Original articles
Allergic Contact Dermatitis to Cosmetics
Dermatitis Alérgica de Contacto por Cosméticos
C. Laguna
, J. de la Cuadra, B. Martín-González, V. Zaragoza, L. Martínez-Casimiro, V. Alegre
Autor para correspondencia
cecipru@comv.es
Correspondence: Servicio de Dermatología, Hospital General Universitario de Valencia, Avda. Tres Cruces, s/n, 46014 Valencia, Spain.
Correspondence: Servicio de Dermatología, Hospital General Universitario de Valencia, Avda. Tres Cruces, s/n, 46014 Valencia, Spain.
Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain
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Ramos-e-Silva" "autores" => array:5 [ 0 => array:2 [ "nombre" => "A.L." "apellidos" => "Cardozo" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Moura-Castro" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Figueiredo" ] 3 => array:2 [ "nombre" => "T." "apellidos" => "Cuzzi" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Ramos-e-Silva" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700095?idApp=UINPBA000044" "url" => "/15782190/0000010000000001/v1_201304241446/S1578219009700095/v1_201304241446/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Allergic Contact Dermatitis to Cosmetics" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "53" "paginaFinal" => "60" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Laguna, J. de la Cuadra, B. Martín-González, V. Zaragoza, L. Martínez-Casimiro, V. Alegre" "autores" => array:6 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Laguna" "email" => array:1 [ 0 => "cecipru@comv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "J." "apellidos" => "de la Cuadra" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Martín-González" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Zaragoza" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Martínez-Casimiro" ] 5 => array:2 [ "nombre" => "V." "apellidos" => "Alegre" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital General Universitario de Valencia, Avda. Tres Cruces, s/n, 46014 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis Alérgica de Contacto por Cosméticos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-04-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84364" "palabras" => array:6 [ 0 => "ontact dermatitis" 1 => "cosmetics" 2 => "methylisothiazolinone" 3 => "paraphenylenediamine" 4 => "fragrances" 5 => "acrylates" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84363" "palabras" => array:6 [ 0 => "dermatitis de contacto" 1 => "cosméticos" 2 => "metilisotiazolinonas" 3 => "parafenilendiamina" 4 => "perfumes" 5 => "acrilatos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Contact dermatitis to cosmetics is a common problem in the general population, although its prevalence appears to be underestimated. We reviewed cases of allergic contact dermatitis to cosmetics diagnosed in our dermatology department over a 7-year period with a view to identifying the allergens responsible, the frequency of occurrence of these allergens, and the cosmetic products implicated.</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">Using the database of the skin allergy department, we undertook a search of all cases of allergic contact dermatitis to cosmetics diagnosed in our department from January 2000 through October 2007.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In this period, patch tests were carried out on 2485 patients, of whom 740 were diagnosed with allergic contact dermatitis and the cause was cosmetics in 202 of these patients (170 women and 32 men), who accounted for 27.3% of all cases. A total of 315 positive results were found for 46 different allergens. Allergens most often responsible for contact dermatitis in a cosmetics user were methylisothiazolinone (19%), paraphenylenediamine (15.2%), and fragrance mixtures (7.8%). Acrylates were the most common allergens in cases of occupational disease. Half of the positive results were obtained with the standard battery of the Spanish Group for Research Into Dermatitis and Skin Allergies (GEIDAC). The cosmetic products most often implicated among cosmetics users were hair dyes (18.5%), gels/soaps (15.7%), and moisturizing creams (12.7%).</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Most patients affected were women. Preservatives, paraphenylenediamine, and fragrances were the most frequently detected cosmetic allergens, in line with previous reports in the literature. Finally, in order to detect new cosmetic allergens, cooperation between physicians and cosmetics producers is needed.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La dermatitis de contacto por cosméticos es un problema frecuente entre la población general, sin embargo, parece ser que su prevalencia está infraestimada.</p><p class="elsevierStyleSimplePara elsevierViewall">Revisamos en este trabajo los casos de dermatitis de contacto alérgica por cosméticos diagnosticados en el Departamento de Dermatología en un periodo de 7 años con el objetivo de detectar los alergenos responsables, la frecuencia de los mismos, así como los productos cosméticos implicados.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Utilizando la base de datos de la sección de Alergia Cutánea se realiza una búsqueda de todos los casos de dermatitis de contacto alérgica por cosméticos diagnosticados en nuestro departamento entre enero de 2000 y octubre de 2007.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Durante este periodo se realizaron pruebas epicutáneas a 2.485 pacientes. De todos ellos, 740 fueron diagnosticados de una dermatitis de contacto alérgica, 202 pacientes (170 mujeres/32 varones), es decir, el 27,3% lo fueron por cosméticos. Se detectaron un total de 315 parches positivos y 46 alergenos diferentes. Los alergenos que con más frecuencia produjeron una dermatitis de contacto en el usuario fueron las metilisotiazolinonas (19%), la parafenilendiamina (15,2%) y la mezcla de perfumes (7,8%). Los acrilatos fueron los alergenos más frecuentes en aquellos casos que tenían un origen laboral. Con la batería estándar del Grupo Español en Investigación en Dermatitis y Alergia Cutánea (GEIDAC) se detectaron la mitad de las pruebas positivas. Los productos cosméticos implicados con mayor frecuencia en el usuario fueron los tintes capilares (18,5%), los geles/jabones (15,7%) y las cremas hidratantes (12,7%).</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p class="elsevierStyleSimplePara elsevierViewall">La mayoría de los pacientes afectados fueron mujeres. Los conservantes, la parafenilendiamina y los perfumes fueron los alergenos cosméticos más frecuentes, tal y como había sido publicado previamente en la literatura. Finalmente, con el objetivo de detectar nuevos alergenos cosméticos debe existir colaboración entre los facultativos y las casas comerciales.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "(GEIDC). 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 10 | 15 |
| 2024 Octubre | 59 | 86 | 145 |
| 2024 Septiembre | 58 | 56 | 114 |
| 2024 Agosto | 77 | 80 | 157 |
| 2024 Julio | 59 | 67 | 126 |
| 2024 Junio | 64 | 68 | 132 |
| 2024 Mayo | 51 | 45 | 96 |
| 2024 Abril | 55 | 42 | 97 |
| 2024 Marzo | 56 | 66 | 122 |
| 2024 Febrero | 47 | 61 | 108 |
| 2024 Enero | 47 | 52 | 99 |
| 2023 Diciembre | 48 | 51 | 99 |
| 2023 Noviembre | 52 | 72 | 124 |
| 2023 Octubre | 43 | 51 | 94 |
| 2023 Septiembre | 38 | 52 | 90 |
| 2023 Agosto | 31 | 39 | 70 |
| 2023 Julio | 29 | 81 | 110 |
| 2023 Junio | 37 | 54 | 91 |
| 2023 Mayo | 29 | 61 | 90 |
| 2023 Abril | 21 | 48 | 69 |
| 2023 Marzo | 21 | 56 | 77 |
| 2023 Febrero | 24 | 40 | 64 |
| 2023 Enero | 34 | 62 | 96 |
| 2022 Diciembre | 33 | 52 | 85 |
| 2022 Noviembre | 18 | 43 | 61 |
| 2022 Octubre | 20 | 31 | 51 |
| 2022 Septiembre | 11 | 55 | 66 |
| 2022 Agosto | 8 | 55 | 63 |
| 2022 Julio | 17 | 45 | 62 |
| 2022 Junio | 20 | 51 | 71 |
| 2022 Mayo | 24 | 52 | 76 |
| 2022 Abril | 30 | 63 | 93 |
| 2022 Marzo | 39 | 75 | 114 |
| 2022 Febrero | 17 | 63 | 80 |
| 2022 Enero | 27 | 55 | 82 |
| 2021 Diciembre | 25 | 50 | 75 |
| 2021 Noviembre | 19 | 55 | 74 |
| 2021 Octubre | 42 | 85 | 127 |
| 2021 Septiembre | 23 | 53 | 76 |
| 2021 Agosto | 14 | 42 | 56 |
| 2021 Julio | 24 | 56 | 80 |
| 2021 Junio | 21 | 51 | 72 |
| 2021 Mayo | 16 | 46 | 62 |
| 2021 Abril | 63 | 96 | 159 |
| 2021 Marzo | 57 | 50 | 107 |
| 2021 Febrero | 56 | 39 | 95 |
| 2021 Enero | 38 | 30 | 68 |
| 2020 Diciembre | 25 | 25 | 50 |
| 2020 Noviembre | 28 | 25 | 53 |
| 2020 Octubre | 31 | 30 | 61 |
| 2020 Septiembre | 17 | 27 | 44 |
| 2020 Agosto | 26 | 36 | 62 |
| 2020 Julio | 24 | 16 | 40 |
| 2020 Junio | 28 | 29 | 57 |
| 2020 Mayo | 19 | 26 | 45 |
| 2020 Abril | 28 | 31 | 59 |
| 2020 Marzo | 22 | 44 | 66 |
| 2020 Febrero | 4 | 10 | 14 |
| 2020 Enero | 0 | 11 | 11 |
| 2019 Diciembre | 0 | 16 | 16 |
| 2019 Noviembre | 0 | 18 | 18 |
| 2019 Octubre | 0 | 9 | 9 |
| 2019 Septiembre | 0 | 10 | 10 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 18 | 18 |
| 2019 Junio | 0 | 17 | 17 |
| 2019 Mayo | 1 | 42 | 43 |
| 2019 Abril | 0 | 27 | 27 |
| 2019 Marzo | 0 | 9 | 9 |
| 2019 Febrero | 0 | 5 | 5 |
| 2019 Enero | 0 | 1 | 1 |
| 2018 Diciembre | 0 | 5 | 5 |
| 2018 Noviembre | 0 | 1 | 1 |
| 2018 Septiembre | 0 | 3 | 3 |
| 2018 Agosto | 0 | 6 | 6 |
| 2018 Abril | 0 | 3 | 3 |
| 2018 Marzo | 0 | 9 | 9 |
| 2018 Febrero | 23 | 9 | 32 |
| 2018 Enero | 21 | 25 | 46 |
| 2017 Diciembre | 20 | 29 | 49 |
| 2017 Noviembre | 14 | 33 | 47 |
| 2017 Octubre | 17 | 30 | 47 |
| 2017 Septiembre | 18 | 17 | 35 |
| 2017 Agosto | 23 | 27 | 50 |
| 2017 Julio | 17 | 26 | 43 |
| 2017 Junio | 23 | 33 | 56 |
| 2017 Mayo | 23 | 47 | 70 |
| 2017 Abril | 22 | 36 | 58 |
| 2017 Marzo | 18 | 20 | 38 |
| 2017 Febrero | 13 | 36 | 49 |
| 2017 Enero | 11 | 22 | 33 |
| 2016 Diciembre | 24 | 16 | 40 |
| 2016 Noviembre | 29 | 35 | 64 |
| 2016 Octubre | 29 | 40 | 69 |
| 2016 Septiembre | 57 | 42 | 99 |
| 2016 Agosto | 50 | 35 | 85 |
| 2016 Julio | 41 | 33 | 74 |
| 2016 Junio | 15 | 16 | 31 |
| 2016 Mayo | 10 | 17 | 27 |
| 2016 Abril | 10 | 24 | 34 |
| 2016 Marzo | 6 | 26 | 32 |
| 2016 Febrero | 6 | 28 | 34 |
| 2016 Enero | 7 | 28 | 35 |
| 2015 Diciembre | 8 | 26 | 34 |
| 2015 Noviembre | 15 | 30 | 45 |
| 2015 Octubre | 19 | 1 | 20 |
| 2015 Septiembre | 11 | 5 | 16 |
| 2015 Agosto | 13 | 9 | 22 |
| 2015 Julio | 27 | 1 | 28 |
| 2015 Junio | 33 | 50 | 83 |
| 2015 Mayo | 46 | 46 | 92 |
| 2015 Abril | 41 | 43 | 84 |
| 2015 Marzo | 35 | 38 | 73 |
| 2015 Febrero | 19 | 29 | 48 |
| 2015 Enero | 29 | 28 | 57 |
| 2014 Diciembre | 25 | 25 | 50 |
| 2014 Noviembre | 28 | 40 | 68 |
| 2014 Octubre | 24 | 18 | 42 |
| 2014 Septiembre | 27 | 42 | 69 |
| 2014 Agosto | 41 | 20 | 61 |
| 2014 Julio | 37 | 22 | 59 |
| 2014 Junio | 46 | 22 | 68 |
| 2014 Mayo | 28 | 19 | 47 |
| 2014 Abril | 36 | 11 | 47 |
| 2014 Marzo | 42 | 50 | 92 |
| 2014 Febrero | 37 | 50 | 87 |
| 2014 Enero | 42 | 64 | 106 |
| 2013 Diciembre | 33 | 46 | 79 |
| 2013 Noviembre | 28 | 43 | 71 |
| 2013 Octubre | 26 | 51 | 77 |
| 2013 Septiembre | 34 | 79 | 113 |
| 2013 Agosto | 33 | 93 | 126 |
| 2013 Julio | 36 | 71 | 107 |
| 2013 Junio | 27 | 166 | 193 |
| 2013 Mayo | 28 | 261 | 289 |
| 2013 Abril | 20 | 123 | 143 |
| 2013 Marzo | 29 | 63 | 92 |
| 2013 Febrero | 39 | 27 | 66 |
| 2013 Enero | 23 | 5 | 28 |
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