. 15707 Santiago de Compostela. A Coruña. Spain.
Correspondence. Servicio de Dermatología. Complejo Hospitalario Universitario de Santiago de Compostela. Facultad de Medicina. Universidad de Compostela. 15707 Santiago de Compostela. A Coruña. Spain.
Leído
6331
Vecesse ha leído el artículo
2593
Total PDF
3738
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1578219009700472" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70047-2" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "aid" => "70047" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:212-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2438 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 1619 "PDF" => 776 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009700484" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70048-4" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "aid" => "70048" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2009;100:222-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3182 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 1825 "PDF" => 1314 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Cerebrotendinous Xanthomatosis: Report of 4 Patients" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "222" "paginaFinal" => "226" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Xantomatosis Cerebrotendinosa: Descripción de 4 Casos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Ferrándiz-Pulido, R. Bartralot, M. Girós, P. Bassas, C. Heras, D. Bodet, R. Savall, V. García-Patos" "autores" => array:8 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Ferrándiz-Pulido" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Bartralot" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Girós" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Bassas" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Heras" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Bodet" ] 6 => array:2 [ "nombre" => "R." "apellidos" => "Savall" ] 7 => array:2 [ "nombre" => "V." "apellidos" => "García-Patos" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700484?idApp=UINPBA000044" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700484/v1_201304241451/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009700460" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70046-0" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "aid" => "70046" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:205-11" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2337 "formatos" => array:3 [ "EPUB" => 40 "HTML" => 1483 "PDF" => 814 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Clinical and Epidemiologic Profile of Melanoma Patients According To Sun Exposure Of The Tumor Site" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "205" "paginaFinal" => "211" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Perfil Clínico y Epidemiológico de los Pacientes con Melanoma Cutáneo Según el Grado de Exposición Solar de la Localización del Melanoma" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Nagore, R. Botella-Estrada, C. Requena, C. Serra-Guillén, A. Martorell, L. Hueso, B. Llombart, O. Sanmartín, C. Guillén" "autores" => array:9 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Nagore" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Botella-Estrada" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Requena" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Serra-Guillén" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Martorell" ] 5 => array:2 [ "nombre" => "L." "apellidos" => "Hueso" ] 6 => array:2 [ "nombre" => "B." "apellidos" => "Llombart" ] 7 => array:2 [ "nombre" => "O." "apellidos" => "Sanmartín" ] 8 => array:2 [ "nombre" => "C." "apellidos" => "Guillén" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700460?idApp=UINPBA000044" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700460/v1_201304241451/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Therapeutic Effectiveness of Psoralen-U V-A Bath Therapy In Psoriasis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "212" "paginaFinal" => "221" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.T. Rodríguez-Granados, M.J. Pereira-Rodríguez, F.L. Vázquez-Vizoso" "autores" => array:3 [ 0 => array:4 [ "nombre" => "M.T." "apellidos" => "Rodríguez-Granados" "email" => array:1 [ 0 => "trgranados@mundo-r.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "M.J." "apellidos" => "Pereira-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "F.L." "apellidos" => "Vázquez-Vizoso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología. Complejo Universitario Juan Canalejo. A Coruña" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Preventiva. Complejo Universitario Juan Canalejo. A Coruña" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Preventiva. Complexo Hospitalario de Pontevedra. Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence. Servicio de Dermatología. Complejo Hospitalario Universitario de Santiago de Compostela. Facultad de Medicina. Universidad de Compostela. 15707 Santiago de Compostela. A Coruña. Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia Terapéutica del Baño-PUVA en Psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84417" "palabras" => array:5 [ 0 => "psoriasis" 1 => "photosensitivity" 2 => "photochemotherapy" 3 => "psoralen-UV-A bath therapy" 4 => "therapeutic effectiveness" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84418" "palabras" => array:5 [ 0 => "psoriasis" 1 => "fotosensibilidad" 2 => "fotoquimioterapia" 3 => "baño-PUVA" 4 => "eficacia terapéutica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">The use of psoralen baths with long-wave UV radiation, known as PUVA bath therapy, is useful in the treatment of psoriasis. The therapy is not associated with systemic adverse effects and the dose of UV-A radiation administered is lower. The objectives of this study aimed to identify the variables that influence the effectiveness of PUVA bath therapy and the duration of remission, as well as to determine factors that predict relapse. It also aimed to assess the effectiveness of a protocol using the minimal phototoxic dose and to compare two concentrations of 8-methoxypsoralen.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Two hundred nine patients with moderate-severe plaque psoriasis attended between 1994 and 2000 were included in the study. The characteristics and therapeutic outcomes of the sample were recorded. Survival curves were plotted for the disease-free interval after a good response to treatment. A proportional hazard model was used to assess the factors that influence the duration of remission.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Therapeutic outcomes were better in patients with greater photosensitivity (p = 0.03). Application of the minimal phototoxic dose protocol was not associated with greater phototoxicity during treatment. The median duration of remission was 7 months. Those patients who had previously undergone oral PUVA therapy and those who did not achieve a substantial reduction in the psoriasis area and severity index (PASI) score were at greater risk of relapse.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">A lower final PASI extended the lesion-free period.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El baño de psoralenos (P) e irradiación con ultravioleta de onda larga (UVA), conocido como baño-PUVA, es útil en el tratamiento de la psoriasis con la ausencia de efectos adversos sistémicos y una menor dosis de UVA administrada. El objetivo de este trabajo es identificar las variables que influyen en la efectividad del tratamiento con baño-PUVA y el período de remisión, así como determinar aquellas que permitan predecir la recidiva; valorar la efectividad de la prueba de fototoxicidad cutánea(DFM), y comparar dos concentraciones del 8-metoxipsoraleno (8-MOP).</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 209 pacientes afectos de psoriasis en placas moderada-grave visitados en el período 1994-2000. Se realizó un estudio descriptivo de las características y resultados terapéuticos de lamuestra estudiada, y un estudio de supervivencia valorando el tiempo libre de enfermedad tras una buena respuesta al tratamiento. El análisis 0de riesgos proporcionales permitió evaluar qué factores influyeron en el período de remisión.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes con mayor fotosensibilidad mostraron los mejores resultados terapéuticos (p = 0,03). El protocolo en que se realizó la DFM no supuso más fototoxicidad durante el tratamiento. La duración del período de remisión fue de 7 meses en el 50% de los pacientes. Aquellos pacientes que previamente realizaron terapia PUVA oral, y los que no consiguieron una reducción importante del <span class="elsevierStyleItalic">Psoriasis Area and Severity Index</span> (PASI), condicionaron un mayor riesgo de recidiva.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Un PASI final reducido incrementa la duración del tiempo libre de lesiones.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This article is the result of the doctoral thesis of María Teresa Rodríguez Granados, “Therapeutic Effectiveness of Psoralen-UV-A Bath in Psoriasis: First Study in the Autonomous Community of Galicia, Spain.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of psoriasis in Spain (Epiderma Project: phase I)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Ferrándiz" 1 => "X. Bordas" 2 => "V. García-Patos" 3 => "S. Puig" 4 => "R. Pujol" 5 => "A. Smandía" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2001" "volumen" => "15" "paginaInicial" => "20" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11451315" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Parrish" 1 => "T. Fitzpatrick" 2 => "L. Tanenbaum" 3 => "M. Pathak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM197412052912301" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "1974" "volumen" => "291" "paginaInicial" => "1207" "paginaFinal" => "1211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4422691" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526010000130" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of psoriasis with trioxsalen baths and dysprosium lamps" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Fischer" 1 => "J. Alsins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "1976" "volumen" => "56" "paginaInicial" => "383" "paginaFinal" => "390" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/78625" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term local trioxsalen photochemotherapy in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Väätäinen" 1 => "M. Hannuksela" 2 => "J. Karvonen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatology" "fecha" => "1981" "volumen" => "163" "paginaInicial" => "229" "paginaFinal" => "231" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A double-blind comparison of acitretin and etretinate in combination with bath PUVA in the treatment of extensive psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Lauharanta" 1 => "J. Geiger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1989" "volumen" => "121" "paginaInicial" => "107" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2527054" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The psoriasis area and severity index is the adequate criterion to define severity in chronic plaquetype psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Schmitt" 1 => "W. Gottfried" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000083509" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2005" "volumen" => "210" "paginaInicial" => "194" "paginaFinal" => "199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15785046" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Documento de consenso sobre fototerapia: terapias PUVA y UVB de banda estrecha" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Carrascosa" 1 => "J. Gardeazábal" 2 => "A. Pérez-Ferriols" 3 => "A. Alomar" 4 => "P. Manrique" 5 => "M. Jones-Caballero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "635" "paginaFinal" => "658" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476315" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526008000848" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "8-MOP bath PUVA in the treatment of psoriasis: Clinical results in 42 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Gómez" 1 => "B. Pérez" 2 => "A. Harto" 3 => "R. De Misa" 4 => "A. Ledo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol Treat" "fecha" => "1996" "volumen" => "7" "paginaInicial" => "11" "paginaFinal" => "12" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phototherapy of psoriasis: comparative experience of different phototherapeutic approaches" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Karrer" 1 => "C. Eholzer" 2 => "G. Ackermann" 3 => "M. Landthaler" 4 => "R.M. Szeimies" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "51608" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2001" "volumen" => "202" "paginaInicial" => "108" "paginaFinal" => "115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11306830" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for topical PUVA: a report of a workshop of the British Photodermatology Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Halpern" 1 => "A. Anstey" 2 => "R. Dawe" 3 => "B. Diffey" 4 => "P. Farr" 5 => "J. Ferguson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2000" "volumen" => "142" "paginaInicial" => "22" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10651690" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural history of psoriasis in 61 twin pairs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Farber" 1 => "L. Nall" 2 => "W. Watson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1974" "volumen" => "109" "paginaInicial" => "207" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4814926" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526009015088" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis of early and late onset: A clinical and epidemiologic study from Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Ferrándiz" 1 => "R. Pujol" 2 => "V. García-Patos" 3 => "X. Bordas" 4 => "J. Smandía" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2002" "volumen" => "46" "paginaInicial" => "867" "paginaFinal" => "873" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12063483" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Henseler" 1 => "E. Christophers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J AmAcad Dermatol" "fecha" => "1985" "volumen" => "15" "paginaInicial" => "450" "paginaFinal" => "456" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized double-blind trial of the treatment of chronic plaque psoriasis: efficacy of psoralen-UV-A therapy vs narrowband UV-B therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Yones" 1 => "R. Palmer" 2 => "T. Garibaldinos" 3 => "J. Hawk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.142.7.836" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2006" "volumen" => "142" "paginaInicial" => "836" "paginaFinal" => "842" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16847198" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma levels of 8-methoxypsoralen following PUVA-bath photochemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Von Kobyletzki" 1 => "K. Hoffmann" 2 => "M. Kerscher" 3 => "P. Altmeyer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed" "fecha" => "1998" "volumen" => "14" "paginaInicial" => "136" "paginaFinal" => "138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9779504" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of the dose-response relationship for psoralen-UVA erythema and UVB erythema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Cox" 1 => "P. Farr" 2 => "B. Diffey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1989" "volumen" => "125" "paginaInicial" => "1653" "paginaFinal" => "1657" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2589859" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and effectiveness of an aggressive and individualized bath-PUVA regimen in the treatment of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Calzavara-Pinton" 1 => "B. Ortel" 2 => "H. Honigsmann" 3 => "C. Zane" 4 => "G. De Panfilis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "1994" "volumen" => "189" "paginaInicial" => "256" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7949478" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Time course of 8-methoxypsoraleninduced skin photosensitization in PUVA-bath photochemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Reuther" 1 => "C. Gruss" 2 => "S. Behrens" 3 => "G. von Kobyletzki" 4 => "N. Neumann" 5 => "P. Lehmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed" "fecha" => "1997" "volumen" => "13" "paginaInicial" => "193" "paginaFinal" => "196" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9542757" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phototesting and phototoxic side effects in bath PUVA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Calzavara-Pinton" 1 => "B. Ortel" 2 => "A. Carlino" 3 => "H. Honigsmann" 4 => "G. De Panfilis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1993" "volumen" => "28" "paginaInicial" => "657" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8463475" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526011000379" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of bathwater and oral delivery of 8-methoxypsoralen in PUVA therapy for plaque psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Cooper" 1 => "R. Herd" 2 => "G. Priestley" 3 => "J. Hunter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2000" "volumen" => "25" "paginaInicial" => "111" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10733632" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does the minimal phototoxic dose after8-methoxypsoralen baths correlate with the individual's skin phototype ?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Schiener" 1 => "S. Behrens-Williams" 2 => "H. Pillekamp" 3 => "R. Peter" 4 => "M. Kerscher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed" "fecha" => "2001" "volumen" => "17" "paginaInicial" => "156" "paginaFinal" => "158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11499535" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultraviolet phototherapy and photochemotherapy of skin disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Bilsland" 1 => "R. Dawe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Photodermatology" "paginaInicial" => "113" "paginaFinal" => "124" "serieFecha" => "2006" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Tegeder" 1 => "L. Bräutigam" 2 => "M. Podda" 3 => "S. Meier" 4 => "R. Kaufmann" 5 => "G. Geisslinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacol Ther" "fecha" => "2002" "volumen" => "71" "paginaInicial" => "153" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8910954" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High plasma levels of 8-methoxypsoralen following bath water delivery in dermatological patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "U. Kappes" 1 => "U. Barta" 2 => "U. Merkel" 3 => "A. Balogh" 4 => "P. Elsner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "72070" "Revista" => array:6 [ "tituloSerie" => "Skin Pharmacol Appl Skin Physiol" "fecha" => "2003" "volumen" => "16" "paginaInicial" => "305" "paginaFinal" => "312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12907835" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between 8-methoxypsoralen bath-water concentration and photosensitivity inbath-PUVA treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Tanew" 1 => "T. Kipfelsperger" 2 => "A. Seeber" 3 => "S. Radakovic-Fijan" 4 => "H. Hönigsmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mjd.2001.112360" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2001" "volumen" => "44" "paginaInicial" => "638" "paginaFinal" => "642" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11260539" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized, double-blind comparison of 1 mg/L versus 5 mg/L methoxsalen bath- PUVA therapy for chronic plaque-type psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Vongthongsri" 1 => "R. Konschitzky" 2 => "A. Seeber" 3 => "C. Treitl" 4 => "H. Hönigsmann" 5 => "A. Tanew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2006.05.024" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2006" "volumen" => "55" "paginaInicial" => "627" "paginaFinal" => "631" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17010742" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid decline in photosensitivity after 8-methoxypsoralen bathwater delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Degitz" 1 => "G. Plewig" 2 => "M. Röcken" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1996" "volumen" => "132" "paginaInicial" => "1394" "paginaFinal" => "1395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8915330" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of PUVA bath phototoxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Neumann" 1 => "M. Kerscher" 2 => "T. Ruzicka" 3 => "P. Lehmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "1997" "volumen" => "77" "paginaInicial" => "385" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9298134" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between bathing time and photosensitivity in 8-methoxypsoralen (8-MOP) bath PUVA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Dolezal" 1 => "A. Seeber" 2 => "H. Hönigsmann" 3 => "A. Tanew" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "183" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11019944" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bath-water delivery of 8-methoxypsoralen therapy for psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Collins" 1 => "S. Rogers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "1991" "volumen" => "16" "paginaInicial" => "165" "paginaFinal" => "167" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1934565" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526009000259" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin phototoxicity variations during repeated bath PUVA exposures to 8-methoxypsoralen and trimethyl psoralen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Koulu" 1 => "C. Jansén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "1984" "volumen" => "9" "paginaInicial" => "64" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6692588" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phototesting in bath-PUVA: marked reduction of 8-methoxypsoralen (8-MOP) activity within one hour after an 8-MOP bath" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Schempp" 1 => "E. Schöpf" 2 => "J. Simon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed" "fecha" => "1996" "volumen" => "12" "paginaInicial" => "100" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8956358" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PUVA therapy for psoriasis: Comparison of oral and bath-water delivery of 8-methoxypsoralen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Lowe" 1 => "D. Weingarten" 2 => "T. Bourget" 3 => "L. Moy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1986" "volumen" => "14" "paginaInicial" => "754" "paginaFinal" => "760" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3711379" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photo(chemo) therapy for psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Hönigsmann" 1 => "A. Tanew" 2 => "T. Ruzicka" 3 => "W. Morison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Dermatological Phototherapy and Photodiagnostic Methods" "paginaInicial" => "72" "paginaFinal" => "81" "edicion" => "1st ed" "serieFecha" => "2001" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of twice-weekly MPD-PUVA and three times-weekly skin typing-PUVA regimens for the treatment of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Buckley" 1 => "E. Healy" 2 => "S. Rogers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1995" "volumen" => "133" "paginaInicial" => "417" "paginaFinal" => "422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8546997" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Large increments in psoralenultraviolet A (PUVA) therapy are unsuitable for fair-skinned individuals with psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Kirby" 1 => "D. Buckley" 2 => "S. Rogers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1999" "volumen" => "140" "paginaInicial" => "661" "paginaFinal" => "666" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10233317" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An intraindividual study of the characteristics of erythema induced by bath and oral methoxsalen photochemotherapy and narrowband ultraviolet B" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Man" 1 => "R. Dawe" 2 => "J. Ferguson" 3 => "S. Ibbotson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Photochem Photobiol" "fecha" => "2003" "volumen" => "78" "paginaInicial" => "55" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12929749" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Turjanmaa" 1 => "H. Salo" 2 => "T. Reunala" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "1985" "volumen" => "65" "paginaInicial" => "86" "paginaFinal" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2578716" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "8-MOP PUVA for psoriasis: a comparison of a minimal phototoxic dose-based regimen with a skin-type approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Collins" 1 => "N. Wainwright" 2 => "I. Amorim" 3 => "T. Lakshmipathi" 4 => "J. Ferguson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1996" "volumen" => "135" "paginaInicial" => "248" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8881668" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700472/v1_201304241451/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000003/v1_201304241451/S1578219009700472/v1_201304241451/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700472?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 2 | 3 | 5 |
| 2024 Octubre | 73 | 33 | 106 |
| 2024 Septiembre | 65 | 24 | 89 |
| 2024 Agosto | 102 | 60 | 162 |
| 2024 Julio | 66 | 32 | 98 |
| 2024 Junio | 62 | 27 | 89 |
| 2024 Mayo | 63 | 32 | 95 |
| 2024 Abril | 65 | 31 | 96 |
| 2024 Marzo | 56 | 37 | 93 |
| 2024 Febrero | 47 | 36 | 83 |
| 2024 Enero | 46 | 33 | 79 |
| 2023 Diciembre | 55 | 38 | 93 |
| 2023 Noviembre | 53 | 39 | 92 |
| 2023 Octubre | 40 | 26 | 66 |
| 2023 Septiembre | 51 | 26 | 77 |
| 2023 Agosto | 26 | 17 | 43 |
| 2023 Julio | 27 | 40 | 67 |
| 2023 Junio | 40 | 40 | 80 |
| 2023 Mayo | 36 | 30 | 66 |
| 2023 Abril | 17 | 25 | 42 |
| 2023 Marzo | 29 | 24 | 53 |
| 2023 Febrero | 35 | 25 | 60 |
| 2023 Enero | 32 | 29 | 61 |
| 2022 Diciembre | 56 | 41 | 97 |
| 2022 Noviembre | 41 | 23 | 64 |
| 2022 Octubre | 23 | 27 | 50 |
| 2022 Septiembre | 25 | 32 | 57 |
| 2022 Agosto | 22 | 34 | 56 |
| 2022 Julio | 12 | 31 | 43 |
| 2022 Junio | 19 | 29 | 48 |
| 2022 Mayo | 31 | 37 | 68 |
| 2022 Abril | 44 | 50 | 94 |
| 2022 Marzo | 37 | 58 | 95 |
| 2022 Febrero | 17 | 37 | 54 |
| 2022 Enero | 30 | 35 | 65 |
| 2021 Diciembre | 16 | 54 | 70 |
| 2021 Noviembre | 31 | 44 | 75 |
| 2021 Octubre | 23 | 44 | 67 |
| 2021 Septiembre | 19 | 41 | 60 |
| 2021 Agosto | 23 | 24 | 47 |
| 2021 Julio | 51 | 31 | 82 |
| 2021 Junio | 14 | 49 | 63 |
| 2021 Mayo | 39 | 44 | 83 |
| 2021 Abril | 40 | 60 | 100 |
| 2021 Marzo | 54 | 21 | 75 |
| 2021 Febrero | 57 | 32 | 89 |
| 2021 Enero | 23 | 23 | 46 |
| 2020 Diciembre | 26 | 15 | 41 |
| 2020 Noviembre | 19 | 22 | 41 |
| 2020 Octubre | 15 | 9 | 24 |
| 2020 Septiembre | 19 | 14 | 33 |
| 2020 Agosto | 24 | 30 | 54 |
| 2020 Julio | 23 | 6 | 29 |
| 2020 Junio | 42 | 33 | 75 |
| 2020 Mayo | 20 | 34 | 54 |
| 2020 Abril | 41 | 24 | 65 |
| 2020 Marzo | 48 | 21 | 69 |
| 2020 Febrero | 7 | 2 | 9 |
| 2020 Enero | 0 | 10 | 10 |
| 2019 Diciembre | 0 | 11 | 11 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Julio | 0 | 1 | 1 |
| 2019 Junio | 0 | 4 | 4 |
| 2019 Mayo | 1 | 37 | 38 |
| 2019 Abril | 0 | 1 | 1 |
| 2019 Marzo | 0 | 5 | 5 |
| 2019 Febrero | 0 | 5 | 5 |
| 2018 Septiembre | 0 | 3 | 3 |
| 2018 Agosto | 0 | 1 | 1 |
| 2018 Junio | 0 | 3 | 3 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 1 | 1 | 2 |
| 2018 Febrero | 8 | 4 | 12 |
| 2018 Enero | 13 | 3 | 16 |
| 2017 Diciembre | 16 | 9 | 25 |
| 2017 Noviembre | 15 | 4 | 19 |
| 2017 Octubre | 15 | 9 | 24 |
| 2017 Septiembre | 12 | 7 | 19 |
| 2017 Agosto | 14 | 9 | 23 |
| 2017 Julio | 24 | 2 | 26 |
| 2017 Junio | 43 | 17 | 60 |
| 2017 Mayo | 40 | 12 | 52 |
| 2017 Abril | 28 | 8 | 36 |
| 2017 Marzo | 31 | 9 | 40 |
| 2017 Febrero | 8 | 7 | 15 |
| 2017 Enero | 13 | 7 | 20 |
| 2016 Diciembre | 25 | 8 | 33 |
| 2016 Noviembre | 19 | 7 | 26 |
| 2016 Octubre | 29 | 11 | 40 |
| 2016 Septiembre | 30 | 5 | 35 |
| 2016 Agosto | 28 | 5 | 33 |
| 2016 Julio | 18 | 5 | 23 |
| 2016 Junio | 18 | 11 | 29 |
| 2016 Mayo | 9 | 3 | 12 |
| 2016 Abril | 9 | 0 | 9 |
| 2016 Marzo | 9 | 0 | 9 |
| 2016 Febrero | 8 | 3 | 11 |
| 2016 Enero | 6 | 1 | 7 |
| 2015 Diciembre | 7 | 3 | 10 |
| 2015 Noviembre | 10 | 1 | 11 |
| 2015 Octubre | 10 | 3 | 13 |
| 2015 Septiembre | 9 | 4 | 13 |
| 2015 Agosto | 14 | 4 | 18 |
| 2015 Julio | 35 | 6 | 41 |
| 2015 Junio | 41 | 6 | 47 |
| 2015 Mayo | 70 | 12 | 82 |
| 2015 Abril | 38 | 6 | 44 |
| 2015 Marzo | 35 | 18 | 53 |
| 2015 Febrero | 38 | 10 | 48 |
| 2015 Enero | 28 | 9 | 37 |
| 2014 Diciembre | 24 | 11 | 35 |
| 2014 Noviembre | 20 | 15 | 35 |
| 2014 Octubre | 29 | 20 | 49 |
| 2014 Septiembre | 27 | 16 | 43 |
| 2014 Agosto | 31 | 20 | 51 |
| 2014 Julio | 41 | 23 | 64 |
| 2014 Junio | 47 | 12 | 59 |
| 2014 Mayo | 50 | 21 | 71 |
| 2014 Abril | 46 | 13 | 59 |
| 2014 Marzo | 58 | 14 | 72 |
| 2014 Febrero | 50 | 24 | 74 |
| 2014 Enero | 41 | 13 | 54 |
| 2013 Diciembre | 30 | 8 | 38 |
| 2013 Noviembre | 28 | 13 | 41 |
| 2013 Octubre | 25 | 13 | 38 |
| 2013 Septiembre | 32 | 26 | 58 |
| 2013 Agosto | 21 | 32 | 53 |
| 2013 Julio | 37 | 21 | 58 |
| 2013 Junio | 24 | 19 | 43 |
| 2013 Mayo | 29 | 28 | 57 |
| 2013 Abril | 17 | 36 | 53 |
| 2013 Marzo | 28 | 25 | 53 |
| 2013 Febrero | 47 | 15 | 62 |
| 2013 Enero | 12 | 5 | 17 |
Mostrar todo
