Original article
Localized Cutaneous Amyloidosis Secondary to Porokeratosis: A Retrospective Histopathologic Study of 30 Patients
Amiloidosis Cutánea Localizada Secundaria A Poroqueratosis. Estudio Histopatológico Retrospectivo de 30 Pacientes
A. Ramírez-Santos
, O. Suárez-Amor, L. Pérez-Pérez, M. Loureiro, C. Peteiro, J. Toribio
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jaime.toribio@usc.es
Correspondence: Departamento de Dermatología, Facultad de Medicina, C/ San Francisco, s/n 15782 Santiago de Compostela, La Coruña, Spain.
Correspondence: Departamento de Dermatología, Facultad de Medicina, C/ San Francisco, s/n 15782 Santiago de Compostela, La Coruña, Spain.
Servicio de Dermatología, Facultad de Medicina, Santiago de Compostela, La Coruña, Spain
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Guiote-Domínguez, A. Muñoz-Hoyos, M.T. Gutiérrez-Salmerón" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.V." "apellidos" => "Guiote-Domínguez" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Muñoz-Hoyos" ] 2 => array:2 [ "nombre" => "M.T." "apellidos" => "Gutiérrez-Salmerón" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703305?idApp=UINPBA000044" "url" => "/15782190/0000009900000008/v1_201304241439/S1578219008703305/v1_201304241439/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Localized Cutaneous Amyloidosis Secondary to Porokeratosis: A Retrospective Histopathologic Study of 30 Patients" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "639" "paginaFinal" => "643" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Ramírez-Santos, O. Suárez-Amor, L. Pérez-Pérez, M. Loureiro, C. Peteiro, J. Toribio" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Ramírez-Santos" "email" => array:1 [ 0 => "jaime.toribio@usc.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Suárez-Amor" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Pérez-Pérez" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Loureiro" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Peteiro" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Toribio" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Facultad de Medicina, Santiago de Compostela, La Coruña, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Departamento de Dermatología, Facultad de Medicina, C/ San Francisco, s/n 15782 Santiago de Compostela, La Coruña, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Amiloidosis Cutánea Localizada Secundaria A Poroqueratosis. Estudio Histopatológico Retrospectivo de 30 Pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84275" "palabras" => array:3 [ 0 => "porokeratosis" 1 => "amyloid" 2 => "secondary amyloidosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84276" "palabras" => array:3 [ 0 => "poroqueratosis" 1 => "amiloide" 2 => "amiloidosis secundaria" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Porokeratosis is a rare disorder of keratinization. The presence of amyloid deposits has been observed in inflammatory and tumoral skin diseases.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine the frequency of cutaneous amyloidosis in histology samples from various types of porokeratosis diagnosed in our department from 1988 to 2005.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Thirty patients were selected and 34 biopsies of lesions clinically and histologically compatible with porokeratosis were performed. Sections were stained with hematoxylin-eosin and thioflavin T.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Amyloid deposits were observed in 11 biopsies from 9 patients. Most were women in their sixties, with disseminated superficial actinic porokeratosis that had begun at least 5 years earlier. No notable histologic differences were observed between porokeratosis specimens with and without amyloid deposits.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The coexistence of porokeratosis and amyloidosis is a rare occurrence but may be underdiagnosed. In our opinion, the advanced age of the patients and the chronic nature of the lesions would have been predisposing factors for amyloid deposition. The possibility of racial or genetic influences, however, cannot be ruled out.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Las poroqueratosis son alteraciones de la queratinización poco frecuentes. La presencia de material amiloide se ha observado en dermatosis de etiología inflamatoria y tumoral.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar la incidencia de amiloidosis cutánea en las muestras histológicas de distintos tipos de poroqueratosis diagnosticados en nuestro servicio entre 1988-2005.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 30 pacientes y se realizaron 34 biopsias de lesiones compatibles clínica e histológicamente con poroqueratosis. Se realizaron tinciones con hematoxilina-eosina y tioflavina T en todas ellas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se detectaron depósitos de amiloide en 11 biopsias que pertenecían a 9 pacientes. La mayoría eran mujeres en la sexta década de la vida, con la variante de poroqueratosis actínica superficial diseminada y con un tiempo de evolución superior a 5 años. No se encontraron diferencias histológicas significativas entre las biopsias de poroqueratosis con amiloide y sin él, a excepción del material anómalo.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La coexistencia de poroqueratosis y amiloidosis es un hecho poco frecuente, posiblemente infradiagnosticado. Consideramos que la edad avanzada y la cronicidad de las lesiones serían factores predisponentes, sin poder descartarse una implicación racial o genética.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 10 | 7 | 17 |
| 2024 Octubre | 57 | 43 | 100 |
| 2024 Septiembre | 46 | 22 | 68 |
| 2024 Agosto | 80 | 54 | 134 |
| 2024 Julio | 58 | 33 | 91 |
| 2024 Junio | 65 | 32 | 97 |
| 2024 Mayo | 57 | 40 | 97 |
| 2024 Abril | 46 | 34 | 80 |
| 2024 Marzo | 57 | 46 | 103 |
| 2024 Febrero | 48 | 35 | 83 |
| 2024 Enero | 50 | 47 | 97 |
| 2023 Diciembre | 40 | 30 | 70 |
| 2023 Noviembre | 45 | 38 | 83 |
| 2023 Octubre | 37 | 33 | 70 |
| 2023 Septiembre | 35 | 30 | 65 |
| 2023 Agosto | 27 | 22 | 49 |
| 2023 Julio | 34 | 73 | 107 |
| 2023 Junio | 51 | 18 | 69 |
| 2023 Mayo | 51 | 35 | 86 |
| 2023 Abril | 32 | 27 | 59 |
| 2023 Marzo | 50 | 40 | 90 |
| 2023 Febrero | 24 | 19 | 43 |
| 2023 Enero | 31 | 25 | 56 |
| 2022 Diciembre | 36 | 43 | 79 |
| 2022 Noviembre | 12 | 21 | 33 |
| 2022 Octubre | 13 | 18 | 31 |
| 2022 Septiembre | 18 | 35 | 53 |
| 2022 Agosto | 20 | 45 | 65 |
| 2022 Julio | 8 | 25 | 33 |
| 2022 Junio | 15 | 30 | 45 |
| 2022 Mayo | 24 | 40 | 64 |
| 2022 Abril | 56 | 59 | 115 |
| 2022 Marzo | 34 | 80 | 114 |
| 2022 Febrero | 30 | 42 | 72 |
| 2022 Enero | 26 | 43 | 69 |
| 2021 Diciembre | 20 | 49 | 69 |
| 2021 Noviembre | 43 | 48 | 91 |
| 2021 Octubre | 47 | 52 | 99 |
| 2021 Septiembre | 30 | 35 | 65 |
| 2021 Agosto | 33 | 30 | 63 |
| 2021 Julio | 23 | 29 | 52 |
| 2021 Junio | 24 | 42 | 66 |
| 2021 Mayo | 37 | 50 | 87 |
| 2021 Abril | 72 | 33 | 105 |
| 2021 Marzo | 123 | 28 | 151 |
| 2021 Febrero | 59 | 27 | 86 |
| 2021 Enero | 32 | 24 | 56 |
| 2020 Diciembre | 35 | 18 | 53 |
| 2020 Noviembre | 19 | 25 | 44 |
| 2020 Octubre | 17 | 11 | 28 |
| 2020 Septiembre | 28 | 12 | 40 |
| 2020 Agosto | 30 | 15 | 45 |
| 2020 Julio | 18 | 8 | 26 |
| 2020 Junio | 19 | 25 | 44 |
| 2020 Mayo | 27 | 20 | 47 |
| 2020 Abril | 16 | 21 | 37 |
| 2020 Marzo | 20 | 24 | 44 |
| 2020 Febrero | 1 | 6 | 7 |
| 2020 Enero | 0 | 8 | 8 |
| 2019 Diciembre | 0 | 4 | 4 |
| 2019 Noviembre | 0 | 6 | 6 |
| 2019 Octubre | 0 | 2 | 2 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 2 | 2 |
| 2019 Julio | 0 | 10 | 10 |
| 2019 Junio | 0 | 4 | 4 |
| 2019 Mayo | 2 | 37 | 39 |
| 2019 Abril | 0 | 1 | 1 |
| 2019 Marzo | 0 | 12 | 12 |
| 2019 Febrero | 3 | 6 | 9 |
| 2019 Enero | 1 | 0 | 1 |
| 2018 Diciembre | 0 | 4 | 4 |
| 2018 Noviembre | 2 | 1 | 3 |
| 2018 Octubre | 4 | 0 | 4 |
| 2018 Septiembre | 2 | 1 | 3 |
| 2018 Agosto | 0 | 4 | 4 |
| 2018 Julio | 0 | 1 | 1 |
| 2018 Junio | 0 | 2 | 2 |
| 2018 Mayo | 0 | 5 | 5 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 1 | 0 | 1 |
| 2018 Febrero | 11 | 8 | 19 |
| 2018 Enero | 19 | 9 | 28 |
| 2017 Diciembre | 16 | 6 | 22 |
| 2017 Noviembre | 14 | 6 | 20 |
| 2017 Octubre | 19 | 4 | 23 |
| 2017 Septiembre | 15 | 4 | 19 |
| 2017 Agosto | 25 | 7 | 32 |
| 2017 Julio | 18 | 3 | 21 |
| 2017 Junio | 31 | 14 | 45 |
| 2017 Mayo | 31 | 8 | 39 |
| 2017 Abril | 18 | 15 | 33 |
| 2017 Marzo | 15 | 51 | 66 |
| 2017 Febrero | 18 | 9 | 27 |
| 2017 Enero | 15 | 9 | 24 |
| 2016 Diciembre | 31 | 8 | 39 |
| 2016 Noviembre | 26 | 6 | 32 |
| 2016 Octubre | 29 | 16 | 45 |
| 2016 Septiembre | 42 | 6 | 48 |
| 2016 Agosto | 28 | 3 | 31 |
| 2016 Julio | 24 | 5 | 29 |
| 2016 Junio | 9 | 2 | 11 |
| 2016 Mayo | 9 | 4 | 13 |
| 2016 Abril | 6 | 4 | 10 |
| 2016 Marzo | 1 | 8 | 9 |
| 2016 Febrero | 6 | 10 | 16 |
| 2016 Enero | 7 | 10 | 17 |
| 2015 Diciembre | 7 | 7 | 14 |
| 2015 Noviembre | 10 | 10 | 20 |
| 2015 Octubre | 6 | 1 | 7 |
| 2015 Septiembre | 4 | 5 | 9 |
| 2015 Agosto | 8 | 2 | 10 |
| 2015 Julio | 15 | 7 | 22 |
| 2015 Junio | 14 | 5 | 19 |
| 2015 Mayo | 47 | 8 | 55 |
| 2015 Abril | 21 | 12 | 33 |
| 2015 Marzo | 30 | 9 | 39 |
| 2015 Febrero | 21 | 6 | 27 |
| 2015 Enero | 12 | 8 | 20 |
| 2014 Diciembre | 7 | 7 | 14 |
| 2014 Noviembre | 25 | 9 | 34 |
| 2014 Octubre | 17 | 9 | 26 |
| 2014 Septiembre | 24 | 12 | 36 |
| 2014 Agosto | 31 | 26 | 57 |
| 2014 Julio | 30 | 22 | 52 |
| 2014 Junio | 24 | 16 | 40 |
| 2014 Mayo | 29 | 21 | 50 |
| 2014 Abril | 25 | 11 | 36 |
| 2014 Marzo | 30 | 20 | 50 |
| 2014 Febrero | 22 | 11 | 33 |
| 2014 Enero | 43 | 13 | 56 |
| 2013 Diciembre | 28 | 17 | 45 |
| 2013 Noviembre | 21 | 28 | 49 |
| 2013 Octubre | 16 | 20 | 36 |
| 2013 Septiembre | 26 | 14 | 40 |
| 2013 Agosto | 23 | 43 | 66 |
| 2013 Julio | 15 | 30 | 45 |
| 2013 Junio | 21 | 28 | 49 |
| 2013 Mayo | 23 | 33 | 56 |
| 2013 Abril | 16 | 36 | 52 |
| 2013 Marzo | 23 | 19 | 42 |
| 2013 Febrero | 23 | 12 | 35 |
| 2013 Enero | 13 | 5 | 18 |
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