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    "titulo" => "Indications for Lumbar Puncture in Patients With Early Active Syphilis and Human Immunodeficiency Virus Coinfection&#58; Experience in a Tertiary Level Hospital in La Coru&#241;a&#44; Spain&#44; 2003-2006"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">In the last years&#44; the incidence of syphilis has incremented in Spain and coinfection with HIV occurs in a high percentage&#46; In HIV-infected patients with syphilis&#44; neurological complications&#44; treatment failure and relapse appear to be slightly raised&#46; Therefore&#44; careful follow-up must be carried out because of the risk of developing neurosyphilis&#46; According to the guidelines&#44; lumbar puncture &#40;LP&#41; is indicated in HIV-infected patients with late latent syphilis or syphilis of unknown duration&#44; but it is discussed in HIV-infected patients with early active syphilis&#46; Recent research has been developed in order to determine clinical and analytical findings for identification of patients with high neurosyphilis risk&#46; We review different opinions about this topic and report our experience&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We have performed LP in all HIV-infected patients with early active syphilis during 2003-2006&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Of the eight studied patients&#44; none met criteria for neurosyphilis&#46; Three of eight &#40;38&#37;&#41; had a peripheral blood CD4 cell count CD4 &#43; &#8804; 350 cells&#47;&#956;L&#46; Seven of eight &#40;87&#8217;5&#37;&#41; had RPR &#8805; 1&#58;32&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">In these patients&#44; performance of LP could be over indicated because of lack of well-established criterion&#46; Our results are in agreement over to recent studies which restrict indication of LP to specific groups&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">En los &#250;ltimos a&#241;os se ha incrementado la incidencia de s&#237;filis en Espa&#241;a&#46; En un porcentaje importante existe coinfecci&#243;n con el virus de la inmunodeficiencia humana &#40;VIH&#41;&#46; Dado que estos pacientes tienen mayor riesgo de complicaciones neurol&#243;gicas y de fracaso del tratamiento&#44; hay que seguirlos cuidadosamente por el riesgo de desarrollar neuros&#237;filis&#46; En los pacientes coinfectados por el VIH &#8211;si bien las gu&#237;as coinciden en realizar punci&#243;n lumbar en aquellos con s&#237;filis latente tard&#237;a o de duraci&#243;n incierta&#8211; la indicaci&#243;n en pacientes con s&#237;filis precoz activa es controvertida&#46; Recientemente se han realizado estudios para determinar par&#225;metros cl&#237;nicos o anal&#237;ticos que identifiquen a aquellos pacientes que se beneficiar&#237;an de la punci&#243;n lumbar&#46; Exponemos las diversas opiniones y aportamos la experiencia en nuestro servicio&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado punci&#243;n lumbar de forma sistem&#225;tica a todos los pacientes con s&#237;filis precoz activa coinfectados por el VIH en el periodo 2003-2006&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En el 100&#37; no se objetiv&#243; neuros&#237;filis en LCR&#44; y los par&#225;metros entraban dentro de la normalidad o eran compatibles con la infecci&#243;n por el VIH&#46; Un 38&#37; present&#243; un recuento de linfocitos CD4 &#43; &#8804; 350 y un 87&#44;5&#37; ten&#237;a una titulaci&#243;n en suero RPR &#8805; 1&#58;32&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Es posible que en la pr&#225;ctica cl&#237;nica se abuse de la realizaci&#243;n de PL en estos pacientes&#44; debido a la ausencia de criterios bien definidos&#46; Nuestros datos est&#225;n en correlaci&#243;n con los criterios actuales que apoyan la idea de restringir la realizaci&#243;n de PL a determinados grupos&#46;</p>"
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Original articles
Indications for Lumbar Puncture in Patients With Early Active Syphilis and Human Immunodeficiency Virus Coinfection: Experience in a Tertiary Level Hospital in La Coruña, Spain, 2003-2006
Indicaciones de la Punción Lumbar en Pacientes con Sífilis Precoz Activa Coinfectados por el VIH. Casuística en un Hospital Terciario de la Coruña (España) 2003-2006
M. Mazaira
Autor para correspondencia
martamazaira@hotmail.com

Correspondence: Servicio de Dermatología, Hospital Juan Canalejo, Xubias de Arriba, 84, 15006 La Coruña, Spain.
, M. Almagro, E. Fonseca
Servicio de Dermatología, Complejo Hospitalario Universitario Juan Canalejo, La Coruña, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">In the last years&#44; the incidence of syphilis has incremented in Spain and coinfection with HIV occurs in a high percentage&#46; In HIV-infected patients with syphilis&#44; neurological complications&#44; treatment failure and relapse appear to be slightly raised&#46; Therefore&#44; careful follow-up must be carried out because of the risk of developing neurosyphilis&#46; According to the guidelines&#44; lumbar puncture &#40;LP&#41; is indicated in HIV-infected patients with late latent syphilis or syphilis of unknown duration&#44; but it is discussed in HIV-infected patients with early active syphilis&#46; Recent research has been developed in order to determine clinical and analytical findings for identification of patients with high neurosyphilis risk&#46; We review different opinions about this topic and report our experience&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We have performed LP in all HIV-infected patients with early active syphilis during 2003-2006&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Of the eight studied patients&#44; none met criteria for neurosyphilis&#46; Three of eight &#40;38&#37;&#41; had a peripheral blood CD4 cell count CD4 &#43; &#8804; 350 cells&#47;&#956;L&#46; Seven of eight &#40;87&#8217;5&#37;&#41; had RPR &#8805; 1&#58;32&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">In these patients&#44; performance of LP could be over indicated because of lack of well-established criterion&#46; Our results are in agreement over to recent studies which restrict indication of LP to specific groups&#46;</p>"
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Información del artículo
ISSN: 15782190
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