array:23 [
  "pii" => "S1578219008703433"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(08)70343-3"
  "estado" => "S300"
  "fechaPublicacion" => "2008-11-01"
  "aid" => "70343"
  "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "rev"
  "cita" => "Actas Dermosifiliogr. 2008;99:671-82"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5506
    "formatos" => array:3 [
      "EPUB" => 32
      "HTML" => 1806
      "PDF" => 3668
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219008703445"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70344-5"
    "estado" => "S300"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "70344"
    "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:683-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6963
      "formatos" => array:3 [
        "EPUB" => 34
        "HTML" => 1544
        "PDF" => 5385
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>"
      "titulo" => "Antibiotic Prophylaxis in Dermatologic Surgery"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "683"
          "paginaFinal" => "689"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Profilaxis Antibi&#243;tica en Cirug&#237;a Dermatol&#243;gica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Yuste, A&#46; Romo, P&#46; de Unamuno"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Yuste"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Romo"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "de Unamuno"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703445?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703445/v1_201304241441/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219008703421"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70342-1"
    "estado" => "S300"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "70342"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:669-70"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2022
      "formatos" => array:3 [
        "EPUB" => 38
        "HTML" => 1307
        "PDF" => 677
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Opinion article</span>"
      "titulo" => "Surgical Training of Dermatologists"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "669"
          "paginaFinal" => "670"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; Serrano"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Serrano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703421?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703421/v1_201304241441/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>"
    "titulo" => "Xerosis&#58; a Dysfunction of the Epidermal Barrier"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "671"
        "paginaFinal" => "682"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "D&#46; Barco, A&#46; Gim&#233;nez-Arnau"
        "autores" => array:2 [
          0 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Barco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Gim&#233;nez-Arnau"
            "email" => array:1 [
              0 => "agimenez&#64;imas&#46;imim&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Hospital del Mar-IMIM&#44; Barcelona Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Dermatolog&#237;a&#44; Hospital del Mar&#44; c&#47; Passeig Marit&#237;m&#44; 25-29&#44; 08003 Barcelona&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Xerosis&#58; una Disfunci&#243;n de la Barrera Epid&#233;rmica"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2008-02-27"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84294"
          "palabras" => array:5 [
            0 => "xerosis"
            1 => "dry skin"
            2 => "stratum corneum"
            3 => "ceramides"
            4 => "lipids"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84293"
          "palabras" => array:5 [
            0 => "xerosis"
            1 => "piel seca"
            2 => "estrato c&#243;rneo"
            3 => "ceramidas"
            4 => "l&#237;pidos"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Xerosis or dry skin is a common skin disorder among the general population&#46; It is characterized clinically by rough&#44; scaly&#44; and often itchy skin&#46; This disorder is present in the course of some dermatoses such as atopic dermatitis&#44; although it can also occur in healthy individuals if a combination of certain etiologic factors is present&#46; It is characterized pathophysiologically by a disrupted stratum corneum&#44; dehydration&#44; and impaired keratinocyte differentiation&#46; Treatment of xerosis should seek to restore physiologic lipids in the epidermis and provide substances that facilitate epidermal differentiation&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La xerosis o piel seca es un trastorno cut&#225;neo de alta prevalencia en la poblaci&#243;n general que se caracteriza cl&#237;nicamente por una piel &#225;spera&#44; descamativa y habitualmente pruriginosa&#46; Ciertas dermatosis como la dermatitis at&#243;pica cursan con este trastorno&#44; aunque puede presentarse en individuos sanos si coinciden varios factores etiol&#243;gicos&#46; Fisiopatol&#243;gicamente consiste en la modificaci&#243;n estructural del estrato c&#243;rneo&#44; su contenido en agua y un defecto en la diferenciaci&#243;n queratinocitaria&#46; El tratamiento de la xerosis debiera buscar la recomposici&#243;n de los l&#237;pidos fisiol&#243;gicos de la epidermis y el aporte de sustancias que faciliten la diferenciaci&#243;n epid&#233;rmica&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eczema&#44; ichthyosis&#44; psoriasis&#58; conditions of cornification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;R&#46; Burdette-Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ostomy Wound Manage"
                        "fecha" => "1995"
                        "volumen" => "41"
                        "paginaInicial" => "36"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7546119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The management of dry skin with topical emollients&#8211;recent perspectives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Proksch"
                            1 => "J&#46;M&#46; Lachapelle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1610-0387.2005.05068.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2005"
                        "volumen" => "3"
                        "paginaInicial" => "768"
                        "paginaFinal" => "774"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16194154"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholesterol synthesis is required for cutaneous barrier function in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;R&#46; Feingold"
                            1 => "M&#46; Mao-Quian"
                            2 => "G&#46;K&#46; Menon"
                            3 => "S&#46;S&#46; Cho"
                            4 => "B&#46;E&#46; Brown"
                            5 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI114899"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1990"
                        "volumen" => "86"
                        "paginaInicial" => "1738"
                        "paginaFinal" => "1745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2243142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipid content and lipid type as determinants of the epidermal permeability barrier"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Grubauer"
                            1 => "K&#46;R&#46; Feingold"
                            2 => "R&#46;M&#46; Harris"
                            3 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lipid Res"
                        "fecha" => "1989"
                        "volumen" => "30"
                        "paginaInicial" => "89"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2918253"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stratum corneum defensive functions&#58; an integrated view"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2005.23668.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "183"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16098026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between NMF &#40;lactate and potassium&#41; content and the physical properties of the stratum corneum in healthy subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Nakagawa"
                            1 => "S&#46; Sakai"
                            2 => "M&#46; Matsumoto"
                            3 => "K&#46; Yamada"
                            4 => "M&#46; Nagano"
                            5 => "T&#46; Yuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2004.22317.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2004"
                        "volumen" => "122"
                        "paginaInicial" => "755"
                        "paginaFinal" => "763"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15086563"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How to choose a suitable emollient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pharm J"
                        "fecha" => "2004"
                        "volumen" => "273"
                        "paginaInicial" => "351"
                        "paginaFinal" => "353"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stratum corneum moisturization at the molecular level&#58; an update in relation to the dry skin cycle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;V&#46; Rawlings"
                            1 => "P&#46;J&#46; Matts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1747.2005.23726.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "124"
                        "paginaInicial" => "1099"
                        "paginaFinal" => "1110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15955083"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low humidity and microtrauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;J&#46;G&#46; Rycroft"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ind Med"
                        "fecha" => "1985"
                        "volumen" => "8"
                        "paginaInicial" => "371"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4073035"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ceramide and cholesterol composition of the skin of patients with atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Di Nardo"
                            1 => "P&#46; Werz"
                            2 => "A&#46; Giannetti"
                            3 => "S&#46; Deidenari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Dermatol Venereol"
                        "fecha" => "1998"
                        "volumen" => "78"
                        "paginaInicial" => "27"
                        "paginaFinal" => "30"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Filaggrin mutations in children with severe atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Morar"
                            1 => "W&#46;O&#46; Cookson"
                            2 => "J&#46;I&#46; Harper"
                            3 => "M&#46;F&#46; Moffatt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.jid.5700739"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2007"
                        "volumen" => "127"
                        "paginaInicial" => "1667"
                        "paginaFinal" => "1672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17301831"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The content of free amino acids in the stratum corneum is increased in senile xerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Takahashi"
                            1 => "T&#46; Tezuka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00403-003-0448-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res"
                        "fecha" => "2004"
                        "volumen" => "295"
                        "paginaInicial" => "448"
                        "paginaFinal" => "452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14762669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content&#44; and the expression of the filaggrin in the epidermis of hairless mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Katagiri"
                            1 => "J&#46; Sato"
                            2 => "J&#46; Nomura"
                            3 => "M&#46; Denda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Sci"
                        "fecha" => "2003"
                        "volumen" => "31"
                        "paginaInicial" => "29"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12615361"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Signaling networks in barrier homeostasis&#58; the mystery widens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;M&#46; Elias"
                            1 => "J&#46;C&#46; Ansel"
                            2 => "L&#46;D&#46; Woods"
                            3 => "K&#46;R&#46; Feingold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1996"
                        "volumen" => "132"
                        "paginaInicial" => "1505"
                        "paginaFinal" => "1506"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8961883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal pathogenesis of inflammatory dermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Elias"
                            1 => "L&#46;D&#46; Woods"
                            2 => "K&#46;R&#46; Feingold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Contact Dermat"
                        "fecha" => "1999"
                        "volumen" => "10"
                        "paginaInicial" => "119"
                        "paginaFinal" => "126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10444104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low humidity occupational dermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;J&#46;G&#46; Rycroft"
                            1 => "W&#46;D&#46;L&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1980"
                        "volumen" => "6"
                        "paginaInicial" => "488"
                        "paginaFinal" => "492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6452248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seasonal variation of skin resistance to irritants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Agner"
                            1 => "J&#46; Serup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1989"
                        "volumen" => "121"
                        "paginaInicial" => "323"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2803958"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of xerosis and ageing on epidermal proliferation and differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Engelke"
                            1 => "J&#46;M&#46; Jensen"
                            2 => "S&#46; Ekanayake-Mudiyanselage"
                            3 => "E&#46; Proksch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1997"
                        "volumen" => "137"
                        "paginaInicial" => "219"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9292070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New perspectives on epidermal barrier dysfunction in atopic dermatitis&#58; geneenvironment interactions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Cork"
                            1 => "D&#46;A&#46; Robinson"
                            2 => "Y&#46; Vasilopoulos"
                            3 => "A&#46; Ferguson"
                            4 => "M&#46; Moustafa"
                            5 => "A&#46; MacGowan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2006.04.042"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2006"
                        "volumen" => "118"
                        "paginaInicial" => "3"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16815133"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Werner"
                            1 => "M&#46; Lindberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "1985"
                        "volumen" => "65"
                        "paginaInicial" => "102"
                        "paginaFinal" => "105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2408409"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673605678890"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the hydration and water binding capacity in atopic skin and so-called dry skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Thune"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "1989"
                        "volumen" => "144"
                        "numero" => "Suppl"
                        "paginaInicial" => "133"
                        "paginaFinal" => "135"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "X-linked ichthyosis due to steroid sulphatase deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;J&#46; Shapiro"
                            1 => "R Weiss"
                            2 => "Webster&#46;"
                            3 => "J&#46;T&#46; Frances"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1978"
                        "volumen" => "1"
                        "paginaInicial" => "70"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6140424"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholesterol sulphate inhibits proteases that are involved in desquamation of stratum corneum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Sato"
                            1 => "M&#46; Denda"
                            2 => "J&#46; Nakinishi"
                            3 => "J&#46; Nomura"
                            4 => "J&#46; Koyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.1998.00244.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1998"
                        "volumen" => "111"
                        "paginaInicial" => "189"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9699715"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatitis de manos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Ram&#237;rez"
                            1 => "S&#46;E&#46; Jacob"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2006"
                        "volumen" => "97"
                        "paginaInicial" => "363"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16956515"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis&#58; changes in barrier function provide a sensitive indicator of disease activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Chamlin"
                            1 => "J&#46; Kao"
                            2 => "I&#46;J&#46; Freiden"
                            3 => "M&#46;Y&#46; Sheu"
                            4 => "A&#46;J&#46; Fowler"
                            5 => "J&#46;W&#46; Fluhr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "198"
                        "paginaFinal" => "208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12140465"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glycerol replacement corrects defective skin hydration&#44; elasticity and barrier function in aquaporin-3-deficient mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Hara"
                            1 => "A&#46;S&#46; Verkman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.1230416100"
                      "Revista" => array:6 [
                        "tituloSerie" => "PNAS"
                        "fecha" => "2003"
                        "volumen" => "100"
                        "paginaInicial" => "7360"
                        "paginaFinal" => "7365"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12771381"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etude in vitro du pouvoir antiprurigineux du glycocolle&#58; effet sur la d&#233;granulation des mastocytes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Paubert-Braquet"
                            1 => "G&#46; Lefran&#231;ois"
                            2 => "S&#46; Picquot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Th&#233;rapeutique"
                        "fecha" => "1992"
                        "volumen" => "95"
                        "paginaInicial" => "2"
                        "paginaFinal" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies on wound healing&#58; effects of calcium pantothenate on the migration&#44; proliferation and protein synthesis of human dermal fibroblasts in culture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46;I&#46; Weimann"
                            1 => "D&#46; Hermann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1024/0300-9831.69.2.113"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Vitam Nutr Res"
                        "fecha" => "1999"
                        "volumen" => "69"
                        "paginaInicial" => "113"
                        "paginaFinal" => "119"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10218148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of pantothenic acid on fibroblastic cell cultures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Lacroix"
                            1 => "E&#46; Didier"
                            2 => "J&#46;F&#46; Grenier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Res Exp Med"
                        "fecha" => "1988"
                        "volumen" => "188"
                        "paginaInicial" => "391"
                        "paginaFinal" => "396"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of bepanthen ointment on the graft-donor site wound-healing model&#58; double-blind biometrological and clinical study&#44; with assessment by the patient versus the vehicle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Girard"
                            1 => "A&#46; Beraud"
                            2 => "C&#46; Goujon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nouv Dermatol"
                        "fecha" => "1998"
                        "volumen" => "17"
                        "paginaInicial" => "559"
                        "paginaFinal" => "570"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703433/v1_201304241441/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6224"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Review article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000009/v1_201304241441/S1578219008703433/v1_201304241441/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703433?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Review article
Xerosis: a Dysfunction of the Epidermal Barrier
Xerosis: una Disfunción de la Barrera Epidérmica
D. Barcoa, A. Giménez-Arnaub,
Autor para correspondencia
agimenez@imas.imim.es

Correspondence: Servicio de Dermatología, Hospital del Mar, c/ Passeig Maritím, 25-29, 08003 Barcelona.
a Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
b Departamento de Dermatología, Hospital del Mar-IMIM, Barcelona Spain
Leído
10918
Veces
se ha leído el artículo
6476
Total PDF
4442
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1578219008703433"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(08)70343-3"
  "estado" => "S300"
  "fechaPublicacion" => "2008-11-01"
  "aid" => "70343"
  "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "rev"
  "cita" => "Actas Dermosifiliogr. 2008;99:671-82"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5506
    "formatos" => array:3 [
      "EPUB" => 32
      "HTML" => 1806
      "PDF" => 3668
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219008703445"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70344-5"
    "estado" => "S300"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "70344"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:683-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6963
      "formatos" => array:3 [
        "EPUB" => 34
        "HTML" => 1544
        "PDF" => 5385
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>"
      "titulo" => "Antibiotic Prophylaxis in Dermatologic Surgery"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "683"
          "paginaFinal" => "689"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Profilaxis Antibi&#243;tica en Cirug&#237;a Dermatol&#243;gica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Yuste, A&#46; Romo, P&#46; de Unamuno"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Yuste"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Romo"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "de Unamuno"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703445?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703445/v1_201304241441/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219008703421"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(08)70342-1"
    "estado" => "S300"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "70342"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2008;99:669-70"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2022
      "formatos" => array:3 [
        "EPUB" => 38
        "HTML" => 1307
        "PDF" => 677
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Opinion article</span>"
      "titulo" => "Surgical Training of Dermatologists"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "669"
          "paginaFinal" => "670"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; Serrano"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Serrano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703421?idApp=UINPBA000044"
    "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703421/v1_201304241441/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>"
    "titulo" => "Xerosis&#58; a Dysfunction of the Epidermal Barrier"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "671"
        "paginaFinal" => "682"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "D&#46; Barco, A&#46; Gim&#233;nez-Arnau"
        "autores" => array:2 [
          0 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Barco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Gim&#233;nez-Arnau"
            "email" => array:1 [
              0 => "agimenez&#64;imas&#46;imim&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Hospital del Mar-IMIM&#44; Barcelona Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Dermatolog&#237;a&#44; Hospital del Mar&#44; c&#47; Passeig Marit&#237;m&#44; 25-29&#44; 08003 Barcelona&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Xerosis&#58; una Disfunci&#243;n de la Barrera Epid&#233;rmica"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2008-02-27"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84294"
          "palabras" => array:5 [
            0 => "xerosis"
            1 => "dry skin"
            2 => "stratum corneum"
            3 => "ceramides"
            4 => "lipids"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84293"
          "palabras" => array:5 [
            0 => "xerosis"
            1 => "piel seca"
            2 => "estrato c&#243;rneo"
            3 => "ceramidas"
            4 => "l&#237;pidos"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Xerosis or dry skin is a common skin disorder among the general population&#46; It is characterized clinically by rough&#44; scaly&#44; and often itchy skin&#46; This disorder is present in the course of some dermatoses such as atopic dermatitis&#44; although it can also occur in healthy individuals if a combination of certain etiologic factors is present&#46; It is characterized pathophysiologically by a disrupted stratum corneum&#44; dehydration&#44; and impaired keratinocyte differentiation&#46; Treatment of xerosis should seek to restore physiologic lipids in the epidermis and provide substances that facilitate epidermal differentiation&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La xerosis o piel seca es un trastorno cut&#225;neo de alta prevalencia en la poblaci&#243;n general que se caracteriza cl&#237;nicamente por una piel &#225;spera&#44; descamativa y habitualmente pruriginosa&#46; Ciertas dermatosis como la dermatitis at&#243;pica cursan con este trastorno&#44; aunque puede presentarse en individuos sanos si coinciden varios factores etiol&#243;gicos&#46; Fisiopatol&#243;gicamente consiste en la modificaci&#243;n estructural del estrato c&#243;rneo&#44; su contenido en agua y un defecto en la diferenciaci&#243;n queratinocitaria&#46; El tratamiento de la xerosis debiera buscar la recomposici&#243;n de los l&#237;pidos fisiol&#243;gicos de la epidermis y el aporte de sustancias que faciliten la diferenciaci&#243;n epid&#233;rmica&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eczema&#44; ichthyosis&#44; psoriasis&#58; conditions of cornification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;R&#46; Burdette-Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ostomy Wound Manage"
                        "fecha" => "1995"
                        "volumen" => "41"
                        "paginaInicial" => "36"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7546119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The management of dry skin with topical emollients&#8211;recent perspectives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Proksch"
                            1 => "J&#46;M&#46; Lachapelle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1610-0387.2005.05068.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2005"
                        "volumen" => "3"
                        "paginaInicial" => "768"
                        "paginaFinal" => "774"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16194154"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholesterol synthesis is required for cutaneous barrier function in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;R&#46; Feingold"
                            1 => "M&#46; Mao-Quian"
                            2 => "G&#46;K&#46; Menon"
                            3 => "S&#46;S&#46; Cho"
                            4 => "B&#46;E&#46; Brown"
                            5 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI114899"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1990"
                        "volumen" => "86"
                        "paginaInicial" => "1738"
                        "paginaFinal" => "1745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2243142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipid content and lipid type as determinants of the epidermal permeability barrier"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Grubauer"
                            1 => "K&#46;R&#46; Feingold"
                            2 => "R&#46;M&#46; Harris"
                            3 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lipid Res"
                        "fecha" => "1989"
                        "volumen" => "30"
                        "paginaInicial" => "89"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2918253"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stratum corneum defensive functions&#58; an integrated view"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;M&#46; Elias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2005.23668.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "183"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16098026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between NMF &#40;lactate and potassium&#41; content and the physical properties of the stratum corneum in healthy subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Nakagawa"
                            1 => "S&#46; Sakai"
                            2 => "M&#46; Matsumoto"
                            3 => "K&#46; Yamada"
                            4 => "M&#46; Nagano"
                            5 => "T&#46; Yuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2004.22317.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2004"
                        "volumen" => "122"
                        "paginaInicial" => "755"
                        "paginaFinal" => "763"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15086563"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How to choose a suitable emollient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pharm J"
                        "fecha" => "2004"
                        "volumen" => "273"
                        "paginaInicial" => "351"
                        "paginaFinal" => "353"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stratum corneum moisturization at the molecular level&#58; an update in relation to the dry skin cycle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;V&#46; Rawlings"
                            1 => "P&#46;J&#46; Matts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1747.2005.23726.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "124"
                        "paginaInicial" => "1099"
                        "paginaFinal" => "1110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15955083"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low humidity and microtrauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;J&#46;G&#46; Rycroft"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ind Med"
                        "fecha" => "1985"
                        "volumen" => "8"
                        "paginaInicial" => "371"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4073035"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ceramide and cholesterol composition of the skin of patients with atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Di Nardo"
                            1 => "P&#46; Werz"
                            2 => "A&#46; Giannetti"
                            3 => "S&#46; Deidenari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Dermatol Venereol"
                        "fecha" => "1998"
                        "volumen" => "78"
                        "paginaInicial" => "27"
                        "paginaFinal" => "30"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Filaggrin mutations in children with severe atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Morar"
                            1 => "W&#46;O&#46; Cookson"
                            2 => "J&#46;I&#46; Harper"
                            3 => "M&#46;F&#46; Moffatt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.jid.5700739"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2007"
                        "volumen" => "127"
                        "paginaInicial" => "1667"
                        "paginaFinal" => "1672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17301831"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The content of free amino acids in the stratum corneum is increased in senile xerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Takahashi"
                            1 => "T&#46; Tezuka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00403-003-0448-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res"
                        "fecha" => "2004"
                        "volumen" => "295"
                        "paginaInicial" => "448"
                        "paginaFinal" => "452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14762669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content&#44; and the expression of the filaggrin in the epidermis of hairless mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Katagiri"
                            1 => "J&#46; Sato"
                            2 => "J&#46; Nomura"
                            3 => "M&#46; Denda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Sci"
                        "fecha" => "2003"
                        "volumen" => "31"
                        "paginaInicial" => "29"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12615361"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Signaling networks in barrier homeostasis&#58; the mystery widens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;M&#46; Elias"
                            1 => "J&#46;C&#46; Ansel"
                            2 => "L&#46;D&#46; Woods"
                            3 => "K&#46;R&#46; Feingold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1996"
                        "volumen" => "132"
                        "paginaInicial" => "1505"
                        "paginaFinal" => "1506"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8961883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal pathogenesis of inflammatory dermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Elias"
                            1 => "L&#46;D&#46; Woods"
                            2 => "K&#46;R&#46; Feingold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Contact Dermat"
                        "fecha" => "1999"
                        "volumen" => "10"
                        "paginaInicial" => "119"
                        "paginaFinal" => "126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10444104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low humidity occupational dermatoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;J&#46;G&#46; Rycroft"
                            1 => "W&#46;D&#46;L&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Contact Dermatitis"
                        "fecha" => "1980"
                        "volumen" => "6"
                        "paginaInicial" => "488"
                        "paginaFinal" => "492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6452248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seasonal variation of skin resistance to irritants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Agner"
                            1 => "J&#46; Serup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1989"
                        "volumen" => "121"
                        "paginaInicial" => "323"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2803958"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of xerosis and ageing on epidermal proliferation and differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Engelke"
                            1 => "J&#46;M&#46; Jensen"
                            2 => "S&#46; Ekanayake-Mudiyanselage"
                            3 => "E&#46; Proksch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1997"
                        "volumen" => "137"
                        "paginaInicial" => "219"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9292070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New perspectives on epidermal barrier dysfunction in atopic dermatitis&#58; geneenvironment interactions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Cork"
                            1 => "D&#46;A&#46; Robinson"
                            2 => "Y&#46; Vasilopoulos"
                            3 => "A&#46; Ferguson"
                            4 => "M&#46; Moustafa"
                            5 => "A&#46; MacGowan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2006.04.042"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2006"
                        "volumen" => "118"
                        "paginaInicial" => "3"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16815133"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Werner"
                            1 => "M&#46; Lindberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "1985"
                        "volumen" => "65"
                        "paginaInicial" => "102"
                        "paginaFinal" => "105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2408409"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673605678890"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the hydration and water binding capacity in atopic skin and so-called dry skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Thune"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "1989"
                        "volumen" => "144"
                        "numero" => "Suppl"
                        "paginaInicial" => "133"
                        "paginaFinal" => "135"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "X-linked ichthyosis due to steroid sulphatase deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;J&#46; Shapiro"
                            1 => "R Weiss"
                            2 => "Webster&#46;"
                            3 => "J&#46;T&#46; Frances"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1978"
                        "volumen" => "1"
                        "paginaInicial" => "70"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6140424"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholesterol sulphate inhibits proteases that are involved in desquamation of stratum corneum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Sato"
                            1 => "M&#46; Denda"
                            2 => "J&#46; Nakinishi"
                            3 => "J&#46; Nomura"
                            4 => "J&#46; Koyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.1998.00244.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1998"
                        "volumen" => "111"
                        "paginaInicial" => "189"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9699715"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatitis de manos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Ram&#237;rez"
                            1 => "S&#46;E&#46; Jacob"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2006"
                        "volumen" => "97"
                        "paginaInicial" => "363"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16956515"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis&#58; changes in barrier function provide a sensitive indicator of disease activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Chamlin"
                            1 => "J&#46; Kao"
                            2 => "I&#46;J&#46; Freiden"
                            3 => "M&#46;Y&#46; Sheu"
                            4 => "A&#46;J&#46; Fowler"
                            5 => "J&#46;W&#46; Fluhr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "198"
                        "paginaFinal" => "208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12140465"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glycerol replacement corrects defective skin hydration&#44; elasticity and barrier function in aquaporin-3-deficient mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Hara"
                            1 => "A&#46;S&#46; Verkman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.1230416100"
                      "Revista" => array:6 [
                        "tituloSerie" => "PNAS"
                        "fecha" => "2003"
                        "volumen" => "100"
                        "paginaInicial" => "7360"
                        "paginaFinal" => "7365"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12771381"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etude in vitro du pouvoir antiprurigineux du glycocolle&#58; effet sur la d&#233;granulation des mastocytes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Paubert-Braquet"
                            1 => "G&#46; Lefran&#231;ois"
                            2 => "S&#46; Picquot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Th&#233;rapeutique"
                        "fecha" => "1992"
                        "volumen" => "95"
                        "paginaInicial" => "2"
                        "paginaFinal" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies on wound healing&#58; effects of calcium pantothenate on the migration&#44; proliferation and protein synthesis of human dermal fibroblasts in culture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46;I&#46; Weimann"
                            1 => "D&#46; Hermann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1024/0300-9831.69.2.113"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Vitam Nutr Res"
                        "fecha" => "1999"
                        "volumen" => "69"
                        "paginaInicial" => "113"
                        "paginaFinal" => "119"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10218148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of pantothenic acid on fibroblastic cell cultures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Lacroix"
                            1 => "E&#46; Didier"
                            2 => "J&#46;F&#46; Grenier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Res Exp Med"
                        "fecha" => "1988"
                        "volumen" => "188"
                        "paginaInicial" => "391"
                        "paginaFinal" => "396"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of bepanthen ointment on the graft-donor site wound-healing model&#58; double-blind biometrological and clinical study&#44; with assessment by the patient versus the vehicle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Girard"
                            1 => "A&#46; Beraud"
                            2 => "C&#46; Goujon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nouv Dermatol"
                        "fecha" => "1998"
                        "volumen" => "17"
                        "paginaInicial" => "559"
                        "paginaFinal" => "570"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000009900000009/v1_201304241441/S1578219008703433/v1_201304241441/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6224"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Review article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000009/v1_201304241441/S1578219008703433/v1_201304241441/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703433?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 5 6 11
2024 Octubre 74 73 147
2024 Septiembre 73 56 129
2024 Agosto 95 99 194
2024 Julio 79 80 159
2024 Junio 69 84 153
2024 Mayo 65 52 117
2024 Abril 60 32 92
2024 Marzo 82 55 137
2024 Febrero 56 48 104
2024 Enero 65 73 138
2023 Diciembre 68 53 121
2023 Noviembre 64 47 111
2023 Octubre 60 56 116
2023 Septiembre 59 49 108
2023 Agosto 42 29 71
2023 Julio 79 75 154
2023 Junio 63 27 90
2023 Mayo 44 33 77
2023 Abril 44 28 72
2023 Marzo 30 45 75
2023 Febrero 24 41 65
2023 Enero 31 44 75
2022 Diciembre 30 50 80
2022 Noviembre 19 36 55
2022 Octubre 13 40 53
2022 Septiembre 14 57 71
2022 Agosto 16 49 65
2022 Julio 15 88 103
2022 Junio 37 46 83
2022 Mayo 56 61 117
2022 Abril 62 63 125
2022 Marzo 37 51 88
2022 Febrero 54 30 84
2022 Enero 31 49 80
2021 Diciembre 38 69 107
2021 Noviembre 49 58 107
2021 Octubre 46 55 101
2021 Septiembre 38 50 88
2021 Agosto 39 47 86
2021 Julio 35 42 77
2021 Junio 37 40 77
2021 Mayo 35 37 72
2021 Abril 44 80 124
2021 Marzo 85 73 158
2021 Febrero 86 56 142
2021 Enero 40 42 82
2020 Diciembre 62 38 100
2020 Noviembre 29 29 58
2020 Octubre 46 20 66
2020 Septiembre 39 17 56
2020 Agosto 32 78 110
2020 Julio 37 35 72
2020 Junio 31 28 59
2020 Mayo 25 35 60
2020 Abril 26 31 57
2020 Marzo 19 32 51
2020 Febrero 3 23 26
2020 Enero 3 11 14
2019 Diciembre 0 32 32
2019 Noviembre 0 32 32
2019 Octubre 0 37 37
2019 Septiembre 0 35 35
2019 Agosto 0 17 17
2019 Julio 0 28 28
2019 Junio 0 21 21
2019 Mayo 1 129 130
2019 Abril 0 79 79
2019 Marzo 0 18 18
2019 Febrero 0 32 32
2019 Enero 1 26 27
2018 Diciembre 1 10 11
2018 Noviembre 0 3 3
2018 Octubre 0 1 1
2018 Septiembre 1 13 14
2018 Agosto 0 27 27
2018 Julio 0 21 21
2018 Junio 0 26 26
2018 Mayo 0 10 10
2018 Abril 0 23 23
2018 Marzo 0 40 40
2018 Febrero 16 46 62
2018 Enero 14 29 43
2017 Diciembre 21 42 63
2017 Noviembre 25 67 92
2017 Octubre 18 53 71
2017 Septiembre 21 51 72
2017 Agosto 27 44 71
2017 Julio 20 63 83
2017 Junio 33 69 102
2017 Mayo 35 48 83
2017 Abril 35 81 116
2017 Marzo 45 90 135
2017 Febrero 24 96 120
2017 Enero 31 98 129
2016 Diciembre 31 55 86
2016 Noviembre 27 76 103
2016 Octubre 29 122 151
2016 Septiembre 42 90 132
2016 Agosto 56 48 104
2016 Julio 35 37 72
2016 Junio 12 35 47
2016 Mayo 5 24 29
2016 Abril 6 17 23
2016 Marzo 3 1 4
2016 Febrero 5 13 18
2016 Enero 6 13 19
2015 Diciembre 13 15 28
2015 Noviembre 19 17 36
2015 Octubre 6 14 20
2015 Septiembre 7 1 8
2015 Agosto 13 10 23
2015 Julio 35 65 100
2015 Junio 42 42 84
2015 Mayo 63 45 108
2015 Abril 45 49 94
2015 Marzo 39 42 81
2015 Febrero 30 48 78
2015 Enero 37 54 91
2014 Diciembre 28 40 68
2014 Noviembre 30 35 65
2014 Octubre 31 38 69
2014 Septiembre 29 32 61
2014 Agosto 34 31 65
2014 Julio 48 33 81
2014 Junio 49 16 65
2014 Mayo 38 18 56
2014 Abril 35 13 48
2014 Marzo 45 55 100
2014 Febrero 40 49 89
2014 Enero 50 44 94
2013 Diciembre 38 39 77
2013 Noviembre 34 67 101
2013 Octubre 37 48 85
2013 Septiembre 34 52 86
2013 Agosto 33 88 121
2013 Julio 20 106 126
2013 Junio 19 102 121
2013 Mayo 54 81 135
2013 Abril 22 78 100
2013 Marzo 28 73 101
2013 Febrero 32 27 59
2013 Enero 20 10 30
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?