array:23 [
  "pii" => "S1578219009700459"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(09)70045-9"
  "estado" => "S300"
  "fechaPublicacion" => "2009-04-01"
  "aid" => "70045"
  "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2009;100:201-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2978
    "formatos" => array:3 [
      "EPUB" => 41
      "HTML" => 1862
      "PDF" => 1075
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219009700460"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70046-0"
    "estado" => "S300"
    "fechaPublicacion" => "2009-04-01"
    "aid" => "70046"
    "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:205-11"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2337
      "formatos" => array:3 [
        "EPUB" => 40
        "HTML" => 1483
        "PDF" => 814
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Clinical and Epidemiologic Profile of Melanoma Patients According To Sun Exposure Of The Tumor Site"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "205"
          "paginaFinal" => "211"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Perfil Cl&#237;nico y Epidemiol&#243;gico de los Pacientes con Melanoma Cut&#225;neo Seg&#250;n el Grado de Exposici&#243;n Solar de la Localizaci&#243;n del Melanoma"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Nagore, R&#46; Botella-Estrada, C&#46; Requena, C&#46; Serra-Guill&#233;n, A&#46; Martorell, L&#46; Hueso, B&#46; Llombart, O&#46; Sanmart&#237;n, C&#46; Guill&#233;n"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Nagore"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Botella-Estrada"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Requena"
            ]
            3 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Serra-Guill&#233;n"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Martorell"
            ]
            5 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Hueso"
            ]
            6 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Llombart"
            ]
            7 => array:2 [
              "nombre" => "O&#46;"
              "apellidos" => "Sanmart&#237;n"
            ]
            8 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Guill&#233;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700460?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700460/v1_201304241451/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219009700447"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70044-7"
    "estado" => "S300"
    "fechaPublicacion" => "2009-04-01"
    "aid" => "70044"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:190-200"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4132
      "formatos" => array:3 [
        "EPUB" => 34
        "HTML" => 1697
        "PDF" => 2401
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Consensus statement</span>"
      "titulo" => "Update of the Topical Treatment of Psoriasis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "190"
          "paginaFinal" => "200"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Revisi&#243;n Actualizada del Tratamiento T&#243;pico de la Psoriasis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;M&#46; Carrascosa, F&#46; Vanacloch, L&#46; Borrego, E&#46; Fern&#225;ndez-L&#243;pez, A&#46; Fuertes, L&#46; Rodr&#237;guez-Fern&#225;ndez-Freire, A&#46; Zulaica, A&#46; Tuneu, G&#46; Caball&#233;, E&#46; Colom&#233;, X&#46; Bordas, J&#46;M&#46; Hernanz, C&#46; Brufau, E&#46; Herrera"
          "autores" => array:14 [
            0 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Carrascosa"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Vanacloch"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Borrego"
            ]
            3 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Fern&#225;ndez-L&#243;pez"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Fuertes"
            ]
            5 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Rodr&#237;guez-Fern&#225;ndez-Freire"
            ]
            6 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Zulaica"
            ]
            7 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tuneu"
            ]
            8 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Caball&#233;"
            ]
            9 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Colom&#233;"
            ]
            10 => array:2 [
              "nombre" => "X&#46;"
              "apellidos" => "Bordas"
            ]
            11 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Hernanz"
            ]
            12 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Brufau"
            ]
            13 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Herrera"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700447?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700447/v1_201304241451/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Contact Sensitization to Euxyl K400"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "201"
        "paginaFinal" => "204"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;T&#46; Bordel-G&#243;mez, A&#46; Miranda-Romero"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "M&#46;T&#46;"
            "apellidos" => "Bordel-G&#243;mez"
            "email" => array:1 [
              0 => "matebordel&#64;yahoo&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Miranda-Romero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Complejo Asistencial Virgen de la Concha&#44; Zamora"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; Facultad de Medicina&#44; Valladolid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Dermatolog&#237;a&#44; Hospital Virgen de la Concha&#44; Avda&#46; Requejo&#44; 35&#44; 9022 Zamora&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sensibilizaci&#243;n de Contacto al Euxyl K-400"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2008-04-21"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84430"
          "palabras" => array:4 [
            0 => "contact allergic dermatitis"
            1 => "Euxyl K400"
            2 => "methyldibromo glutaronitrile"
            3 => "2-phenoxyethanol"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84429"
          "palabras" => array:4 [
            0 => "dermatitis al&#233;rgica de contacto"
            1 => "Euxyl K-400"
            2 => "metildibromo glutaronitrilo"
            3 => "2-fenoxietanol"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Euxyl K400 is a widely used preservative in cosmetics&#44; topical drugs&#44; cutting fluids&#44; etc&#46; This antimicrobial product has two active components&#8212;methyldibromo glutaronitrile &#40;MDGN&#41;&#44; also known as 1&#44;2-dibromo-2&#44;4-dicyanobutane&#44; and 2-phenoxyethanol&#44; in a proportion of 1 to 4&#46;The aim of this study was to assess the prevalence of sensitization to this preservative in cases in our dermatology department over a 5-year period&#46; We also assessed the prevalence of sensitization to the two active components of Euxyl K400 and calculated the agreement with sensitization to Euxyl K400&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">In this retrospective study&#44; we analyzed the medical records of 1&#44;092 patients attended in our skin allergy unit between January 2000 and December 2005&#46;We undertook testing with a standard battery that included&#44; in addition to the allergens recommended by the Spanish Group for Research Into Dermatitis and Skin Allergies &#40;GEIDAC&#41;&#44; 0&#46;3&#37; MDGN and 1&#37; 2-phenoxyethanol in Vaseline &#40;Trolab<span class="elsevierStyleSup">&#174;</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Only 15 patients developed a positive reaction to Euxyl K400&#46; Of these&#44; 11 were positive to MDGN and 2 to phenoxyethanol&#46; Sensitization to Euxyl K400 was significantly more common in men&#46; The agreement between sensitization to Euxyl K400 and MDGN was good &#40;Kp &#61; 0&#46;68&#41;&#44; whereas agreement between Euxyl K400 and phenoxyethanol was poor &#40;Kp &#61; 0&#46;23&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of Euxyl K400 sensitization in this study was 1&#46;4&#37;&#46; Most cases of Euxyl K400 sensitization were associated with the MDGN component&#44; as indicated by the good agreement between the two substances&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">I</span>El Euxyl K-400 es un conservante muy utilizado en cosm&#233;ticos&#44; medicamentos de uso t&#243;pico&#44; fluidos de corte&#44; etc&#46; Este producto antimicrobiano consta de dos componentes activos&#58; metildibromoglutaronitrilo &#40;MDGN&#41;&#44; tambi&#233;n llamado 1&#44;2-dibromo-2&#44;4-dicianobutano&#44; y 2-fenoxietanol&#44; en una proporci&#243;n 1&#58;4&#46; El objetivo de este estudio fue evaluar la prevalencia de sensibilizaci&#243;n a este conservante en nuestro departamento de Dermatolog&#237;a&#44; en un per&#237;odo de 5 a&#241;os&#46; Evaluamos tambi&#233;n la prevalencia de sensibilizaci&#243;n de los dos componentes del Euxyl K-400 y calculamos la concordancia entre dichas sensibilizaciones&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado un estudio retrospectivo analizando las historias cl&#237;nicas de 1&#46;092 pacientes estudiados en nuestra unidad de Alergia Cut&#225;nea desde enero de 2000 hasta diciembre de 2005&#46; Realizamos pruebas con una bater&#237;a est&#225;ndar que conten&#237;a&#44; adem&#225;s de todos los al&#233;rgenos recomendados por el Grupo Espa&#241;ol de Investigaci&#243;n en Dermatitis y Alergia Cut&#225;nea &#40;GEIDAC&#41;&#44; el MDGN al 0&#44;3&#37; y el 2-fenoxietanol al 1&#37; en vaselina &#40;Trolab<span class="elsevierStyleSup">&#174;</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Solo 15 pacientes presentaron positividad al Euxyl K-400&#44; de los que 11 fueron positivos al MDGN y 2 al fenoxietanol&#46; La sensibilizaci&#243;n al Euxyl K-400 fue significativamente superior en los hombres&#46; La concordancia entre la sensibilizaci&#243;n al Euxyl K-400 y el MDGN fue buena &#40;Kp &#61; 0&#44;68&#41;&#44; mientras que la concordancia entre el Euxyl K-400 y el fenoxietanol solo fue regular &#40;Kp &#61; 0&#44;23&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de sensibilizaci&#243;n al Euxyl K-400 en nuestro estudio fue de 1&#44;4&#37;&#46; La mayor&#237;a de las sensibilizaciones al Euxyl K-400 se debe al componente MDGN&#44; hecho corroborado en nuestro trabajo&#44; en el que se observa una buena concordancia entre ambos al&#233;rgenos<span class="elsevierStyleItalic">&#46;</span></p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Euxyl K 400&#58; incidence of sensitization&#44; patch test concentration and vehicle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Tosti"
                            1 => "C&#46; Vincenzi"
                            2 => "P&#46; Trevisti"
                            3 => "L&#46; Guerra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1995"
                        "volumen" => "33"
                        "paginaInicial" => "193"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8565462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypersensitivity to preservatives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Sasseville"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1396-0296.2004.04028.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Ther"
                        "fecha" => "2004"
                        "volumen" => "17"
                        "paginaInicial" => "251"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15186371"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monitoring levels of preservative sensitivity in Europe&#46; A 10-year overview &#40;1991-2000&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Wilkinson"
                            1 => "S&#46; Shaw"
                            2 => "K&#46;E&#46; Andersen"
                            3 => "F&#46;M&#46; Brandao"
                            4 => "D&#46;P&#46; Bruynzeel"
                            5 => "M&#46; Bruze"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "207"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12081698"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510708026953"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sensitization studies in the guinea pig with the active ingredients of Euxyl K-400"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Bruze"
                            1 => "B&#46; Gruvberger"
                            2 => "G&#46; Agrup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1988"
                        "volumen" => "18"
                        "paginaInicial" => "37"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3349777"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709028338"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis features of atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Hanifin"
                            1 => "G&#46; Rajka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Dermato Venereol"
                        "fecha" => "1980"
                        "volumen" => "92"
                        "paginaInicial" => "44"
                        "paginaFinal" => "47"
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709020653"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for the descriptive presentation and statistical analysis of contact allergy data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Uter"
                            1 => "A&#46; Schnunch"
                            2 => "O&#46; Gefeller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0105-1873.2004.00406.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2004"
                        "volumen" => "51"
                        "paginaInicial" => "47"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15373843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased rate of patch test reactivity to methyldibromo glutaronitrile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; McFadden"
                            1 => "J&#46;S&#46; Ross"
                            2 => "A&#46;B&#46; Jones"
                            3 => "R&#46;J&#46; Rycroft"
                            4 => "H&#46;R&#46; Smith"
                            5 => "I&#46;R&#46; White"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2000"
                        "volumen" => "42"
                        "paginaInicial" => "54"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10644036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estudio epidemiol&#243;gico de la dermatitis al&#233;rgica de contacto en Espa&#241;a &#40;2001&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Garc&#237;a-Bravo"
                            1 => "L&#46; Conde-Salazar"
                            2 => "J&#46; de la Cuadra-Oyanguren"
                            3 => "V&#46; Fern&#225;ndez-Redondo"
                            4 => "J&#46;M&#46; Fern&#225;ndez-Vozmediano"
                            5 => "D&#46; Guimaraens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2004"
                        "volumen" => "95"
                        "paginaInicial" => "14"
                        "paginaFinal" => "24"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Euxyl K-400&#58; una revisi&#243;n de los &#250;ltimos 7 a&#241;os"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Gonz&#225;lez-Guerra"
                            1 => "F&#46; Heras-Mendaza"
                            2 => "M&#46;J&#46; Cabello-Herranz"
                            3 => "S&#46; V&#225;zquez-Cort&#233;s"
                            4 => "L&#46; Conde-Salazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actualidad Dermatol"
                        "fecha" => "2006"
                        "volumen" => "45"
                        "paginaInicial" => "329"
                        "paginaFinal" => "332"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Allergic contact dermatitis due to methyldibromo glutaronitrile in Euxyl K-400 in an ultrasonic gel"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Erdmann"
                            1 => "B&#46; Sachs"
                            2 => "H&#46;F&#46; Merk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2001"
                        "volumen" => "44"
                        "paginaInicial" => "57"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11156032"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Allergic contact dermatitis from methyldibromo glutaronitrile&#46; Clinical cases from 2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Zachariae"
                            1 => "J&#46;D&#46; Johansen"
                            2 => "S&#46;C&#46; Rastogi"
                            3 => "T&#46; Menn&#233;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0105-1873.2005.00478.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "6"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15701121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methyldibromoglutaronitrile is an important contact allergen in The Netherlands"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; De Groot"
                            1 => "P&#46;A&#46; de Cock"
                            2 => "P&#46;J&#46; Coenraads"
                            3 => "C&#46;J&#46; van Ginkel"
                            4 => "B&#46;A&#46; Jagtman"
                            5 => "T&#46; van Joost"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1996"
                        "volumen" => "34"
                        "paginaInicial" => "118"
                        "paginaFinal" => "120"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8681539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Occupational allergic contact dermatitis to methyldibromoglutaronitrile in hand degreasing toilet paper"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;E&#46; Marcano"
                            1 => "F&#46; Heras"
                            2 => "L&#46; Conde-Salazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0536.2006.01083.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "126"
                        "paginaFinal" => "127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17627659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The sensitizing potency of Euxyl<span class="elsevierStyleSup">&#174;</span> K 400 and its components 1&#44;2-dibromo-2&#44;4-dicyanobutane and 2-phenoxyethanol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;M&#46; Hausen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1993"
                        "volumen" => "28"
                        "paginaInicial" => "149"
                        "paginaFinal" => "153"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8462291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700459/v1_201304241451/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000003/v1_201304241451/S1578219009700459/v1_201304241451/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700459?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Original article
Contact Sensitization to Euxyl K400
Sensibilización de Contacto al Euxyl K-400
M.T. Bordel-Gómeza,
Autor para correspondencia
matebordel@yahoo.es

Correspondence: Servicio de Dermatología, Hospital Virgen de la Concha, Avda. Requejo, 35, 9022 Zamora, Spain.
, A. Miranda-Romerob
a Servicio de Dermatología, Complejo Asistencial Virgen de la Concha, Zamora
b Servicio de Dermatología, Hospital Clínico Universitario de Valladolid, Facultad de Medicina, Valladolid, Spain
Leído
7134
Veces
se ha leído el artículo
3301
Total PDF
3833
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1578219009700459"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(09)70045-9"
  "estado" => "S300"
  "fechaPublicacion" => "2009-04-01"
  "aid" => "70045"
  "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2009;100:201-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2978
    "formatos" => array:3 [
      "EPUB" => 41
      "HTML" => 1862
      "PDF" => 1075
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219009700460"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70046-0"
    "estado" => "S300"
    "fechaPublicacion" => "2009-04-01"
    "aid" => "70046"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:205-11"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2337
      "formatos" => array:3 [
        "EPUB" => 40
        "HTML" => 1483
        "PDF" => 814
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Clinical and Epidemiologic Profile of Melanoma Patients According To Sun Exposure Of The Tumor Site"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "205"
          "paginaFinal" => "211"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Perfil Cl&#237;nico y Epidemiol&#243;gico de los Pacientes con Melanoma Cut&#225;neo Seg&#250;n el Grado de Exposici&#243;n Solar de la Localizaci&#243;n del Melanoma"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Nagore, R&#46; Botella-Estrada, C&#46; Requena, C&#46; Serra-Guill&#233;n, A&#46; Martorell, L&#46; Hueso, B&#46; Llombart, O&#46; Sanmart&#237;n, C&#46; Guill&#233;n"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Nagore"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Botella-Estrada"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Requena"
            ]
            3 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Serra-Guill&#233;n"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Martorell"
            ]
            5 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Hueso"
            ]
            6 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Llombart"
            ]
            7 => array:2 [
              "nombre" => "O&#46;"
              "apellidos" => "Sanmart&#237;n"
            ]
            8 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Guill&#233;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700460?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700460/v1_201304241451/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219009700447"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70044-7"
    "estado" => "S300"
    "fechaPublicacion" => "2009-04-01"
    "aid" => "70044"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:190-200"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4132
      "formatos" => array:3 [
        "EPUB" => 34
        "HTML" => 1697
        "PDF" => 2401
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Consensus statement</span>"
      "titulo" => "Update of the Topical Treatment of Psoriasis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "190"
          "paginaFinal" => "200"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Revisi&#243;n Actualizada del Tratamiento T&#243;pico de la Psoriasis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;M&#46; Carrascosa, F&#46; Vanacloch, L&#46; Borrego, E&#46; Fern&#225;ndez-L&#243;pez, A&#46; Fuertes, L&#46; Rodr&#237;guez-Fern&#225;ndez-Freire, A&#46; Zulaica, A&#46; Tuneu, G&#46; Caball&#233;, E&#46; Colom&#233;, X&#46; Bordas, J&#46;M&#46; Hernanz, C&#46; Brufau, E&#46; Herrera"
          "autores" => array:14 [
            0 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Carrascosa"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Vanacloch"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Borrego"
            ]
            3 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Fern&#225;ndez-L&#243;pez"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Fuertes"
            ]
            5 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Rodr&#237;guez-Fern&#225;ndez-Freire"
            ]
            6 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Zulaica"
            ]
            7 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tuneu"
            ]
            8 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Caball&#233;"
            ]
            9 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Colom&#233;"
            ]
            10 => array:2 [
              "nombre" => "X&#46;"
              "apellidos" => "Bordas"
            ]
            11 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Hernanz"
            ]
            12 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Brufau"
            ]
            13 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Herrera"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700447?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700447/v1_201304241451/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Contact Sensitization to Euxyl K400"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "201"
        "paginaFinal" => "204"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;T&#46; Bordel-G&#243;mez, A&#46; Miranda-Romero"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "M&#46;T&#46;"
            "apellidos" => "Bordel-G&#243;mez"
            "email" => array:1 [
              0 => "matebordel&#64;yahoo&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Miranda-Romero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Complejo Asistencial Virgen de la Concha&#44; Zamora"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; Facultad de Medicina&#44; Valladolid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Dermatolog&#237;a&#44; Hospital Virgen de la Concha&#44; Avda&#46; Requejo&#44; 35&#44; 9022 Zamora&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sensibilizaci&#243;n de Contacto al Euxyl K-400"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2008-04-21"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84430"
          "palabras" => array:4 [
            0 => "contact allergic dermatitis"
            1 => "Euxyl K400"
            2 => "methyldibromo glutaronitrile"
            3 => "2-phenoxyethanol"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84429"
          "palabras" => array:4 [
            0 => "dermatitis al&#233;rgica de contacto"
            1 => "Euxyl K-400"
            2 => "metildibromo glutaronitrilo"
            3 => "2-fenoxietanol"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Euxyl K400 is a widely used preservative in cosmetics&#44; topical drugs&#44; cutting fluids&#44; etc&#46; This antimicrobial product has two active components&#8212;methyldibromo glutaronitrile &#40;MDGN&#41;&#44; also known as 1&#44;2-dibromo-2&#44;4-dicyanobutane&#44; and 2-phenoxyethanol&#44; in a proportion of 1 to 4&#46;The aim of this study was to assess the prevalence of sensitization to this preservative in cases in our dermatology department over a 5-year period&#46; We also assessed the prevalence of sensitization to the two active components of Euxyl K400 and calculated the agreement with sensitization to Euxyl K400&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">In this retrospective study&#44; we analyzed the medical records of 1&#44;092 patients attended in our skin allergy unit between January 2000 and December 2005&#46;We undertook testing with a standard battery that included&#44; in addition to the allergens recommended by the Spanish Group for Research Into Dermatitis and Skin Allergies &#40;GEIDAC&#41;&#44; 0&#46;3&#37; MDGN and 1&#37; 2-phenoxyethanol in Vaseline &#40;Trolab<span class="elsevierStyleSup">&#174;</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Only 15 patients developed a positive reaction to Euxyl K400&#46; Of these&#44; 11 were positive to MDGN and 2 to phenoxyethanol&#46; Sensitization to Euxyl K400 was significantly more common in men&#46; The agreement between sensitization to Euxyl K400 and MDGN was good &#40;Kp &#61; 0&#46;68&#41;&#44; whereas agreement between Euxyl K400 and phenoxyethanol was poor &#40;Kp &#61; 0&#46;23&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of Euxyl K400 sensitization in this study was 1&#46;4&#37;&#46; Most cases of Euxyl K400 sensitization were associated with the MDGN component&#44; as indicated by the good agreement between the two substances&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">I</span>El Euxyl K-400 es un conservante muy utilizado en cosm&#233;ticos&#44; medicamentos de uso t&#243;pico&#44; fluidos de corte&#44; etc&#46; Este producto antimicrobiano consta de dos componentes activos&#58; metildibromoglutaronitrilo &#40;MDGN&#41;&#44; tambi&#233;n llamado 1&#44;2-dibromo-2&#44;4-dicianobutano&#44; y 2-fenoxietanol&#44; en una proporci&#243;n 1&#58;4&#46; El objetivo de este estudio fue evaluar la prevalencia de sensibilizaci&#243;n a este conservante en nuestro departamento de Dermatolog&#237;a&#44; en un per&#237;odo de 5 a&#241;os&#46; Evaluamos tambi&#233;n la prevalencia de sensibilizaci&#243;n de los dos componentes del Euxyl K-400 y calculamos la concordancia entre dichas sensibilizaciones&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado un estudio retrospectivo analizando las historias cl&#237;nicas de 1&#46;092 pacientes estudiados en nuestra unidad de Alergia Cut&#225;nea desde enero de 2000 hasta diciembre de 2005&#46; Realizamos pruebas con una bater&#237;a est&#225;ndar que conten&#237;a&#44; adem&#225;s de todos los al&#233;rgenos recomendados por el Grupo Espa&#241;ol de Investigaci&#243;n en Dermatitis y Alergia Cut&#225;nea &#40;GEIDAC&#41;&#44; el MDGN al 0&#44;3&#37; y el 2-fenoxietanol al 1&#37; en vaselina &#40;Trolab<span class="elsevierStyleSup">&#174;</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Solo 15 pacientes presentaron positividad al Euxyl K-400&#44; de los que 11 fueron positivos al MDGN y 2 al fenoxietanol&#46; La sensibilizaci&#243;n al Euxyl K-400 fue significativamente superior en los hombres&#46; La concordancia entre la sensibilizaci&#243;n al Euxyl K-400 y el MDGN fue buena &#40;Kp &#61; 0&#44;68&#41;&#44; mientras que la concordancia entre el Euxyl K-400 y el fenoxietanol solo fue regular &#40;Kp &#61; 0&#44;23&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de sensibilizaci&#243;n al Euxyl K-400 en nuestro estudio fue de 1&#44;4&#37;&#46; La mayor&#237;a de las sensibilizaciones al Euxyl K-400 se debe al componente MDGN&#44; hecho corroborado en nuestro trabajo&#44; en el que se observa una buena concordancia entre ambos al&#233;rgenos<span class="elsevierStyleItalic">&#46;</span></p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Euxyl K 400&#58; incidence of sensitization&#44; patch test concentration and vehicle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Tosti"
                            1 => "C&#46; Vincenzi"
                            2 => "P&#46; Trevisti"
                            3 => "L&#46; Guerra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1995"
                        "volumen" => "33"
                        "paginaInicial" => "193"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8565462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypersensitivity to preservatives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Sasseville"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1396-0296.2004.04028.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Ther"
                        "fecha" => "2004"
                        "volumen" => "17"
                        "paginaInicial" => "251"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15186371"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monitoring levels of preservative sensitivity in Europe&#46; A 10-year overview &#40;1991-2000&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Wilkinson"
                            1 => "S&#46; Shaw"
                            2 => "K&#46;E&#46; Andersen"
                            3 => "F&#46;M&#46; Brandao"
                            4 => "D&#46;P&#46; Bruynzeel"
                            5 => "M&#46; Bruze"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "207"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12081698"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510708026953"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sensitization studies in the guinea pig with the active ingredients of Euxyl K-400"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Bruze"
                            1 => "B&#46; Gruvberger"
                            2 => "G&#46; Agrup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1988"
                        "volumen" => "18"
                        "paginaInicial" => "37"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3349777"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709028338"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis features of atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Hanifin"
                            1 => "G&#46; Rajka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Dermato Venereol"
                        "fecha" => "1980"
                        "volumen" => "92"
                        "paginaInicial" => "44"
                        "paginaFinal" => "47"
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709020653"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for the descriptive presentation and statistical analysis of contact allergy data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Uter"
                            1 => "A&#46; Schnunch"
                            2 => "O&#46; Gefeller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0105-1873.2004.00406.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2004"
                        "volumen" => "51"
                        "paginaInicial" => "47"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15373843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased rate of patch test reactivity to methyldibromo glutaronitrile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; McFadden"
                            1 => "J&#46;S&#46; Ross"
                            2 => "A&#46;B&#46; Jones"
                            3 => "R&#46;J&#46; Rycroft"
                            4 => "H&#46;R&#46; Smith"
                            5 => "I&#46;R&#46; White"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2000"
                        "volumen" => "42"
                        "paginaInicial" => "54"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10644036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estudio epidemiol&#243;gico de la dermatitis al&#233;rgica de contacto en Espa&#241;a &#40;2001&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Garc&#237;a-Bravo"
                            1 => "L&#46; Conde-Salazar"
                            2 => "J&#46; de la Cuadra-Oyanguren"
                            3 => "V&#46; Fern&#225;ndez-Redondo"
                            4 => "J&#46;M&#46; Fern&#225;ndez-Vozmediano"
                            5 => "D&#46; Guimaraens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2004"
                        "volumen" => "95"
                        "paginaInicial" => "14"
                        "paginaFinal" => "24"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Euxyl K-400&#58; una revisi&#243;n de los &#250;ltimos 7 a&#241;os"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Gonz&#225;lez-Guerra"
                            1 => "F&#46; Heras-Mendaza"
                            2 => "M&#46;J&#46; Cabello-Herranz"
                            3 => "S&#46; V&#225;zquez-Cort&#233;s"
                            4 => "L&#46; Conde-Salazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actualidad Dermatol"
                        "fecha" => "2006"
                        "volumen" => "45"
                        "paginaInicial" => "329"
                        "paginaFinal" => "332"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Allergic contact dermatitis due to methyldibromo glutaronitrile in Euxyl K-400 in an ultrasonic gel"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Erdmann"
                            1 => "B&#46; Sachs"
                            2 => "H&#46;F&#46; Merk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2001"
                        "volumen" => "44"
                        "paginaInicial" => "57"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11156032"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Allergic contact dermatitis from methyldibromo glutaronitrile&#46; Clinical cases from 2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Zachariae"
                            1 => "J&#46;D&#46; Johansen"
                            2 => "S&#46;C&#46; Rastogi"
                            3 => "T&#46; Menn&#233;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0105-1873.2005.00478.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "6"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15701121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methyldibromoglutaronitrile is an important contact allergen in The Netherlands"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; De Groot"
                            1 => "P&#46;A&#46; de Cock"
                            2 => "P&#46;J&#46; Coenraads"
                            3 => "C&#46;J&#46; van Ginkel"
                            4 => "B&#46;A&#46; Jagtman"
                            5 => "T&#46; van Joost"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1996"
                        "volumen" => "34"
                        "paginaInicial" => "118"
                        "paginaFinal" => "120"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8681539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Occupational allergic contact dermatitis to methyldibromoglutaronitrile in hand degreasing toilet paper"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;E&#46; Marcano"
                            1 => "F&#46; Heras"
                            2 => "L&#46; Conde-Salazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0536.2006.01083.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "126"
                        "paginaFinal" => "127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17627659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The sensitizing potency of Euxyl<span class="elsevierStyleSup">&#174;</span> K 400 and its components 1&#44;2-dibromo-2&#44;4-dicyanobutane and 2-phenoxyethanol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;M&#46; Hausen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1993"
                        "volumen" => "28"
                        "paginaInicial" => "149"
                        "paginaFinal" => "153"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8462291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700459/v1_201304241451/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000003/v1_201304241451/S1578219009700459/v1_201304241451/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700459?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 3 9 12
2024 Octubre 60 55 115
2024 Septiembre 66 45 111
2024 Agosto 82 54 136
2024 Julio 57 42 99
2024 Junio 56 38 94
2024 Mayo 45 37 82
2024 Abril 67 31 98
2024 Marzo 49 42 91
2024 Febrero 58 50 108
2024 Enero 43 44 87
2023 Diciembre 38 56 94
2023 Noviembre 43 66 109
2023 Octubre 30 41 71
2023 Septiembre 31 34 65
2023 Agosto 22 32 54
2023 Julio 27 68 95
2023 Junio 25 37 62
2023 Mayo 33 41 74
2023 Abril 19 45 64
2023 Marzo 21 32 53
2023 Febrero 26 28 54
2023 Enero 22 44 66
2022 Diciembre 34 56 90
2022 Noviembre 19 41 60
2022 Octubre 19 29 48
2022 Septiembre 12 48 60
2022 Agosto 19 50 69
2022 Julio 12 36 48
2022 Junio 20 31 51
2022 Mayo 32 51 83
2022 Abril 44 61 105
2022 Marzo 27 62 89
2022 Febrero 30 37 67
2022 Enero 34 60 94
2021 Diciembre 27 50 77
2021 Noviembre 45 53 98
2021 Octubre 59 54 113
2021 Septiembre 45 51 96
2021 Agosto 25 43 68
2021 Julio 25 39 64
2021 Junio 28 29 57
2021 Mayo 22 41 63
2021 Abril 38 31 69
2021 Marzo 67 24 91
2021 Febrero 54 40 94
2021 Enero 35 28 63
2020 Diciembre 15 16 31
2020 Noviembre 29 26 55
2020 Octubre 16 7 23
2020 Septiembre 31 5 36
2020 Agosto 35 23 58
2020 Julio 24 18 42
2020 Junio 29 27 56
2020 Mayo 30 33 63
2020 Abril 34 25 59
2020 Marzo 27 28 55
2020 Febrero 6 7 13
2020 Enero 0 8 8
2019 Diciembre 0 11 11
2019 Noviembre 0 4 4
2019 Octubre 0 2 2
2019 Septiembre 0 3 3
2019 Agosto 0 2 2
2019 Julio 0 5 5
2019 Junio 0 6 6
2019 Mayo 0 42 42
2019 Abril 0 2 2
2019 Marzo 0 7 7
2019 Febrero 0 5 5
2018 Abril 0 5 5
2018 Marzo 0 1 1
2018 Febrero 9 4 13
2018 Enero 31 6 37
2017 Diciembre 17 8 25
2017 Noviembre 20 9 29
2017 Octubre 16 13 29
2017 Septiembre 21 7 28
2017 Agosto 25 18 43
2017 Julio 32 4 36
2017 Junio 36 17 53
2017 Mayo 18 20 38
2017 Abril 29 10 39
2017 Marzo 25 8 33
2017 Febrero 16 9 25
2017 Enero 17 16 33
2016 Diciembre 43 10 53
2016 Noviembre 34 12 46
2016 Octubre 31 27 58
2016 Septiembre 60 21 81
2016 Agosto 54 22 76
2016 Julio 37 9 46
2016 Junio 15 12 27
2016 Mayo 10 2 12
2016 Abril 7 21 28
2016 Marzo 6 1 7
2016 Febrero 12 20 32
2016 Enero 6 24 30
2015 Diciembre 6 13 19
2015 Noviembre 14 22 36
2015 Octubre 8 19 27
2015 Septiembre 8 18 26
2015 Agosto 19 7 26
2015 Julio 31 13 44
2015 Junio 48 14 62
2015 Mayo 63 21 84
2015 Abril 28 22 50
2015 Marzo 32 27 59
2015 Febrero 24 11 35
2015 Enero 28 8 36
2014 Diciembre 26 6 32
2014 Noviembre 24 18 42
2014 Octubre 45 24 69
2014 Septiembre 40 29 69
2014 Agosto 42 19 61
2014 Julio 56 22 78
2014 Junio 54 11 65
2014 Mayo 53 16 69
2014 Abril 49 12 61
2014 Marzo 64 21 85
2014 Febrero 50 19 69
2014 Enero 43 14 57
2013 Diciembre 46 8 54
2013 Noviembre 30 15 45
2013 Octubre 35 24 59
2013 Septiembre 32 17 49
2013 Agosto 25 20 45
2013 Julio 33 43 76
2013 Junio 23 19 42
2013 Mayo 20 22 42
2013 Abril 27 30 57
2013 Marzo 21 21 42
2013 Febrero 35 9 44
2013 Enero 53 3 56
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?