Novelties in dermatology
New Antibodies in Dermatomyositis
Nuevos Autoanticuerpos en la Dermatomiositis
I. Bielsa
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Servicio de Dermatología, Hospital Universitario Germans Trias i Pujol, Universidad Autónoma de Barcelona, Badalona, Barcelona, Spain
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"documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2009;100:166-81" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2925 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 1748 "PDF" => 1130 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Radiotherapy inb Dermatology" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "166" "paginaFinal" => "181" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Radioterapia en Dermatología" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Marín, E. Vargas-Díez, L. Cerezo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Marín" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Vargas-Díez" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Cerezo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700423?idApp=UINPBA000044" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700423/v1_201304241451/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Novelties in dermatology</span>" "titulo" => "New Antibodies in Dermatomyositis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "182" "paginaFinal" => "189" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Bielsa" "autores" => array:1 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Bielsa" "email" => array:1 [ 0 => "ibielsa.germanstrias@gencat.cat" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Germans Trias i Pujol, Universidad Autónoma de Barcelona, Badalona, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: C/ Molas, 8 08302 Mataró, Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nuevos Autoanticuerpos en la Dermatomiositis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84426" "palabras" => array:5 [ 0 => "idiopathic inflammatory myopathy" 1 => "polymyositis" 2 => "amyopathic dermatomyositis" 3 => "cancer-associated dermatomyositis" 4 => "myositis-specific antibodies" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84425" "palabras" => array:5 [ 0 => "miopatía inflamatoria idiopática" 1 => "polimiositis" 2 => "dermatomiositis amiopática" 3 => "dermatomiositis asociada a cáncer" 4 => "anticuerpos específicos de miositis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Dermatomyositis is an idiopathic inflammatory myopathy that affects skeletal muscle and the skin. Idiopathic inflammatory myopathies are characterized by the production of autoantibodies directed against different cell structures. Some of these autoantibodies are specific to idiopathic inflammatory myopathies (myositis-specific antibodies) whereas others are found in a range of overlap syndromes (myositis-associated antibodies). Although they are all associated with certain clinical and physiopathological characteristics of myositis, myositis-specific antibodies are essentially the most useful markers for clinical diagnosis, classification, and prognosis in idiopathic inflammatory myopathies. In recent years, two new myositis-specific antibodies–-in clinically amyopathic dermatomyositis (CADM), CADM-140 and, in cancer-associated dermatomyositis, anti-p155/p140–-have been identified. This is of great importance as no myositis-specific antibodies had previously been detected in these clinical subgroups. The identification of target antigens that are recognized by these antibodies is essential for a better understanding of the pathogenesis of these diseases.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La dermatomiositis es un tipo de miopatía inflamatoria idiopática que afecta al músculo esquelético y a la piel. Las miopatías inflamatorias idiopáticas se caracterizan por la producción de autoanticuerpos que se dirigen frente a diversas estructuras de la célula. Algunos de estos autoanticuerpos resultan específicos de las miopatías inflamatorias idiopáticas (anticuerpos específicos de miositis), mientras que otros se encuentran en diversos síndromes de solapamiento (anticuerpos asociados a miositis). Todos ellos determinan ciertas características clínicas y patofisiológicas de miositis, pero son principalmente los anticuerpos específicos de miositis los que constituyen marcadores muy útiles para el diagnóstico clínico, la clasificación y la predicción del pronóstico en las miopatías inflamatorias idiopáticas. En los últimos años se han identificado dos nuevos anticuerpos específicos de miositis, el anti-CADM-140 en la dermatomiositis amiopática y el anti-p155 y anti-p155/p140 en la dermatomiositis asociada a cáncer. Ello tiene una gran trascendencia ya que en estos subgrupos clínicos no se detectaban anticuerpos específicos de miositis. La identificación de los antígenos diana que reconocen estos anticuerpos resultará fundamental para comprender mejor la etiopatogenia de estas enfermedades.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymyositis, dermatomyositis and inclusion-body myositis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.C. 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| 2024 Junio | 71 | 51 | 122 |
| 2024 Mayo | 68 | 47 | 115 |
| 2024 Abril | 79 | 40 | 119 |
| 2024 Marzo | 76 | 45 | 121 |
| 2024 Febrero | 89 | 41 | 130 |
| 2024 Enero | 100 | 47 | 147 |
| 2023 Diciembre | 100 | 42 | 142 |
| 2023 Noviembre | 97 | 49 | 146 |
| 2023 Octubre | 70 | 42 | 112 |
| 2023 Septiembre | 57 | 29 | 86 |
| 2023 Agosto | 65 | 79 | 144 |
| 2023 Julio | 81 | 56 | 137 |
| 2023 Junio | 62 | 24 | 86 |
| 2023 Mayo | 56 | 23 | 79 |
| 2023 Abril | 47 | 19 | 66 |
| 2023 Marzo | 28 | 31 | 59 |
| 2023 Febrero | 40 | 22 | 62 |
| 2023 Enero | 48 | 27 | 75 |
| 2022 Diciembre | 49 | 37 | 86 |
| 2022 Noviembre | 35 | 30 | 65 |
| 2022 Octubre | 26 | 27 | 53 |
| 2022 Septiembre | 35 | 54 | 89 |
| 2022 Agosto | 16 | 44 | 60 |
| 2022 Julio | 19 | 28 | 47 |
| 2022 Junio | 13 | 25 | 38 |
| 2022 Mayo | 35 | 42 | 77 |
| 2022 Abril | 36 | 42 | 78 |
| 2022 Marzo | 29 | 51 | 80 |
| 2022 Febrero | 22 | 33 | 55 |
| 2022 Enero | 30 | 42 | 72 |
| 2021 Diciembre | 19 | 41 | 60 |
| 2021 Noviembre | 31 | 51 | 82 |
| 2021 Octubre | 34 | 41 | 75 |
| 2021 Septiembre | 20 | 45 | 65 |
| 2021 Agosto | 21 | 23 | 44 |
| 2021 Julio | 30 | 34 | 64 |
| 2021 Junio | 17 | 31 | 48 |
| 2021 Mayo | 20 | 35 | 55 |
| 2021 Abril | 21 | 34 | 55 |
| 2021 Marzo | 57 | 17 | 74 |
| 2021 Febrero | 59 | 23 | 82 |
| 2021 Enero | 28 | 18 | 46 |
| 2020 Diciembre | 21 | 6 | 27 |
| 2020 Noviembre | 34 | 18 | 52 |
| 2020 Octubre | 17 | 6 | 23 |
| 2020 Septiembre | 25 | 13 | 38 |
| 2020 Agosto | 30 | 24 | 54 |
| 2020 Julio | 31 | 12 | 43 |
| 2020 Junio | 34 | 29 | 63 |
| 2020 Mayo | 24 | 27 | 51 |
| 2020 Abril | 31 | 21 | 52 |
| 2020 Marzo | 22 | 23 | 45 |
| 2020 Febrero | 2 | 2 | 4 |
| 2020 Enero | 0 | 8 | 8 |
| 2019 Diciembre | 0 | 3 | 3 |
| 2019 Noviembre | 0 | 9 | 9 |
| 2019 Octubre | 0 | 2 | 2 |
| 2019 Septiembre | 0 | 4 | 4 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Julio | 0 | 6 | 6 |
| 2019 Mayo | 0 | 35 | 35 |
| 2019 Abril | 0 | 1 | 1 |
| 2019 Marzo | 0 | 2 | 2 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Mayo | 0 | 8 | 8 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 2 | 5 | 7 |
| 2018 Febrero | 11 | 9 | 20 |
| 2018 Enero | 20 | 6 | 26 |
| 2017 Diciembre | 31 | 8 | 39 |
| 2017 Noviembre | 23 | 6 | 29 |
| 2017 Octubre | 21 | 1 | 22 |
| 2017 Septiembre | 13 | 12 | 25 |
| 2017 Agosto | 24 | 12 | 36 |
| 2017 Julio | 26 | 6 | 32 |
| 2017 Junio | 33 | 11 | 44 |
| 2017 Mayo | 32 | 14 | 46 |
| 2017 Abril | 38 | 6 | 44 |
| 2017 Marzo | 36 | 16 | 52 |
| 2017 Febrero | 16 | 11 | 27 |
| 2017 Enero | 15 | 13 | 28 |
| 2016 Diciembre | 22 | 10 | 32 |
| 2016 Noviembre | 19 | 10 | 29 |
| 2016 Octubre | 20 | 15 | 35 |
| 2016 Septiembre | 46 | 8 | 54 |
| 2016 Agosto | 33 | 6 | 39 |
| 2016 Julio | 24 | 4 | 28 |
| 2016 Junio | 10 | 14 | 24 |
| 2016 Mayo | 11 | 28 | 39 |
| 2016 Abril | 8 | 17 | 25 |
| 2016 Marzo | 5 | 15 | 20 |
| 2016 Febrero | 9 | 15 | 24 |
| 2016 Enero | 11 | 17 | 28 |
| 2015 Diciembre | 16 | 14 | 30 |
| 2015 Noviembre | 17 | 15 | 32 |
| 2015 Octubre | 14 | 18 | 32 |
| 2015 Septiembre | 10 | 7 | 17 |
| 2015 Agosto | 11 | 2 | 13 |
| 2015 Julio | 47 | 16 | 63 |
| 2015 Junio | 39 | 8 | 47 |
| 2015 Mayo | 62 | 5 | 67 |
| 2015 Abril | 41 | 18 | 59 |
| 2015 Marzo | 45 | 14 | 59 |
| 2015 Febrero | 26 | 5 | 31 |
| 2015 Enero | 29 | 8 | 37 |
| 2014 Diciembre | 29 | 10 | 39 |
| 2014 Noviembre | 25 | 21 | 46 |
| 2014 Octubre | 39 | 13 | 52 |
| 2014 Septiembre | 35 | 14 | 49 |
| 2014 Agosto | 39 | 18 | 57 |
| 2014 Julio | 69 | 17 | 86 |
| 2014 Junio | 103 | 13 | 116 |
| 2014 Mayo | 58 | 13 | 71 |
| 2014 Abril | 67 | 8 | 75 |
| 2014 Marzo | 63 | 13 | 76 |
| 2014 Febrero | 46 | 16 | 62 |
| 2014 Enero | 47 | 15 | 62 |
| 2013 Diciembre | 54 | 17 | 71 |
| 2013 Noviembre | 38 | 21 | 59 |
| 2013 Octubre | 34 | 21 | 55 |
| 2013 Septiembre | 56 | 21 | 77 |
| 2013 Agosto | 28 | 18 | 46 |
| 2013 Julio | 38 | 23 | 61 |
| 2013 Junio | 31 | 22 | 53 |
| 2013 Mayo | 30 | 18 | 48 |
| 2013 Abril | 34 | 33 | 67 |
| 2013 Marzo | 47 | 23 | 70 |
| 2013 Febrero | 35 | 10 | 45 |
| 2013 Enero | 12 | 4 | 16 |
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