Correspondence: Servicio de Dermatología, Hospital Vall d’Hebron, Paseo Vall d’Hebron 119-129 08035 Barcelona, Spain.
se ha leído el artículo
array:23 [ "pii" => "S1578219009700046" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70004-6" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70004" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2009;100:7-16" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3246 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 1436 "PDF" => 1773 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009700058" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70005-8" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70005" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:17-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2307 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 1405 "PDF" => 869 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actas 1909-2009</span>" "titulo" => "Actas Dermo-Sifiliográficas, Volume 1, Number 1" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "17" "paginaFinal" => "21" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Actas Dermo-Sifiliográficas,Año 1, Número 1" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. del Río" "autores" => array:1 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "del Río" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700058?idApp=UINPBA000044" "url" => "/15782190/0000010000000001/v1_201304241446/S1578219009700058/v1_201304241446/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009700034" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70003-4" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70003" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2009;100:3-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2361 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 1281 "PDF" => 1042 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion article</span>" "titulo" => "Narrowband Ultraviolet B Therapy in Psoriasis: Reality, Outlook, and Uncertainty" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "6" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.M. Carrascosa" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Carrascosa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700034?idApp=UINPBA000044" "url" => "/15782190/0000010000000001/v1_201304241446/S1578219009700034/v1_201304241446/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Anticoagulation and Antiplatelet Therapy in Dermatology" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "7" "paginaFinal" => "16" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Bassas, R. Bartralot, V. García-Patos" "autores" => array:3 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Bassas" "email" => array:1 [ 0 => "patriciabassas@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Bartralot" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "García-Patos" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Vall d’Hebron, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Vall d’Hebron, Paseo Vall d’Hebron 119-129 08035 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Anticoagulación y Antiagregación en Dermatología" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-04-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84360" "palabras" => array:6 [ 0 => "anticoagulants" 1 => "warfarin" 2 => "heparin" 3 => "surgery" 4 => "acetylsalicylic acid" 5 => "bleeding" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84359" "palabras" => array:6 [ 0 => "anticoagulantes" 1 => "warfarina" 2 => "heparina" 3 => "cirugía" 4 => "ácido acetilsalicílico" 5 => "sangrado" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">An increasing number of patients who are receiving anticoagulation or antiplatelet therapy require cutaneous surgery. Such pharmacotherapies are usually suspended based on experience in gynecologic, thoracic, and abdominal surgery. However, this practice may increase the risk of suffering a thromboembolic event. We review perioperative management of anticoagulant and antiplatelet therapy, complications associated with suspending therapy, and side effects.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Cada vez es mayor el número de pacientes que recibe tratamiento anticoagulante o antiagregante y que debe someterse a cirugía cutánea. Interrumpir estos tratamientos para prevenir el sangrado es una práctica habitual, extrapolada de las experiencias en cirugía ginecológica, torácica y abdominal. En este contexto, la suspensión de dichos tratamientos puede incrementar el riesgo de sufrir un evento tromboembólico. Realizamos una revisión sobre el manejo peroperatorio de los tratamientos anticoagulantes y antiagregantes, de las complicaciones acontecidas tras su suspensión, así como de sus efectos secundarios.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The management of patients on anticoagulants prior to cutaneous surgery: case report of a thromboembolic complication, review of the literature, and evidence-based recommendations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Khalifeh" 1 => "R. Redett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Plast Reconstr Surg" "fecha" => "2006" "volumen" => "118" "paginaInicial" => "110" "paginaFinal" => "117" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postoperative stroke after stopping warfarin for cutaneous surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.F. Schanbacher" 1 => "R.G. Bennet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2000" "volumen" => "26" "paginaInicial" => "785" "paginaFinal" => "789" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10940066" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioperative management of anticoagulants and platelet inhibitors for cutaneous surgery: a survey of current practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O. Kovich" 1 => "C.C. Otley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2002" "volumen" => "28" "paginaInicial" => "513" "paginaFinal" => "517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12081682" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Controversies in perioperative management of blood thinners in dermatologic surgery: continue or discontinue?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Alcalay" 1 => "R. Alkalay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2004.30333.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2004" "volumen" => "30" "paginaInicial" => "1091" "paginaFinal" => "1094" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15274698" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Hirsh" 1 => "J.E. Dalen" 2 => "D.R. Anderson" 3 => "L. Poller" 4 => "H. Bussey" 5 => "J. Ansell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2001" "volumen" => "119" "paginaInicial" => "8S" "paginaFinal" => "21S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11157640" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of anticoagulation before and after elective surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Kearon" 1 => "J. Hirsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "22" "paginaInicial" => "506" "paginaFinal" => "511" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous surgery in patients receiving warfarin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Alcalay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2001" "volumen" => "27" "paginaInicial" => "756" "paginaFinal" => "758" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11493301" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complications of cutaneous surgery in patients who are taking warfarin, aspirin, or nonsteroidal anti-inflammatory drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.C. Otley" 1 => "J.L. Fewkes" 2 => "W. Frank" 3 => "S.M. Olbricht" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1996" "volumen" => "132" "paginaInicial" => "161" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8629823" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complications of minor cutaneous surgery in patients under anticoagulant treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Kargi" 1 => "O. Babuccu" 2 => "M. Hosnuter" 3 => "B. Babuccu" 4 => "C. Altinyazar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Aesth Plast Surg" "fecha" => "2002" "volumen" => "26" "paginaInicial" => "483" "paginaFinal" => "485" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraoperative and postoperative bleeding problems in patients taking warfarin, aspirin, and nonsteroidal anti-inflammatory agents: a prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.M. Billingsley" 1 => "M.E. Maloney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "1997" "volumen" => "23" "paginaInicial" => "381" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9179249" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioperative monitoring of warfarin in cutaneous surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Ah-Weng" 1 => "S. Natarajan" 2 => "S. Velangi" 3 => "J.A.A. Langtry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "149" "paginaInicial" => "386" "paginaFinal" => "389" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12932248" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bleeding complications in skin cancer surgery are associated with warfarin but not aspirin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.J. Dixon" 1 => "M.P. Dixon" 2 => "J.B. Dixon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/bjs.5864" "Revista" => array:6 [ "tituloSerie" => "Br J Surg" "fecha" => "2007" "volumen" => "94" "paginaInicial" => "1356" "paginaFinal" => "1360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17654609" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postoperative bleeding and warfarin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Blasdale" 1 => "C.M. Lawrence" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08419.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "522" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18241270" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioperative management of the chronically anti-coagulated patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. Heit" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Thromb Thrombolysis" "fecha" => "2001" "volumen" => "77" "paginaInicial" => "81" "paginaFinal" => "87" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of perioperative enoxaparin versus unfractionated heparin on bleeding indices in patients undergoing coronary artery bypass grafting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.H. Kincaid" 1 => "M.L. Monroe" 2 => "D.L. Saliba" 3 => "N.D. Kon" 4 => "W.G. Byerly" 5 => "M.G. Reichert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2003" "volumen" => "76" "paginaInicial" => "124" "paginaFinal" => "128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12842525" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preoperative use of enoxaparin is not a risk factor for postoperative bleeding after coronary artery bypass surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Medalion" 1 => "G. Frenkel" 2 => "P. Patachenko" 3 => "E. Hauptman" 4 => "L. Sasson" 5 => "A. Schachner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0022" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2003" "volumen" => "126" "paginaInicial" => "1875" "paginaFinal" => "1879" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14688699" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of patients taking anticoagulant, aspirin, non-steroidal anti-inflammatory and other anti-platelet drugs undergoing dermatological surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Stables" 1 => "C.M. Lawrence" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2002" "volumen" => "27" "paginaInicial" => "432" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12372076" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Buvanendran" 1 => "J.S. Kroin" 2 => "K.J. Tuman" 3 => "T.R. Lubenow" 4 => "D. Elmofty" 5 => "M. Moric" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.290.18.2411" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2003" "volumen" => "290" "paginaInicial" => "2411" "paginaFinal" => "2418" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14612477" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does aspirin affect the outcome of minor cutaneous surgery?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.R. Bartlett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Plast Surg" "fecha" => "2001" "volumen" => "54" "paginaInicial" => "214" "paginaFinal" => "216" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of aspirin and nonsteroidal anti-inflammatory drug therapy on bleeding complications in dermatological surgery patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Lawrence" 1 => "A. Sakuntabhai" 2 => "S. Tiling-Grosse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1994" "volumen" => "31" "paginaInicial" => "988" "paginaFinal" => "992" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7962782" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ticlopidine and clopidogrel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.J. Quinn" 1 => "D.J. Fitzgerald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1999" "volumen" => "100" "paginaInicial" => "1667" "paginaFinal" => "1672" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10517740" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced skin, nail and hair disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Valeyrie-Allanore" 1 => "B. Sassolas" 2 => "J.C. Roujeau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drug Saf" "fecha" => "2007" "volumen" => "30" "paginaInicial" => "1011" "paginaFinal" => "1030" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17973540" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug eruption reference manual" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.Z. Litt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "10th ed." "fecha" => "2004" "editorial" => "Taylor and Francis" "editorialLocalizacion" => "London" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.J. Birchner" 1 => "T. Harr" 2 => "L. Hohenstein" 3 => "D.A. Tsakiris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2006.01227.x" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "1432" "paginaFinal" => "1440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17073874" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous necrosis induced by acenocumarol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Valdivielso" 1 => "I. Longo" 2 => "M. Lecona" 3 => "P. Lázaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2004" "volumen" => "18" "paginaInicial" => "211" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15009309" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late-onset warfarin-induced skin necrosis: case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.W. Essex" 1 => "S.S. Wynn" 2 => "D.K. Jin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hematol" "fecha" => "1998" "volumen" => "57" "paginaInicial" => "233" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9495376" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Purple toes syndrome associated with warfarin therapy in a patient with antiphospholipid syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.B. Talmadge" 1 => "A.C. Spyropoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacotherapy" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "674" "paginaFinal" => "677" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12741443" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An unusual cutaneous reaction to anticoagulant therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.P. Soisson" 1 => "K.K. Vu" 2 => "P.C. Brittain" 3 => "I. Chamales" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mil Med" "fecha" => "1994" "volumen" => "159" "paginaInicial" => "252" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7518893" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maculopapular rash due to coumarin derivatives" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Kruis-de Vries" 1 => "B.H. Stricker" 2 => "P.J. Coenraads" 3 => "J.P. Nater" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatologica" "fecha" => "1989" "volumen" => "178" "paginaInicial" => "109" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2522402" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unusual cutaneous adverse reaction to warfarin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.J. Anthony" 1 => "S.K. Krick" 2 => "P.M. Mehta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "South Med J" "fecha" => "1993" "volumen" => "86" "paginaInicial" => "1413" "paginaFinal" => "1414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8272925" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute generalized exanthematous pustulosis from dalteparin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Komericki" 1 => "R. Grims" 2 => "B. Kränke" 3 => "W. Aberer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.05.025" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "718" "paginaFinal" => "721" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17610994" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heparin-induced thrombocytopenia: pathophysiology and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Mureebe" 1 => "D. Silver" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Vasc Endovascular Surg" "fecha" => "2002" "volumen" => "36" "paginaInicial" => "163" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12075381" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low-molecular-weight heparin-induced skin necrosis: a potential association with pre-existent hypercoagulable states" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Toll" 1 => "F. Gallardo" 2 => "E. Abella" 3 => "J. Fontcuberta" 4 => "C. Barranco" 5 => "R.M. Pujol" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2004.02326.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "964" "paginaFinal" => "966" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16336536" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heparin-induced thrombocytopenia: a ten-year retrospective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.E. Warkentin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.med.50.1.129" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Med" "fecha" => "1999" "volumen" => "50" "paginaInicial" => "129" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10073268" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergy to heparin, heparinoids, and recombinant hirudin. Diagnostic and therapeutic alternatives" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "U. Jappe" 1 => "H. Gollnick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Hautartzt" "fecha" => "1999" "volumen" => "50" "paginaInicial" => "406" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "CAPRIE Steering Comittee" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1996" "volumen" => "348" "paginaInicial" => "1329" "paginaFinal" => "1339" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8918275" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Zakarija" 1 => "N. Bandarenko" 2 => "D.K. Pandey" 3 => "A. Auerbach" 4 => "D.W. Raisch" 5 => "B. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.STR.0000109253.66918.5E" "Revista" => array:6 [ "tituloSerie" => "Stroke" "fecha" => "2004" "volumen" => "35" "paginaInicial" => "533" "paginaFinal" => "537" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14707231" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Suberythrodermic pustular psoriasis induced by clopidogrel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Meissner" 1 => "C. Beier" 2 => "M. Wolter" 3 => "R. Kaufmann" 4 => "J. Gille" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07370.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "155" "paginaInicial" => "627" "paginaFinal" => "644" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16911294" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel bisulphate-induced photosensitive lichenoid eruption: first report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Dogra" 1 => "A.J. Kanwar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "148" "paginaInicial" => "609" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12653774" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel-induced hypersensitivity syndrome associated with febrile pancytopenia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Comert" 1 => "S. Akgun" 2 => "A. Civelek" 3 => "M. Kavala" 4 => "S. Sarigül" 5 => "T. Yildirim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2005.02366b.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "882" "paginaFinal" => "884" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16207199" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.P. Doogue" 1 => "E.J. Begg" 2 => "P. Bridgman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Mayo Clinic Proc" "fecha" => "2005" "volumen" => "80" "paginaInicial" => "1368" "paginaFinal" => "1370" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasculitis leucocitoclástica en relación con ticlopidina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Pintor" 1 => "M. Sanmartín" 2 => "L. Azcona" 3 => "R. Hernández" 4 => "A. Fernández-Cruz" 5 => "C. Macaya" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2001" "volumen" => "54" "paginaInicial" => "114" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11141463" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rash in patients receiving ticlopidine after coronary stent placement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.R. Whetsel" 1 => "D.M. Bell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacotherapy" "fecha" => "1999" "volumen" => "19" "paginaInicial" => "228" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10030774" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Fukushima" 1 => "Y. Kobayashi" 2 => "T. Okuno" 3 => "Y. Nakamura" 4 => "M. Sakakibara" 5 => "T. Nakayama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Circ J" "fecha" => "2007" "paginaInicial" => "617" "paginaFinal" => "619" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fixed drug eruption from ticlopidine, with positive lesional patch test" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. García" 1 => "R. Carmena" 2 => "R. García" 3 => "P. Berges" 4 => "E. Camacho" 5 => "M.P. Cotter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2001" "volumen" => "44" "paginaInicial" => "40" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11156015" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxic erythroderma due to ticlopidine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.H. His" 1 => "D.J. Mock" 2 => "T.A. Rocco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199904153401514" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "340" "paginaInicial" => "1212" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10206848" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse cutaneous reactions to ticlopidine in patients with coronary stents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Yosipovitz" 1 => "E. Rechavia" 2 => "M. Feinmesser" 3 => "M. David" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "473" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10459126" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lichen planus-type drug eruption resulting from ticlopidine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I. Kurokawa" 1 => "M. Umehara" 2 => "S. Nishijima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2005.02277.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "437" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15869549" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A paradoxical side-effect of antiaggregating treatment with ticlopidine: the Moschowitz syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Fabris" 1 => "G. Luzzatto" 2 => "M.T. Sartori" 3 => "I. Zanella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Haematologica" "fecha" => "1999" "volumen" => "84" "paginaInicial" => "760" "paginaFinal" => "762" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10457422" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thrombotic thrombocytopenic purpura associated with ticlopidine: a review of 60 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.L. Bennet" 1 => "P.D. Weinberg" 2 => "K. Rozenberg-Ben-Dor" 3 => "R.D. Yarnold" 4 => "H.C. Kwaan" 5 => "D. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1998" "volumen" => "128" "paginaInicial" => "541" "paginaFinal" => "544" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9518398" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526010000166" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of surgical patients receiving anticoagulation and antiplatelet agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Thachil" 1 => "A. Gatt" 2 => "V. Martlew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/bjs.6381" "Revista" => array:6 [ "tituloSerie" => "Br J Surg" "fecha" => "2008" "volumen" => "95" "paginaInicial" => "1437" "paginaFinal" => "1448" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18991253" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000001/v1_201304241446/S1578219009700046/v1_201304241446/en/main.assets" "Apartado" => array:4 [ "identificador" => "6224" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000001/v1_201304241446/S1578219009700046/v1_201304241446/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700046?idApp=UINPBA000044" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 7 | 8 | 15 |
2024 Octubre | 71 | 63 | 134 |
2024 Septiembre | 73 | 56 | 129 |
2024 Agosto | 94 | 76 | 170 |
2024 Julio | 80 | 59 | 139 |
2024 Junio | 70 | 60 | 130 |
2024 Mayo | 71 | 62 | 133 |
2024 Abril | 65 | 45 | 110 |
2024 Marzo | 56 | 54 | 110 |
2024 Febrero | 47 | 51 | 98 |
2024 Enero | 44 | 69 | 113 |
2023 Diciembre | 43 | 96 | 139 |
2023 Noviembre | 41 | 94 | 135 |
2023 Octubre | 47 | 61 | 108 |
2023 Septiembre | 36 | 62 | 98 |
2023 Agosto | 27 | 45 | 72 |
2023 Julio | 39 | 93 | 132 |
2023 Junio | 37 | 55 | 92 |
2023 Mayo | 39 | 78 | 117 |
2023 Abril | 26 | 70 | 96 |
2023 Marzo | 33 | 62 | 95 |
2023 Febrero | 29 | 50 | 79 |
2023 Enero | 29 | 65 | 94 |
2022 Diciembre | 32 | 57 | 89 |
2022 Noviembre | 15 | 44 | 59 |
2022 Octubre | 12 | 39 | 51 |
2022 Septiembre | 14 | 57 | 71 |
2022 Agosto | 19 | 47 | 66 |
2022 Julio | 12 | 54 | 66 |
2022 Junio | 16 | 58 | 74 |
2022 Mayo | 22 | 68 | 90 |
2022 Abril | 24 | 78 | 102 |
2022 Marzo | 28 | 79 | 107 |
2022 Febrero | 19 | 76 | 95 |
2022 Enero | 27 | 67 | 94 |
2021 Diciembre | 44 | 62 | 106 |
2021 Noviembre | 32 | 70 | 102 |
2021 Octubre | 28 | 77 | 105 |
2021 Septiembre | 25 | 83 | 108 |
2021 Agosto | 24 | 57 | 81 |
2021 Julio | 55 | 42 | 97 |
2021 Junio | 26 | 60 | 86 |
2021 Mayo | 40 | 57 | 97 |
2021 Abril | 65 | 106 | 171 |
2021 Marzo | 73 | 43 | 116 |
2021 Febrero | 67 | 57 | 124 |
2021 Enero | 52 | 28 | 80 |
2020 Diciembre | 23 | 31 | 54 |
2020 Noviembre | 37 | 28 | 65 |
2020 Octubre | 38 | 23 | 61 |
2020 Septiembre | 15 | 19 | 34 |
2020 Agosto | 30 | 35 | 65 |
2020 Julio | 43 | 33 | 76 |
2020 Junio | 23 | 37 | 60 |
2020 Mayo | 25 | 36 | 61 |
2020 Abril | 34 | 29 | 63 |
2020 Marzo | 24 | 42 | 66 |
2020 Febrero | 1 | 17 | 18 |
2020 Enero | 0 | 37 | 37 |
2019 Diciembre | 0 | 38 | 38 |
2019 Noviembre | 0 | 19 | 19 |
2019 Octubre | 0 | 22 | 22 |
2019 Septiembre | 0 | 9 | 9 |
2019 Agosto | 0 | 9 | 9 |
2019 Julio | 0 | 17 | 17 |
2019 Junio | 0 | 10 | 10 |
2019 Mayo | 0 | 48 | 48 |
2019 Abril | 0 | 15 | 15 |
2019 Marzo | 0 | 3 | 3 |
2019 Febrero | 0 | 11 | 11 |
2019 Enero | 0 | 2 | 2 |
2018 Diciembre | 0 | 2 | 2 |
2018 Septiembre | 0 | 12 | 12 |
2018 Agosto | 0 | 22 | 22 |
2018 Julio | 0 | 16 | 16 |
2018 Junio | 0 | 12 | 12 |
2018 Mayo | 0 | 8 | 8 |
2018 Abril | 0 | 9 | 9 |
2018 Marzo | 0 | 10 | 10 |
2018 Febrero | 8 | 23 | 31 |
2018 Enero | 14 | 20 | 34 |
2017 Diciembre | 12 | 20 | 32 |
2017 Noviembre | 15 | 24 | 39 |
2017 Octubre | 14 | 22 | 36 |
2017 Septiembre | 12 | 33 | 45 |
2017 Agosto | 25 | 22 | 47 |
2017 Julio | 11 | 31 | 42 |
2017 Junio | 16 | 47 | 63 |
2017 Mayo | 18 | 24 | 42 |
2017 Abril | 24 | 21 | 45 |
2017 Marzo | 41 | 47 | 88 |
2017 Febrero | 12 | 16 | 28 |
2017 Enero | 13 | 13 | 26 |
2016 Diciembre | 23 | 12 | 35 |
2016 Noviembre | 28 | 29 | 57 |
2016 Octubre | 25 | 28 | 53 |
2016 Septiembre | 28 | 25 | 53 |
2016 Agosto | 32 | 35 | 67 |
2016 Julio | 22 | 11 | 33 |
2016 Junio | 7 | 10 | 17 |
2016 Mayo | 6 | 10 | 16 |
2016 Abril | 7 | 10 | 17 |
2016 Marzo | 7 | 11 | 18 |
2016 Febrero | 10 | 12 | 22 |
2016 Enero | 13 | 10 | 23 |
2015 Diciembre | 7 | 10 | 17 |
2015 Noviembre | 16 | 12 | 28 |
2015 Octubre | 11 | 16 | 27 |
2015 Septiembre | 6 | 2 | 8 |
2015 Agosto | 18 | 5 | 23 |
2015 Julio | 32 | 31 | 63 |
2015 Junio | 31 | 25 | 56 |
2015 Mayo | 56 | 33 | 89 |
2015 Abril | 28 | 36 | 64 |
2015 Marzo | 33 | 39 | 72 |
2015 Febrero | 15 | 22 | 37 |
2015 Enero | 17 | 30 | 47 |
2014 Diciembre | 26 | 28 | 54 |
2014 Noviembre | 21 | 35 | 56 |
2014 Octubre | 30 | 24 | 54 |
2014 Septiembre | 23 | 23 | 46 |
2014 Agosto | 48 | 27 | 75 |
2014 Julio | 41 | 25 | 66 |
2014 Junio | 46 | 11 | 57 |
2014 Mayo | 39 | 18 | 57 |
2014 Abril | 27 | 17 | 44 |
2014 Marzo | 38 | 25 | 63 |
2014 Febrero | 32 | 27 | 59 |
2014 Enero | 26 | 27 | 53 |
2013 Diciembre | 27 | 22 | 49 |
2013 Noviembre | 26 | 24 | 50 |
2013 Octubre | 33 | 21 | 54 |
2013 Septiembre | 32 | 26 | 58 |
2013 Agosto | 27 | 35 | 62 |
2013 Julio | 27 | 35 | 62 |
2013 Junio | 26 | 38 | 64 |
2013 Mayo | 22 | 35 | 57 |
2013 Abril | 22 | 40 | 62 |
2013 Marzo | 37 | 26 | 63 |
2013 Febrero | 36 | 14 | 50 |
2013 Enero | 11 | 5 | 16 |